Eric Schmidt
Title | Principal Investigator |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-MED |
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Phone | 303/602-5040 |
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Biography Johns Hopkins Hospital | | 06/2009 | Pulmonary and Critical Care Medicine Fellowship | Johns Hopkins Hospital | | 06/2006 | Assistant Chief of Service (Chief Resident) | Johns Hopkins Hospital | | 06/2004 | Medicine Residency | University of Pittsburgh | MD | 06/2001 | Medicine | Dartmouth College | BA | 06/1997 | Government |
2019 | Fellow of the American Thoracic Society, American Thoracic Society | 2019 | Associate Editor, American Journal of Physiology Lung Cellular and Molecular Physiology | 2019 - 2025 | Surgery, Anesthesiology, and Trauma Study Section Member, NIH/CSR | 2015 | Early Career Research Achievement Award, Pulmonary Circulation Assembly, American Thoracic Society | 2014 | Academic Excellence Award, Denver Health Medical Center | 2013 | Giles F. Filley Memorial Award, American Physiological Society | 2013 | Outstanding Early Career Scholar, University of Colorado Department of Medicine | 2013 | Peak Performer: Intensive Care Medicine, Rocky Mountain Hospital Medicine Symposium | 2010 | Recovery Act Investigator, NHLBI |
Overview Our laboratory focuses on the mechanisms underlying sepsis and septic organ injury. We are particularly interested in the role of glycosaminoglycans (such as heparan sulfate) in the onset, propagation, and resolution of septic lung, kidney, and brain injury.
Research F32HL090296 (SCHMIDT, ERIC PETER)Jul 1, 2007 - Jun 30, 2009 NIH cGMP Compartmentalization in Pulmonary Endothelial Barrier Dysfunction Role: Principal Investigator |
| K08HL105538 (SCHMIDT, ERIC PETER)Sep 1, 2011 - Jul 31, 2017 NIH Pulmonary endothelial glycocalyx degradation causes ARDS during sepsis Role: Principal Investigator |
| R01HL125371 (SCHMIDT, ERIC PETER)Sep 15, 2014 - May 31, 2020 NIH Endothelial glycocalyx reconstitution during sepsis Role: Principal Investigator |
| R01GM125095 (SCHMIDT, ERIC PETER)Jul 15, 2017 - May 31, 2021 NIH Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy Role: Principal Investigator |
| R01HL149422 (SHAPIRO, NATHAN I)Sep 1, 2019 - May 31, 2023 NIH The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock Role: Co-Principal Investigator |
| R13HL152479 (SCHMIDT, ERIC PETER)Jul 1, 2020 - Jun 30, 2021 NIH ARDS in the 21st Century: New Insights into Clinical and Mechanistic Heterogeneity Role: Principal Investigator |
Bibliographic
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Rizzo AN, Schmidt EP. ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility. J Clin Invest. 2021 Jan 04; 131(1). PMID: 33141764.
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Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Am J Respir Crit Care Med. 2020 09 15; 202(6):885-887. PMID: 32357306.
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Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L211-L217. PMID: 32519894.
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LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1198-L1210. PMID: 32320623.
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LaRivière WB, Schmidt EP. Using the Extremes of Human Inflammation to Understand the Transcriptional Control of IL-18. Am J Respir Crit Care Med. 2020 03 01; 201(5):503-504. PMID: 31898912.
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Gómez BI, Dubick MA, Schmidt EP, Shupp JW, Burmeister DM. Plasma and Urinary Glycosaminoglycans as Evidence for Endotheliopathy in a Swine Burn Model. J Surg Res. 2020 04; 248:28-37. PMID: 31841734.
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Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS. Grant Writing for Clinicians in Training: An Important Career Development Exercise. Chest. 2020 04; 157(4):932-935. PMID: 31730834.
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Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, Yue X, Vivès RR, Linhardt RJ, Schmidt EP. Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L667-L677. PMID: 31461325.
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Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 07 23; 23(1):259. PMID: 31337421.
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Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS Pathog. 2019 05; 15(5):e1007800. PMID: 31116795.
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Liao S, Eickelberg O, Schmidt EP, Yang Y. Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung. J Vis Exp. 2019 05 20; (147). PMID: 31157786.
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Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9208-9213. PMID: 31010931.
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Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 04 01; 129(4):1779-1784. PMID: 30720464.
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Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17; 23(1):16. PMID: 30654825.
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Hippensteel JA, Shapiro NI, Schmidt EP. Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis. Am J Respir Crit Care Med. 2018 10 15; 198(8):981-983. PMID: 29940124.
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LaRivière WB, Schmidt EP. The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role for Heparan Sulfate. Curr Top Membr. 2018; 82:33-52. PMID: 30360782.
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Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 09; 59(3):363-374. PMID: 29584451.
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Hippensteel JA, Schmidt EP. Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte. Am J Respir Crit Care Med. 2018 02 15; 197(4):416-418. PMID: 29120664.
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Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP. More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745786. PMID: 29199903.
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Yang Y, Hippensteel JA, Schmidt EP. Intravital Microscopy in the Mouse Lung. Methods Mol Biol. 2018; 1809:331-339. PMID: 29987798.
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Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP. Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. Shock. 2017 12; 48(6):666-673. PMID: 28538085.
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Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
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Rau AS, Reinikovaite V, Schmidt EP, Taraseviciene-Stewart L, Deleyiannis FW. Electronic Cigarettes Are as Toxic to Skin Flap Survival as Tobacco Cigarettes. Ann Plast Surg. 2017 Jul; 79(1):86-91. PMID: 28252546.
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Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 06; 56(6):727-737. PMID: 28187268.
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Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F553-F559. PMID: 28515178.
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Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 02; 47(2):128-131. PMID: 27617672.
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Zhang X, Xu Y, Hsieh PH, Liu J, Lin L, Schmidt EP, Linhardt RJ. Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation. Org Biomol Chem. 2017 Feb 01; 15(5):1222-1227. PMID: 28091666.
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Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 08 15; 194(4):439-49. PMID: 26926297.
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Haeger SM, Yang Y, Schmidt EP. Heparan Sulfate in the Developing, Healthy, and Injured Lung. Am J Respir Cell Mol Biol. 2016 07; 55(1):5-11. PMID: 26982577.
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Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15; 6(2):945-73. PMID: 27065171.
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Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 06; 37(2):263-75. PMID: 27229643.
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Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556.
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Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D. The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus. PLoS One. 2015; 10(6):e0127032. PMID: 26039697.
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Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16; 87(12):6220-7. PMID: 26005898.
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Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827.
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Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep; 184(9):2382-9. PMID: 25016184.
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Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am J Respir Cell Mol Biol. 2014 May; 50(5):932-41. PMID: 24304496.
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Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21; 289(12):8194-202. PMID: 24509853.
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Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013; 8(11):e79037. PMID: 24265742.
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Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov; 1(6):e00153. PMID: 24400155.
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Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):1-5. PMID: 23815257.
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Yang Y, Yang G, Schmidt EP. In vivo measurement of the mouse pulmonary endothelial surface layer. J Vis Exp. 2013 Feb 22; (72):e50322. PMID: 23462690.
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Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173.
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Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013 Jan 01; 1(1). PMID: 24073386.
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Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644.
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Schmidt EP. The expanding appreciation of heparanase in human disease. Neurosci Lett. 2012 Mar 05; 511(1):1-3. PMID: 22300958.
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Carpenter TC, Schroeder W, Stenmark KR, Schmidt EP. Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):40-7. PMID: 21799118.
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Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47. PMID: 22013192.
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Tuder RM, Hunt JM, Schmidt EP. Hyperoxia and apoptosis. Too much of a good thing? Am J Respir Crit Care Med. 2011 Apr 15; 183(8):964-5. PMID: 21498818.
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Schmidt EP, Tuder RM. Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death. 2010 Jul 20; 2010(3):41-53. PMID: 22081757.
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Schmidt EP, Damarla M, Rentsendorj O, Servinsky LE, Zhu B, Moldobaeva A, Gonzalez A, Hassoun PM, Pearse DB. Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. . 2008 Dec; 295(6):L1056-65. PMID: 18849438.
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Brandes JC, Schmidt E, Yung R. Occlusive endobronchial stent placement as a novel management approach to massive hemoptysis from lung cancer. J Thorac Oncol. 2008 Sep; 3(9):1071-2. PMID: 18758315.
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Schmidt EP, Drachman DB, Wiener CM, Clawson L, Kimball R, Lechtzin N. Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design. Muscle Nerve. 2006 Jan; 33(1):127-32. PMID: 16258948.
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Hann CL, Schmidt EP. Images in clinical medicine. Toxic neutrophils in Streptococcus pneumoniae sepsis. N Engl J Med. 2004 Dec 16; 351(25):2636. PMID: 15602024.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2004 | 1 | 2006 | 1 | 2008 | 2 | 2010 | 1 | 2011 | 2 | 2012 | 3 | 2013 | 6 | 2014 | 3 | 2015 | 4 | 2016 | 4 | 2017 | 7 | 2018 | 6 | 2019 | 9 | 2020 | 4 | 2021 | 1 |
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