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Eric Schmidt

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/602-5040

    Collapse Biography 
    Collapse awards and honors
    2015Early Career Research Achievement Award, Pulmonary Circulation Assembly, American Thoracic Society
    2014Academic Excellence Award, Denver Health Medical Center
    2013Giles F. Filley Memorial Award, American Physiological Society
    2013Outstanding Early Career Scholar, University of Colorado Department of Medicine
    2013Peak Performer: Intensive Care Medicine, Rocky Mountain Hospital Medicine Symposium
    2010Recovery Act Investigator, NHLBI

    Collapse Overview 
    Collapse overview
    Our laboratory focuses on the mechanisms underlying sepsis and septic organ injury. We are particularly interested in the role of glycosaminoglycans (such as heparan sulfate) in the onset, propagation, and resolution of septic lung, kidney, and brain injury.


    Collapse Research 
    Collapse research activities and funding
    F32HL090296     (SCHMIDT, ERIC PETER)Jul 1, 2007 - Jun 30, 2009
    NIH/NHLBI
    cGMP Compartmentalization in Pulmonary Endothelial Barrier Dysfunction
    Role: Principal Investigator

    K08HL105538     (SCHMIDT, ERIC PETER)Sep 1, 2011 - Jul 31, 2016
    NIH/NHLBI
    Pulmonary endothelial glycocalyx degradation causes ARDS during sepsis
    Role: Principal Investigator

    R01HL125371     (LINHARDT, ROBERT J)Sep 15, 2014 - May 31, 2019
    NIH/NHLBI
    Endothelial glycocalyx reconstitution during sepsis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 Jun; 56(6):727-737. PMID: 28187268.
      View in: PubMed
    2. Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP. Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. Shock. 2017 May 23. PMID: 28538085.
      View in: PubMed
    3. Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky K, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A Model Specific Role of MicroRNA-223 as a Mediator of Kidney Injury During Experimental Sepsis. Am J Physiol Renal Physiol. 2017 May 17; ajprenal.00493.2016. PMID: 28515178.
      View in: PubMed
    4. Zhang X, Xu Y, Hsieh PH, Liu J, Lin L, Schmidt EP, Linhardt RJ. Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation. Org Biomol Chem. 2017 Feb 01; 15(5):1222-1227. PMID: 28091666.
      View in: PubMed
    5. Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 Feb; 47(2):128-131. PMID: 27617672.
      View in: PubMed
    6. Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Aug 15; 194(4):439-49. PMID: 26926297; PMCID: PMC5003330 [Available on 08/15/17].
    7. Haeger SM, Yang Y, Schmidt EP. Heparan Sulfate in the Developing, Healthy, and Injured Lung. Am J Respir Cell Mol Biol. 2016 Jul; 55(1):5-11. PMID: 26982577; PMCID: PMC4942210 [Available on 07/01/17].
    8. Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15; 6(2):945-73. PMID: 27065171.
      View in: PubMed
    9. Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 06; 37(2):263-75. PMID: 27229643; PMCID: PMC4884305 [Available on 06/01/17].
    10. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556; PMCID: PMC4642207 [Available on 10/15/16].
    11. Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D. The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus. PLoS One. 2015; 10(6):e0127032. PMID: 26039697; PMCID: PMC4454641.
    12. Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16; 87(12):6220-7. PMID: 26005898; PMCID: PMC4822829.
    13. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827; PMCID: PMC4430970.
    14. Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep; 184(9):2382-9. PMID: 25016184; PMCID: PMC4188171.
    15. Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3. Am J Respir Cell Mol Biol. 2014 May; 50(5):932-41. PMID: 24304496; PMCID: PMC4068950.
    16. Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21; 289(12):8194-202. PMID: 24509853; PMCID: PMC3961648.
    17. Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013; 8(11):e79037. PMID: 24265742; PMCID: PMC3827109.
    18. Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov; 1(6):e00153. PMID: 24400155; PMCID: PMC3871468.
    19. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):1-5. PMID: 23815257; PMCID: PMC3727882.
    20. Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil Intercellular Communication in Acute Lung Injury: Emerging Roles of Microparticles and Gap Junctions. Am J Respir Cell Mol Biol. 2013 Mar 14. PMID: 23492190.
      View in: PubMed
    21. Yang Y, Yang G, Schmidt EP. In vivo measurement of the mouse pulmonary endothelial surface layer. J Vis Exp. 2013 Feb 22; (72):e50322. PMID: 23462690; PMCID: PMC3605806.
    22. Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013 Jan 01; 1(1). PMID: 24073386.
      View in: PubMed
    23. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173; PMCID: PMC3641738.
    24. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644; PMCID: PMC3723751.
    25. Schmidt EP. The expanding appreciation of heparanase in human disease. Neurosci Lett. 2012 Mar 05; 511(1):1-3. PMID: 22300958.
      View in: PubMed
    26. Carpenter TC, Schroeder W, Stenmark KR, Schmidt EP. Eph-A2 promotes permeability and inflammatory responses to bleomycin-induced lung injury. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):40-7. PMID: 21799118; PMCID: PMC3262654.
    27. Schmidt EP, Lee WL, Zemans RL, Yamashita C, Downey GP. On, around, and through: neutrophil-endothelial interactions in innate immunity. Physiology (Bethesda). 2011 Oct; 26(5):334-47. PMID: 22013192; PMCID: PMC3684246.
    28. Tuder RM, Hunt JM, Schmidt EP. Hyperoxia and apoptosis. Too much of a good thing? Am J Respir Crit Care Med. 2011 Apr 15; 183(8):964-5. PMID: 21498818.
      View in: PubMed
    29. Schmidt EP, Tuder RM. Role of Apoptosis in Amplifying Inflammatory Responses in Lung Diseases. J Cell Death. 2010 Jul 20; 2010(3):41-53. PMID: 22081757.
      View in: PubMed
    30. Schmidt EP, Damarla M, Rentsendorj O, Servinsky LE, Zhu B, Moldobaeva A, Gonzalez A, Hassoun PM, Pearse DB. Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1056-65. PMID: 18849438; PMCID: PMC2604795.
    31. Brandes JC, Schmidt E, Yung R. Occlusive endobronchial stent placement as a novel management approach to massive hemoptysis from lung cancer. J Thorac Oncol. 2008 Sep; 3(9):1071-2. PMID: 18758315.
      View in: PubMed
    32. Schmidt EP, Drachman DB, Wiener CM, Clawson L, Kimball R, Lechtzin N. Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design. Muscle Nerve. 2006 Jan; 33(1):127-32. PMID: 16258948.
      View in: PubMed
    33. Hann CL, Schmidt EP. Images in clinical medicine. Toxic neutrophils in Streptococcus pneumoniae sepsis. N Engl J Med. 2004 Dec 16; 351(25):2636. PMID: 15602024.
      View in: PubMed
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