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Alex J Polotsky

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN ARM

    Collapse Research 
    Collapse research activities and funding
    U10HD038998     (ALVERO, RUBEN)Jun 30, 2000 - Jun 30, 2016
    Colorado Reproductive Medicine Unit
    Role: Co-Principal Investigator

    R21HD060944     (POLOTSKY, ALEX JOEL)Sep 3, 2010 - Jul 31, 2013
    Vervet Monkey: Modeling Effects of Diet-Induced Obesity on Reproduction
    Role: Principal Investigator

    R01HD081162     (POLOTSKY, ALEX JOEL)Aug 28, 2015 - May 31, 2020
    Dysregulation of FSH in Obesity: Functional and Statistical Analysis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kallen A, Polotsky AJ, Johnson J. Untapped Reserves: Controlling Primordial Follicle Growth Activation. Trends Mol Med. 2018 Feb 13. PMID: 29452791.
      View in: PubMed
    2. Liu H, Polotsky AJ, Grunwald GK, Carlson NE. Bayesian analysis improves pulse secretion characterization in reproductive hormones. Syst Biol Reprod Med. 2018 Feb; 64(1):80-91. PMID: 29287490.
      View in: PubMed
    3. Roeca C, Polotsky AJ. Influenza vaccination in early pregnancy. Vaccine. 2017 Dec 21. PMID: 29275989.
      View in: PubMed
    4. Liu H, Carlson NE, Grunwald GK, Polotsky AJ. Modeling associations between latent event processes governing time series of pulsing hormones. Biometrics. 2017 Oct 31. PMID: 29088494.
      View in: PubMed
    5. Al-Safi ZA, Polotsky A, Chosich J, Roth L, Allshouse AA, Bradford AP, Santoro N. Evidence for disruption of normal circadian cortisol rhythm in women with obesity. Gynecol Endocrinol. 2017 Oct 25; 1-5. PMID: 29068243.
      View in: PubMed
    6. Aly JM, Polotsky AJ. Paternal Diet and Obesity: Effects on Reproduction. Semin Reprod Med. 2017 Jul; 35(4):313-317. PMID: 29036738.
      View in: PubMed
    7. Horton KW, Carlson NE, Grunwald GK, Mulvahill MJ, Polotsky AJ. A population-based approach to analyzing pulses in time series of hormone data. Stat Med. 2017 Jul 20; 36(16):2576-2589. PMID: 28393373.
      View in: PubMed
    8. Engmann L, Jin S, Sun F, Legro RS, Polotsky AJ, Hansen KR, Coutifaris C, Diamond MP, Eisenberg E, Zhang H, Santoro N. Racial and ethnic differences in the polycystic ovary syndrome metabolic phenotype. Am J Obstet Gynecol. 2017 05; 216(5):493.e1-493.e13. PMID: 28104402.
      View in: PubMed
    9. Styer AK, Jin S, Liu D, Wang B, Polotsky AJ, Christianson MS, Vitek W, Engmann L, Hansen K, Wild R, Legro RS, Coutifaris C, Alvero R, Robinson RD, Casson P, Christman GM, Christy A, Diamond MP, Eisenberg E, Zhang H, Santoro N. Association of uterine fibroids and pregnancy outcomes after ovarian stimulation-intrauterine insemination for unexplained infertility. Fertil Steril. 2017 Mar; 107(3):756-762.e3. PMID: 28089575.
      View in: PubMed
    10. Aubuchon M, Liu Y, Petroski GF, Thomas TR, Polotsky AJ. The impact of supervised weight loss and intentional weight regain on sex hormone binding globulin and testosterone in premenopausal women. Syst Biol Reprod Med. 2016 Aug; 62(4):283-9. PMID: 27192090.
      View in: PubMed
    11. Kuokkanen S, Polotsky AJ, Chosich J, Bradford AP, Jasinska A, Phang T, Santoro N, Appt SE. Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med. 2016 Aug; 62(4):227-42. PMID: 27187064; PMCID: PMC4996623 [Available on 08/01/17].
    12. Skaznik-Wikiel ME, Swindle DC, Allshouse AA, Polotsky AJ, McManaman JL. High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice. Biol Reprod. 2016 05; 94(5):108. PMID: 27030045; PMCID: PMC4939738 [Available on 05/01/17].
    13. Styer AK, Luke B, Vitek W, Christianson MS, Baker VL, Christy AY, Polotsky AJ. Factors associated with the use of elective single-embryo transfer and pregnancy outcomes in the United States, 2004-2012. Fertil Steril. 2016 07; 106(1):80-89. PMID: 26997248.
      View in: PubMed
    14. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Harris M, Bradford AP, Robledo C, Eckel RH, Polotsky AJ. Omega-3 Fatty Acid Supplementation Lowers Serum FSH in Normal Weight But Not Obese Women. J Clin Endocrinol Metab. 2016 Jan; 101(1):324-33. PMID: 26523525; PMCID: PMC4701838 [Available on 01/01/17].
    15. Al-Safi ZA, Liu H, Carlson NE, Chosich J, Lesh J, Robledo C, Bradford AP, Gee NA, Phang T, Santoro N, Kohrt W, Polotsky AJ. Estradiol Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese Women. J Clin Endocrinol Metab. 2015 Nov; 100(11):4372-81. PMID: 26425884; PMCID: PMC4702462 [Available on 11/01/16].
    16. Bradford AP, Jones K, Kechris K, Chosich J, Montague M, Warren WC, May MC, Al-Safi Z, Kuokkanen S, Appt SE, Polotsky AJ. Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One. 2015; 10(8):e0135163. PMID: 26258540; PMCID: PMC4530955.
    17. Polotsky AJ, Allshouse AA, Casson PR, Coutifaris C, Diamond MP, Christman GM, Schlaff WD, Alvero R, Trussell JC, Krawetz SA, Santoro N, Eisenberg E, Zhang H, Legro RS. Impact of Male and Female Weight, Smoking, and Intercourse Frequency on Live Birth in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2015 Jun; 100(6):2405-12. PMID: 25856211; PMCID: PMC4454812.
    18. Allshouse AA, Polotsky A, Crawford S, Chen HY, El Khoudary SR, Santoro N. Consistent ovulation may not be enough to make women healthy when approaching menopause: an update from the Study of Women's Health Across the Nation. Menopause. 2015 Mar; 22(3):267-74. PMID: 25714237; PMCID: PMC4341112.
    19. Merhi Z, Polotsky AJ, Bradford AP, Buyuk E, Chosich J, Phang T, Jindal S, Santoro N. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015 Oct; 22(10):1220-8. PMID: 25676576.
      View in: PubMed
    20. Al-Safi ZA, Polotsky AJ. Obesity and menopause. Best Pract Res Clin Obstet Gynaecol. 2015 May; 29(4):548-53. PMID: 25579233.
      View in: PubMed
    21. Skaznik-Wikiel ME, Polotsky AJ. The health pros and cons of continuous versus intermittent calorie restriction: more questions than answers. Maturitas. 2014 Nov; 79(3):275-8. PMID: 25216760.
      View in: PubMed
    22. Ryan A, Wang S, Alvero R, Polotsky AJ. Prolonged gonadotropin stimulation for assisted reproductive technology cycles is associated with decreased pregnancy rates for all women except for women with polycystic ovary syndrome. J Assist Reprod Genet. 2014 Jul; 31(7):837-42. PMID: 24865669; PMCID: PMC4096873.
    23. Trussell JC, Ohl DA, Krawetz SA, Snyder PJ, Polotsky AJ, Patrizio P, Christman GM. We need a prospective varicocelectomy trial. Fertil Steril. 2014 Jun; 101(6):1563-4.e1. PMID: 24726225; PMCID: PMC4052753.
    24. Roth LW, Allshouse AA, Bradshaw-Pierce EL, Lesh J, Chosich J, Kohrt W, Bradford AP, Polotsky AJ, Santoro N. Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women. Clin Endocrinol (Oxf). 2014 Sep; 81(3):418-25. PMID: 24576183; PMCID: PMC4115008.
    25. Roth LW, Bradshaw-Pierce EL, Allshouse AA, Lesh J, Chosich J, Bradford AP, Polotsky AJ, Santoro N. Evidence of GnRH antagonist escape in obese women. J Clin Endocrinol Metab. 2014 May; 99(5):E871-5. PMID: 24650013; PMCID: PMC4010706.
    26. Ross LA, Polotsky AJ, Kucherov A, Bradford AP, Lesh J, Chosich J, Gee N, Santoro N. Profound reduction of ovarian estrogen by aromatase inhibition in obese women. Obesity (Silver Spring). 2014 Jun; 22(6):1464-9. PMID: 24482405; PMCID: PMC4037337.
    27. Polotsky AJ, Allshouse AA, Crawford SL, Harlow SD, Khalil N, Kazlauskaite R, Santoro N, Legro RS. Hyperandrogenic oligomenorrhea and metabolic risks across menopausal transition. J Clin Endocrinol Metab. 2014 Jun; 99(6):2120-7. PMID: 24517154; PMCID: PMC4037727.
    28. Berger DS, Zapantis A, Merhi Z, Younger J, Polotsky AJ, Jindal SK. Embryo quality but not pronuclear score is associated with clinical pregnancy following IVF. J Assist Reprod Genet. 2014 Mar; 31(3):279-83. PMID: 24390678; PMCID: PMC3947071.
    29. Stephens SM, Pau FK, Yalcinkaya TM, May MC, Berga SL, Post MD, Appt SE, Polotsky AJ. Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med. 2013 Oct; 63(5):432-8. PMID: 24210020; PMCID: PMC3796754.
    30. Roth LW, Allshouse AA, Lesh J, Polotsky AJ, Santoro N. The correlation between self-reported and measured height, weight, and BMI in reproductive age women. Maturitas. 2013 Oct; 76(2):185-8. PMID: 23958434; PMCID: PMC3816555.
    31. Stephens SM, Polotsky AJ. Big enough for an aromatase inhibitor? How adiposity affects male fertility. Semin Reprod Med. 2013 Jul; 31(4):251-7. PMID: 23775380.
      View in: PubMed
    32. Merhi ZO, Keltz J, Zapantis A, Younger J, Berger D, Lieman HJ, Jindal SK, Polotsky AJ. Male adiposity impairs clinical pregnancy rate by in vitro fertilization without affecting day 3 embryo quality. Obesity (Silver Spring). 2013 Aug; 21(8):1608-12. PMID: 23754329.
      View in: PubMed
    33. Al-Safi ZA, Russ PD, Post MD, Polotsky AJ. Adenomyosis within a uterine septum in a patient with secondary infertility. Gynecol Endocrinol. 2013 Aug; 29(8):804-6. PMID: 23741967.
      View in: PubMed
    34. Shaum KM, Polotsky AJ. Nutrition and reproduction: is there evidence to support a "Fertility Diet" to improve mitochondrial function? Maturitas. 2013 Apr; 74(4):309-12. PMID: 23376023; PMCID: PMC4019337.
    35. Ross LA, Polotsky AJ. Metabolic correlates of menopause: an update. Curr Opin Obstet Gynecol. 2012 Dec; 24(6):402-7. PMID: 23138438.
      View in: PubMed
    36. Kulak D, Polotsky AJ. Should the ketogenic diet be considered for enhancing fertility? Maturitas. 2013 Jan; 74(1):10-3. PMID: 23122539.
      View in: PubMed
    37. Harris ID, Polotsky AJ. SGI 2012: what's new in obstetrics/gynecology and reproductive medicine: an update from the Society for Gynecologic Investigation. Womens Health (Lond). 2012 Jul; 8(4):359-61. PMID: 22757726.
      View in: PubMed
    38. Polotsky AJ. Does menopause make your heart sick? Not according to MONET. Menopause. 2012 Jul; 19(7):722-3. PMID: 22735097.
      View in: PubMed
    39. Polotsky HN, Brokhin M, Omry G, Polotsky AJ, Tuttle RM. Iatrogenic hyperthyroidism does not promote weight loss or prevent ageing-related increases in body mass in thyroid cancer survivors. Clin Endocrinol (Oxf). 2012 Apr; 76(4):582-5. PMID: 22004309.
      View in: PubMed
    40. Polotsky AJ, Allshouse A, Crawford SL, Harlow SD, Khalil N, Santoro N, Legro RS. Relative contributions of oligomenorrhea and hyperandrogenemia to the risk of metabolic syndrome in midlife women. J Clin Endocrinol Metab. 2012 Jun; 97(6):E868-77. PMID: 22466350; PMCID: PMC3387411.
    41. Roth LW, Polotsky AJ. Can we live longer by eating less? A review of caloric restriction and longevity. Maturitas. 2012 Apr; 71(4):315-9. PMID: 22281163.
      View in: PubMed
    42. Trussell JC, Christman GM, Ohl DA, Legro RS, Krawetz SA, Snyder PJ, Patrizio P, Polotsky AJ, Diamond MP, Casson PR, Coutifaris C, Barnhart K, Brzyski RG, Schlaff WD, Meacham R, Shin D, Thomas T, Zhang M, Santoro N, Eisenberg E, Zhang H. Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertil Steril. 2011 Dec; 96(6):1299-305. PMID: 22130101; PMCID: PMC3243664.
    43. Karmon A, Hailpern SM, Neal-Perry G, Green RR, Santoro N, Polotsky AJ. Association of ethnicity with involuntary childlessness and perceived reasons for infertility: baseline data from the Study of Women's Health Across the Nation (SWAN). Fertil Steril. 2011 Nov; 96(5):1200-5.e1. PMID: 21958690; PMCID: PMC3278161.
    44. McAvey B, Zapantis A, Jindal SK, Lieman HJ, Polotsky AJ. How many eggs are needed to produce an assisted reproductive technology baby: is more always better? Fertil Steril. 2011 Aug; 96(2):332-5. PMID: 21718991.
      View in: PubMed
    45. Lasley BL, Crawford SL, Laughlin GA, Santoro N, McConnell DS, Crandall C, Greendale GA, Polotsky AJ, Vuga M. Circulating dehydroepiandrosterone sulfate levels in women who underwent bilateral salpingo-oophorectomy during the menopausal transition. Menopause. 2011 May; 18(5):494-8. PMID: 21178790; PMCID: PMC3123411.
    46. Kucherov A, Polotsky AJ, Menke M, Isaac B, McAvey B, Buyuk E, Bradford AP, Hickmon C, Babbs B, Berga S, Loucks T, Santoro N. Aromatase inhibition causes increased amplitude, but not frequency, of hypothalamic-pituitary output in normal women. Fertil Steril. 2011 May; 95(6):2063-6. PMID: 21353673; PMCID: PMC3080458.
    47. Rybak EA, Szmyga MJ, Zapantis G, Rausch M, Beshay VE, Polotsky AJ, Coutifaris C, Carr BR, Santoro N, Meier UT. The nucleolar channel system reliably marks the midluteal endometrium regardless of fertility status: a fresh look at an old organelle. Fertil Steril. 2011 Mar 15; 95(4):1385-9.e1. PMID: 21067716; PMCID: PMC3347775.
    48. Relwani R, Berger D, Santoro N, Hickmon C, Nihsen M, Zapantis A, Werner M, Polotsky AJ, Jindal S. Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery. Reprod Sci. 2011 Apr; 18(4):391-7. PMID: 20959643.
      View in: PubMed
    49. Polotsky HN, Polotsky AJ. Metabolic implications of menopause. Semin Reprod Med. 2010 Sep; 28(5):426-34. PMID: 20865657.
      View in: PubMed
    50. Green R, Polotsky AJ, Wildman RP, McGinn AP, Lin J, Derby C, Johnston J, Ram KT, Crandall CJ, Thurston R, Gold E, Weiss G, Santoro N. Menopausal symptoms within a Hispanic cohort: SWAN, the Study of Women's Health Across the Nation. Climacteric. 2010 Aug; 13(4):376-84. PMID: 20136411; PMCID: PMC3268678.
    51. Keltz J, Zapantis A, Jindal SK, Lieman HJ, Santoro N, Polotsky AJ. Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles. J Assist Reprod Genet. 2010 Sep; 27(9-10):539-44. PMID: 20635132; PMCID: PMC2965348.
    52. Polotsky HN, Polotsky AJ. One size may not fit all: pondering antibiotic dosing in obesity. Maturitas. 2010 Aug; 66(4):381-2. PMID: 20356691.
      View in: PubMed
    53. Green R, Santoro NF, McGinn AP, Wildman RP, Derby CA, Polotsky AJ, Weiss G. The relationship between psychosocial status, acculturation and country of origin in mid-life Hispanic women: data from the Study of Women's Health Across the Nation (SWAN). Climacteric. 2010 Dec; 13(6):534-43. PMID: 20210631; PMCID: PMC3677597.
    54. Derby CA, Wildman RP, McGinn AP, Green RR, Polotsky AJ, Ram KT, Barnhart J, Weiss G, Santoro N. Cardiovascular risk factor variation within a Hispanic cohort: SWAN, the Study of Women's Health Across the Nation. Ethn Dis. 2010; 20(4):396-402. PMID: 21305828; PMCID: PMC3059124.
    55. Nejat EJ, Polotsky AJ, Pal L. Predictors of chronic disease at midlife and beyond--the health risks of obesity. Maturitas. 2010 Feb; 65(2):106-11. PMID: 19796885.
      View in: PubMed
    56. Aubuchon M, Lieman H, Stein D, Cohen HW, Isaac B, Adel G, Weitzman V, Tetrokalashvili M, Polotsky AJ, Santoro N. Metformin does not improve the reproductive or metabolic profile in women with polycystic ovary syndrome (PCOS). Reprod Sci. 2009 Oct; 16(10):938-46. PMID: 19692630.
      View in: PubMed
    57. Polotsky AJ, Zhu L, Santoro N, Pollard JW. Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium. Hum Reprod. 2009 Aug; 24(8):1960-7. PMID: 19403565; PMCID: PMC2710285.
    58. Polotsky AJ, Hailpern SM, Skurnick JH, Lo JC, Sternfeld B, Santoro N. Association of adolescent obesity and lifetime nulliparity--the Study of Women's Health Across the Nation (SWAN). Fertil Steril. 2010 Apr; 93(6):2004-11. PMID: 19185860; PMCID: PMC2891509.
    59. Polotsky AJ, Daif JL, Jindal S, Lieman HJ, Santoro N, Pal L. Serum progesterone on the day of human chorionic gonadotropin administration predicts clinical pregnancy of sibling frozen embryos. Fertil Steril. 2009 Dec; 92(6):1880-5. PMID: 18851847; PMCID: PMC2814243.
    60. Rochester D, Jain A, Polotsky AJ, Polotsky H, Gibbs K, Isaac B, Zeitlian G, Hickmon C, Feng S, Santoro N. Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril. 2009 Oct; 92(4):1410-5. PMID: 18829008; PMCID: PMC2818247.
    61. Guffanti E, Kittur N, Brodt ZN, Polotsky AJ, Kuokkanen SM, Heller DS, Young SL, Santoro N, Meier UT. Nuclear pore complex proteins mark the implantation window in human endometrium. J Cell Sci. 2008 Jun 15; 121(Pt 12):2037-45. PMID: 18505792; PMCID: PMC2657873.
    62. Rybak EA, Polotsky AJ, Woreta T, Hailpern SM, Bristow RE. Explained compared with unexplained fever in postoperative myomectomy and hysterectomy patients. Obstet Gynecol. 2008 May; 111(5):1137-42. PMID: 18448746.
      View in: PubMed
    63. Jain A, Polotsky AJ, Rochester D, Berga SL, Loucks T, Zeitlian G, Gibbs K, Polotsky HN, Feng S, Isaac B, Santoro N. Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women. J Clin Endocrinol Metab. 2007 Jul; 92(7):2468-73. PMID: 17440019.
      View in: PubMed
    64. Polotsky AJ, Rieder J, Santoro N. Case 31-2006: a girl with severe obesity. N Engl J Med. 2007 Jan 11; 356(2):194-5; author reply 195-6. PMID: 17225291.
      View in: PubMed
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