Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Peter Buttrick

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-2089
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionCardiology


    Collapse Research 
    Collapse research activities and funding
    R01HL015498     (BUTTRICK, PETER)Jan 1, 1978 - Jun 30, 1997
    NIH
    PHYSICAL TRAINING EFFECTS ON THE HEART
    Role: Principal Investigator

    K08HL001552     (BUTTRICK, PETER)Jul 1, 1985 - Jun 30, 1990
    NIH
    CARDIAC RESPONSES TO PHYSIOLOGIC AND PATHOLOGIC OVERLOAD
    Role: Principal Investigator

    R29HL046034     (BUTTRICK, PETER)Jan 1, 1991 - Dec 31, 1995
    NIH
    MOLECULAR ADAPTATIONS IN CARDIAC HYPERTROPHY
    Role: Principal Investigator

    T32HL007822     (BUTTRICK, PETER N.)Jul 1, 1996 - Jun 30, 2024
    NIH
    Post Graduate Studies in Cardiovascular Research
    Role: Principal Investigator

    R03AG016443     (BUTTRICK, PETER)Apr 1, 1999 - Mar 31, 2001
    NIH
    PROTEIN KINASE C EFFECTS ON SENESCENT HEART FUNCTION
    Role: Principal Investigator

    R01HL062230     (BUTTRICK, PETER)Jan 15, 2000 - May 31, 2000
    NIH
    EFFECTS OF PROTEIN KINASE C ON CARDIAC HYPERTROPHY
    Role: Principal Investigator

    R01HL063704     (BUTTRICK, PETER)Feb 1, 2001 - Jan 31, 2006
    NIH
    MECHANISM OF DIABETIC CARDIOMYOPATHY
    Role: Principal Investigator

    T32HL072742     (TOBACMAN, LARRY S)Aug 1, 2003 - Jul 31, 2015
    NIH
    Training in Mechanisms of Cardiovascular Diseases
    Role: Co-Principal Investigator

    R01HL077195     (BUTTRICK, PETER)Jun 1, 2005 - Sep 30, 2006
    NIH
    Myofilament Function in Human Heart Failure
    Role: Principal Investigator

    P20HL101435     (BUTTRICK, PETER)Apr 1, 2010 - Mar 31, 2013
    NIH
    Using Molecular Pathology to Predict Response in Heart Failure
    Role: Principal Investigator

    R21HL104352     (BUTTRICK, PETER N.)Apr 1, 2011 - Dec 31, 2012
    NIH
    Biochemical Markers of Progressive Heart Disease
    Role: Principal Investigator

    R01HL114887     (STENMARK, KURT R.)Aug 15, 2012 - Jun 30, 2018
    NIH
    Fibroblasts and Mononuclear Fibrogenic Cells Drive Right Ventricular Pulmonary Ar
    Role: Co-Principal Investigator

    S10OD018156     (BUTTRICK, PETER N.)Jul 1, 2014 - Jun 30, 2015
    NIH
    Small Animal Ultrasound Imager - Vevo 2100
    Role: Principal Investigator

    R38HL143511     (SCHWARTZ, DAVID ALBERT)Mar 1, 2020 - Feb 29, 2024
    NIH
    Colorado StARR Program in Medicine and Pediatrics (CSPMP)
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 Mar 09; 16(3):519-533. PMID: 33636116.
      View in: PubMed
    2. Riching AS, Danis E, Zhao Y, Cao Y, Chi C, Bagchi RA, Klein BJ, Xu H, Kutateladze TG, McKinsey TA, Buttrick PM, Song K. Suppression of canonical TGF-ß signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. J Mol Cell Cardiol. 2020 Dec 24; 153:44-59. PMID: 33359755.
      View in: PubMed
    3. Allen LA, Venechuk G, McIlvennan CK, Page RL, Knoepke CE, Helmkamp LJ, Khazanie P, Peterson PN, Pierce K, Harger G, Thompson JS, Dow TJ, Richards L, Huang J, Strader JR, Trinkley KE, Kao DP, Magid DJ, Buttrick PM, Matlock DD. An Electronically Delivered Patient-Activation Tool for Intensification of Medications for Chronic Heart Failure With Reduced Ejection Fraction: The EPIC-HF Trial. Circulation. 2021 Feb 02; 143(5):427-437. PMID: 33201741.
      View in: PubMed
    4. Venechuk GE, Khazanie P, Page RL, Knoepke CE, Helmkamp LJ, Peterson PN, Pierce K, Thompson JS, Huang J, Strader JR, Dow TJ, Richards L, Trinkley KE, Kao DP, McIlvennan CK, Magid DJ, Buttrick PM, Matlock DD, Allen LA. An Electronically delivered, Patient-activation tool for Intensification of medications for Chronic Heart Failure with reduced ejection fraction: Rationale and design of the EPIC-HF trial. Am Heart J. 2020 11; 229:144-155. PMID: 32866454.
      View in: PubMed
    5. Buttrick P. A Modern Library of Babel. J Card Fail. 2020 08; 26(8):643-644. PMID: 32854926.
      View in: PubMed
    6. Bristow MR, Zisman LS, Altman NL, Gilbert EM, Lowes BD, Minobe WA, Slavov D, Schwisow JA, Rodriguez EM, Carroll IA, Keuer TA, Buttrick PM, Kao DP. Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium. JACC Basic Transl Sci. 2020 Sep; 5(9):871-883. PMID: 32838074.
      View in: PubMed
    7. Cornwell WK, Tran T, Cerbin L, Coe G, Muralidhar A, Hunter K, Altman N, Ambardekar AV, Tompkins C, Zipse M, Schulte M, O'Gean K, Ostertag M, Hoffman J, Pal JD, Lawley JS, Levine BD, Wolfel E, Kohrt WM, Buttrick P. New insights into resting and exertional right ventricular performance in the healthy heart through real-time pressure-volume analysis. J Physiol. 2020 07; 598(13):2575-2587. PMID: 32347547.
      View in: PubMed
    8. Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019; 14(10):e0224389. PMID: 31639152.
      View in: PubMed
    9. Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019; 14(8):e0221519. PMID: 31469842.
      View in: PubMed
    10. Oyama Y, Bartman CM, Bonney S, Lee JS, Walker LA, Han J, Borchers CH, Buttrick PM, Aherne CM, Clendenen N, Colgan SP, Eckle T. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019 08 06; 28(6):1471-1484.e11. PMID: 31390562.
      View in: PubMed
    11. Bruns DR, Tatman PD, Kalkur RS, Brown RD, Stenmark KR, Buttrick PM, Walker LA. The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation. PLoS One. 2019; 14(8):e0220573. PMID: 31374110.
      View in: PubMed
    12. Buttrick P. Research Integrity. J Card Fail. 2019 May; 25(5):401-403. PMID: 30974162.
      View in: PubMed
    13. Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K. LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):556-565. PMID: 30584088.
      View in: PubMed
    14. Buttrick P. Neprilysin Inhibition: What We Know and What We Don't Know. J Card Fail. 2018 04; 24(4):276-277. PMID: 29378257.
      View in: PubMed
    15. Koeppen M, Lee JW, Seo SW, Brodsky KS, Kreth S, Yang IV, Buttrick PM, Eckle T, Eltzschig HK. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018 02 26; 9(1):816. PMID: 29483579.
      View in: PubMed
    16. Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 04; 4(4):504-514. PMID: 30067491.
      View in: PubMed
    17. Leary PJ, Kronmal RA, Bluemke DA, Buttrick PM, Jones KL, Kao DP, Kawut SM, Krieger EV, Lima JA, Minobe W, Ralph DD, Tedford RJ, Weiss NS, Bristow MR. Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Am J Cardiol. 2018 01 15; 121(2):256-261. PMID: 29191567.
      View in: PubMed
    18. Buttrick P. Should We Be More Interested in the Question or the Answer? J Card Fail. 2017 03; 23(3):207-208. PMID: 28115290.
      View in: PubMed
    19. Bruns DR, Buttrick PM, Walker LA. Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy. . 2016 Mar 15; 310(6):L542-50. PMID: 26747780.
      View in: PubMed
    20. Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015 Sep 10; 6:8243. PMID: 26354680.
      View in: PubMed
    21. Bruns DR, Brown RD, Stenmark KR, Buttrick PM, Walker LA. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. . 2015 Jan 15; 308(2):L158-67. PMID: 25416385.
      View in: PubMed
    22. Thoemmes SF, Stutzke CA, Du Y, Browning MD, Buttrick PM, Walker LA. Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation. J Immunol Methods. 2014 Jan 31; 403(1-2):66-71. PMID: 24291343.
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    23. Zhao L, Chen CN, Hajji N, Oliver E, Cotroneo E, Wharton J, Wilkins MR, Wang D, Li M, Stenmark KR, McKinsey TA, Buttrick P. Response to letter regarding article, “histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid”. Circulation. 2013 Apr 09; 127(14):e540. PMID: 23691553.
      View in: PubMed
    24. Walker LA, Fullerton DA, Buttrick PM. Contractile protein phosphorylation predicts human heart disease phenotypes. . 2013 Jun 15; 304(12):H1644-50. PMID: 23564307.
      View in: PubMed
    25. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease: updated. Curr Cardiol Rev. 2013 Feb 01; 9(1):73-81. PMID: 23092273.
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    26. Ambardekar AV, Dorosz JL, Cleveland JC, Lindenfeld J, Buttrick PM. Longitudinal left ventricular structural and functional imaging during full support with continuous-flow ventricular assist devices: a retrospective, preliminary analysis. J Heart Lung Transplant. 2012 Dec; 31(12):1311-3. PMID: 23063323.
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    27. Eckle T, Hartmann K, Bonney S, Reithel S, Mittelbronn M, Walker LA, Lowes BD, Han J, Borchers CH, Buttrick PM, Kominsky DJ, Colgan SP, Eltzschig HK. Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med. 2012 Apr 15; 18(5):774-82. PMID: 22504483.
      View in: PubMed
    28. Vitello AM, Du Y, Buttrick PM, Walker LA. Serendipitous discovery of a novel protein signaling mechanism in heart failure. Biochem Biophys Res Commun. 2012 May 11; 421(3):431-5. PMID: 22503978.
      View in: PubMed
    29. Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 02; 110(5):739-48. PMID: 22282194.
      View in: PubMed
    30. Port JD, Walker LA, Polk J, Nunley K, Buttrick PM, Sucharov CC. Temporal expression of miRNAs and mRNAs in a mouse model of myocardial infarction. Physiol Genomics. 2011 Oct 06; 43(19):1087-95. PMID: 21771878.
      View in: PubMed
    31. Walker LA, Walker JS, Glazier A, Brown DR, Stenmark KR, Buttrick PM. Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. . 2011 Sep; 301(3):H832-40. PMID: 21622821.
      View in: PubMed
    32. Ambardekar AV, Walker JS, Walker LA, Cleveland JC, Lowes BD, Buttrick PM. Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail. 2011 Jul; 4(4):425-32. PMID: 21540356.
      View in: PubMed
    33. Walker JS, Walker LA, Margulies K, Buttrick P, de Tombe P. Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils. . 2011 Jul; 301(1):H138-46. PMID: 21498779.
      View in: PubMed
    34. Ambardekar AV, Buttrick PM. Reverse remodeling with left ventricular assist devices: a review of clinical, cellular, and molecular effects. Circ Heart Fail. 2011 Mar; 4(2):224-33. PMID: 21406678.
      View in: PubMed
    35. Walker LA, Medway AM, Walker JS, Cleveland JC, Buttrick PM. Tissue procurement strategies affect the protein biochemistry of human heart samples. J Muscle Res Cell Motil. 2011 Mar; 31(5-6):309-14. PMID: 21184256.
      View in: PubMed
    36. Walker JS, Li X, Buttrick PM. Analysing force-pCa curves. J Muscle Res Cell Motil. 2010 Jul; 31(1):59-69. PMID: 20490629.
      View in: PubMed
    37. Scruggs SB, Reisdorph R, Armstrong ML, Warren CM, Reisdorph N, Solaro RJ, Buttrick PM. A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain. Mol Cell Proteomics. 2010 Sep; 9(9):1804-18. PMID: 20445002.
      View in: PubMed
    38. Walker LA, Walker JS, Ambler SK, Buttrick PM. Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice. J Mol Cell Cardiol. 2010 Jun; 48(6):1180-6. PMID: 19799909.
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    39. Walker LA, Buttrick PM. The right ventricle: biologic insights and response to disease. Curr Cardiol Rev. 2009 Jan; 5(1):22-8. PMID: 20066144.
      View in: PubMed
    40. Scruggs SB, Hinken AC, Thawornkaiwong A, Robbins J, Walker LA, de Tombe PP, Geenen DL, Buttrick PM, Solaro RJ. Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem. 2009 Feb 20; 284(8):5097-106. PMID: 19106098.
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    41. Lowes BD, Buttrick PM. Genetic determinants of drug response in heart failure. Curr Cardiol Rep. 2008 May; 10(3):176-81. PMID: 18489860.
      View in: PubMed
    42. Goldspink P, Ruch S, Los T, Buttrick P, García J. Maladaptation of calcium homoeostasis in aging cardiac myocytes. Pflugers Arch. 2008 Jun; 456(3):479-87. PMID: 18172603.
      View in: PubMed
    43. Hankiewicz JH, Goldspink PH, Buttrick PM, Lewandowski ED. Principal strain changes precede ventricular wall thinning during transition to heart failure in a mouse model of dilated cardiomyopathy. . 2008 Jan; 294(1):H330-6. PMID: 17965277.
      View in: PubMed
    44. Xiao L, Zhao Q, Du Y, Yuan C, Solaro RJ, Buttrick PM. PKCepsilon increases phosphorylation of the cardiac myosin binding protein C at serine 302 both in vitro and in vivo. Biochemistry. 2007 Jun 12; 46(23):7054-61. PMID: 17503784.
      View in: PubMed
    45. Sorokina N, O'Donnell JM, McKinney RD, Pound KM, Woldegiorgis G, LaNoue KF, Ballal K, Taegtmeyer H, Buttrick PM, Lewandowski ED. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation. 2007 Apr 17; 115(15):2033-41. PMID: 17404155.
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    46. Jweied E, deTombe P, Buttrick PM. The use of human cardiac tissue in biophysical research: the risks of translation. J Mol Cell Cardiol. 2007 Apr; 42(4):722-6. PMID: 17350034.
      View in: PubMed
    47. Lewandowski ED, O'donnell JM, Scholz TD, Sorokina N, Buttrick PM. Recruitment of NADH shuttling in pressure-overloaded and hypertrophic rat hearts. . 2007 May; 292(5):C1880-6. PMID: 17229809.
      View in: PubMed
    48. Buttrick P. The regulation of heat shock protein expression: how, when and where. J Mol Cell Cardiol. 2006 Nov; 41(5):785-6. PMID: 16982066.
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    49. Nazarloo HP, Buttrick PM, Saadat H, Dunn AJ. The roles of corticotropin-releasing factor-related peptides and their receptors in the cardiovascular system. Curr Protein Pept Sci. 2006 Jun; 7(3):229-39. PMID: 16787262.
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    50. Zampino M, Yuzhakova M, Hansen J, McKinney RD, Goldspink PH, Geenen DL, Buttrick PM. Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. . 2006 Aug; 291(2):H957-64. PMID: 16603692.
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    51. Scruggs SB, Walker LA, Lyu T, Geenen DL, Solaro RJ, Buttrick PM, Goldspink PH. Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol. 2006 Apr; 40(4):465-73. PMID: 16445938.
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    52. Jweied EE, McKinney RD, Walker LA, Brodsky I, Geha AS, Massad MG, Buttrick PM, de Tombe PP. Depressed cardiac myofilament function in human diabetes mellitus. . 2005 Dec; 289(6):H2478-83. PMID: 16085678.
      View in: PubMed
    53. Montgomery DE, Rundell VL, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM. Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism. . 2005 Nov; 289(5):H1881-8. PMID: 15951344.
      View in: PubMed
    54. Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM. Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res. 2004 Aug 20; 95(4):424-32. PMID: 15242976.
      View in: PubMed
    55. Rundell VL, Geenen DL, Buttrick PM, de Tombe PP. Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression. . 2004 Jul; 287(1):H408-13. PMID: 15001437.
      View in: PubMed
    56. Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM. Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo. . 2004 Jun; 286(6):H2089-95. PMID: 14726296.
      View in: PubMed
    57. Solaro RJ, Montgomery DM, Wang L, Burkart EM, Ke Y, Vahebi S, Buttrick P. Integration of pathways that signal cardiac growth with modulation of myofilament activity. J Nucl Cardiol. 2002 Sep-Oct; 9(5):523-33. PMID: 12360133.
      View in: PubMed
    58. Shizukuda Y, Buttrick PM. Oxygen free radicals and heart failure: new insight into an old question. . 2002 Aug; 283(2):L237-8. PMID: 12114183.
      View in: PubMed
    59. Shizukuda Y, Buttrick PM. Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. J Mol Cell Cardiol. 2002 Jul; 34(7):823-31. PMID: 12099721.
      View in: PubMed
    60. Montgomery DE, Wolska BM, Pyle WG, Roman BB, Dowell JC, Buttrick PM, Koretsky AP, Del Nido P, Solaro RJ. alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI. . 2002 Jun; 282(6):H2397-405. PMID: 12003851.
      View in: PubMed
    61. Shizukuda Y, Reyland ME, Buttrick PM. Protein kinase C-delta modulates apoptosis induced by hyperglycemia in adult ventricular myocytes. . 2002 May; 282(5):H1625-34. PMID: 11959624.
      View in: PubMed
    62. Alden KJ, Goldspink PH, Ruch SW, Buttrick PM, García J. Enhancement of L-type Ca(2+) current from neonatal mouse ventricular myocytes by constitutively active PKC-betaII. . 2002 Apr; 282(4):C768-74. PMID: 11880265.
      View in: PubMed
    63. Shizukuda Y, Buttrick PM. Isoprotrenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation. 2002 Jan 15; 105(2):E9. PMID: 11790716.
      View in: PubMed
    64. Shizukuda Y, Buttrick PM. Coronary flow reserve or brachial artery flow to assess endothelial dysfunction: is it time to look at the heart again? Am J Cardiol. 2002 Jan 01; 89(1):113. PMID: 11779545.
      View in: PubMed
    65. Shizukuda Y, Buttrick PM. Protein kinase C-zeta modulates thromboxane A(2)-mediated apoptosis in adult ventricular myocytes via Akt. . 2002 Jan; 282(1):H320-7. PMID: 11748077.
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    66. Nwogu JI, Geenen D, Bean M, Brenner MC, Huang X, Buttrick PM. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation. 2001 Oct 30; 104(18):2216-21. PMID: 11684634.
      View in: PubMed
    67. Shizukuda Y, Buttrick PM. Protein kinase C(epsilon) modulates apoptosis induced by beta -adrenergic stimulation in adult rat ventricular myocytes via extracellular signal-regulated kinase (ERK) activity. J Mol Cell Cardiol. 2001 Oct; 33(10):1791-803. PMID: 11603922.
      View in: PubMed
    68. Goldspink PH, McKinney RD, Kimball VA, Geenen DL, Buttrick PM. Angiotensin II induced cardiac hypertrophy in vivo is inhibited by cyclosporin A in adult rats. Mol Cell Biochem. 2001 Oct; 226(1-2):83-8. PMID: 11768242.
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    69. Huang L, Wolska BM, Montgomery DE, Burkart EM, Buttrick PM, Solaro RJ. Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta. . 2001 May; 280(5):C1114-20. PMID: 11287324.
      View in: PubMed
    70. Roman BB, Geenen DL, Leitges M, Buttrick PM. PKC-beta is not necessary for cardiac hypertrophy. . 2001 May; 280(5):H2264-70. PMID: 11299230.
      View in: PubMed
    71. Medin JA, Buttrick PM. Gene transfer in the cardiovascular system: update 2000. Heart Dis. 2000 Nov-Dec; 2(6):409-21. PMID: 11728292.
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    72. Tian R, Miao W, Spindler M, Javadpour MM, McKinney R, Bowman JC, Buttrick PM, Ingwall JS. Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13536-41. PMID: 10557356.
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    73. Yan SF, Lu J, Zou YS, Soh-Won J, Cohen DM, Buttrick PM, Cooper DR, Steinberg SF, Mackman N, Pinsky DJ, Stern DM. Hypoxia-associated induction of early growth response-1 gene expression. J Biol Chem. 1999 May 21; 274(21):15030-40. PMID: 10329706.
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    74. Shizukuda Y, Buttrick PM, Geenen DL, Borczuk AC, Kitsis RN, Sonnenblick EH. beta-adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy. Am J Physiol. 1998 09; 275(3):H961-8. PMID: 9724301.
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    75. Malhotra A, Reich D, Reich D, Nakouzi A, Sanghi V, Geenen DL, Buttrick PM. Experimental diabetes is associated with functional activation of protein kinase C epsilon and phosphorylation of troponin I in the heart, which are prevented by angiotensin II receptor blockade. Circ Res. 1997 Dec; 81(6):1027-33. PMID: 9400384.
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    76. Bowman JC, Steinberg SF, Jiang T, Geenen DL, Fishman GI, Buttrick PM. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest. 1997 Nov 01; 100(9):2189-95. PMID: 9410895.
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    77. Geenen DL, Malhotra A, Scheuer J, Buttrick PM. Repeated catecholamine surges alter cardiac isomyosin expression but not protein synthesis in the rat heart. J Mol Cell Cardiol. 1997 Oct; 29(10):2711-6. PMID: 9344765.
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    78. Malhotra A, Nakouzi A, Bowman J, Buttrick P. Expression and regulation of mutant forms of cardiac TnI in a reconstituted actomyosin system: role of kinase dependent phosphorylation. Mol Cell Biochem. 1997 May; 170(1-2):99-107. PMID: 9144323.
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    79. Rybin VO, Buttrick PM, Steinberg SF. PKC-lambda is the atypical protein kinase C isoform expressed by immature ventricle. Am J Physiol. 1997 Apr; 272(4 Pt 2):H1636-42. PMID: 9139945.
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    80. Spencer RG, Buttrick PM, Ingwall JS. Function and bioenergetics in isolated perfused trained rat hearts. Am J Physiol. 1997 Jan; 272(1 Pt 2):H409-17. PMID: 9038963.
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    81. Geenen DL, Malhotra A, Buttrick PM. Angiotensin receptor 1 blockade does not prevent physiological cardiac hypertrophy in the adult rat. J Appl Physiol (1985). 1996 Aug; 81(2):816-21. PMID: 8872651.
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    82. Kang PM, Nakouzi A, Simpson T, Scheuer J, Buttrick PM. Role of endogenous renin-angiotensin system in c-fos activation and PKC-epsilon translocation in adult rat hearts. Am J Physiol. 1996 Jun; 270(6 Pt 2):H2177-83. PMID: 8764271.
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    83. Wiese S, Askanazi J, Manner T, Katz DP, Buttrick P. Effect of substrate manipulation on reducing ischemia/reperfusion injury in isolated perfused rat hearts. Clin Nutr. 1995 Apr; 14(2):123-8. PMID: 16843910.
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    84. Geenen DL, Malhotra A, Buttrick PM, Scheuer J. Ventricular pacing attenuates but does not reverse cardiac atrophy and an isomyosin shift in the rat heart. Am J Physiol. 1994 Dec; 267(6 Pt 2):H2149-54. PMID: 7810714.
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    85. Kass-Eisler A, Falck-Pedersen E, Elfenbein DH, Alvira M, Buttrick PM, Leinwand LA. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer. Gene Ther. 1994 Nov; 1(6):395-402. PMID: 7584105.
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    86. Kaplan ML, Cheslow Y, Vikstrom K, Malhotra A, Geenen DL, Nakouzi A, Leinwand LA, Buttrick PM. Cardiac adaptations to chronic exercise in mice. Am J Physiol. 1994 Sep; 267(3 Pt 2):H1167-73. PMID: 8092282.
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    87. Fishman GI, Kaplan ML, Buttrick PM. Tetracycline-regulated cardiac gene expression in vivo. J Clin Invest. 1994 Apr; 93(4):1864-8. PMID: 8163686.
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    88. De Leon JR, Buttrick PM, Fishman GI. Functional analysis of the connexin43 gene promoter in vivo and in vitro. J Mol Cell Cardiol. 1994 Mar; 26(3):379-89. PMID: 8028021.
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    89. Buttrick PM, Kaplan M, Leinwand LA, Scheuer J. Alterations in gene expression in the rat heart after chronic pathological and physiological loads. J Mol Cell Cardiol. 1994 Jan; 26(1):61-7. PMID: 8196070.
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    90. Kass-Eisler A, Falck-Pedersen E, Alvira M, Rivera J, Buttrick PM, Wittenberg BA, Cipriani L, Leinwand LA. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11498-502. PMID: 8265580.
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    91. Fisher SA, Buttrick PM, Sukovich D, Periasamy M. Characterization of promoter elements of the rabbit cardiac sarcoplasmic reticulum Ca(2+)-ATPase gene required for expression in cardiac muscle cells. Circ Res. 1993 Oct; 73(4):622-8. PMID: 8370120.
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    92. Buttrick P, Kaplan M, Camargo MJ, deSimone G, Laragh JH, Wallerson D, Devereux RB. The influence of dietary salt and plasma renin activity on myosin heavy chain gene expression in rat hearts. Am J Hypertens. 1993 Jul; 6(7 Pt 1):579-85. PMID: 8397998.
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    93. Buttrick PM, Kaplan ML, Kitsis RN, Leinwand LA. Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results. Circ Res. 1993 Jun; 72(6):1211-7. PMID: 8495550.
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    94. Buttrick P, Scheuer J. Sex-associated differences in left ventricular function in aortic stenosis of the elderly. Circulation. 1992 Oct; 86(4):1336-8. PMID: 1394941.
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    95. Cowley AW, Dzau V, Buttrick P, Cooke J, Devereux RB, Grines CL, Haidet GC, Thames MD. Working group on noncoronary cardiovascular disease and exercise in women. Med Sci Sports Exerc. 1992 Jun; 24(6 Suppl):S277-87. PMID: 1352614.
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    96. Geenen DL, Malhotra A, Buttrick PM, Scheuer J. Increased heart rate prevents the isomyosin shift after cardiac transplantation in the rat. Circ Res. 1992 Mar; 70(3):554-8. PMID: 1531621.
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    97. Buttrick PM, Kass A, Kitsis RN, Kaplan ML, Leinwand LA. Behavior of genes directly injected into the rat heart in vivo. Circ Res. 1992 Jan; 70(1):193-8. PMID: 1309314.
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    98. Amin M, Gabelman G, Buttrick P. Cocaine-induced myocardial infarction. A growing threat to men in their 30s. Postgrad Med. 1991 Sep 15; 90(4):50-5. PMID: 1891433.
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    99. Rosen S, Lahorra M, Cohen MV, Buttrick P. Ventricular fibrillation threshold is influenced by left ventricular stretch and mass in the absence of ischaemia. Cardiovasc Res. 1991 Jun; 25(6):458-62. PMID: 1889059.
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    100. Kitsis RN, Buttrick PM, McNally EM, Kaplan ML, Leinwand LA. Hormonal modulation of a gene injected into rat heart in vivo. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4138-42. PMID: 2034660.
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    101. Buttrick P, Malhotra A, Factor S, Greenen D, Leinwand L, Scheuer J. Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart. Circ Res. 1991 Mar; 68(3):645-52. PMID: 1835908.
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    102. Buttrick P, Perla C, Malhotra A, Geenen D, Lahorra M, Scheuer J. Effects of chronic dobutamine on cardiac mechanics and biochemistry after myocardial infarction in rats. Am J Physiol. 1991 Feb; 260(2 Pt 2):H473-9. PMID: 1996690.
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    103. Amin M, Gabelman G, Karpel J, Buttrick P. Acute myocardial infarction and chest pain syndromes after cocaine use. Am J Cardiol. 1990 Dec 15; 66(20):1434-7. PMID: 2251988.
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    104. Malhotra A, Buttrick P, Scheuer J. Effects of sex hormones on development of physiological and pathological cardiac hypertrophy in male and female rats. Am J Physiol. 1990 Sep; 259(3 Pt 2):H866-71. PMID: 2144404.
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    105. Rubin SA, Buttrick P, Malhotra A, Melmed S, Fishbein MC. Cardiac physiology, biochemistry and morphology in response to excess growth hormone in the rat. J Mol Cell Cardiol. 1990 Apr; 22(4):429-38. PMID: 2143788.
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    106. McNally EM, Buttrick PM, Leinwand LA. Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension. Nucleic Acids Res. 1989 Apr 11; 17(7):2753-67. PMID: 2717409.
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    107. Eghbali M, Blumenfeld OO, Seifter S, Buttrick PM, Leinwand LA, Robinson TF, Zern MA, Giambrone MA. Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization. J Mol Cell Cardiol. 1989 Jan; 21(1):103-13. PMID: 2716064.
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    108. Geenen D, Buttrick P, Scheuer J. Cardiovascular and hormonal responses to swimming and running in the rat. J Appl Physiol (1985). 1988 Jul; 65(1):116-23. PMID: 3403456.
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    109. Buttrick P, Malhotra A, Factor S, Geenen D, Scheuer J. Effects of chronic dobutamine administration on hearts of normal and hypertensive rats. Circ Res. 1988 Jul; 63(1):173-81. PMID: 2968193.
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    110. Buttrick PM, Malhotra A, Scheuer J. Effects of systolic overload and swim training on cardiac mechanics and biochemistry in rats. J Appl Physiol (1985). 1988 Apr; 64(4):1466-71. PMID: 2967813.
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    111. Schaible T, Malhotra A, Ciambrone G, Buttrick P, Scheuer J. Combined effects of hypertension and chronic running program on rat heart. J Appl Physiol (1985). 1987 Jul; 63(1):322-7. PMID: 2957351.
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    112. Buttrick PM, Scheuer J. Physiologic, biochemical, and coronary adaptation to exercise conditioning. Cardiol Clin. 1987 May; 5(2):259-70. PMID: 2953417.
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    113. Buttrick PM, Schaible TF, Malhotra A, Mattioli S, Scheuer J. Effects of pregnancy on cardiac function and myosin enzymology in the rat. Am J Physiol. 1987 Apr; 252(4 Pt 2):H846-50. PMID: 2952023.
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    114. Schaible T, Malhotra A, Ciambrone G, Buttrick P, Scheuer J. Effect of hypertension on hearts of rats trained by swimming. J Appl Physiol (1985). 1987 Jan; 62(1):328-34. PMID: 2951361.
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    115. Scheuer J, Buttrick P. The cardiac hypertrophic responses to pathologic and physiologic loads. Circulation. 1987 Jan; 75(1 Pt 2):I63-8. PMID: 2947753.
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    116. Buttrick PM, Malhotra A, Brodman R, McDermott L, Lam L. Myosin isoenzyme distribution in overloaded human atrial tissue. Circulation. 1986 Sep; 74(3):477-83. PMID: 3742750.
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    117. Mueller HS, Rao PS, Greenberg MA, Buttrick PM, Sussman II, Levite HA, Grose RM, Perez-Davila V, Strain JE, Spaet TH. Platelet hyperactivity in acute myocardial infarction in man--effects of prostacyclin. Herz. 1986 Apr; 11(2):116-26. PMID: 2939012.
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    118. Buttrick PM, Schaible TF, Scheuer J. Combined effects of hypertension and conditioning on coronary vascular reserve in rats. J Appl Physiol (1985). 1986 Jan; 60(1):275-9. PMID: 3944036.
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    119. Mueller HS, Rao PS, Greenberg MA, Buttrick PM, Sussman II, Levite HA, Grose RM, Perez-Davila V, Strain JE, Spaet TH. Systemic and transcardiac platelet activity in acute myocardial infarction in man: resistance to prostacyclin. Circulation. 1985 Dec; 72(6):1336-45. PMID: 2933181.
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    120. Buttrick PM, Levite HA, Schaible TF, Ciambrone G, Scheuer J. Early increases in coronary vascular reserve in exercised rats are independent of cardiac hypertrophy. J Appl Physiol (1985). 1985 Dec; 59(6):1861-5. PMID: 2934365.
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    121. Buttrick PM, Forscher CA, Sussman II, Mueller HS. Sub-aggregatory doses of catecholamines prevent prostacyclin-induced inhibition of platelet aggregation. Am Heart J. 1985 Jun; 109(6):1258-63. PMID: 2988323.
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    122. Masiel A, Buttrick P, Bitran J. Tamoxifen in the treatment of malignant melanoma. Cancer Treat Rep. 1981 May-Jun; 65(5-6):531-2. PMID: 7237476.
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    123. Bloch R, Maccecchini ML, Jumblatt J, Buttrick P, Burger MM. Sugar-specific antibodies reactive towards cell-surface carbohydrates. Eur J Biochem. 1977 Oct 17; 80(1):261-6. PMID: 562753.
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    124. Kersey JH, Hom DJ, Buttrick P. Human T lymphocyte receptors for sheep erythrocytes: conditions for binding including inhibition by cytochalasin B. J Immunol. 1974 Feb; 112(2):862-5. PMID: 4544364.
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