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Jing Hong Wang

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER

    Collapse Biography 
    Collapse education and training
    Beijing Medical University, Beijing, ChinaMD07/1996Basic Medicine
    Ohio State University, Columbus, OHMS12/1998Molecular Genetics
    University of Chicago, Chicago, ILPhD06/2004Immunology
    Collapse awards and honors
    2011 - 2014Boettcher Foundation Webb-Waring Early Career Investigator Award, University of Colorado
    2012 - 2015American Society of Hematology (ASH) Scholar, American Society of Hematology
    2012Outstanding Junior Faculty Award, National Jewish Health
    2017AAI Lustgarten-Thermo Fisher Scientific Memorial Award, American Association of Immunologist

    Collapse Research 
    Collapse research activities and funding
    R01CA166325     (WANG, JING HONG)Jul 9, 2012 - Apr 30, 2017
    NIH/NCI
    Mechanisms promoting translocations and mature B cell lymphomas
    Role: Principal Investigator
    R21AI110777     (WANG, JING HONG)Nov 6, 2014 - Oct 31, 2016
    NIH/NIAID
    Role of Target DNA sequences in mutation and DNA Break Generation
    Role: Principal Investigator
    R21CA184707     (WANG, JING HONG)Dec 1, 2014 - Nov 30, 2016
    NIH/NCI
    Genomic instability mediated via differential DNA repair mechanisms in B cells
    Role: Principal Investigator
    R21AI133110     (WANG, JING HONG)Jan 15, 2018 - Dec 31, 2019
    NIH/NIAID
    A Novel Approach to Evaluate Genetic Variants in Primary Antibody Deficiency
    Role: Principal Investigator
    R01DE027329     (WANG, JING HONG)Aug 9, 2018 - Jul 31, 2023
    NIH/NIDCR
    Elucidating Mechanism of Immune Evasion in Head and Neck Cancers
    Role: Principal Investigator
    R01DE028420     (WANG, XIAO-JING)Jan 1, 2019 - Dec 31, 2023
    NIH/NIDCR
    Mechanisms of dual inhibition of TGFbeta/PD-L1 in HNSCC
    Role: Principal Investigator
    R01CA229174     (WANG, JING HONG)Apr 1, 2019 - Mar 31, 2024
    NIH/NCI
    Developing newly combined therapeutic strategies for mature B cell lymphoma
    Role: Principal Investigator
    R01CA249940     (WANG, JING HONG)Jun 8, 2020 - May 31, 2025
    NIH/NCI
    B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Morton JJ, Alzofon N, Keysar SB, Chimed TS, Reisinger J, Perrenoud L, Le PN, Nieto C, Gomez K, Miller B, Yeager R, Gao D, Tan AC, Somerset H, Medina T, Wang XJ, Wang JH, Robinson W, Roop DR, Gonzalez R, Jimeno A. Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft. Mol Cancer Res. 2020 Oct 21. PMID: 33087417.
      View in: PubMed
    2. Wang JH. Why the Outcome of Anti-Tumor Immune Responses is Heterogeneous: A Novel Idea in the Context of Immunological Heterogeneity in Cancers. Bioessays. 2020 10; 42(10):e2000024. PMID: 32767371.
      View in: PubMed
    3. Chen Z, Krinsky A, Woolaver RA, Wang X, Chen SMY, Popolizio V, Xie P, Wang JH. TRAF3 Acts as a Checkpoint of B Cell Receptor Signaling to Control Antibody Class Switch Recombination and Anergy. J Immunol. 2020 Aug 01; 205(3):830-841. PMID: 32591397.
      View in: PubMed
    4. Wang X, Waschke BC, Woolaver RA, Chen SMY, Chen Z, Wang JH. MHC class I-independent activation of virtual memory CD8 T cells induced by chemotherapeutic agent-treated cancer cells. Cell Mol Immunol. 2020 May 19. PMID: 32427883.
      View in: PubMed
    5. Wang X, Waschke BC, Woolaver RA, Chen SMY, Chen Z, Wang JH. HDAC inhibitors overcome immunotherapy resistance in B-cell lymphoma. Protein Cell. 2020 07; 11(7):472-482. PMID: 32162275.
      View in: PubMed
    6. Chen SMY, Krinsky AL, Woolaver RA, Wang X, Chen Z, Wang JH. Tumor immune microenvironment in head and neck cancers. Mol Carcinog. 2020 07; 59(7):766-774. PMID: 32017286.
      View in: PubMed
    7. Wang X, Waschke BC, Woolaver RA, Chen Z, Zhang G, Piscopio AD, Liu X, Wang JH. Histone Deacetylase Inhibition Sensitizes PD1 Blockade-Resistant B-cell Lymphomas. Cancer Immunol Res. 2019 08; 7(8):1318-1331. PMID: 31235619.
      View in: PubMed
    8. Wu FL, Nolan K, Strait AA, Bian L, Nguyen KA, Wang JH, Jimeno A, Zhou HM, Young CD, Wang XJ. Macrophages Promote Growth of Squamous Cancer Independent of T cells. J Dent Res. 2019 07; 98(8):896-903. PMID: 31189369.
      View in: PubMed
    9. Hernandez AL, Young CD, Wang JH, Wang XJ. Lessons learned from SMAD4 loss in squamous cell carcinomas. Mol Carcinog. 2019 09; 58(9):1648-1655. PMID: 31140647.
      View in: PubMed
    10. Chen Z, Wang JH. Signaling control of antibody isotype switching. Adv Immunol. 2019; 141:105-164. PMID: 30904131.
      View in: PubMed
    11. Woolaver RA, Wang X, Dollin Y, Xie P, Wang JH, Chen Z. TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-?B1 Activation. J Immunol. 2018 12 01; 201(11):3421-3430. PMID: 30341187.
      View in: PubMed
    12. Wang X, Chen Z, Mishra AK, Silva A, Ren W, Pan Z, Wang JH. Chemotherapy-induced differential cell cycle arrest in B-cell lymphomas affects their sensitivity to Wee1 inhibition. Haematologica. 2018 03; 103(3):466-476. PMID: 29217775.
      View in: PubMed
    13. Mishra AK, Kadoishi T, Wang X, Driver E, Chen Z, Wang XJ, Wang JH. Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors. Oncotarget. 2016 Dec 06; 7(49):81341-81356. PMID: 27835902.
      View in: PubMed
    14. Chen Z, Gowan K, Leach SM, Viboolsittiseri SS, Mishra AK, Kadoishi T, Diener K, Gao B, Jones K, Wang JH. Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing. BMC Genomics. 2016 10 21; 17(1):823. PMID: 27769169.
      View in: PubMed
    15. Chen Z, Eder MD, Elos MT, Viboolsittiseri SS, Chen X, Wang JH. Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions. J Immunol. 2016 Mar 01; 196(5):2335-47. PMID: 26810227.
      View in: PubMed
    16. Chen Z, Elos MT, Viboolsittiseri SS, Gowan K, Leach SM, Rice M, Eder MD, Jones K, Wang JH. Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity. J Hematol Oncol. 2016 Jan 07; 9:2. PMID: 26740101.
      View in: PubMed
    17. Yeap LS, Hwang JK, Du Z, Meyers RM, Meng FL, Jakubauskaite A, Liu M, Mani V, Neuberg D, Kepler TB, Wang JH, Alt FW. Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes. Cell. 2015 Nov 19; 163(5):1124-1137. PMID: 26582132.
      View in: PubMed
    18. Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 01; 195(11):5461-5471. PMID: 26500350.
      View in: PubMed
    19. Chen Z, Ranganath S, Viboolsittiseri SS, Eder MD, Chen X, Elos MT, Yuan S, Hansen E, Wang JH. Correction: AID-Initiated DNA Lesions Are Differentially Processed in Distinct B Cell Populations. J Immunol. 2015 Feb 01; 194(3):1383. PMID: 25596302.
      View in: PubMed
    20. Chen Z, Ranganath S, Viboolsittiseri SS, Eder MD, Chen X, Elos MT, Yuan S, Yuan S, Hansen E, Wang JH. AID-initiated DNA lesions are differentially processed in distinct B cell populations. J Immunol. 2014 Dec 01; 193(11):5545-56. PMID: 25339658.
      View in: PubMed
    21. Chen Z, Wang JH. Generation and repair of AID-initiated DNA lesions in B lymphocytes. Front Med. 2014 Jun; 8(2):201-16. PMID: 24748462.
      View in: PubMed
    22. Lu Y, Wu Y, Feng X, Shen R, Wang JH, Fallahi M, Li W, Yang C, Hankey W, Zhao W, Ganju RK, Li MO, Cleveland JL, Zou X. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis. J Clin Invest. 2014 Apr; 124(4):1672-84. PMID: 24614102.
      View in: PubMed
    23. Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep; 43(9):2473-83. PMID: 23696226.
      View in: PubMed
    24. Wang JH. The role of activation-induced deaminase in antibody diversification and genomic instability. Immunol Res. 2013 Mar; 55(1-3):287-97. PMID: 22956489.
      View in: PubMed
    25. Chen Z, Wang JH. Impact of chromosomal translocation and genomic instability on personalized medicine. Per Med. 2013 Mar; 10(2):111-114. PMID: 29758842.
      View in: PubMed
    26. Chen Z, Yan CT, Dou Y, Viboolsittiseri SS, Wang JH. The role of a newly identified SET domain-containing protein, SETD3, in oncogenesis. Haematologica. 2013 May; 98(5):739-43. PMID: 23065515.
      View in: PubMed
    27. Chen Z, Viboolsittiseri SS, O'Connor BP, Wang JH. Target DNA sequence directly regulates the frequency of activation-induced deaminase-dependent mutations. J Immunol. 2012 Oct 15; 189(8):3970-82. PMID: 22962683.
      View in: PubMed
    28. Wang JH. Mechanisms and impacts of chromosomal translocations in cancers. Front Med. 2012 Sep; 6(3):263-74. PMID: 22865120.
      View in: PubMed
    29. Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2473-8. PMID: 22308491.
      View in: PubMed
    30. Jeevan-Raj BP, Robert I, Heyer V, Page A, Wang JH, Cammas F, Alt FW, Losson R, Reina-San-Martin B. Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination. J Exp Med. 2011 Aug 01; 208(8):1649-60. PMID: 21746811.
      View in: PubMed
    31. Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. J Exp Med. 2010 Feb 15; 207(2):417-27. PMID: 20142431.
      View in: PubMed
    32. Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, Recher M, Andersson EM, Zha S, Giliani S, Terhorst C, Alt FW, Yan CT. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3024-9. PMID: 20133615.
      View in: PubMed
    33. Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3034-9. PMID: 20133803.
      View in: PubMed
    34. Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 2009 Jul 09; 460(7252):231-6. PMID: 19587764.
      View in: PubMed
    35. Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med. 2008 Dec 22; 205(13):3079-90. PMID: 19064702.
      View in: PubMed
    36. Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW. Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol. 2007; 94:157-214. PMID: 17560275.
      View in: PubMed
    37. Lee Y, Chin RK, Christiansen P, Sun Y, Tumanov AV, Wang J, Chervonsky AV, Fu YX. Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structure. Immunity. 2006 Sep; 25(3):499-509. PMID: 16934497.
      View in: PubMed
    38. Wang YG, Kim KD, Wang J, Yu P, Fu YX. Stimulating lymphotoxin beta receptor on the dendritic cells is critical for their homeostasis and expansion. J Immunol. 2005 Nov 15; 175(10):6997-7002. PMID: 16272360.
      View in: PubMed
    39. Anders RA, Subudhi SK, Wang J, Pfeffer K, Fu YX. Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol. 2005 Jul 15; 175(2):1295-300. PMID: 16002734.
      View in: PubMed
    40. Wang J, Anders RA, Wang Y, Turner JR, Abraham C, Pfeffer K, Fu YX. The critical role of LIGHT in promoting intestinal inflammation and Crohn's disease. J Immunol. 2005 Jun 15; 174(12):8173-82. PMID: 15944326.
      View in: PubMed
    41. Wang J, Fu YX. Tumor necrosis factor family members and inflammatory bowel disease. Immunol Rev. 2005 Apr; 204:144-55. PMID: 15790356.
      View in: PubMed
    42. Wang Y, Subudhi SK, Anders RA, Lo J, Sun Y, Blink S, Wang Y, Wang J, Liu X, Mink K, Degrandi D, Pfeffer K, Fu YX. The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses. J Clin Invest. 2005 Mar; 115(3):711-7. PMID: 15696194.
      View in: PubMed
    43. Zarrin AA, Tian M, Wang J, Borjeson T, Alt FW. Influence of switch region length on immunoglobulin class switch recombination. Proc Natl Acad Sci U S A. 2005 Feb 15; 102(7):2466-70. PMID: 15684074.
      View in: PubMed
    44. Wang J, Anders RA, Wu Q, Peng D, Cho JH, Sun Y, Karaliukas R, Kang HS, Turner JR, Fu YX. Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy. J Clin Invest. 2004 Mar; 113(6):826-35. PMID: 15067315.
      View in: PubMed
    45. Yu P, Lee Y, Liu W, Chin RK, Wang J, Wang Y, Schietinger A, Philip M, Schreiber H, Fu YX. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol. 2004 Feb; 5(2):141-9. PMID: 14704792.
      View in: PubMed
    46. Wang J, Fu YX. The role of LIGHT in T cell-mediated immunity. Immunol Res. 2004; 30(2):201-14. PMID: 15477661.
      View in: PubMed
    47. Wang J and Fu Y-X. The Role of LIGHT in Autoimmunity. The TNF Superfamily. 2004.
    48. Chin R, Wang J, Fu YX. Lymphoid microenvironment in the gut for immunoglobulin A and inflammation. Immunol Rev. 2003 Oct; 195:190-201. PMID: 12969319.
      View in: PubMed
    49. Wang J, Fu YX. LIGHT (a cellular ligand for herpes virus entry mediator and lymphotoxin receptor)-mediated thymocyte deletion is dependent on the interaction between TCR and MHC/self-peptide. J Immunol. 2003 Apr 15; 170(8):3986-93. PMID: 12682226.
      View in: PubMed
    50. Wang J, Foster A, Chin R, Yu P, Sun Y, Wang Y, Pfeffer K, Fu YX. The complementation of lymphotoxin deficiency with LIGHT, a newly discovered TNF family member, for the restoration of secondary lymphoid structure and function. Eur J Immunol. 2002 Jul; 32(7):1969-79. PMID: 12115617.
      View in: PubMed
    51. Wang J, Lo JC, Foster A, Yu P, Chen HM, Wang Y, Tamada K, Chen L, Fu YX. The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT. J Clin Invest. 2001 Dec; 108(12):1771-80. PMID: 11748260.
      View in: PubMed
    52. Wang J, Chun T, Lo JC, Wu Q, Wang Y, Foster A, Roca K, Chen M, Tamada K, Chen L, Wang CR, Fu YX. The critical role of LIGHT, a TNF family member, in T cell development. J Immunol. 2001 Nov 01; 167(9):5099-105. PMID: 11673520.
      View in: PubMed
    53. Wu Q, Sun Y, Wang J, Lin X, Wang Y, Pegg LE, Fütterer A, Pfeffer K, Fu YX. Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell development. J Immunol. 2001 Feb 01; 166(3):1684-9. PMID: 11160211.
      View in: PubMed
    54. Wang Y, Wang J, Sun Y, Wu Q, Fu YX. Complementary effects of TNF and lymphotoxin on the formation of germinal center and follicular dendritic cells. J Immunol. 2001 Jan 01; 166(1):330-7. PMID: 11123309.
      View in: PubMed
    55. Wang Y, Huang G, Wang J, Molina H, Chaplin DD, Fu YX. Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin. Eur J Immunol. 2000 Aug; 30(8):2226-34. PMID: 10940914.
      View in: PubMed
    56. Wu Q, Wang Y, Wang J, Hedgeman EO, Browning JL, Fu YX. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med. 1999 Sep 06; 190(5):629-38. PMID: 10477548.
      View in: PubMed
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