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Tobias Eckle

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology
Phone303/724-2932

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Eckle T. New "Guidance" for the Treatment of Hepatic Ischemia Reperfusion Injury Through Semaphorins and Plexins. Crit Care Med. 2016 Aug; 44(8):1623-4.
      View in: PubMed
    2. Gile J, Eckle T. ADORA2b Signaling in Cardioprotection. J Nat Sci. 2016; 2(10).
      View in: PubMed
    3. Scott B, Eckle T. The impact of sedation protocols on outcomes in critical illness. Ann Transl Med. 2016 Jan; 4(2):33.
      View in: PubMed
    4. Seo SW, Koeppen M, Bonney S, Gobel M, Thayer M, Harter PN, Ravid K, Eltzschig HK, Mittelbronn M, Walker L, Eckle T. Differential Tissue-Specific Function of Adora2b in Cardioprotection. J Immunol. 2015 Aug 15; 195(4):1732-43.
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    5. Brainard J, Gobel M, Scott B, Koeppen M, Eckle T. Health implications of disrupted circadian rhythms and the potential for daylight as therapy. Anesthesiology. 2015 May; 122(5):1170-5.
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    6. Koeppen M, Eckle T, Eltzschig HK. Next generation of cardiovascular studies: transcriptional responses of the human myocardium during cardiac surgery. Anesthesiology. 2015 Mar; 122(3):486-8.
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    7. Eckle T. Editorial: Health Impact and Management of a Disrupted Circadian Rhythm and Sleep in Critical Illnesses. Curr Pharm Des. 2015; 21(24):3428-30.
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    8. Brainard J, Gobel M, Bartels K, Scott B, Koeppen M, Eckle T. Circadian rhythms in anesthesia and critical care medicine: potential importance of circadian disruptions. Semin Cardiothorac Vasc Anesth. 2015 Mar; 19(1):49-60.
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    9. Eckle T. About Dogs, Mice, and Men: From Ischemic Preconditioning to Anesthetic Postconditioning of the Heart. Semin Cardiothorac Vasc Anesth. 2014 Sep; 18(3):247-8.
      View in: PubMed
    10. Eckle T, Kewley EM, Brodsky KS, Tak E, Bonney S, Gobel M, Anderson D, Glover LE, Riegel AK, Colgan SP, Eltzschig HK. Identification of hypoxia-inducible factor HIF-1A as transcriptional regulator of the A2B adenosine receptor during acute lung injury. J Immunol. 2014 Feb 01; 192(3):1249-56.
      View in: PubMed
    11. Bonney S, Hughes K, Eckle T. Anesthetic cardioprotection: the role of adenosine. Curr Pharm Des. 2014; 20(36):5690-5.
      View in: PubMed
    12. Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013 Sep; 11(9):e1001665.
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    13. Bonney S, Kominsky D, Brodsky K, Eltzschig H, Walker L, Eckle T. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013; 8(8):e71493.
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    14. Han J, Gagnon S, Eckle T, Borchers CH. Metabolomic analysis of key central carbon metabolism carboxylic acids as their 3-nitrophenylhydrazones by UPLC/ESI-MS. Electrophoresis. 2013 Oct; 34(19):2891-900.
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    15. Han J, Tschernutter V, Yang J, Eckle T, Borchers CH. Analysis of selected sugars and sugar phosphates in mouse heart tissue by reductive amination and liquid chromatography-electrospray ionization mass spectrometry. Anal Chem. 2013 Jun 18; 85(12):5965-73.
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    16. Eckle T, Hughes K, Ehrentraut H, Brodsky KS, Rosenberger P, Choi DS, Ravid K, Weng T, Xia Y, Blackburn MR, Eltzschig HK. Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury. FASEB J. 2013 Aug; 27(8):3078-89.
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    17. Eltzschig HK, Bonney SK, Eckle T. Attenuating myocardial ischemia by targeting A2B adenosine receptors. Trends Mol Med. 2013 Jun; 19(6):345-54.
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    18. Bonney S, Hughes K, Harter PN, Mittelbronn M, Walker L, Eckle T. Cardiac period 2 in myocardial ischemia: clinical implications of a light dependent protein. Int J Biochem Cell Biol. 2013 Mar; 45(3):667-71.
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    19. Eckle T, Peter J, Rüttimann S. [A very uncommon reason for chest pain]. Ther Umsch. 2012 Dec; 69(12):679-82.
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    20. Koeppen M, Gravlee GP, Nasrallah F, Eckle T. Transesophageal echocardiography in the diagnosis of acute pericardial tamponade during hiatal hernia repair. J Cardiothorac Vasc Anesth. 2014 Feb; 28(1):112-4.
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    21. Koeppen M, Harter PN, Bonney S, Bonney M, Reithel S, Zachskorn C, Mittelbronn M, Eckle T. Adora2b signaling on bone marrow derived cells dampens myocardial ischemia-reperfusion injury. Anesthesiology. 2012 Jun; 116(6):1245-57.
      View in: PubMed
    22. Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 Apr 15; 18(5):774-82.
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    23. Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin Cardiothorac Vasc Anesth. 2012 Sep; 16(3):123-32.
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    24. Eltzschig HK, Eckle T. Ischemia and reperfusion--from mechanism to translation. Nat Med. 2011 Nov 07; 17(11):1391-401.
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    25. Koeppen M, Eckle T, Eltzschig HK. The hypoxia-inflammation link and potential drug targets. Curr Opin Anaesthesiol. 2011 Aug; 24(4):363-9.
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    26. Koeppen M, Eckle T, Eltzschig HK. Pressure controlled ventilation to induce acute lung injury in mice. J Vis Exp. 2011 May 05; (51).
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    27. Eckle T, Koeppen M, Eltzschig H. Use of a hanging weight system for coronary artery occlusion in mice. J Vis Exp. 2011 Apr 19; (50).
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    28. Magarzo JG, Fulchini R, Eckle T, Rüttimann S. [Unclear neurological condition and fever]. Praxis (Bern 1994). 2011 Mar 30; 100(7):429-33.
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    29. Eckle T, Eltzschig HK. Toll-like receptor signaling during myocardial ischemia. Anesthesiology. 2011 Mar; 114(3):490-2.
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    30. Koeppen M, Eckle T, Eltzschig HK. Interplay of hypoxia and A2B adenosine receptors in tissue protection. Adv Pharmacol. 2011; 61:145-86.
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    31. Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK. Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury. J Immunol. 2010 May 01; 184(9):5271-9.
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    32. Eckle T, Koeppen M, Eltzschig HK. Role of extracellular adenosine in acute lung injury. Physiology (Bethesda). 2009 Oct; 24:298-306.
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    33. Koeppen M, Eckle T, Eltzschig HK. Selective deletion of the A1 adenosine receptor abolishes heart-rate slowing effects of intravascular adenosine in vivo. PLoS One. 2009 Aug 26; 4(8):e6784.
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    34. Eltzschig HK, Eckle T, Grenz A. PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med. 2009 Mar 26; 360(13):1361-2; author reply 1362.
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    35. Eckle T, Grenz A, Laucher S, Eltzschig HK. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest. 2008 Oct; 118(10):3301-15.
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    36. Eltzschig HK, Köhler D, Eckle T, Kong T, Robson SC, Colgan SP. Central role of Sp1-regulated CD39 in hypoxia/ischemia protection. Blood. 2009 Jan 01; 113(1):224-32.
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    37. Eckle T, Füllbier L, Grenz A, Eltzschig HK. Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L718-24.
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    38. Eckle T, Köhler D, Lehmann R, El Kasmi K, Eltzschig HK. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation. 2008 Jul 08; 118(2):166-75.
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    39. Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK. The reno-vascular A2B adenosine receptor protects the kidney from ischemia. PLoS Med. 2008 Jun 24; 5(6):e137.
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    40. Hart ML, Köhler D, Eckle T, Kloor D, Stahl GL, Eltzschig HK. Direct treatment of mouse or human blood with soluble 5'-nucleotidase inhibits platelet aggregation. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1477-83.
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    41. Eltzschig HK, El Kasmi KC, Eckle T. The HIF2A gene in familial erythrocytosis. N Engl J Med. 2008 May 01; 358(18):1965-6; author reply 1966-7.
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    42. Redel A, Jazbutyte V, Smul TM, Lange M, Eckle T, Eltzschig H, Roewer N, Kehl F. Impact of ischemia and reperfusion times on myocardial infarct size in mice in vivo. Exp Biol Med (Maywood). 2008 Jan; 233(1):84-93.
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    43. Eckle T, Faigle M, Grenz A, Laucher S, Thompson LF, Eltzschig HK. A2B adenosine receptor dampens hypoxia-induced vascular leak. Blood. 2008 Feb 15; 111(4):2024-35.
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    44. Köhler D, Eckle T, Faigle M, Grenz A, Mittelbronn M, Laucher S, Hart ML, Robson SC, Müller CE, Eltzschig HK. CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury. Circulation. 2007 Oct 16; 116(16):1784-94.
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    45. Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann J, Köhle C, Kloor D, Gleiter CH, Vallon V, Eltzschig HK, Osswald H. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1501-11.
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    46. Eckle T, Füllbier L, Wehrmann M, Khoury J, Mittelbronn M, Ibla J, Rosenberger P, Eltzschig HK. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol. 2007 Jun 15; 178(12):8127-37.
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    47. Grenz A, Zhang H, Hermes M, Eckle T, Klingel K, Huang DY, Müller CE, Robson SC, Osswald H, Eltzschig HK. Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J. 2007 Sep; 21(11):2863-73.
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    48. Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK. Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors. Circulation. 2007 Mar 27; 115(12):1581-90.
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    49. Warth A, Eckle T, Köhler D, Faigle M, Zug S, Klingel K, Eltzschig HK, Wolburg H. Upregulation of the water channel aquaporin-4 as a potential cause of postischemic cell swelling in a murine model of myocardial infarction. Cardiology. 2007; 107(4):402-10.
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    50. Grenz A, Zhang H, Eckle T, Mittelbronn M, Wehrmann M, Köhle C, Kloor D, Thompson LF, Osswald H, Eltzschig HK. Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia. J Am Soc Nephrol. 2007 Mar; 18(3):833-45.
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    51. Eltzschig HK, Eckle T, Mager A, Küper N, Karcher C, Weissmüller T, Boengler K, Schulz R, Robson SC, Colgan SP. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006 Nov 10; 99(10):1100-8.
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    52. Grenz A, Eckle T, Zhang H, Huang DY, Wehrmann M, Köhle C, Unertl K, Osswald H, Eltzschig HK. Use of a hanging-weight system for isolated renal artery occlusion during ischemic preconditioning in mice. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F475-85.
      View in: PubMed
    53. Eckle T, Grenz A, Köhler D, Redel A, Falk M, Rolauffs B, Osswald H, Kehl F, Eltzschig HK. Systematic evaluation of a novel model for cardiac ischemic preconditioning in mice. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2533-40.
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    54. Colgan SP, Eltzschig HK, Eckle T, Thompson LF. Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal. 2006 Jun; 2(2):351-60.
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    55. Eltzschig HK, Weissmüller T, Mager A, Eckle T. Nucleotide metabolism and cell-cell interactions. Methods Mol Biol. 2006; 341:73-87.
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    56. Eckle T, Ghanayim N, Trick M, Unertl K, Eltzschig HK. Intraoperative metamizol as cause for acute anaphylactic collapse. Eur J Anaesthesiol. 2005 Oct; 22(10):810-12.
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    57. Eltzschig HK, Eckle T, Felbinger TW. Management of chronic obstructive pulmonary disease. N Engl J Med. 2004 Sep 30; 351(14):1461-3; author reply 1461-3.
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    58. Eckle T, Jahn G, Hamprecht K. The influence of mixed HCMV UL97 wildtype and mutant strains on ganciclovir susceptibility in a cell associated plaque reduction assay. J Clin Virol. 2004 May; 30(1):50-6.
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    59. Eckle T, Jahn G, Hamprecht K. High impact of an expanded restriction fragment length polymorphism assay on detection of ganciclovir-resistant UL97 mutants of human cytomegalovirus. Antimicrob Agents Chemother. 2003 Jan; 47(1):442-3.
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    60. Hamprecht K, Eckle T, Prix L, Faul C, Einsele H, Jahn G. Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain. J Infect Dis. 2003 Jan 01; 187(1):139-43.
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    61. Eckle T, Lang P, Prix L, Jahn G, Klingebiel T, Handgretinger R, Selle B, Niethammer D, Hamprecht K. Rapid development of ganciclovir-resistant cytomegalovirus infection in children after allogeneic stem cell transplantation in the early phase of immune cell recovery. Bone Marrow Transplant. 2002 Oct; 30(7):433-9.
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    62. Eckle T, Prix L, Jahn G, Klingebiel T, Handgretinger R, Selle B, Hamprecht K. Drug-resistant human cytomegalovirus infection in children after allogeneic stem cell transplantation may have different clinical outcomes. Blood. 2000 Nov 01; 96(9):3286-9.
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    63. Bock KW, Eckle T, Ouzzine M, Fournel-Gigleux S. Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells. Biochem Pharmacol. 2000 Mar 01; 59(5):467-70.
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