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Stephen Paul Malkoski

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Overview 
    Collapse overview
    Our laboratory is interested in how the loss of tumor suppressors promotes the development of lung cancer but potential creates targetable tumor phenotypes. We are currently studying how loss of the tumor suppressor Smad4 reduces DNA repair, rendering lung cancer cells more sensitive to treatment with DNA topoisomerase inhibitors and inhibitors of DNA repair by non-homologous end joining. Our lab uses human lung cancer samples, sophisticated mouse models of lung cancer, and lung cancer cell lines to address these questions. Other areas of interest include lung cancer screening and the diagnosis and management of solitary pulmonary nodules.

    Collapse Research 
    Collapse research activities and funding
    F32CA119467     (MALKOSKI, STEPHEN P)Aug 1, 2006 - Jul 31, 2008
    Regulation of delta-Np63 in squamous cell carcinoma
    Role: Principal Investigator

    K08CA131483     (MALKOSKI, STEPHEN P)Sep 23, 2008 - Aug 31, 2014
    TGFbeta and lung squamous cell carcinoma
    Role: Principal Investigator

    R21CA194662     (MALKOSKI, STEPHEN P)Apr 1, 2015 - Mar 31, 2017
    Targeting defective DNA pathways in Smad4 deficient lung cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 01; 78(1):143-156. PMID: 29118090.
      View in: PubMed
    2. Mansoori JN, Little N, Malkoski SP. Maximizing Benefits and Minimizing Harms of Lung Cancer Screening: A Teachable Moment. JAMA Intern Med. 2017 Aug 01; 177(8):1197-1198. PMID: 28628709.
      View in: PubMed
    3. Barón AE, Kako S, Feser WJ, Malinowski H, Merrick D, Garg K, Malkoski S, Pretzel S, Siegfried JM, Franklin WA, Miller Y, Wolf HJ, Varella-Garcia M. Clinical Utility of Chromosomal Aneusomy in Individuals at High Risk of Lung Cancer. J Thorac Oncol. 2017 Oct; 12(10):1512-1523. PMID: 28634123.
      View in: PubMed
    4. Ziemke M, Patil T, Nolan K, Tippimanchai D, Malkoski SP. Reduced Smad4 expression and DNA topoisomerase inhibitor chemosensitivity in non-small cell lung cancer. Lung Cancer. 2017 07; 109:28-35. PMID: 28577946.
      View in: PubMed
    5. Du L, Chen X, Cao Y, Lu L, Zhang F, Bornstein S, Li Y, Owens P, Malkoski S, Said S, Jin F, Kulesz-Martin M, Gross N, Wang XJ, Lu SL. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFß signaling. Oncogene. 2016 Sep 01; 35(35):4641-52. PMID: 26876212; PMCID: PMC4985507 [Available on 03/01/17].
    6. Haeger SM, Thompson JJ, Kalra S, Cleaver TG, Merrick D, Wang XJ, Malkoski SP. Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors. Oncogene. 2016 Feb 04; 35(5):577-586. PMID: 25893305; PMCID: PMC4615192.
    7. Mueller SW, Preslaski CR, Kiser TH, Fish DN, Lavelle JC, Malkoski SP, MacLaren R. A randomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal. Crit Care Med. 2014 May; 42(5):1131-9. PMID: 24351375.
      View in: PubMed
    8. MacLaren R, Preslaski CR, Mueller SW, Kiser TH, Fish DN, Lavelle JC, Malkoski SP. A randomized, double-blind pilot study of dexmedetomidine versus midazolam for intensive care unit sedation: patient recall of their experiences and short-term psychological outcomes. J Intensive Care Med. 2015 Mar; 30(3):167-75. PMID: 24227448.
      View in: PubMed
    9. Malkoski SP, Cleaver TG, Thompson JJ, Sutton WP, Haeger SM, Rodriguez KJ, Lu SL, Merrick D, Wang XJ. Role of PTEN in basal cell derived lung carcinogenesis. Mol Carcinog. 2014 Oct; 53(10):841-6. PMID: 23625632; PMCID: PMC3906215.
    10. Malkoski SP, Haeger SM, Cleaver TG, Rodriguez KJ, Li H, Lu SL, Feser WJ, Barón AE, Merrick D, Lighthall JG, Ijichi H, Franklin W, Wang XJ. Loss of transforming growth factor beta type II receptor increases aggressive tumor behavior and reduces survival in lung adenocarcinoma and squamous cell carcinoma. Clin Cancer Res. 2012 Apr 15; 18(8):2173-83. PMID: 22399565; PMCID: PMC3328594.
    11. Malkoski SP, Wang XJ. Two sides of the story? Smad4 loss in pancreatic cancer versus head-and-neck cancer. FEBS Lett. 2012 Jul 04; 586(14):1984-92. PMID: 22321641; PMCID: PMC3285395.
    12. Hudish TM, Opincariu LI, Mozer AB, Johnson MS, Cleaver TG, Malkoski SP, Merrick DT, Keith RL. N-nitroso-tris-chloroethylurea induces premalignant squamous dysplasia in mice. Cancer Prev Res (Phila). 2012 Feb; 5(2):283-9. PMID: 22086679; PMCID: PMC4461023.
    13. Weber SM, Bornstein S, Li Y, Malkoski SP, Wang D, Rustgi AK, Kulesz-Martin MF, Wang XJ, Lu SL. Tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces AKT activation in head and neck epithelia. Int J Oncol. 2011 Nov; 39(5):1193-8. PMID: 21822536; PMCID: PMC3249931.
    14. Hegab AE, Ha VL, Gilbert JL, Zhang KX, Malkoski SP, Chon AT, Darmawan DO, Bisht B, Ooi AT, Pellegrini M, Nickerson DW, Gomperts BN. Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential. Stem Cells. 2011 Aug; 29(8):1283-93. PMID: 21710468; PMCID: PMC3403816.
    15. Deng Y, Deng H, Liu J, Han G, Malkoski S, Liu B, Zhao R, Wang XJ, Zhang Q. Transcriptional down-regulation of Brca1 and E-cadherin by CtBP1 in breast cancer. Mol Carcinog. 2012 Jun; 51(6):500-7. PMID: 21681822; PMCID: PMC3177013.
    16. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr; 29(4):725-35. PMID: 21312316; PMCID: PMC3322548.
    17. Mitra D, Malkoski SP, Wang XJ. Cancer stem cells in head and neck cancer. Cancers (Basel). 2011 Jan 20; 3(1):415-27. PMID: 24212622; PMCID: PMC3756369.
    18. Deng Y, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene. 2010 Dec 16; 29(50):6603-8. PMID: 20818429; PMCID: PMC3081720.
    19. White RA, Malkoski SP, Wang XJ. TGFß signaling in head and neck squamous cell carcinoma. Oncogene. 2010 Oct 07; 29(40):5437-46. PMID: 20676130; PMCID: PMC3942159.
    20. Malkoski SP, Cleaver TG, Lu SL, Lighthall JG, Wang XJ. Keratin promoter based gene manipulation in the murine conducting airway. Int J Biol Sci. 2010 Jan 20; 6(1):68-79. PMID: 20140084; PMCID: PMC2815352.
    21. Bornstein S, White R, Malkoski S, Oka M, Han G, Cleaver T, Reh D, Andersen P, Gross N, Olson S, Deng C, Lu SL, Wang XJ. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest. 2009 Nov; 119(11):3408-19. PMID: 19841536.
      View in: PubMed
    22. Bredow S, Falgout MM, March TH, Yingling CM, Malkoski SP, Aden J, Bedrick EJ, Lewis JL, Divine KK. Subchronic inhalation of soluble manganese induces expression of hypoxia-associated angiogenic genes in adult mouse lungs. Toxicol Appl Pharmacol. 2007 Jun 01; 221(2):148-57. PMID: 17467022; PMCID: PMC2478672.
    23. Malkoski SP, Dorin RI. Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene. Mol Endocrinol. 1999 Oct; 13(10):1629-44. PMID: 10517666.
      View in: PubMed
    24. Malkoski SP, Handanos CM, Dorin RI. Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol Cell Endocrinol. 1997 Mar 28; 127(2):189-99. PMID: 9099914.
      View in: PubMed
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