Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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James Crapo

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/398-1436

    Collapse Research 
    Collapse research activities and funding
    R44CA195749     (CRAPO, JAMES D)Sep 18, 2015 - Aug 31, 2017
    NIH
    BMX-001 as a Therapeutic Agent for Treatment of High-Grade Gliomas
    Role: Principal Investigator

    R13HL102943     (CRAPO, JAMES D)Feb 1, 2010 - Jan 31, 2011
    NIH
    Building Consensus on Qualitative Chest CT-based Subphenotypes for COPD
    Role: Principal Investigator

    U01HL089897     (CRAPO, JAMES D)Sep 27, 2007 - Jul 31, 2022
    NIH
    (1 of 2) Genetic Epidemiology of COPD
    Role: Principal Investigator

    R01HL089897     (CRAPO, JAMES D)Jul 1, 2007 - Aug 31, 2017
    NIH
    (1 of 2) Genetic Epidemiology of COPD
    Role: Principal Investigator

    S07RR018132     (JOHNSTON, RICHARD B.)Sep 1, 2002 - Aug 31, 2005
    NIH
    IRB Assessment and Education Project
    Role: Co-Principal Investigator

    U01HL063397     (CRAPO, JAMES D)Aug 1, 1999 - Sep 29, 2003
    NIH
    Treatment of BPD Using Mimetics of Superoxide Dismutase
    Role: Principal Investigator

    K30RR022279     (CRAPO, JAMES D)Jun 1, 1999 - May 31, 2010
    NIH
    Advanced Training for Clinical Investigators
    Role: Principal Investigator

    K30HL004111     (CRAPO, JAMES D)Jun 1, 1999 - May 31, 2005
    NIH
    ADVANCED TRAINING FOR CLINICAL INVESTIGATORS
    Role: Principal Investigator

    P01HL031992     (CRAPO, JAMES D)Apr 1, 1998 - Aug 31, 1997
    NIH
    ACUTE LUNG INJURY-MECHANISMS AND THERAPY
    Role: Principal Investigator

    R13HL045391     (CRAPO, JAMES D)May 1, 1990 - Apr 30, 1991
    NIH
    WORLD CONFERENCE ON LUNG HEALTH
    Role: Principal Investigator

    R01HL042609     (CRAPO, JAMES D)May 1, 1989 - Aug 31, 1997
    NIH
    EC-SOD IN AIRWAY AND PULMONARY VASCULAR BIOLOGY
    Role: Principal Investigator

    R01HL037721     (CRAPO, JAMES D)Sep 30, 1986 - Sep 29, 1988
    NIH
    HYPO- AND HYPERBARIC RESEARCH SUPPORT FACILITIES
    Role: Principal Investigator

    S10RR002699     (CRAPO, JAMES D)Feb 1, 1986 - Jan 31, 1987
    NIH
    ELECTRON MICROSCOPE
    Role: Principal Investigator

    C06HL035525     (CRAPO, JAMES D)Sep 30, 1985 - Sep 29, 1987
    NIH
    NHLBI SHARED RESEARCH FACILITY
    Role: Principal Investigator

    T32HL007538     (PIANTADOSI, CLAUDE A)Jul 1, 1982 - Jun 30, 2021
    NIH
    Interdisciplinary Training Program in Lung Disease
    Role: Co-Principal Investigator

    T32ES007031     (DI GIULIO, RICHARD)Jul 1, 1978 - Jun 30, 2008
    NIH
    Integrated Toxicology Program
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Strand M, Khatiwada A, Baraghoshi D, Lynch D, Silverman EK, Bhatt SP, Austin E, Regan EA, Boriek AM, Crapo JD. Predicting COPD Progression in Current and Former Smokers Using a Joint Model for Forced Expiratory Volume in 1 Second and Forced Expiratory Volume in 1 Second to Forced Vital Capacity Ratio. Chronic Obstr Pulm Dis. 2022 Jul 29; 9(3):439-453. PMID: 35905755.
      View in: PubMed
    2. Boueiz A, Xu Z, Chang Y, Masoomi A, Gregory A, Lutz SM, Qiao D, Crapo JD, Dy JG, Silverman EK, Castaldi PJ. Machine Learning Prediction of Progression in Forced Expiratory Volume in 1 Second in the COPDGene® Study. Chronic Obstr Pulm Dis. 2022 May 20. PMID: 35649102.
      View in: PubMed
    3. Oh AS, Baraghoshi D, Lynch DA, Ash SY, Crapo JD, Humphries SM. Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study. Radiology. 2022 May 17; 213054. PMID: 35579519.
      View in: PubMed
    4. Ragland MF, Strand M, Baraghoshi D, Young KA, Kinney GL, Austin E, Hokanson JE, Regan E, Crapo J, Silverman EK, Make B. 10-Year Follow-Up of Lung Function, Respiratory Symptoms, and Functional Capacity in the COPDGene Study. Ann Am Thorac Soc. 2022 03; 19(3):381-388. PMID: 34461026.
      View in: PubMed
    5. Koo HK, Hoth KF, Make BJ, Regan EA, Crapo JD, Silverman EK, DeMeo DL. Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease. Respir Res. 2022 Jan 29; 23(1):19. PMID: 35093071.
      View in: PubMed
    6. Thomashow BM, Mannino DM, Tal-Singer R, Crapo JD. A rapidly changing understanding of COPD: World COPD Day from the COPD Foundation. Am J Physiol Lung Cell Mol Physiol. 2021 11 01; 321(5):L983-L987. PMID: 34612086.
      View in: PubMed
    7. Wan ES, Hokanson JE, Regan EA, Young KA, Make BJ, DeMeo DL, Mason SE, San Jose Estepar R, Crapo JD, Silverman EK. Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers. Chest. 2022 03; 161(3):651-661. PMID: 34592319.
      View in: PubMed
    8. Wade RC, Simmons JP, Boueiz A, Gregory A, Wan ES, Regan EA, Bhatt SP, Han MK, Bowler RP, Crapo JD, Silverman EK, Washko GR, Dransfield MT, Wells JM. Pulmonary Artery Enlargement Is Associated with Exacerbations and Mortality in Ever-Smokers with Preserved Ratio Impaired Spirometry. Am J Respir Crit Care Med. 2021 08 15; 204(4):481-485. PMID: 34014810.
      View in: PubMed
    9. Lindsay HG, Wamboldt FS, Holm KE, Make BJ, Hokanson J, Crapo JD, Regan EA. Impact of a Medical Diagnosis on Decision to Stop Smoking and Successful Smoking Cessation. Chronic Obstr Pulm Dis. 2021 Jul 28; 8(3):360-370. PMID: 34010545.
      View in: PubMed
    10. Morris AH, Stagg B, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas F, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar SS, Bernard GR, Taylor Thompson B, Brower R, Truwit JD, Steingrub J, Duncan Hite R, Willson DF, Zimmerman JJ, Nadkarni VM, Randolph A, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Scott Evans R, Sorenson DK, Wong A, Boland MV, Grainger DW, Dere WH, Crandall AS, Facelli JC, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Wesley Ely E, Gajic O, Pickering B, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Angus D, Pinsky MR, James B, Berwick D. Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. J Am Med Inform Assoc. 2021 06 12; 28(6):1330-1344. PMID: 33594410.
      View in: PubMed
    11. Luehrs RE, Moreau KL, Pierce GL, Wamboldt F, Aloia M, Weinberger HD, Make B, Bowler R, Crapo JD, Meschede K, Kozora E, Moser DJ, Hoth KF. Cognitive performance is lower among individuals with overlap syndrome than in individuals with COPD or obstructive sleep apnea alone: association with carotid artery stiffness. J Appl Physiol (1985). 2021 07 01; 131(1):131-141. PMID: 33982592.
      View in: PubMed
    12. Pompe E, Moore CM, Mohamed Hoesein FAA, de Jong PA, Charbonnier JP, Han MK, Humphries SM, Hatt CR, Galbán CJ, Silverman EK, Crapo JD, Washko GR, Regan EA, Make B, Strand M, Lammers JJ, van Rikxoort EM, Lynch DA. Progression of Emphysema and Small Airways Disease in Cigarette Smokers. Chronic Obstr Pulm Dis. 2021 Apr 27; 8(2):198-212. PMID: 33290645.
      View in: PubMed
    13. Crapo J, Gupta A, Lynch DA, Vogel-Claussen J, Watz H, Turner AM, Mroz RM, Janssens W, Ludwig-Sengpiel A, Beck M, Langellier B, Ittrich C, Risse F, Diefenbach C. FOOTPRINTS study protocol: rationale and methodology of a 3-year longitudinal observational study to phenotype patients with COPD. BMJ Open. 2021 03 22; 11(3):e042526. PMID: 33753437.
      View in: PubMed
    14. Lindsay SE, Lindsay HG, Kallet J, Weaver MR, Curran-Everett D, Crapo JD, Regan EA. MnTE-2-PyP disrupts Staphylococcus aureus biofilms in a novel fracture model. J Orthop Res. 2021 11; 39(11):2439-2445. PMID: 33347639.
      View in: PubMed
    15. Strand M, Austin E, Moll M, Pratte KA, Regan EA, Hayden LP, Bhatt SP, Boriek AM, Casaburi R, Silverman EK, Fortis S, Ruczinski I, Koegler H, Rossiter HB, Occhipinti M, Hanania NA, Gebrekristos HT, Lynch DA, Kunisaki KM, Young KA, Sieren JC, Ragland M, Hokanson JE, Lutz SM, Make BJ, Kinney GL, Cho MH, Pistolesi M, DeMeo DL, Sciurba FC, Comellas AP, Diaz AA, Barjaktarevic I, Bowler RP, Kanner RE, Peters SP, Ortega VE, Dransfield MT, Crapo JD. A Risk Prediction Model for Mortality Among Smokers in the COPDGene® Study. Chronic Obstr Pulm Dis. 2020 Oct; 7(4):346-361. PMID: 32877963.
      View in: PubMed
    16. Moll M, Sakornsakolpat P, Shrine N, Hobbs BD, DeMeo DL, John C, Guyatt AL, McGeachie MJ, Gharib SA, Obeidat M, Lahousse L, Wijnant SRA, Brusselle G, Meyers DA, Bleecker ER, Li X, Tal-Singer R, Manichaikul A, Rich SS, Won S, Kim WJ, Do AR, Washko GR, Barr RG, Psaty BM, Bartz TM, Hansel NN, Barnes K, Hokanson JE, Crapo JD, Lynch D, Bakke P, Gulsvik A, Hall IP, Wain L, Weiss ST, Silverman EK, Dudbridge F, Tobin MD, Cho MH. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Lancet Respir Med. 2020 07; 8(7):696-708. PMID: 32649918.
      View in: PubMed
    17. Occhipinti M, Paoletti M, Crapo JD, Make BJ, Lynch DA, Brusasco V, Lavorini F, Silverman EK, Regan EA, Pistolesi M. Validation of a method to assess emphysema severity by spirometry in the COPDGene study. Respir Res. 2020 May 01; 21(1):103. PMID: 32357885.
      View in: PubMed
    18. Moll M, Qiao D, Regan EA, Hunninghake GM, Make BJ, Tal-Singer R, McGeachie MJ, Castaldi PJ, San Jose Estepar R, Washko GR, Wells JM, LaFon D, Strand M, Bowler RP, Han MK, Vestbo J, Celli B, Calverley P, Crapo J, Silverman EK, Hobbs BD, Cho MH. Machine Learning and Prediction of All-Cause Mortality in COPD. Chest. 2020 09; 158(3):952-964. PMID: 32353417.
      View in: PubMed
    19. Tal-Singer R, Crapo JD. COPD at the Time of COVID-19: A COPD Foundation Perspective. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):73-75. PMID: 32324976.
      View in: PubMed
    20. Lowe KE, Hokanson JE, Make BJ, Pratte KA, Regan EA, Silverman EK, Young KA, Kinney GL, Crapo JD. Letter to the Editor: Response by Authors. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):82-85. PMID: 32324979.
      View in: PubMed
    21. Fortis S, Comellas A, Kim V, Casaburi R, Hokanson JE, Crapo JD, Silverman EK, Wan ES. Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease. Sci Rep. 2020 03 20; 10(1):5169. PMID: 32198360.
      View in: PubMed
    22. LaFon DC, Bhatt SP, Labaki WW, Rahaghi FN, Moll M, Bowler RP, Regan EA, Make BJ, Crapo JD, San Jose Estepar R, Diaz AA, Silverman EK, Han MK, Hobbs B, Cho MH, Washko GR, Dransfield MT, Wells JM. Pulmonary artery enlargement and mortality risk in moderate to severe COPD: results from COPDGene. Eur Respir J. 2020 02; 55(2). PMID: 31772001.
      View in: PubMed
    23. Pompe E, Strand M, van Rikxoort EM, Hoffman EA, Barr RG, Charbonnier JP, Humphries S, Han MK, Hokanson JE, Make BJ, Regan EA, Silverman EK, Crapo JD, Lynch DA. Five-year Progression of Emphysema and Air Trapping at CT in Smokers with and Those without Chronic Obstructive Pulmonary Disease: Results from the COPDGene Study. Radiology. 2020 04; 295(1):218-226. PMID: 32013794.
      View in: PubMed
    24. Humphries SM, Notary AM, Centeno JP, Strand MJ, Crapo JD, Silverman EK, Lynch DA. Deep Learning Enables Automatic Classification of Emphysema Pattern at CT. Radiology. 2020 02; 294(2):434-444. PMID: 31793851.
      View in: PubMed
    25. Young KA, Regan EA, Han MK, Lutz SM, Ragland M, Castaldi PJ, Washko GR, Cho MH, Strand M, Curran-Everett D, Beaty TH, Bowler RP, Wan ES, Lynch DA, Make BJ, Silverman EK, Crapo JD, Hokanson JE, Kinney GL. Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):400-413. PMID: 31710795.
      View in: PubMed
    26. Lowe KE, Regan EA, Anzueto A, Austin E, Austin JHM, Beaty TH, Benos PV, Benway CJ, Bhatt SP, Bleecker ER, Bodduluri S, Bon J, Boriek AM, Boueiz AR, Bowler RP, Budoff M, Casaburi R, Castaldi PJ, Charbonnier JP, Cho MH, Comellas A, Conrad D, Costa Davis C, Criner GJ, Curran-Everett D, Curtis JL, DeMeo DL, Diaz AA, Dransfield MT, Dy JG, Fawzy A, Fleming M, Flenaugh EL, Foreman MG, Fortis S, Gebrekristos H, Grant S, Grenier PA, Gu T, Gupta A, Han MK, Hanania NA, Hansel NN, Hayden LP, Hersh CP, Hobbs BD, Hoffman EA, Hogg JC, Hokanson JE, Hoth KF, Hsiao A, Humphries S, Jacobs K, Jacobson FL, Kazerooni EA, Kim V, Kim WJ, Kinney GL, Koegler H, Lutz SM, Lynch DA, MacIntye NR, Make BJ, Marchetti N, Martinez FJ, Maselli DJ, Mathews AM, McCormack MC, McDonald MN, McEvoy CE, Moll M, Molye SS, Murray S, Nath H, Newell JD, Occhipinti M, Paoletti M, Parekh T, Pistolesi M, Pratte KA, Putcha N, Ragland M, Reinhardt JM, Rennard SI, Rosiello RA, Ross JC, Rossiter HB, Ruczinski I, San Jose Estepar R, Sciurba FC, Sieren JC, Singh H, Soler X, Steiner RM, Strand MJ, Stringer WW, Tal-Singer R, Thomashow B, Vegas Sánchez-Ferrero G, Walsh JW, Wan ES, Washko GR, Michael Wells J, Wendt CH, Westney G, Wilson A, Wise RA, Yen A, Young K, Yun J, Silverman EK, Crapo JD. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399. PMID: 31710793.
      View in: PubMed
    27. Young KA, Strand M, Ragland MF, Kinney GL, Austin EE, Regan EA, Lowe KE, Make BJ, Silverman EK, Crapo JD, Hokanson JE. Pulmonary Subtypes Exhibit Differential Global Initiative for Chronic Obstructive Lung Disease Spirometry Stage Progression: The COPDGene® Study. Chronic Obstr Pulm Dis. 2019 11; 6(5):414-429. PMID: 31710796.
      View in: PubMed
    28. Crapo JD. Fifty Years of the Division of Lung Diseases and the Evolution of Pulmonary Research and Medicine. Chronic Obstr Pulm Dis. 2019 Oct 23; 6(4). PMID: 31647853.
      View in: PubMed
    29. Regan EA, Hersh CP, Castaldi PJ, DeMeo DL, Silverman EK, Crapo JD, Bowler RP. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149. PMID: 30874442.
      View in: PubMed
    30. Regan EA, Lowe KE, Make BJ, Lynch DA, Kinney GL, Budoff MJ, Mao SS, Dyer D, Curtis JL, Bowler RP, Han MK, Beaty TH, Hokanson JE, Kern E, Humphries S, Curran-Everett D, van Beek EJR, Silverman EK, Crapo JD, Finigan JH. Identifying Smoking-Related Disease on Lung Cancer Screening CT Scans: Increasing the Value. Chronic Obstr Pulm Dis. 2019 Jul 24; 6(3):233-245. PMID: 31342730.
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    31. Thomashow B, Crapo JD, Drummond MB, Han MK, Kalhan R, Malanga E, Malanga V, Mannino DM, Rennard S, Sciurba FC, Willard KS, Wise R, Yawn B. Introducing the New COPD Pocket Consultant Guide App: Can A Digital Approach Improve Care? A Statement of the COPD Foundation. Chronic Obstr Pulm Dis. 2019 Jul 24; 6(3):210-220. PMID: 31075813.
      View in: PubMed
    32. Moore C, Blumhagen RZ, Yang IV, Walts A, Powers J, Walker T, Bishop M, Russell P, Vestal B, Cardwell J, Markin CR, Mathai SK, Schwarz MI, Steele MP, Lee J, Brown KK, Loyd JE, Crapo JD, Silverman EK, Cho MH, James JA, Guthridge JM, Cogan JD, Kropski JA, Swigris JJ, Bair C, Kim DS, Ji W, Kim H, Song JW, Maier LA, Pacheco KA, Hirani N, Poon AS, Li F, Jenkins RG, Braybrooke R, Saini G, Maher TM, Molyneaux PL, Saunders P, Zhang Y, Gibson KF, Kass DJ, Rojas M, Sembrat J, Wolters PJ, Collard HR, Sundy JS, O'Riordan T, Strek ME, Noth I, Ma SF, Porteous MK, Kreider ME, Patel NB, Inoue Y, Hirose M, Arai T, Akagawa S, Eickelberg O, Fernandez IE, Behr J, Mogulkoc N, Corte TJ, Glaspole I, Tomassetti S, Ravaglia C, Poletti V, Crestani B, Borie R, Kannengiesser C, Parfrey H, Fiddler C, Rassl D, Molina-Molina M, Machahua C, Worboys AM, Gudmundsson G, Isaksson HJ, Lederer DJ, Podolanczuk AJ, Montesi SB, Bendstrup E, Danchel V, Selman M, Pardo A, Henry MT, Keane MP, Doran P, Vašáková M, Sterclova M, Ryerson CJ, Wilcox PG, Okamoto T, Furusawa H, Miyazaki Y, Laurent G, Baltic S, Prele C, Moodley Y, Shea BS, Ohta K, Suzukawa M, Narumoto O, Nathan SD, Venuto DC, Woldehanna ML, Kokturk N, de Andrade JA, Luckhardt T, Kulkarni T, Bonella F, Donnelly SC, McElroy A, Armstong ME, Aranda A, Carbone RG, Puppo F, Beckman KB, Nickerson DA, Fingerlin TE, Schwartz DA. Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 07 15; 200(2):199-208. PMID: 31034279.
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    33. Park J, Hobbs BD, Crapo JD, Make BJ, Regan EA, Humphries S, Carey VJ, Lynch DA, Silverman EK. Subtyping COPD by Using Visual and Quantitative CT Imaging Features. Chest. 2020 01; 157(1):47-60. PMID: 31283919.
      View in: PubMed
    34. Gad SC, Sullivan DW, Mujer CV, Spainhour CB, Crapo JD. Nonclinical Safety and Toxicokinetics of MnTE-2-PyP (BMX-010), a Topical Agent in Phase 2 Trials for Psoriasis and Atopic Dermatitis. Int J Toxicol. 2019 Jul/Aug; 38(4):291-302. PMID: 31333066.
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    35. Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtimäki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Bossé Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Artigas MS, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV. Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 Jun; 51(6):1067. PMID: 31110354.
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    36. Lutz SM, Frederiksen B, Begum F, McDonald MN, Cho MH, Hobbs BD, Parker MM, DeMeo DL, Hersh CP, Ehringer MA, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE. Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine Tob Res. 2019 05 21; 21(6):714-722. PMID: 29767774.
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    37. Kim V, Zhao H, Regan E, Han MK, Make BJ, Crapo JD, Jones PW, Curtis JL, Silverman EK, Criner GJ. The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition. Chest. 2019 10; 156(4):685-695. PMID: 31047955.
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    38. Oudkerk SF, Mohamed Hoesein FAA, Öner FC, Verlaan JJ, de Jong PA, Kuperus JS, Cho M, McDonald ML, Lynch DA, Silverman EK, Crapo JD, Make BJ, Lowe KE, Regan EA. Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort. J Rheumatol. 2020 04; 47(4):531-538. PMID: 31043539.
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    39. Sakornsakolpat P, McCormack M, Bakke P, Gulsvik A, Make BJ, Crapo JD, Cho MH, Silverman EK. Genome-Wide Association Analysis of Single-Breath DlCO. Am J Respir Cell Mol Biol. 2019 05; 60(5):523-531. PMID: 30694715.
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    40. Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing ZZC, Cho MH, Parker MM, Sakornsakolpat P, Hersh CP, Crapo JD, Stergachis AB, Tal-Singer R, DeMeo DL, Silverman EK, Zhou X, Castaldi PJ. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398. PMID: 30335480.
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    41. Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 03; 51(3):494-505. PMID: 30804561.
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    42. Criner RN, Labaki WW, Regan EA, Bon JM, Soler X, Bhatt SP, Murray S, Hokanson JE, Silverman EK, Crapo JD, Curtis JL, Martinez FJ, Make BJ, Han MK, Martinez CH. Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGene® Cohort. Chronic Obstr Pulm Dis. 2019 Jan 10; 6(1):64-73. PMID: 30775425.
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    43. Lederer DJ, Bell SC, Branson RD, Chalmers JD, Marshall R, Maslove DM, Ost DE, Punjabi NM, Schatz M, Smyth AR, Stewart PW, Suissa S, Adjei AA, Akdis CA, Azoulay É, Bakker J, Ballas ZK, Bardin PG, Barreiro E, Bellomo R, Bernstein JA, Brusasco V, Buchman TG, Chokroverty S, Collop NA, Crapo JD, Fitzgerald DA, Hale L, Hart N, Herth FJ, Iwashyna TJ, Jenkins G, Kolb M, Marks GB, Mazzone P, Moorman JR, Murphy TM, Noah TL, Reynolds P, Riemann D, Russell RE, Sheikh A, Sotgiu G, Swenson ER, Szczesniak R, Szymusiak R, Teboul JL, Vincent JL. Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals. Ann Am Thorac Soc. 2019 01; 16(1):22-28. PMID: 30230362.
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    44. Wan ES, Fortis S, Regan EA, Hokanson J, Han MK, Casaburi R, Make BJ, Crapo JD, DeMeo DL, Silverman EK. Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. Am J Respir Crit Care Med. 2018 12 01; 198(11):1397-1405. PMID: 29874098.
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    196. Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A, Agustí A, Wouters E, Celli B, Coxson H, Vestbo J, MacNee W, Yates JC, Rennard S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012 Dec 15; 186(12):1238-47. PMID: 23144326.
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    199. Oberley-Deegan RE, Steffan JJ, Rove KO, Pate KM, Weaver MW, Spasojevic I, Frederick B, Raben D, Meacham RB, Crapo JD, Koul HK. The antioxidant, MnTE-2-PyP, prevents side-effects incurred by prostate cancer irradiation. PLoS One. 2012; 7(9):e44178. PMID: 22984473.
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    206. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57. PMID: 22080838.
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    207. Bai X, Ovrutsky AR, Kartalija M, Chmura K, Kamali A, Honda JR, Oberley-Deegan RE, Dinarello CA, Crapo JD, Chang LY, Chan ED. IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease. Int Immunol. 2011 Nov; 23(11):679-91. PMID: 22033195.
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    208. Karaaslan C, Hirakawa H, Yasumatsu R, Chang LY, Pierce RA, Crapo JD, Cataltepe S. Elastase inhibitory activity of airway a1-antitrypsin is protected by treatment with a catalytic antioxidant in a baboon model of severe bronchopulmonary dysplasia. Pediatr Res. 2011 Oct; 70(4):363-7. PMID: 21705962.
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    209. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R. Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest. 2012 Apr; 141(4):867-875. PMID: 21960696.
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    210. Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP. The clinical features of the overlap between COPD and asthma. Respir Res. 2011 Sep 27; 12:127. PMID: 21951550.
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    211. Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, DeMeo DL. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):414-20. PMID: 21562134.
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    212. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make BJ, Hokanson JE, Crapo JD, Silverman EK, Martinez FJ, Washko GR. Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology. 2011 Oct; 261(1):274-82. PMID: 21788524.
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    213. Siedlinski M, Cho MH, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Silverman EK. Genome-wide association study of smoking behaviours in patients with COPD. Thorax. 2011 Oct; 66(10):894-902. PMID: 21685187.
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    214. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1147-53. PMID: 21659657.
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    215. Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL. Smoking and COPD increase sputum levels of extracellular superoxide dismutase. Free Radic Biol Med. 2011 Aug 01; 51(3):726-32. PMID: 21621610.
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    216. Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK. Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med. 2011 Jul 01; 184(1):57-63. PMID: 21493737.
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    217. Silverman EK, Vestbo J, Agusti A, Anderson W, Bakke PS, Barnes KC, Barr RG, Bleecker ER, Boezen HM, Burkart KM, Celli BR, Cho MH, Cookson WO, Croxton T, Daley D, DeMeo DL, Gan W, Garcia-Aymerich J, Hall IP, Hansel NN, Hersh CP, Kalsheker N, Kiley JP, Kim WJ, Lambrechts D, Lee SD, Litonjua AA, Lomas DA, London SJ, Nishimura M, Nørdestgaard BG, O'Donnell CJ, Postma DS, Puhan MA, Tesfaigzi Y, Tobin MD, Vogelmeier C, Wilk JB, Wouters E, Young RP, Ziegler-Heitbrock L, MacNee W, Crapo JD. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD. 2011 Apr; 8(2):121-35. PMID: 21495840.
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    218. Kim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP. Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study. Respir Med. 2011 Aug; 105(8):1211-21. PMID: 21396809.
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    219. Hersh CP, Hokanson JE, Lynch DA, Washko GR, Make BJ, Crapo JD, Silverman EK. Family history is a risk factor for COPD. Chest. 2011 Aug; 140(2):343-350. PMID: 21310839.
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    220. Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK. Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res. 2011 Jan 13; 12:9. PMID: 21232152.
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    221. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10. PMID: 21037115.
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    222. Oberley-Deegan RE, Rebits BW, Weaver MR, Tollefson AK, Bai X, McGibney M, Ovrutsky AR, Chan ED, Crapo JD. An oxidative environment promotes growth of Mycobacterium abscessus. Free Radic Biol Med. 2010 Dec 01; 49(11):1666-73. PMID: 20807564.
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    223. Crapo JD. Preclinical vascular disease identifies smokers at risk for COPD. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8503-4. PMID: 20442330.
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    224. Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, Piganelli JD. Redox modulation protects islets from transplant-related injury. Diabetes. 2010 Jul; 59(7):1731-8. PMID: 20413509.
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    225. Makinde AY, Rizvi A, Crapo JD, Pearlstein RD, Slater JM, Gridley DS. A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model. Radiat Res. 2010 Apr; 173(4):441-52. PMID: 20334516.
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    226. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2. PMID: 20173748.
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    227. Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD. Genetic epidemiology of COPD (COPDGene) study design. COPD. 2010 Feb; 7(1):32-43. PMID: 20214461.
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    228. Pearlstein RD, Higuchi Y, Moldovan M, Johnson K, Fukuda S, Gridley DS, Crapo JD, Warner DS, Slater JM. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. Int J Radiat Biol. 2010 Feb; 86(2):145-63. PMID: 20148700.
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    229. Kinnula VL, Crapo JD. Smoking and COPD-mechanisms and prevention. COPD. 2009 Aug; 6(4):231-3. PMID: 19811380.
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    230. Oberley-Deegan RE, Regan EA, Kinnula VL, Crapo JD. Extracellular superoxide dismutase and risk of COPD. COPD. 2009 Aug; 6(4):307-12. PMID: 19811392.
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    231. Jaramillo MC, Frye JB, Crapo JD, Briehl MM, Tome ME. Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells. Cancer Res. 2009 Jul 01; 69(13):5450-7. PMID: 19549914.
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    232. McCurnin DC, Pierce RA, Willis BC, Chang LY, Yoder BA, Yuhanna IS, Ballard PL, Clyman RI, Waleh N, Maniscalco W, Crapo JD, Grubb PH, Shaul PW. Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2009 Mar 15; 179(6):492-500. PMID: 19151197.
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    233. Oberley-Deegan RE, Lee YM, Morey GE, Cook DM, Chan ED, Crapo JD. The antioxidant mimetic, MnTE-2-PyP, reduces intracellular growth of Mycobacterium abscessus. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):170-8. PMID: 19097985.
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    234. Dahl M, Bowler RP, Juul K, Crapo JD, Levy S, Nordestgaard BG. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am J Respir Crit Care Med. 2008 Nov 01; 178(9):906-12. PMID: 18703790.
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    235. Petersen SV, Kristensen T, Petersen JS, Ramsgaard L, Oury TD, Crapo JD, Nielsen NC, Enghild JJ. The folding of human active and inactive extracellular superoxide dismutases is an intracellular event. J Biol Chem. 2008 May 30; 283(22):15031-6. PMID: 18385137.
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    236. Petersen SV, Valnickova Z, Oury TD, Crapo JD, Chr Nielsen N, Enghild JJ. The subunit composition of human extracellular superoxide dismutase (EC-SOD) regulates enzymatic activity. BMC Biochem. 2007 Oct 15; 8:19. PMID: 17937792.
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    237. Gridley DS, Makinde AY, Luo X, Rizvi A, Crapo JD, Dewhirst MW, Moeller BJ, Pearlstein RD, Slater JM. Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer Res. 2007 Sep-Oct; 27(5A):3101-9. PMID: 17970050.
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    238. Subramaniam M, Bausch C, Twomey A, Andreeva S, Yoder BA, Chang L, Crapo JD, Pierce RA, Cuttitta F, Sunday ME. Bombesin-like peptides modulate alveolarization and angiogenesis in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2007 Nov 01; 176(9):902-12. PMID: 17585105.
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    239. Sutherland ER, Crapo JD, Bowler RP. N-acetylcysteine and exacerbations of chronic obstructive pulmonary disease. COPD. 2006 Dec; 3(4):195-202. PMID: 17361500.
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    240. Crapo JD. The burden of tobacco on life and health and the voice of the Journal of COPD. COPD. 2006 Aug; 3(3):121-2. PMID: 17240612.
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    241. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006 Aug; 20(10):1698-700. PMID: 16807366.
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    242. Due AV, Petersen SV, Valnickova Z, Østergaard L, Oury TD, Crapo JD, Enghild JJ. Extracellular superoxide dismutase exists as an octamer. FEBS Lett. 2006 Feb 20; 580(5):1485-9. PMID: 16469315.
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    243. Heijnen HF, van Donselaar E, Slot JW, Fries DM, Blachard-Fillion B, Hodara R, Lightfoot R, Polydoro M, Spielberg D, Thomson L, Regan EA, Crapo J, Ischiropoulos H. Subcellular localization of tyrosine-nitrated proteins is dictated by reactive oxygen species generating enzymes and by proximity to nitric oxide synthase. Free Radic Biol Med. 2006 Jun 01; 40(11):1903-13. PMID: 16716892.
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    244. Dewald O, Sharma S, Adrogue J, Salazar R, Duerr GD, Crapo JD, Entman ML, Taegtmeyer H. Downregulation of peroxisome proliferator-activated receptor-alpha gene expression in a mouse model of ischemic cardiomyopathy is dependent on reactive oxygen species and prevents lipotoxicity. Circulation. 2005 Jul 19; 112(3):407-15. PMID: 16009788.
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    245. Reid L, Meyrick B, Antony VB, Chang LY, Crapo JD, Reynolds HY. The mysterious pulmonary brush cell: a cell in search of a function. Am J Respir Crit Care Med. 2005 Jul 01; 172(1):136-9. PMID: 15817800.
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    246. Petersen SV, Olsen DA, Kenney JM, Oury TD, Valnickova Z, Thøgersen IB, Crapo JD, Enghild JJ. The high concentration of Arg213-->Gly extracellular superoxide dismutase (EC-SOD) in plasma is caused by a reduction of both heparin and collagen affinities. Biochem J. 2005 Jan 15; 385(Pt 2):427-32. PMID: 15362977.
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    247. Patel M, Li QY, Chang LY, Crapo J, Liang LP. Activation of NADPH oxidase and extracellular superoxide production in seizure-induced hippocampal damage. J Neurochem. 2005 Jan; 92(1):123-31. PMID: 15606902.
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    248. McCurnin DC, Pierce RA, Chang LY, Gibson LL, Osborne-Lawrence S, Yoder BA, Kerecman JD, Albertine KH, Winter VT, Coalson JJ, Crapo JD, Grubb PH, Shaul PW. Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol. 2005 Mar; 288(3):L450-9. PMID: 15591412.
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    249. Petersen SV, Due AV, Valnickova Z, Oury TD, Crapo JD, Enghild JJ. The structure of rabbit extracellular superoxide dismutase differs from the human protein. Biochemistry. 2004 Nov 09; 43(44):14275-81. PMID: 15518578.
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    250. Heijnen HF, Waaijenborg S, Crapo JD, Bowler RP, Akkerman JW, Slot JW. Colocalization of eNOS and the catalytic subunit of PKA in endothelial cell junctions: a clue for regulated NO production. J Histochem Cytochem. 2004 Oct; 52(10):1277-85. PMID: 15385574.
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    251. Petersen SV, Oury TD, Ostergaard L, Valnickova Z, Wegrzyn J, Thøgersen IB, Jacobsen C, Bowler RP, Fattman CL, Crapo JD, Enghild JJ. Extracellular superoxide dismutase (EC-SOD) binds to type i collagen and protects against oxidative fragmentation. J Biol Chem. 2004 Apr 02; 279(14):13705-10. PMID: 14736885.
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    252. Petersen SV, Oury TD, Valnickova Z, Thøgersen IB, Højrup P, Crapo JD, Enghild JJ. The dual nature of human extracellular superoxide dismutase: one sequence and two structures. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):13875-80. PMID: 14615576.
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    253. Crapo JD, Broaddus VC, Brody AR, Malindzak G, Samet J, Wright JR. Workshop on lung disease and the environment: where do we go from here? Am J Respir Crit Care Med. 2003 Jul 15; 168(2):250-4. PMID: 12851246.
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    254. Trova MP, Gauuan PJ, Pechulis AD, Bubb SM, Bocckino SB, Crapo JD, Day BJ. Superoxide dismutase mimetics. Part 2: synthesis and structure-activity relationship of glyoxylate- and glyoxamide-derived metalloporphyrins. Bioorg Med Chem. 2003 Jul 03; 11(13):2695-707. PMID: 12788343.
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    255. Lubbers NL, Polakowski JS, Crapo JD, Wegner CD, Cox BF. Preischemic and postischemic administration of AEOL10113 reduces infarct size in a rat model of myocardial ischemia and reperfusion. J Cardiovasc Pharmacol. 2003 May; 41(5):714-9. PMID: 12717101.
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    256. Croxton TL, Weinmann GG, Senior RM, Wise RA, Crapo JD, Buist AS. Clinical research in chronic obstructive pulmonary disease: needs and opportunities. Am J Respir Crit Care Med. 2003 Apr 15; 167(8):1142-9. PMID: 12684252.
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    257. Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by a catalytic antioxidant. Chest. 2003 Mar; 123(3 Suppl):446S. PMID: 12629031.
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    258. Bowler RP, Arcaroli J, Abraham E, Patel M, Chang LY, Crapo JD. Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2003 Apr; 284(4):L680-7. PMID: 12618426.
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    259. Chang LY, Subramaniam M, Yoder BA, Day BJ, Ellison MC, Sunday ME, Crapo JD. A catalytic antioxidant attenuates alveolar structural remodeling in bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2003 Jan 01; 167(1):57-64. PMID: 12502477.
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    260. Ross AD, Sheng H, Warner DS, Piantadosi CA, Batinic-Haberle I, Day BJ, Crapo JD. Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity. Free Radic Biol Med. 2002 Dec 15; 33(12):1657-69. PMID: 12488134.
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    261. Demchenko IT, Oury TD, Crapo JD, Piantadosi CA. Regulation of the brain's vascular responses to oxygen. Circ Res. 2002 Nov 29; 91(11):1031-7. PMID: 12456489.
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    262. Smith KR, Uyeminami DL, Kodavanti UP, Crapo JD, Chang LY, Pinkerton KE. Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant. Free Radic Biol Med. 2002 Oct 15; 33(8):1106-14. PMID: 12374622.
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    263. Bowler RP, Sheng H, Enghild JJ, Pearlstein RD, Warner DS, Crapo JD. A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. Free Radic Biol Med. 2002 Oct 15; 33(8):1141-52. PMID: 12374626.
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    264. Bowler RP, Crapo JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol. 2002 Sep; 110(3):349-56. PMID: 12209079.
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    265. Chang LY, Crapo JD. Inhibition of airway inflammation and hyperreactivity by an antioxidant mimetic. Free Radic Biol Med. 2002 Aug 01; 33(3):379-86. PMID: 12126760.
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    266. Bowler RP, Nicks M, Warnick K, Crapo JD. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L719-26. PMID: 11880297.
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    267. Levin ED, Christopher NC, Lateef S, Elamir BM, Patel M, Liang LP, Crapo JD. Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice. Behav Genet. 2002 Mar; 32(2):119-25. PMID: 12036109.
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    268. Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, Haskins K. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes. 2002 Feb; 51(2):347-55. PMID: 11812741.
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