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Karen E Stevens

TitleLecturer
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSDM-Craniofacial Biology
Phone303/724-4423

    Collapse Research 
    Collapse research activities and funding
    F31DA005288     (STEVENS, KAREN E)Mar 1, 1986
    NIH/NIDA
    IDENTIFICATION OF OPIATE REWARD RECEPTORS
    Role: Principal Investigator

    F32MH010173     (STEVENS, KAREN E)Feb 20, 1992
    NIH/NIMH
    CHOLINERGIC MODULATION OF SENSORY GATING
    Role: Principal Investigator

    R29MH051931     (STEVENS, KAREN E)Jul 1, 1994 - Jun 30, 1999
    NIH/NIMH
    GENETIC ANALYSIS OF SENSORY GATING
    Role: Principal Investigator

    R01MH058680     (STEVENS, KAREN E)Apr 1, 1999 - Mar 31, 2004
    NIH/NIMH
    GENETIC LINKAGE OF AUDITORY GATING
    Role: Principal Investigator

    R01MH073725     (STEVENS, KAREN E)Aug 15, 2006 - Jul 31, 2010
    NIH/NIMH
    Gestational Choline Levels and Sensory Inhibition
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 Aug 03; 627:1-6. PMID: 27233215.
      View in: PubMed
    2. Smucny J, Stevens KE, Tregellas JR. Erratum: The antiepileptic drug levetiracetam improves auditory gating in DBA/2 mice. NPJ Schizophr. 2015; 1:15053. PMID: 27336049.
      View in: PubMed
    3. Tregellas JR, Smucny J, Legget KT, Stevens KE. Effects of a ketogenic diet on auditory gating in DBA/2 mice: A proof-of-concept study. Schizophr Res. 2015 Dec; 169(1-3):351-4. PMID: 26453015; PMCID: PMC4827327 [Available on 12/01/16].
    4. Bates RC, Stith BJ, Stevens KE. Increasing pro-survival factors within whole brain tissue of Sprague Dawley rats via intracerebral administration of modified valproic acid. J Pharmacol Sci. 2015 Aug; 128(4):193-201. PMID: 26275469.
      View in: PubMed
    5. Stevens KE, Zheng L, Floyd KL, Stitzel JA. Maximizing the effect of an a7 nicotinic receptor PAM in a mouse model of schizophrenia-like sensory inhibition deficits. Brain Res. 2015 Jun 22; 1611:8-17. PMID: 25744161; PMCID: PMC4607052.
    6. Wu WL, Adams CE, Stevens KE, Chow KH, Freedman R, Patterson PH. The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring. Brain Behav Immun. 2015 May; 46:192-202. PMID: 25683697; PMCID: PMC4414803.
    7. Smucny J, Stevens KE, Tregellas JR. The antiepileptic drug levetiracetam improves auditory gating in DBA/2 mice. NPJ Schizophr. 2015; 1. PMID: 26317115.
      View in: PubMed
    8. Schulz KM, Pearson JN, Gasparrini ME, Brooks KF, Drake-Frazier C, Zajkowski ME, Kreisler AD, Adams CE, Leonard S, Stevens KE. Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors. Behav Brain Res. 2014 Jul 15; 268:104-10. PMID: 24675162; PMCID: PMC4144861.
    9. Stevens KE, Choo KS, Stitzel JA, Marks MJ, Adams CE. Long-term improvements in sensory inhibition with gestational choline supplementation linked to a7 nicotinic receptors through studies in Chrna7 null mutation mice. Brain Res. 2014 Mar 13; 1552:26-33. PMID: 24462939; PMCID: PMC4405170.
    10. Smucny J, Stevens KE, Tregellas JR. Acute administration of ?? tetrahydrocannabinol does not prevent enhancement of sensory gating by clozapine in DBA/2 mice. Pharmacol Biochem Behav. 2014 Mar; 118:22-9. PMID: 24418217; PMCID: PMC3945413.
    11. Wildeboer-Andrud KM, Zheng L, Choo KS, Stevens KE. Cotinine impacts sensory processing in DBA/2 mice through changes in the conditioning amplitude. Pharmacol Biochem Behav. 2014 Feb; 117:144-50. PMID: 24374321; PMCID: PMC3932945.
    12. Schulz KM, Andrud KM, Burke MB, Pearson JN, Kreisler AD, Stevens KE, Leonard S, Adams CE. The effects of prenatal stress on alpha4 beta2 and alpha7 hippocampal nicotinic acetylcholine receptor levels in adult offspring. Dev Neurobiol. 2013 Nov; 73(11):806-14. PMID: 23749479; PMCID: PMC4438756.
    13. Smucny J, Wylie K, Rojas D, Stevens K, Olincy A, Kronberg E, Zheng L, Tregellas J. Evidence for gamma and beta sensory gating deficits as translational endophenotypes for schizophrenia. Psychiatry Res. 2013 Nov 30; 214(2):169-74. PMID: 23972946; PMCID: PMC4111638.
    14. Stevens KE, Zheng L, Abrams DJ. Intermittent versus continuous central administration of clozapine in DBA/2 mice, improvement in sensory inhibition deficits. Schizophr Res. 2013 Sep; 149(1-3):121-6. PMID: 23863771.
      View in: PubMed
    15. Subaiea GM, Adwan LI, Ahmed AH, Stevens KE, Zawia NH. Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice. Neurobiol Aging. 2013 Oct; 34(10):2421-30. PMID: 23639209; PMCID: PMC3706573.
    16. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S, Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar; 170(3):290-8. PMID: 23318559; PMCID: PMC3640283.
    17. Radek RJ, Robb HM, Stevens KE, Gopalakrishnan M, Bitner RS. Effects of the novel a7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA/2 mice: pharmacodynamic characterization. J Pharmacol Exp Ther. 2012 Dec; 343(3):736-45. PMID: 22988063.
      View in: PubMed
    18. Bates RC, Stith BJ, Stevens KE. Chronic central administration of valproic acid: Increased pro-survival phospho-proteins and growth cone associated proteins with no behavioral pathology. Pharmacol Biochem Behav. 2012 Dec; 103(2):237-44. PMID: 22960225.
      View in: PubMed
    19. Swerdlow NR, Light GA, Breier MR, Shoemaker JM, Saint Marie RL, Neary AC, Geyer MA, Stevens KE, Powell SB. Sensory and sensorimotor gating deficits after neonatal ventral hippocampal lesions in rats. Dev Neurosci. 2012; 34(2-3):240-9. PMID: 22572564.
      View in: PubMed
    20. Wildeboer-Andrud KM, Stevens KE. The smoking cessation drug varenicline improves deficient P20-N40 inhibition in DBA/2 mice. Pharmacol Biochem Behav. 2011 Nov; 100(1):17-24. PMID: 21763340; PMCID: PMC3183147.
    21. Schulz KM, Pearson JN, Neeley EW, Berger R, Leonard S, Adams CE, Stevens KE. Maternal stress during pregnancy causes sex-specific alterations in offspring memory performance, social interactions, indices of anxiety, and body mass. Physiol Behav. 2011 Aug 03; 104(2):340-7. PMID: 21334352; PMCID: PMC4420621.
    22. Dinklo T, Shaban H, Thuring JW, Lavreysen H, Stevens KE, Zheng L, Mackie C, Grantham C, Vandenberk I, Meulders G, Peeters L, Verachtert H, De Prins E, Lesage AS. Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther. 2011 Feb; 336(2):560-74. PMID: 21084390.
      View in: PubMed
    23. Stevens KE, Cornejo B, Adams CE, Zheng L, Yonchek J, Hoffman KL, Christians U, Kem WR. Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain Res. 2010 Sep 17; 1352:140-6. PMID: 20599427; PMCID: PMC3932956.
    24. Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE. Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry. 2010 May; 51(5):535-49. PMID: 19925602; PMCID: PMC2862788.
    25. Wildeboer KM, Zheng L, Choo KS, Stevens KE. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 01; 1300:41-50. PMID: 19728991; PMCID: PMC2784252.
    26. Stevens KE, Adams CE, Mellott TJ, Robbins E, Kisley MA. Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. Brain Res. 2008 Oct 27; 1237:84-90. PMID: 18778692; PMCID: PMC2586157.
    27. Simosky JK, Freedman R, Stevens KE. Olanzapine improves deficient sensory inhibition in DBA/2 mice. Brain Res. 2008 Oct 03; 1233:129-36. PMID: 18687314; PMCID: PMC2586158.
    28. Wildeboer KM, Stevens KE. Stimulation of the alpha4beta2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice. Brain Res. 2008 Aug 11; 1224:29-36. PMID: 18582447; PMCID: PMC2596929.
    29. Stevens KE, Adams CE, Yonchek J, Hickel C, Danielson J, Kisley MA. Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline. Psychopharmacology (Berl). 2008 Jun; 198(3):413-20. PMID: 18446322.
      View in: PubMed
    30. Freedman R, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, Allensworth D, Guzman-Bonilla A, Clement B, Ball MP, Kutnick J, Pender V, Martin LF, Stevens KE, Wagner BD, Zerbe GO, Soti F, Kem WR. Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am J Psychiatry. 2008 Aug; 165(8):1040-7. PMID: 18381905; PMCID: PMC3746983.
    31. Abrams DJ, Zheng L, Choo KS, Yang JJ, Wei W, Anchordoquy TJ, Zawia NH, Stevens KE. An initial animal proof-of-concept study for central administration of clozapine to schizophrenia patients. Schizophr Res. 2008 Mar; 100(1-3):86-96. PMID: 18178385; PMCID: PMC2288754.
    32. Olincy A, Stevens KE. Treating schizophrenia symptoms with an alpha7 nicotinic agonist, from mice to men. Biochem Pharmacol. 2007 Oct 15; 74(8):1192-201. PMID: 17714692; PMCID: PMC2134979.
    33. Adams CE, Stevens KE. Evidence for a role of nicotinic acetylcholine receptors in schizophrenia. Front Biosci. 2007 May 01; 12:4755-72. PMID: 17485411.
      View in: PubMed
    34. Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, Johnstone TB, Zheng L, Stevens KE, Gee KW. Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8059-64. PMID: 17470817; PMCID: PMC1876571.
    35. Olincy A, Harris JG, Johnson LL, Pender V, Kongs S, Allensworth D, Ellis J, Zerbe GO, Leonard S, Stevens KE, Stevens JO, Martin L, Adler LE, Soti F, Kem WR, Freedman R. Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry. 2006 Jun; 63(6):630-8. PMID: 16754836.
      View in: PubMed
    36. Swerdlow NR, Geyer MA, Shoemaker JM, Light GA, Braff DL, Stevens KE, Sharp R, Breier M, Neary A, Auerbach PP. Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats. Neuropsychopharmacology. 2006 Mar; 31(3):506-15. PMID: 16123772; PMCID: PMC1373667.
    37. Hashimoto K, Iyo M, Freedman R, Stevens KE. Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha 7 nicotinic acetylcholine receptors. Psychopharmacology (Berl). 2005 Nov; 183(1):13-9. PMID: 16136299.
      View in: PubMed
    38. Koike K, Hashimoto K, Takai N, Shimizu E, Komatsu N, Watanabe H, Nakazato M, Okamura N, Stevens KE, Freedman R, Iyo M. Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Schizophr Res. 2005 Jul 01; 76(1):67-72. PMID: 15927799.
      View in: PubMed
    39. Freedman R, Ross R, Leonard S, Myles-Worsley M, Adams CE, Waldo M, Tregellas J, Martin L, Olincy A, Tanabe J, Kisley MA, Hunter S, Stevens KE. Early biomarkers of psychosis. Dialogues Clin Neurosci. 2005; 7(1):17-29. PMID: 16060593; PMCID: PMC3181722.
    40. O'Neill HC, Schmitt MP, Stevens KE. Lithium alters measures of auditory gating in two strains of mice. Biol Psychiatry. 2003 Oct 15; 54(8):847-53. PMID: 14550685.
      View in: PubMed
    41. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S. The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep. 2003 Jun; 5(2):155-61. PMID: 12685995.
      View in: PubMed
    42. O'Neill HC, Rieger K, Kem WR, Stevens KE. DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats. Psychopharmacology (Berl). 2003 Sep; 169(3-4):332-9. PMID: 12759805.
      View in: PubMed
    43. Simosky JK, Stevens KE, Adler LE, Freedman R. Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism. Psychopharmacology (Berl). 2003 Feb; 165(4):386-96. PMID: 12459928.
      View in: PubMed
    44. Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, Leonard S. Input dysfunction, schizotypy, and genetic models of schizophrenia. Schizophr Res. 2002 Mar 01; 54(1-2):25-32. PMID: 11853975.
      View in: PubMed
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