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Eric Schmidt

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/602-5040

    Collapse Biography 
    Collapse education and training
    Johns Hopkins Hospital06/2009Pulmonary and Critical Care Medicine Fellowship
    Johns Hopkins Hospital06/2006Assistant Chief of Service (Chief Resident)
    Johns Hopkins Hospital06/2004Medicine Residency
    University of PittsburghMD06/2001Medicine
    Dartmouth CollegeBA06/1997Government
    Collapse awards and honors
    2019Fellow of the American Thoracic Society, American Thoracic Society
    2019Associate Editor, American Journal of Physiology Lung Cellular and Molecular Physiology
    2019 - 2025Surgery, Anesthesiology, and Trauma Study Section Member, NIH/CSR
    2015Early Career Research Achievement Award, Pulmonary Circulation Assembly, American Thoracic Society
    2014Academic Excellence Award, Denver Health Medical Center
    2013Giles F. Filley Memorial Award, American Physiological Society
    2013Outstanding Early Career Scholar, University of Colorado Department of Medicine
    2013Peak Performer: Intensive Care Medicine, Rocky Mountain Hospital Medicine Symposium
    2010Recovery Act Investigator, NHLBI

    Collapse Overview 
    Collapse overview
    Our laboratory focuses on the mechanisms underlying sepsis and septic organ injury. We are particularly interested in the role of glycosaminoglycans (such as heparan sulfate) in the onset, propagation, and resolution of septic lung, kidney, and brain injury.

    Collapse Research 
    Collapse research activities and funding
    F32HL090296     (SCHMIDT, ERIC PETER)Jul 1, 2007 - Jun 30, 2009
    NIH
    cGMP Compartmentalization in Pulmonary Endothelial Barrier Dysfunction
    Role: Principal Investigator
    K08HL105538     (SCHMIDT, ERIC PETER)Sep 1, 2011 - Jul 31, 2017
    NIH
    Pulmonary endothelial glycocalyx degradation causes ARDS during sepsis
    Role: Principal Investigator
    R01HL125371     (SCHMIDT, ERIC PETER)Sep 15, 2014 - May 31, 2020
    NIH
    Endothelial glycocalyx reconstitution during sepsis
    Role: Principal Investigator
    R01GM125095     (SCHMIDT, ERIC PETER)Jul 15, 2017 - May 31, 2021
    NIH
    Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy
    Role: Principal Investigator
    R01HL149422     (SHAPIRO, NATHAN I)Sep 1, 2019 - May 31, 2023
    NIH
    The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock
    Role: Co-Principal Investigator
    R13HL152479     (SCHMIDT, ERIC PETER)Jul 1, 2020 - Jun 30, 2021
    NIH
    ARDS in the 21st Century: New Insights into Clinical and Mechanistic Heterogeneity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung: the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal. Am J Physiol Lung Cell Mol Physiol. 2021 11 01; 321(5):L844-L846. PMID: 34585617.
      View in: PubMed
    2. Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2021 Jul 23. PMID: 34310901.
      View in: PubMed
    3. Oshima K, King SI, McMurtry SA, Schmidt EP. Endothelial Heparan Sulfate Proteoglycans in Sepsis: The Role of the Glycocalyx. Semin Thromb Hemost. 2021 Apr; 47(3):274-282. PMID: 33794552.
      View in: PubMed
    4. Douglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier A. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med. 2021 03 01; 49(3):490-502. PMID: 33405409.
      View in: PubMed
    5. LaRiviere WB, Han X, Oshima K, McMurtry SA, Linhardt RJ, Schmidt EP. Detection of Glycosaminoglycans by Polyacrylamide Gel Electrophoresis and Silver Staining. J Vis Exp. 2021 02 25; (168). PMID: 33720131.
      View in: PubMed
    6. Rizzo AN, Schmidt EP. ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility. J Clin Invest. 2021 01 04; 131(1). PMID: 33141764.
      View in: PubMed
    7. Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Am J Respir Crit Care Med. 2020 09 15; 202(6):885-887. PMID: 32357306.
      View in: PubMed
    8. Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L211-L217. PMID: 32519894.
      View in: PubMed
    9. LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1198-L1210. PMID: 32320623.
      View in: PubMed
    10. LaRivière WB, Schmidt EP. Using the Extremes of Human Inflammation to Understand the Transcriptional Control of IL-18. Am J Respir Crit Care Med. 2020 03 01; 201(5):503-504. PMID: 31898912.
      View in: PubMed
    11. Gómez BI, Dubick MA, Schmidt EP, Shupp JW, Burmeister DM. Plasma and Urinary Glycosaminoglycans as Evidence for Endotheliopathy in a Swine Burn Model. J Surg Res. 2020 04; 248:28-37. PMID: 31841734.
      View in: PubMed
    12. Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS. Grant Writing for Clinicians in Training: An Important Career Development Exercise. Chest. 2020 04; 157(4):932-935. PMID: 31730834.
      View in: PubMed
    13. Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, Yue X, Vivès RR, Linhardt RJ, Schmidt EP. Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L667-L677. PMID: 31461325.
      View in: PubMed
    14. Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 07 23; 23(1):259. PMID: 31337421.
      View in: PubMed
    15. Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS Pathog. 2019 05; 15(5):e1007800. PMID: 31116795.
      View in: PubMed
    16. Liao S, Eickelberg O, Schmidt EP, Yang Y. Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung. J Vis Exp. 2019 05 20; (147). PMID: 31157786.
      View in: PubMed
    17. Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9208-9213. PMID: 31010931.
      View in: PubMed
    18. Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 04 01; 129(4):1779-1784. PMID: 30720464.
      View in: PubMed
    19. Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17; 23(1):16. PMID: 30654825.
      View in: PubMed
    20. Hippensteel JA, Shapiro NI, Schmidt EP. Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis. Am J Respir Crit Care Med. 2018 10 15; 198(8):981-983. PMID: 29940124.
      View in: PubMed
    21. LaRivière WB, Schmidt EP. The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role for Heparan Sulfate. Curr Top Membr. 2018; 82:33-52. PMID: 30360782.
      View in: PubMed
    22. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 09; 59(3):363-374. PMID: 29584451.
      View in: PubMed
    23. Hippensteel JA, Schmidt EP. Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte. Am J Respir Crit Care Med. 2018 02 15; 197(4):416-418. PMID: 29120664.
      View in: PubMed
    24. Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP. More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745786. PMID: 29199903.
      View in: PubMed
    25. Yang Y, Hippensteel JA, Schmidt EP. Intravital Microscopy in the Mouse Lung. Methods Mol Biol. 2018; 1809:331-339. PMID: 29987798.
      View in: PubMed
    26. Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP. Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. Shock. 2017 12; 48(6):666-673. PMID: 28538085.
      View in: PubMed
    27. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
      View in: PubMed
    28. Rau AS, Reinikovaite V, Schmidt EP, Taraseviciene-Stewart L, Deleyiannis FW. Electronic Cigarettes Are as Toxic to Skin Flap Survival as Tobacco Cigarettes. Ann Plast Surg. 2017 Jul; 79(1):86-91. PMID: 28252546.
      View in: PubMed
    29. Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 06; 56(6):727-737. PMID: 28187268.
      View in: PubMed
    30. Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F553-F559. PMID: 28515178.
      View in: PubMed
    31. Zhang X, Xu Y, Hsieh PH, Liu J, Lin L, Schmidt EP, Linhardt RJ. Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation. Org Biomol Chem. 2017 Feb 01; 15(5):1222-1227. PMID: 28091666.
      View in: PubMed
    32. Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 02; 47(2):128-131. PMID: 27617672.
      View in: PubMed
    33. Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 08 15; 194(4):439-49. PMID: 26926297.
      View in: PubMed
    34. Haeger SM, Yang Y, Schmidt EP. Heparan Sulfate in the Developing, Healthy, and Injured Lung. Am J Respir Cell Mol Biol. 2016 07; 55(1):5-11. PMID: 26982577.
      View in: PubMed
    35. Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15; 6(2):945-73. PMID: 27065171.
      View in: PubMed
    36. Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 06; 37(2):263-75. PMID: 27229643.
      View in: PubMed
    37. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556.
      View in: PubMed
    38. Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D. The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus. PLoS One. 2015; 10(6):e0127032. PMID: 26039697.
      View in: PubMed
    39. Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16; 87(12):6220-7. PMID: 26005898.
      View in: PubMed
    40. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827.
      View in: PubMed
    41. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep; 184(9):2382-9. PMID: 25016184.
      View in: PubMed
    42. Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am J Respir Cell Mol Biol. 2014 May; 50(5):932-41. PMID: 24304496.
      View in: PubMed
    43. Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21; 289(12):8194-202. PMID: 24509853.
      View in: PubMed
    44. Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013; 8(11):e79037. PMID: 24265742.
      View in: PubMed
    45. Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov; 1(6):e00153. PMID: 24400155.
      View in: PubMed
    46. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):1-5. PMID: 23815257.
      View in: PubMed
    47. Yang Y, Yang G, Schmidt EP. In vivo measurement of the mouse pulmonary endothelial surface layer. J Vis Exp. 2013 Feb 22; (72):e50322. PMID: 23462690.
      View in: PubMed
    48. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173.
      View in: PubMed
    49. Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013 Jan 01; 1(1). PMID: 24073386.
      View in: PubMed
    50. Ross LA, Schmidt EL, Ball K. Interventions to maintain mobility: What works? Accid Anal Prev. 2013 Dec; 61:167-96. PMID: 23083492.
      View in: PubMed
    51. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644.
      View in: PubMed
    52. Schmidt EP. The expanding appreciation of heparanase in human disease. Neurosci Lett. 2012 Mar 05; 511(1):1-3. PMID: 22300958.
      View in: PubMed
    53. Carpenter TC, Schroeder W, Stenmark KR, Schmidt EP. Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):40-7. PMID: 21799118.
      View in: PubMed
    54. Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47. PMID: 22013192.
      View in: PubMed
    55. Tuder RM, Hunt JM, Schmidt EP. Hyperoxia and apoptosis. Too much of a good thing? Am J Respir Crit Care Med. 2011 Apr 15; 183(8):964-5. PMID: 21498818.
      View in: PubMed
    56. Schmidt EP, Tuder RM. Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death. 2010 Jul 20; 2010(3):41-53. PMID: 22081757.
      View in: PubMed
    57. Schmidt EP, Damarla M, Rentsendorj O, Servinsky LE, Zhu B, Moldobaeva A, Gonzalez A, Hassoun PM, Pearse DB. Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. . 2008 Dec; 295(6):L1056-65. PMID: 18849438.
      View in: PubMed
    58. Schmidt EP, Drachman DB, Wiener CM, Clawson L, Kimball R, Lechtzin N. Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design. Muscle Nerve. 2006 Jan; 33(1):127-32. PMID: 16258948.
      View in: PubMed
    59. Hann CL, Schmidt EP. Images in clinical medicine. Toxic neutrophils in Streptococcus pneumoniae sepsis. N Engl J Med. 2004 Dec 16; 351(25):2636. PMID: 15602024.
      View in: PubMed
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