Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Katheleen J Gardiner

TitleProfessor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Address2RC1N
Research North Tower
12800 E 19th Ave, Bldg. RC1 North Room P18-9103
Aurora CO 80010

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Higuera C, Gardiner KJ, Cios KJ. Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS One. 2015; 10(6):e0129126.
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    2. Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Stasko M, Gardiner KJ. Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome. PLoS One. 2015; 10(3):e0119491.
      View in: PubMed
    3. Gardiner KJ. Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Des Devel Ther. 2015; 9:103-25.
      View in: PubMed
    4. Hartley D, Blumenthal T, Carrillo M, DiPaolo G, Esralew L, Gardiner K, Granholm AC, Iqbal K, Krams M, Lemere C, Lott I, Mobley W, Ness S, Nixon R, Potter H, Reeves R, Sabbagh M, Silverman W, Tycko B, Whitten M, Wisniewski T. Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimers Dement. 2015 Jun; 11(6):700-9.
      View in: PubMed
    5. Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Gardiner KJ. Protein profiles associated with context fear conditioning and their modulation by memantine. Mol Cell Proteomics. 2014 Apr; 13(4):919-37.
      View in: PubMed
    6. Busciglio J, Capone G, O'Bryan J, O'Byran JP, Gardiner KJ. Down syndrome: genes, model systems, and progress towards pharmacotherapies and clinical trials for cognitive deficits. Cytogenet Genome Res. 2013; 141(4):260-71.
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    7. Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ. Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Hum Mol Genet. 2013 May 1; 22(9):1709-24.
      View in: PubMed
    8. Spellman C, Ahmed MM, Dubach D, Gardiner KJ. Expression of trisomic proteins in Down syndrome model systems. Gene. 2013 Jan 10; 512(2):219-25.
      View in: PubMed
    9. Sturgeon XH, Gardiner KJ. RCDA: a highly sensitive and specific alternatively spliced transcript assembly tool featuring upstream consecutive exon structures. Genomics. 2012 Dec; 100(6):357-62.
      View in: PubMed
    10. Ahmed MM, Sturgeon X, Ellison M, Davisson MT, Gardiner KJ. Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome. J Proteome Res. 2012 Feb 3; 11(2):1251-63.
      View in: PubMed
    11. Sturgeon X, Le T, Ahmed MM, Gardiner KJ. Pathways to cognitive deficits in Down syndrome. Prog Brain Res. 2012; 197:73-100.
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    12. Nguyen CD, Gardiner KJ, Cios KJ. Protein annotation from protein interaction networks and Gene Ontology. J Biomed Inform. 2011 Oct; 44(5):824-9.
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    13. Liu C, Morishima M, Yu T, Matsui S, Zhang L, Fu D, Pao A, Costa AC, Gardiner KJ, Cowell JK, Nowak NJ, Nowak NJ, Parmacek MS, Liang P, Baldini A, Yu YE. Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet. 2011 Nov; 130(5):623-32.
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    14. Sturgeon X, Gardiner KJ. Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mamm Genome. 2011 Jun; 22(5-6):261-71.
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    15. Nguyen CD, Costa AC, Cios KJ, Gardiner KJ. Machine learning methods predict locomotor response to MK-801 in mouse models of down syndrome. J Neurogenet. 2011 Mar; 25(1-2):40-51.
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    16. Ahmed MM, Gardiner KJ. Preserving protein profiles in tissue samples: differing outcomes with and without heat stabilization. J Neurosci Methods. 2011 Mar 15; 196(1):99-106.
      View in: PubMed
    17. Gardiner K, Herault Y, Lott IT, Antonarakis SE, Reeves RH, Dierssen M. Down syndrome: from understanding the neurobiology to therapy. J Neurosci. 2010 Nov 10; 30(45):14943-5.
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    18. Le T, Altman T, Gardiner K. HIGEDA: a hierarchical gene-set genetics based algorithm for finding subtle motifs in biological sequences. Bioinformatics. 2010 Feb 1; 26(3):302-9.
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    19. Gardiner KJ. Molecular basis of pharmacotherapies for cognition in Down syndrome. Trends Pharmacol Sci. 2010 Feb; 31(2):66-73.
      View in: PubMed
    20. Siddiqui A, Lacroix T, Stasko MR, Scott-McKean JJ, Costa AC, Gardiner KJ. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav. 2008 Oct; 7(7):810-20.
      View in: PubMed
    21. Voronov SV, Frere SG, Giovedi S, Pollina EA, Borel C, Zhang H, Schmidt C, Akeson EC, Wenk MR, Cimasoni L, Arancio O, Davisson MT, Antonarakis SE, Gardiner K, De Camilli P, Di Paolo G. Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A. 2008 Jul 8; 105(27):9415-20.
      View in: PubMed
    22. Pritchard M, Reeves RH, Dierssen M, Patterson D, Gardiner KJ. Down syndrome and the genes of human chromosome 21: current knowledge and future potentials. Report on the Expert workshop on the biology of chromosome 21 genes: towards gene-phenotype correlations in Down syndrome. Washington D.C., September 28-October 1, 2007. Cytogenet Genome Res. 2008; 121(1):67-77.
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    23. Kuhn DE, Nuovo GJ, Martin MM, Malana GE, Pleister AP, Jiang J, Schmittgen TD, Terry AV, Gardiner K, Head E, Feldman DS, Elton TS. Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun. 2008 Jun 6; 370(3):473-7.
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    24. Nguyen C, Mannino M, Gardiner K, Cios KJ. ClusFCM: an algorithm for predicting protein functions using homologies and protein interactions. J Bioinform Comput Biol. 2008 Feb; 6(1):203-22.
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    25. Nguyen C, Gardiner KJ, Cios KJ. A hidden Markov model for predicting protein interfaces. J Bioinform Comput Biol. 2007 Jun; 5(3):739-53.
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    26. Nguyen C, Thaicharoen S, Lacroix T, Gardiner K, Cios KJ. A comprehensive human chromosome 21 database. IEEE Eng Med Biol Mag. 2007 Mar-Apr; 26(2):86-93.
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    27. Du Y, Stasko M, Costa AC, Davisson MT, Gardiner KJ. Editing of the serotonin 2C receptor pre-mRNA: Effects of the Morris Water Maze. Gene. 2007 Apr 15; 391(1-2):186-97.
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    28. Gardiner K, Costa AC. The proteins of human chromosome 21. Am J Med Genet C Semin Med Genet. 2006 Aug 15; 142C(3):196-205.
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    29. Ma'ayan A, Gardiner K, Iyengar R. The cognitive phenotype of Down syndrome: insights from intracellular network analysis. NeuroRx. 2006 Jul; 3(3):396-406.
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    30. Du Y, Davisson MT, Kafadar K, Gardiner K. A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains. Gene. 2006 Nov 1; 382:39-46.
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    31. Gardiner K. Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors. Behav Genet. 2006 May; 36(3):439-53.
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    32. Gardiner K, Du Y. A-to-I editing of the 5HT2C receptor and behaviour. Brief Funct Genomic Proteomic. 2006 Mar; 5(1):37-42.
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    33. Nikolaienko O, Nguyen C, Crinc LS, Cios KJ, Gardiner K. Human chromosome 21/Down syndrome gene function and pathway database. Gene. 2005 Dec 30; 364:90-8.
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    34. Gardiner K, Davisson MT, Pritchard M, Patterson D, Groner Y, Crnic LS, Antonarakis S, Mobley W. Report on the 'Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype correlations in Down syndrome', held June 11-14, 2004, Washington D.C. Cytogenet Genome Res. 2005; 108(4):269-77.
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    35. Gardiner K. Gene-dosage effects in Down syndrome and trisomic mouse models. Genome Biol. 2004; 5(10):244.
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    36. Gardiner K, Davisson MT, Crnic LS. Building protein interaction maps for Down's syndrome. Brief Funct Genomic Proteomic. 2004 Aug; 3(2):142-56.
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    37. Tsyba L, Skrypkina I, Rynditch A, Nikolaienko O, Ferenets G, Fortna A, Gardiner K. Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities. Genomics. 2004 Jul; 84(1):106-13.
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    38. Gardiner K, Fortna A, Bechtel L, Davisson MT. Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene. 2003 Oct 30; 318:137-47.
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    39. Gardiner K. Predicting pathway perturbations in Down syndrome. J Neural Transm Suppl. 2003; (67):21-37.
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    40. Slavov D, Gardiner K. Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns. Gene. 2002 Oct 16; 299(1-2):83-94.
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    41. Gardiner K, Slavov D, Bechtel L, Davisson M. Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis. Genomics. 2002 Jun; 79(6):833-43.
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    42. Werner T, Weissman S, Hedges SB, Gardiner K. Report on the twelfth international workshop on the identification of transcribed sequences: functional, expression and evolutionary analysis. Cytogenet Genome Res. 2002; 98(2-3):109-17.
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    43. Davisson MT, Bechtel LJ, Akeson EC, Fortna A, Slavov D, Gardiner K. Evolutionary breakpoints on human chromosome 21. Genomics. 2001 Nov; 78(1-2):99-106.
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    44. Kurdyukov SG, Lebedev YB, Artamonova II, Gorodentseva TN, Batrak AV, Mamedov IZ, Azhikina TL, Legchilina SP, Efimenko IG, Gardiner K, Sverdlov ED. Full-sized HERV-K (HML-2) human endogenous retroviral LTR sequences on human chromosome 21: map locations and evolutionary history. Gene. 2001 Jul 25; 273(1):51-61.
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    45. Fortna A, Gardiner K. Genomic sequence analysis tools: a user's guide. Trends Genet. 2001 Mar; 17(3):158-64.
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    46. Akeson EC, Lambert JP, Narayanswami S, Gardiner K, Bechtel LJ, Davisson MT. Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome. Cytogenet Cell Genet. 2001; 93(3-4):270-6.
      View in: PubMed
    47. Davisson MT, Gardiner K, Costa AC. Report and abstracts of the ninth international workshop on the molecular biology of human chromosome 21 and Down syndrome. Bar Harbor, Maine, USA. 23-26 September 2000. Cytogenet Cell Genet. 2001; 92(1-2):1-22.
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    48. Gardiner K, Weissman S, Werner T. Report on the Eleventh International Workshop on the Identification of Transcribed Sequences 2001. November 9-11, 2001. Washington, DC, USA. Cytogenet Cell Genet. 2001; 95(1-2):1-8.
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    49. Gardiner K, Davisson M. The sequence of human chromosome 21 and implications for research into Down syndrome. Genome Biol. 2000; 1(2):REVIEWS0002.
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    50. Slavov D, Crnogorac-Jurcevic T, Clark M, Gardiner K. Comparative analysis of the DRADA A-to-I RNA editing gene from mammals, pufferfish and zebrafish. Gene. 2000 May 30; 250(1-2):53-60.
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    51. Slavov D, Clark M, Gardiner K. Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish. Gene. 2000 May 30; 250(1-2):41-51.
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    52. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML. The DNA sequence of human chromosome 21. Nature. 2000 May 18; 405(6784):311-9.
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    53. Slavov D, Hattori M, Sakaki Y, Rosenthal A, Shimizu N, Minoshima S, Kudoh J, Yaspo ML, Ramser J, Reinhardt R, Reimer C, Clancy K, Rynditch A, Gardiner K. Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21. Gene. 2000 Apr 18; 247(1-2):215-32.
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    54. Gardiner K, Mural R, Werner T. Report of the ninth international workshop on the identification of transcribed sequences. Cytogenet Cell Genet. 2000; 88(1-2):1-10.
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    55. Patterson D, Bleskan J, Gardiner K, Bowersox J. Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis. Gene. 1999 Nov 1; 239(2):381-91.
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    56. Ruault M, Trichet V, Gimenez S, Boyle S, Gardiner K, Rolland M, Roizès G, De Sario A. Juxta-centromeric region of human chromosome 21 is enriched for pseudogenes and gene fragments. Gene. 1999 Oct 18; 239(1):55-64.
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    57. Gardiner K. Human chromosome 21. Why 40 Mb? Ann N Y Acad Sci. 1999 May 18; 870:362-8.
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    58. Tassone F, Villard L, Clancy K, Gardiner K. Structures, sequence characteristics, and synteny relationships of the transcription factor E4TF1, the splicing factor U2AF35 and the cystathionine beta synthetase genes from Fugu rubripes. Gene. 1999 Jan 21; 226(2):211-23.
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    59. Gardiner K. Saturation identification of coding sequences in genomic DNA. Methods Enzymol. 1999; 303:144-61.
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    60. Tassone F, Lucas R, Slavov D, Kavsan V, Crnic L, Gardiner K. Gene expression relevant to Down syndrome: problems and approaches. J Neural Transm Suppl. 1999; 57:179-95.
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    61. Gardiner K, Mural R, Werner T. Report of the eighth international workshop on the identification of transcribed sequences. Cytogenet Cell Genet. 1999; 84(1-2):2-10.
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    62. Saupe S, Roizès G, Peter M, Boyle S, Gardiner K, De Sario A. Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13. Genomics. 1998 Sep 15; 52(3):305-11.
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    63. Villard L, Tassone F, Crnogorac-Jurcevic T, Clancy K, Gardiner K. Analysis of pufferfish homologues of the AT-rich human APP gene. Gene. 1998 Mar 27; 210(1):17-24.
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    64. Gardiner K, Yaspo ML. Report of the seventh international workshop on human chromosome 21 mapping 1997. Cytogenet Cell Genet. 1998; 82(1-2):1-12.
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    65. Gardiner K. Clonability and gene distribution on human chromosome 21: reflections of junk DNA content? Gene. 1997 Dec 31; 205(1-2):39-46.
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    66. Pekarsky Y, Rynditch A, Wieser R, Fonatsch C, Gardiner K. Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. Cancer Res. 1997 Sep 15; 57(18):3914-9.
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    67. Rynditch A, Pekarsky Y, Schnittger S, Gardiner K. Leukemia breakpoint region in 3q21 is gene rich. Gene. 1997 Jul 1; 193(1):49-57.
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    68. Gardiner K, Brookes A, Mural R. Of messages and meaning. Trends Genet. 1997 Mar; 13(3):92-3.
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    69. Villard L, Tassone F, Haymowicz M, Welborn R, Gardiner K. Map location, genomic organization and expression patterns of the human RED1 RNA editase. Somat Cell Mol Genet. 1997 Mar; 23(2):135-45.
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    70. Korenberg JR, Aaltonen J, Brahe C, Cabin D, Creau N, Delabar JM, Doering J, Gardiner K, Hubert RS, Ives J, Kessling A, Kudoh J, Lafrenière R, Murakami Y, Ohira M, Ohki M, Patterson D, Potier MC, Quackenbush J, Reeves RH, Sakaki Y, Shimizu N, Soeda E, Van Broeckhoven C, Yaspo ML. Report and abstracts of the Sixth International Workshop on Human Chromosome 21 Mapping 1996. Cold Spring Harbor, New York, USA. May 6-8,1996. Cytogenet Cell Genet. 1997; 79(1-2):21-52.
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    71. Gardiner K. Base composition and gene distribution: critical patterns in mammalian genome organization. Trends Genet. 1996 Dec; 12(12):519-24.
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    72. Cabin DE, Gardiner K, Reeves RH. Molecular genetic characterization and comparative mapping of the human PCP4 gene. Somat Cell Mol Genet. 1996 May; 22(3):167-75.
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    73. Bosch A, Guimerà J, Graw S, Gardiner K, Chumakov I, Patterson D, Estivill X. Integration of 30 CA-repeat markers into the cytogenetic, genetic and YAC maps of human chromosome 21. Eur J Hum Genet. 1996; 4(3):135-42.
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    74. Gardiner K, Ichikawa H, Ohki M, Patterson D, Cheng JF. Localization of cDNAs to a region poorly represented in the CEPH chromosome 21 YAC contig: candidate genes for genetic diseases mapped to 21q22.3. Genomics. 1995 Nov 20; 30(2):376-9.
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    75. Gardiner K, Graw S, Ichikawa H, Ohki M, Joetham A, Gervy P, Chumakov I, Patterson D. YAC analysis and minimal tiling path construction for chromosome 21q. Somat Cell Mol Genet. 1995 Nov; 21(6):399-414.
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    76. Graw SL, Gardiner K, Hall-Johnson K, Hart I, Joetham A, Walton K, Donaldson D, Patterson D. Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids. Somat Cell Mol Genet. 1995 Nov; 21(6):415-28.
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    77. Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE, et al. Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 1995 Oct 16; 14(20):5100-8.
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    78. Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG. The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. Genomics. 1995 Oct 10; 29(3):562-70.
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    79. Gemmill RM, Chumakov I, Scott P, Waggoner B, Rigault P, Cypser J, Chen Q, Weissenbach J, Gardiner K, Wang H, et al. A second-generation YAC contig map of human chromosome 3. Nature. 1995 Sep 28; 377(6547 Suppl):299-319.
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    80. Tassone F, Xu H, Burkin H, Weissman S, Gardiner K. cDNA selection from 10 Mb of chromosome 21 DNA: efficiency in transcriptional mapping and reflections of genome organization. Hum Mol Genet. 1995 Sep; 4(9):1509-18.
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    81. Xu H, Wei H, Tassone F, Graw S, Gardiner K, Weissman SM. A search for genes from the dark band regions of human chromosome 21. Genomics. 1995 May 1; 27(1):1-8.
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    82. Gardiner K, Mural RJ. Getting the message: identifying transcribed sequences. Trends Genet. 1995 Mar; 11(3):77-9.
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    83. Pekarsky Y, Zabarovsky E, Kashuba V, Drabkin H, Sandberg AA, Morgan R, Rynditch A, Gardiner K. Cloning of breakpoints in 3q21 associated with hematologic malignancy. Cancer Genet Cytogenet. 1995 Mar; 80(1):1-8.
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    84. Williams RF, Pekarsky Y, Cheng S, Gardiner K. YAC clones targeting gene-rich regions of human chromosome 3. Mamm Genome. 1994 Jun; 5(6):380-3.
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    85. Lutfalla G, Gardiner K, Uzé G. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Genomics. 1993 May; 16(2):366-73.
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    86. Cheng S, Lutfalla G, Uze G, Chumakov IM, Gardiner K. GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16. Mamm Genome. 1993; 4(6):338-42.
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    87. Patterson D, Rahmani Z, Donaldson D, Gardiner K, Jones C. Physical mapping of chromosome 21. Prog Clin Biol Res. 1993; 384:33-50.
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    88. Tassone F, Cheng S, Gardiner K. Analysis of chromosome 21 yeast artificial chromosome (YAC) clones. Am J Hum Genet. 1992 Dec; 51(6):1251-64.
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    89. Goto J, Tassone F, Demczuk S, Gardiner K, Figlewicz DA, Khodr N, Rouleau GA. Dinucleotide repeat polymorphism at the D21S65 locus. Hum Mol Genet. 1992 Aug; 1(5):350.
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    90. Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM. Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):5857-61.
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    91. Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G. The structure of the human interferon alpha/beta receptor gene. J Biol Chem. 1992 Feb 5; 267(4):2802-9.
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    92. Gardiner K, Patterson D. The role of somatic cell hybrids in physical mapping. Cytogenet Cell Genet. 1992; 59(2-3):82-5.
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    93. Gardiner K. Transverse alternating-field electrophoresis. Methods Mol Biol. 1992; 12:51-61.
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    94. Gao J, Erickson P, Gardiner K, Le Beau MM, Diaz MO, Patterson D, Rowley JD, Drabkin HA. Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia. Proc Natl Acad Sci U S A. 1991 Jun 1; 88(11):4882-6.
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    95. Gardiner K. Pulsed field gel electrophoresis. Anal Chem. 1991 Apr 1; 63(7):658-65.
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    96. Gardiner K, Aissani B, Bernardi G. A compositional map of human chromosome 21. EMBO J. 1990 Jun; 9(6):1853-8.
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    97. Gardiner K. Pulsed field gel electrophoresis and investigations into mammalian genome organization. J Cell Sci. 1990 May; 96 ( Pt 1):5-8.
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    98. Brahe C, Tassone F, Millington-Ward A, Serra A, Gardiner K. Potential gene sequence isolation and regional mapping in human chromosome 21. Am J Med Genet Suppl. 1990; 7:120-4.
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    99. Gardiner K, Horisberger M, Kraus J, Tantravahi U, Korenberg J, Rao V, Reddy S, Patterson D. Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J. 1990 Jan; 9(1):25-34.
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    100. Gardiner K. Physical mapping of the long arm of chromosome 21. Prog Clin Biol Res. 1990; 360:1-14.
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    101. Gardiner K, Patterson D. Transverse alternating field electrophoresis and applications to mammalian genome mapping. Electrophoresis. 1989 May-Jun; 10(5-6):296-302.
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    102. Gardiner K, Watkins P, Münke M, Drabkin H, Jones C, Patterson D. Partial physical map of human chromosome 21. Somat Cell Mol Genet. 1988 Nov; 14(6):623-37.
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    103. Patterson D, Gardiner K, Kao FT, Tanzi R, Watkins P, Gusella JF. Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8266-70.
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    104. Gardiner K, Laas W, Patterson D. Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis. Somat Cell Mol Genet. 1986 Mar; 12(2):185-95.
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    105. Cann JR, Gardiner KJ. Isoelectric focusing of interacting systems. V. Determination of ligand-binding constants. Biophys Chem. 1979 Sep; 10(2):211-6.
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    106. Cann JR, Gardiner KJ. Isoelectric focusing of interacting systems. IV. interaction of macromolecules with each other and with ligands. Biophys Chem. 1979 Sep; 10(2):203-10.
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