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Eileen T O'Toole

TitleResearch Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-7980

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jin J, Galaz-Montoya JG, Sherman MB, Sun SY, Goldsmith CS, O'Toole ET, Ackerman L, Carlson LA, Weaver SC, Chiu W, Simmons G. Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane. Cell Host Microbe. 2018 Aug 18. PMID: 30146390.
      View in: PubMed
    2. Jones MH, O'Toole ET, Fabritius AS, Muller EG, Meehl JB, Jaspersen SL, Winey M. Key phosphorylation events in Spc29 and Spc42 guide multiple steps of yeast centrosome duplication. Mol Biol Cell. 2018 Jul 25; mbcE18050296. PMID: 30044722.
      View in: PubMed
    3. McIntosh JR, O'Toole E, Morgan G, Austin J, Ulyanov E, Ataullakhanov F, Gudimchuk N. Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments. J Cell Biol. 2018 Aug 06; 217(8):2691-2708. PMID: 29794031.
      View in: PubMed
    4. O'Toole ET, Giddings TH, Winey M. Cryopreparation and Electron Tomography of Yeast Cells. Cold Spring Harb Protoc. 2017 Mar 01; 2017(3):pdb.prot085589. PMID: 28250212.
      View in: PubMed
    5. O'Toole ET, Giddings TH, Winey M. Building Cell Structures in Three Dimensions: Electron Tomography Methods for Budding Yeast. Cold Spring Harb Protoc. 2017 Mar 01; 2017(3):pdb.top077685. PMID: 28250232.
      View in: PubMed
    6. Blackwell R, Edelmaier C, Sweezy-Schindler O, Lamson A, Gergely ZR, O'Toole E, Crapo A, Hough LE, McIntosh JR, Glaser MA, Betterton MD. Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast. Sci Adv. 2017 Jan; 3(1):e1601603. PMID: 28116355.
      View in: PubMed
    7. Quinn TA, Camelliti P, Rog-Zielinska EA, Siedlecka U, Poggioli T, O'Toole ET, Knöpfel T, Kohl P. Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics. Proc Natl Acad Sci U S A. 2016 12 20; 113(51):14852-14857. PMID: 27930302.
      View in: PubMed
    8. Fernández-Álvarez A, Bez C, O'Toole ET, Morphew M, Cooper JP. Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope. Dev Cell. 2016 12 05; 39(5):544-559. PMID: 27889481.
      View in: PubMed
    9. Dutcher SK, O'Toole ET. The basal bodies of Chlamydomonas reinhardtii. Cilia. 2016; 5:18. PMID: 27252853; PMCID: PMC4888484.
      View in: PubMed, PubMed Central
    10. Rog-Zielinska EA, Johnston CM, O'Toole ET, Morphew M, Hoenger A, Kohl P. Electron tomography of rabbit cardiomyocyte three-dimensional ultrastructure. Prog Biophys Mol Biol. 2016 07; 121(2):77-84. PMID: 27210305; PMCID: PMC4959512.
      View in: PubMed, PubMed Central
    11. Rao AN, Falnikar A, O'Toole ET, Morphew MK, Hoenger A, Davidson MW, Yuan X, Baas PW. Sliding of centrosome-unattached microtubules defines key features of neuronal phenotype. J Cell Biol. 2016 05 09; 213(3):329-41. PMID: 27138250.
      View in: PubMed
    12. Fees CP, Aiken J, O'Toole ET, Giddings TH, Moore JK. The negatively charged carboxy-terminal tail of ß-tubulin promotes proper chromosome segregation. Mol Biol Cell. 2016 06 01; 27(11):1786-96. PMID: 27053662; PMCID: PMC4884069.
      View in: PubMed, PubMed Central
    13. Esparza JM, O'Toole E, Li L, Giddings TH, Kozak B, Albee AJ, Dutcher SK. Correction: Katanin Localization Requires Triplet Microtubules in Chlamydomonas reinhardtii. PLoS One. 2016; 11(1):e0145569. PMID: 26771461; PMCID: PMC4714803.
      View in: PubMed, PubMed Central
    14. McCoy KM, Tubman ES, Claas A, Tank D, Clancy SA, O'Toole ET, Berman J, Odde DJ. Physical limits on kinesin-5-mediated chromosome congression in the smallest mitotic spindles. Mol Biol Cell. 2015 Nov 05; 26(22):3999-4014. PMID: 26354423; PMCID: PMC4710232.
      View in: PubMed, PubMed Central
    15. Nannas NJ, O'Toole ET, Winey M, Murray AW. Chromosomal attachments set length and microtubule number in the Saccharomyces cerevisiae mitotic spindle. Mol Biol Cell. 2014 Dec 15; 25(25):4034-48. PMID: 25318669; PMCID: PMC4263447.
      View in: PubMed, PubMed Central
    16. Hepperla AJ, Willey PT, Coombes CE, Schuster BM, Gerami-Nejad M, McClellan M, Mukherjee S, Fox J, Winey M, Odde DJ, O'Toole E, Gardner MK. Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length. Dev Cell. 2014 Oct 13; 31(1):61-72. PMID: 25313961; PMCID: PMC4197412.
      View in: PubMed, PubMed Central
    17. Winey M, O'Toole E. Centriole structure. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 05; 369(1650). PMID: 25047611; PMCID: PMC4113101.
      View in: PubMed, PubMed Central
    18. Cole ES, Giddings TH, Ozzello C, Winey M, O'Toole E, Orias J, Hamilton E, Guerrier S, Ballard A, Aronstein T. Membrane dynamics at the nuclear exchange junction during early mating (one to four hours) in the ciliate Tetrahymena thermophila. Eukaryot Cell. 2015 Feb; 14(2):116-27. PMID: 25107923; PMCID: PMC4311919.
      View in: PubMed, PubMed Central
    19. Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P. A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Elife. 2014 Jun 24; 3:e01621. PMID: 24963135; PMCID: PMC4107917.
      View in: PubMed, PubMed Central
    20. Winey M, Meehl JB, O'Toole ET, Giddings TH. Conventional transmission electron microscopy. Mol Biol Cell. 2014 Feb; 25(3):319-23. PMID: 24482357; PMCID: PMC3907272.
      View in: PubMed, PubMed Central
    21. Höög JL, Lacomble S, O'Toole ET, Hoenger A, McIntosh JR, Gull K. Modes of flagellar assembly in Chlamydomonas reinhardtii and Trypanosoma brucei. Elife. 2014; 3:e01479. PMID: 24448408; PMCID: PMC3896119.
      View in: PubMed, PubMed Central
    22. O'Toole ET, Dutcher SK. Site-specific basal body duplication in Chlamydomonas. Cytoskeleton (Hoboken). 2014 Feb; 71(2):108-18. PMID: 24166861; PMCID: PMC4067263.
      View in: PubMed, PubMed Central
    23. Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Am J Hum Genet. 2013 Oct 03; 93(4):672-86. PMID: 24094744; PMCID: PMC3791264.
      View in: PubMed, PubMed Central
    24. Nazarova E, O'Toole E, Kaitna S, Francois P, Winey M, Vogel J. Distinct roles for antiparallel microtubule pairing and overlap during early spindle assembly. Mol Biol Cell. 2013 Oct; 24(20):3238-50. PMID: 23966467; PMCID: PMC3806661.
      View in: PubMed, PubMed Central
    25. Choy JS, O'Toole E, Schuster BM, Crisp MJ, Karpova TS, McNally JG, Winey M, Gardner MK, Basrai MA. Genome-wide haploinsufficiency screen reveals a novel role for ?-TuSC in spindle organization and genome stability. Mol Biol Cell. 2013 Sep; 24(17):2753-63. PMID: 23825022; PMCID: PMC3756926.
      View in: PubMed, PubMed Central
    26. Kamasaki T, O'Toole E, Kita S, Osumi M, Usukura J, McIntosh JR, Goshima G. Augmin-dependent microtubule nucleation at microtubule walls in the spindle. J Cell Biol. 2013 Jul 08; 202(1):25-33. PMID: 23816620; PMCID: PMC3704994.
      View in: PubMed, PubMed Central
    27. McIntosh JR, O'Toole E, Zhudenkov K, Morphew M, Schwartz C, Ataullakhanov FI, Grishchuk EL. Conserved and divergent features of kinetochores and spindle microtubule ends from five species. J Cell Biol. 2013 Feb 18; 200(4):459-74. PMID: 23420873; PMCID: PMC3575531.
      View in: PubMed, PubMed Central
    28. Esparza JM, O'Toole E, Li L, Giddings TH, Kozak B, Albee AJ, Dutcher SK. Katanin localization requires triplet microtubules in Chlamydomonas reinhardtii. PLoS One. 2013; 8(1):e53940. PMID: 23320108; PMCID: PMC3540033.
      View in: PubMed, PubMed Central
    29. O'Toole ET, Giddings TH, Porter ME, Ostrowski LE. Computer-assisted image analysis of human cilia and Chlamydomonas flagella reveals both similarities and differences in axoneme structure. Cytoskeleton (Hoboken). 2012 Aug; 69(8):577-90. PMID: 22573610; PMCID: PMC3423584.
      View in: PubMed, PubMed Central
    30. O'Toole E, Greenan G, Lange KI, Srayko M, Müller-Reichert T. The role of ?-tubulin in centrosomal microtubule organization. PLoS One. 2012; 7(1):e29795. PMID: 22253783; PMCID: PMC3254605.
      View in: PubMed, PubMed Central
    31. Milosevic I, Giovedi S, Lou X, Raimondi A, Collesi C, Shen H, Paradise S, O'Toole E, Ferguson S, Cremona O, De Camilli P. Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission. Neuron. 2011 Nov 17; 72(4):587-601. PMID: 22099461; PMCID: PMC3258500.
      View in: PubMed, PubMed Central
    32. Raimondi A, Ferguson SM, Lou X, Armbruster M, Paradise S, Giovedi S, Messa M, Kono N, Takasaki J, Cappello V, O'Toole E, Ryan TA, De Camilli P. Overlapping role of dynamin isoforms in synaptic vesicle endocytosis. Neuron. 2011 Jun 23; 70(6):1100-14. PMID: 21689597; PMCID: PMC3190241.
      View in: PubMed, PubMed Central
    33. Müller-Reichert T, Greenan G, O'Toole E, Srayko M. The elegans of spindle assembly. Cell Mol Life Sci. 2010 Jul; 67(13):2195-213. PMID: 20339898; PMCID: PMC2883083.
      View in: PubMed, PubMed Central
    34. O'Toole ET. Chlamydomonas cryopreparation methods for the 3-D analysis of cellular organelles. Methods Cell Biol. 2010; 96:71-91. PMID: 20869519.
      View in: PubMed
    35. Bower R, VanderWaal K, O'Toole E, Fox L, Perrone C, Mueller J, Wirschell M, Kamiya R, Sale WS, Porter ME. IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility. Mol Biol Cell. 2009 Jul; 20(13):3055-63. PMID: 19420135.
      View in: PubMed
    36. Palsdottir H, Remis JP, Schaudinn C, O'Toole E, Lux R, Shi W, McDonald KL, Costerton JW, Auer M. Three-dimensional macromolecular organization of cryofixed Myxococcus xanthus biofilms as revealed by electron microscopic tomography. J Bacteriol. 2009 Apr; 191(7):2077-82. PMID: 19168614; PMCID: PMC2655519.
      View in: PubMed, PubMed Central
    37. O'Toole E, Müller-Reichert T. Electron tomography of microtubule end-morphologies in C. elegans embryos. Methods Mol Biol. 2009; 545:135-44. PMID: 19475386.
      View in: PubMed
    38. Omran H, Kobayashi D, Olbrich H, Tsukahara T, Loges NT, Hagiwara H, Zhang Q, Leblond G, O'Toole E, Hara C, Mizuno H, Kawano H, Fliegauf M, Yagi T, Koshida S, Miyawaki A, Zentgraf H, Seithe H, Reinhardt R, Watanabe Y, Kamiya R, Mitchell DR, Takeda H. Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins. Nature. 2008 Dec 04; 456(7222):611-6. PMID: 19052621; PMCID: PMC3279746.
      View in: PubMed, PubMed Central
    39. Gardner MK, Bouck DC, Paliulis LV, Meehl JB, O'Toole ET, Haase J, Soubry A, Joglekar AP, Winey M, Salmon ED, Bloom K, Odde DJ. Chromosome congression by Kinesin-5 motor-mediated disassembly of longer kinetochore microtubules. Cell. 2008 Nov 28; 135(5):894-906. PMID: 19041752; PMCID: PMC2683758.
      View in: PubMed, PubMed Central
    40. Hayashi M, Raimondi A, O'Toole E, Paradise S, Collesi C, Cremona O, Ferguson SM, De Camilli P. Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2175-80. PMID: 18250322; PMCID: PMC2538894.
      View in: PubMed, PubMed Central
    41. Gardner MK, Haase J, Mythreye K, Molk JN, Anderson M, Joglekar AP, O'Toole ET, Winey M, Salmon ED, Odde DJ, Bloom K. The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle. J Cell Biol. 2008 Jan 14; 180(1):91-100. PMID: 18180364; PMCID: PMC2213616.
      View in: PubMed, PubMed Central
    42. Bahmanyar S, Kaplan DD, Deluca JG, Giddings TH, O'Toole ET, Winey M, Salmon ED, Casey PJ, Nelson WJ, Barth AI. beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev. 2008 Jan 01; 22(1):91-105. PMID: 18086858; PMCID: PMC2151018.
      View in: PubMed, PubMed Central
    43. Ferguson SM, Brasnjo G, Hayashi M, Wölfel M, Collesi C, Giovedi S, Raimondi A, Gong LW, Ariel P, Paradise S, O'toole E, Flavell R, Cremona O, Miesenböck G, Ryan TA, De Camilli P. A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science. 2007 Apr 27; 316(5824):570-4. PMID: 17463283.
      View in: PubMed
    44. Höög JL, Schwartz C, Noon AT, O'Toole ET, Mastronarde DN, McIntosh JR, Antony C. Organization of interphase microtubules in fission yeast analyzed by electron tomography. Dev Cell. 2007 Mar; 12(3):349-61. PMID: 17336902.
      View in: PubMed
    45. Müller-Reichert T, Srayko M, Hyman A, O'Toole ET, McDonald K. Correlative light and electron microscopy of early Caenorhabditis elegans embryos in mitosis. Methods Cell Biol. 2007; 79:101-19. PMID: 17327153.
      View in: PubMed
    46. O'Toole ET, Giddings TH, Dutcher SK. Understanding microtubule organizing centers by comparing mutant and wild-type structures with electron tomography. Methods Cell Biol. 2007; 79:125-43. PMID: 17327155.
      View in: PubMed
    47. Pelletier L, O'Toole E, Schwager A, Hyman AA, Müller-Reichert T. Centriole assembly in Caenorhabditis elegans. Nature. 2006 Nov 30; 444(7119):619-23. PMID: 17136092.
      View in: PubMed
    48. Srayko M, O'toole ET, Hyman AA, Müller-Reichert T. Katanin disrupts the microtubule lattice and increases polymer number in C. elegans meiosis. Curr Biol. 2006 Oct 10; 16(19):1944-9. PMID: 17027492.
      View in: PubMed
    49. Storchová Z, Breneman A, Cande J, Dunn J, Burbank K, O'Toole E, Pellman D. Genome-wide genetic analysis of polyploidy in yeast. Nature. 2006 Oct 05; 443(7111):541-7. PMID: 17024086.
      View in: PubMed
    50. Canty EG, Starborg T, Lu Y, Humphries SM, Holmes DF, Meadows RS, Huffman A, O'Toole ET, Kadler KE. Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon. J Biol Chem. 2006 Dec 15; 281(50):38592-8. PMID: 17020878.
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    51. Ozlü N, Srayko M, Kinoshita K, Habermann B, O'toole ET, Müller-Reichert T, Schmalz N, Desai A, Hyman AA. An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles. Dev Cell. 2005 Aug; 9(2):237-48. PMID: 16054030.
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    52. Muller EG, Snydsman BE, Novik I, Hailey DW, Gestaut DR, Niemann CA, O'Toole ET, Giddings TH, Sundin BA, Davis TN. The organization of the core proteins of the yeast spindle pole body. Mol Biol Cell. 2005 Jul; 16(7):3341-52. PMID: 15872084.
      View in: PubMed
    53. Yokoyama R, O'toole E, Ghosh S, Mitchell DR. Regulation of flagellar dynein activity by a central pair kinesin. Proc Natl Acad Sci U S A. 2004 Dec 14; 101(50):17398-403. PMID: 15572440; PMCID: PMC536025.
      View in: PubMed, PubMed Central
    54. Yoder TJ, McElwain MA, Francis SE, Bagley J, Muller EG, Pak B, O'Toole ET, Winey M, Davis TN. Analysis of a spindle pole body mutant reveals a defect in biorientation and illuminates spindle forces. Mol Biol Cell. 2005 Jan; 16(1):141-52. PMID: 15525672.
      View in: PubMed
    55. O'Toole ET, McDonald KL, Mäntler J, McIntosh JR, Hyman AA, Müller-Reichert T. Morphologically distinct microtubule ends in the mitotic centrosome of Caenorhabditis elegans. J Cell Biol. 2003 Nov 10; 163(3):451-6. PMID: 14610052; PMCID: PMC2173630.
      View in: PubMed, PubMed Central
    56. O'Toole ET, Giddings TH, McIntosh JR, Dutcher SK. Three-dimensional organization of basal bodies from wild-type and delta-tubulin deletion strains of Chlamydomonas reinhardtii. Mol Biol Cell. 2003 Jul; 14(7):2999-3012. PMID: 12857881.
      View in: PubMed
    57. Müller-Reichert T, Sassoon I, O'Toole E, Romao M, Ashford AJ, Hyman AA, Antony C. Analysis of the distribution of the kinetochore protein Ndc10p in Saccharomyces cerevisiae using 3-D modeling of mitotic spindles. Chromosoma. 2003 Apr; 111(7):417-28. PMID: 12707779.
      View in: PubMed
    58. Roberts P, Moshitch-Moshkovitz S, Kvam E, O'Toole E, Winey M, Goldfarb DS. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol Biol Cell. 2003 Jan; 14(1):129-41. PMID: 12529432.
      View in: PubMed
    59. Burns CG, Ohi R, Mehta S, O'Toole ET, Winey M, Clark TA, Sugnet CW, Ares M, Gould KL. Removal of a single alpha-tubulin gene intron suppresses cell cycle arrest phenotypes of splicing factor mutations in Saccharomyces cerevisiae. Mol Cell Biol. 2002 Feb; 22(3):801-15. PMID: 11784857; PMCID: PMC133559.
      View in: PubMed, PubMed Central
    60. O'Toole ET, Winey M, McIntosh JR, Mastronarde DN. Electron tomography of yeast cells. Methods Enzymol. 2002; 351:81-95. PMID: 12073377; PMCID: PMC4440791.
      View in: PubMed, PubMed Central
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