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Karen Lynn Swisshelm

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology
Phone303/724-5706

    Collapse Research 
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    R03AG015552     (SWISSHELM, KAREN L)Mar 15, 1998 - Feb 28, 2001
    NIH/NIA
    MAST CELLS IN AGING AND WERNER SYNDROME
    Role: Principal Investigator

    R01CA082455     (SWISSHELM, KAREN L)Aug 4, 1999 - May 31, 2005
    NIH/NCI
    RETINOIC ACID RECEPTOR BETA AND BREAST CANCER
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Alpatov R, Carstens B, Harding K, Jarrett C, Balakhani S, Lincoln J, Brzeskiewicz P, Guo Y, Ohene-Mobley A, LeRoux J, McDaniel V, Meltesen L, Minka D, Patel M, Manavi C, Swisshelm K. Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia. Mol Cytogenet. 2015; 8:101. PMID: 26719766; PMCID: PMC4696310.
    2. Stevens B, Maxson J, Tyner J, Smith CA, Gutman JA, Robinson W, Jordan CT, Lee CK, Swisshelm K, Tobin J, Wei Q, Schowinsky J, Rinella S, Lee HG, Pollyea DA. Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series. Leuk Lymphoma. 2016; 57(4):927-34. PMID: 26389776; PMCID: PMC4794392 [Available on 04/01/17].
    3. Knez VM, Carstens BJ, Swisshelm KL, McGranahan AN, Liang X. Heterogeneity of Abnormal RUNX1 Leading to Clinicopathologic Variations in Childhood B-Lymphoblastic Leukemia. Am J Clin Pathol. 2015 Aug; 144(2):305-14. PMID: 26185316.
      View in: PubMed
    4. Graw SL, Swisshelm K, Floyd K, Carstens BJ, Wamboldt MZ, Ross RG, Leonard S. Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. Mol Cytogenet. 2012 Jan 03; 5(1):2. PMID: 22214315; PMCID: PMC3274485.
    5. Liang X, Jones A, Giller RH, Swisshelm K, McGavran L, Meltesen L, Carstens B, McGranahan AN, Albano EA. Primary high-grade B-cell lymphoma of the breast with concurrent IGH-BCL2 and MYC-IGL translocations in an adolescent patient. Pediatr Dev Pathol. 2011 Sep-Oct; 14(5):402-6. PMID: 21491965.
      View in: PubMed
    6. Baker PR, Tsai AC, Springer M, Swisshelm K, March J, Brown K, Bellus G. Male with mosaicism for supernumerary ring X chromosome: analysis of phenotype and characterization of genotype using array comparative genome hybridization. J Craniofac Surg. 2010 Sep; 21(5):1369-75. PMID: 20856023.
      View in: PubMed
    7. Hsu JJ, Kamath-Loeb AS, Glick E, Wallden B, Swisshelm K, Rubin BP, Loeb LA. Werner syndrome gene variants in human sarcomas. Mol Carcinog. 2010 Feb; 49(2):166-74. PMID: 19824023; PMCID: PMC2813347.
    8. Taylor MR, Jirikowic J, Wells C, Springer M, McGavran L, Lunt B, Swisshelm K. High prevalence of array comparative genomic hybridization abnormalities in adults with unexplained intellectual disability. Genet Med. 2010 Jan; 12(1):32-8. PMID: 20009761.
      View in: PubMed
    9. Teoh N, Pyakurel P, Dan YY, Swisshelm K, Hou J, Mitchell C, Fausto N, Gu Y, Farrell G. Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. Gastroenterology. 2010 Mar; 138(3):1155-65.e1-2. PMID: 19919837.
      View in: PubMed
    10. Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, Feiler HS, Wyrobek AJ, Stampfer MR. Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res. 2009 Oct 01; 69(19):7557-68. PMID: 19773443; PMCID: PMC2782785.
    11. Teoh NC, Dan YY, Swisshelm K, Lehman S, Wright JH, Haque J, Gu Y, Fausto N. Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice. Hepatology. 2008 Jun; 47(6):2078-88. PMID: 18506893.
      View in: PubMed
    12. Wolf N, Pendergrass W, Singh N, Swisshelm K, Schwartz J. Radiation cataracts: mechanisms involved in their long delayed occurrence but then rapid progression. Mol Vis. 2008 Feb 05; 14:274-85. PMID: 18334943; PMCID: PMC2254966.
    13. Mikheev AM, Mikheeva SA, Maxwell JP, Rivo JV, Rostomily R, Swisshelm K, Zarbl H. Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. Breast Cancer Res Treat. 2008 Nov; 112(2):263-73. PMID: 18157634.
      View in: PubMed
    14. Swift ME, Wallden B, Wayner EA, Swisshelm K. Truncated RAR beta isoform enhances proliferation and retinoid resistance. J Cell Physiol. 2006 Dec; 209(3):718-25. PMID: 17001699.
      View in: PubMed
    15. Wallden B, Emond M, Swift ME, Disis ML, Swisshelm K. Antimetastatic gene expression profiles mediated by retinoic acid receptor beta 2 in MDA-MB-435 breast cancer cells. BMC Cancer. 2005 Oct 28; 5:140. PMID: 16255778; PMCID: PMC1283145.
    16. Swisshelm K, Macek R, Kubbies M. Role of claudins in tumorigenesis. Adv Drug Deliv Rev. 2005 Apr 25; 57(6):919-28. PMID: 15820559.
      View in: PubMed
    17. Chang A, Schuetze SM, Conrad EU, Swisshelm KL, Norwood TH, Rubin BP. So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity. Int J Surg Pathol. 2005 Apr; 13(2):185-95. PMID: 15864383.
      View in: PubMed
    18. Paik J, Blaner WS, Swisshelm K. Cis-retinol dehydrogenase: 9-cis-retinol metabolism and its effect on proliferation of human MCF7 breast cancer cells. Exp Cell Res. 2005 Feb 01; 303(1):183-96. PMID: 15572038.
      View in: PubMed
    19. Bassett MD, Schuetze SM, Disteche C, Norwood TH, Swisshelm K, Chen X, Bruckner J, Conrad EU, Rubin BP. Deep-seated, well differentiated lipomatous tumors of the chest wall and extremities: the role of cytogenetics in classification and prognostication. Cancer. 2005 Jan 15; 103(2):409-16. PMID: 15593324.
      View in: PubMed
    20. True LD, Swisshelm K. Endothelial cells in B-cell lymphomas. N Engl J Med. 2004 Nov 04; 351(19):2019; author reply 2019. PMID: 15525732.
      View in: PubMed
    21. Hoevel T, Macek R, Swisshelm K, Kubbies M. Reexpression of the TJ protein CLDN1 induces apoptosis in breast tumor spheroids. Int J Cancer. 2004 Jan 20; 108(3):374-83. PMID: 14648703.
      View in: PubMed
    22. Grandori C, Robinson KL, Galloway DA, Swisshelm K. Functional link between Myc and the Werner gene in tumorigenesis. Cell Cycle. 2004 Jan; 3(1):22-5. PMID: 14657658.
      View in: PubMed
    23. Stampfer MR, Garbe J, Nijjar T, Wigington D, Swisshelm K, Yaswen P. Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines. Oncogene. 2003 Aug 14; 22(34):5238-51. PMID: 12917625.
      View in: PubMed
    24. Grandori C, Wu KJ, Fernandez P, Ngouenet C, Grim J, Clurman BE, Moser MJ, Oshima J, Russell DW, Swisshelm K, Frank S, Amati B, Dalla-Favera R, Monnat RJ. Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev. 2003 Jul 01; 17(13):1569-74. PMID: 12842909; PMCID: PMC196129.
    25. Macek R, Swisshelm K, Kubbies M. Expression and function of tight junction associated molecules in human breast tumor cells is not affected by the Ras-MEK1 pathway. Cell Mol Biol (Noisy-le-grand). 2003 Feb; 49(1):1-11. PMID: 12839332.
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    26. Dietze EC, Caldwell LE, Marcom K, Collins SJ, Yee L, Swisshelm K, Hobbs KB, Bean GR, Seewaldt VL. Retinoids and retinoic acid receptors regulate growth arrest and apoptosis in human mammary epithelial cells and modulate expression of CBP/p300. Microsc Res Tech. 2002 Oct 01; 59(1):23-40. PMID: 12242694.
      View in: PubMed
    27. Poot M, Hosier S, Swisshelm K. Distinct patterns of mitochondrial changes precede induction of apoptosis by all-trans-retinoic acid and N-(4-hydroxyphenyl)retinamide in MCF7 breast cancer cells. Exp Cell Res. 2002 Sep 10; 279(1):128-40. PMID: 12213221.
      View in: PubMed
    28. Chen LI, Sommer KM, Swisshelm K. Downstream codons in the retinoic acid receptor beta -2 and beta -4 mRNAs initiate translation of a protein isoform that disrupts retinoid-activated transcription. J Biol Chem. 2002 Sep 20; 277(38):35411-21. PMID: 12118004.
      View in: PubMed
    29. Wilson HM, Birnbaum RS, Poot M, Quinn LS, Swisshelm K. Insulin-like growth factor binding protein-related protein 1 inhibits proliferation of MCF-7 breast cancer cells via a senescence-like mechanism. Cell Growth Differ. 2002 May; 13(5):205-13. PMID: 12065244.
      View in: PubMed
    30. Hoevel T, Macek R, Mundigl O, Swisshelm K, Kubbies M. Expression and targeting of the tight junction protein CLDN1 in CLDN1-negative human breast tumor cells. J Cell Physiol. 2002 Apr; 191(1):60-8. PMID: 11920682.
      View in: PubMed
    31. Treuting PM, Chen LI, Buetow BS, Zeng W, Birkebak TA, Seewaldt VL, Sommer KM, Emond M, Maggio-Price L, Swisshelm K. Retinoic acid receptor beta2 inhibition of metastasis in mouse mammary gland xenografts. Breast Cancer Res Treat. 2002 Mar; 72(1):79-88. PMID: 12000222.
      View in: PubMed
    32. Krämer F, White K, Kubbies M, Swisshelm K, Weber BH. Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. Hum Genet. 2000 Sep; 107(3):249-56. PMID: 11071387.
      View in: PubMed
    33. Paik J, Vogel S, Piantedosi R, Sykes A, Blaner WS, Swisshelm K. 9-cis-retinoids: biosynthesis of 9-cis-retinoic acid. Biochemistry. 2000 Jul 11; 39(27):8073-84. PMID: 10891090.
      View in: PubMed
    34. Haugk KL, Wilson HM, Swisshelm K, Quinn LS. Insulin-like growth factor (IGF)-binding protein-related protein-1: an autocrine/paracrine factor that inhibits skeletal myoblast differentiation but permits proliferation in response to IGF. Endocrinology. 2000 Jan; 141(1):100-10. PMID: 10614628.
      View in: PubMed
    35. Swisshelm K. Concepts of immortalization in human mammary epithelial cells. Prog Mol Subcell Biol. 2000; 24:155-72. PMID: 10547862.
      View in: PubMed
    36. Haugk KL, Wilson HP, Swisshelm K, Quinn LS. Insulin-Like Growth Factor (IGF)-Binding Protein-Related Protein-1: An Autocrine/Paracrine Factor That Inhibits Skeletal Myoblast Differentiation but Permits Proliferation in Response to IGF1. Endocrinology. 2000 Jan 01; 141(1):100-110. PMID: 28201153.
      View in: PubMed
    37. Buetow BS, Chen LI, Maggio-Price L, Swisshelm K. Peritonitis in Nude Mice in a Xenograft Study. Contemp Top Lab Anim Sci. 1999 Nov; 38(6):47-49. PMID: 12086450.
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    38. Sommer KM, Chen LI, Treuting PM, Smith LT, Swisshelm K. Elevated retinoic acid receptor beta(4) protein in human breast tumor cells with nuclear and cytoplasmic localization. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8651-6. PMID: 10411930; PMCID: PMC17571.
    39. Swisshelm K, Machl A, Planitzer S, Robertson R, Kubbies M, Hosier S. SEMP1, a senescence-associated cDNA isolated from human mammary epithelial cells, is a member of an epithelial membrane protein superfamily. Gene. 1999 Jan 21; 226(2):285-95. PMID: 9931503.
      View in: PubMed
    40. Tsou HC, Ping XL, Xie XX, Gruener AC, Zhang H, Nini R, Swisshelm K, Sybert V, Diamond TM, Sutphen R, Peacocke M. The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1. Hum Genet. 1998 Apr; 102(4):467-73. PMID: 9600246.
      View in: PubMed
    41. Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, Suchard D, MacLeod PM, Kvinnsland S, Gjertsen BT, Heimdal K, Lubs H, Møller P, King MC. Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis. Am J Hum Genet. 1997 Dec; 61(6):1254-60. PMID: 9399897; PMCID: PMC1716102.
    42. Damon SE, Haugk KL, Swisshelm K, Quinn LS. Developmental regulation of Mac25/insulin-like growth factor-binding protein-7 expression in skeletal myogenesis. Exp Cell Res. 1997 Nov 25; 237(1):192-5. PMID: 9417882.
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    43. Seewaldt VL, Caldwell LE, Johnson BS, Swisshelm K, Collins SJ, Tsai S. Inhibition of retinoic acid receptor function in normal human mammary epithelial cells results in increased cellular proliferation and inhibits the formation of a polarized epithelium in vitro. Exp Cell Res. 1997 Oct 10; 236(1):16-28. PMID: 9344581.
      View in: PubMed
    44. Seewaldt VL, Kim JH, Caldwell LE, Johnson BS, Swisshelm K, Collins SJ. All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells. Cell Growth Differ. 1997 Jun; 8(6):631-41. PMID: 9185997.
      View in: PubMed
    45. Seewaldt VL, Johnson BS, Parker MB, Collins SJ, Swisshelm K. Expression of retinoic acid receptor beta mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. Cell Growth Differ. 1995 Sep; 6(9):1077-88. PMID: 8519684.
      View in: PubMed
    46. Swisshelm K, Ryan K, Tsuchiya K, Sager R. Enhanced expression of an insulin growth factor-like binding protein (mac25) in senescent human mammary epithelial cells and induced expression with retinoic acid. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4472-6. PMID: 7538673; PMCID: PMC41966.
    47. Chen Z, Swisshelm K, Sager R. A cautionary note on reaction tubes for differential display and cDNA amplification in thermal cycling. Biotechniques. 1994 Jun; 16(6):1002-4, 1006. PMID: 8074859.
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    48. Swisshelm K, Ryan K, Lee X, Tsou HC, Peacocke M, Sager R. Down-regulation of retinoic acid receptor beta in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ. 1994 Feb; 5(2):133-41. PMID: 8180126.
      View in: PubMed
    49. Sager R, Sheng S, Anisowicz A, Sotiropoulou G, Zou Z, Stenman G, Swisshelm K, Chen Z, Hendrix MJ, Pemberton P, et al. RNA genetics of breast cancer: maspin as paradigm. Cold Spring Harb Symp Quant Biol. 1994; 59:537-46. PMID: 7587110.
      View in: PubMed
    50. Swisshelm K, Leonard M, Sager R. Preferential chromosome loss in human papilloma virus DNA-immortalized mammary epithelial cells. Genes Chromosomes Cancer. 1992 Oct; 5(3):219-26. PMID: 1384674.
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    51. Lee SW, Tomasetto C, Swisshelm K, Keyomarsi K, Sager R. Down-regulation of a member of the S100 gene family in mammary carcinoma cells and reexpression by azadeoxycytidine treatment. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2504-8. PMID: 1372446; PMCID: PMC48687.
    52. Band V, Zajchowski D, Swisshelm K, Trask D, Kulesa V, Cohen C, Connolly J, Sager R. Tumor progression in four mammary epithelial cell lines derived from the same patient. Cancer Res. 1990 Nov 15; 50(22):7351-7. PMID: 1977518.
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    53. Swisshelm K, Disteche CM, Thorvaldsen J, Nelson A, Salk D. Age-related increase in methylation of ribosomal genes and inactivation of chromosome-specific rRNA gene clusters in mouse. Mutat Res. 1990 May-Jul; 237(3-4):131-46. PMID: 1700292.
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    54. Turker MS, Swisshelm K, Smith AC, Martin GM. A partial methylation profile for a CpG site is stably maintained in mammalian tissues and cultured cell lines. J Biol Chem. 1989 Jul 15; 264(20):11632-6. PMID: 2545677.
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    55. Murray JC, Buetow KH, Donovan M, Hornung S, Motulsky AG, Disteche C, Dyer K, Swisshelm K, Anderson J, Giblett E, et al. Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27. Am J Hum Genet. 1987 Apr; 40(4):338-50. PMID: 2883890; PMCID: PMC1684087.
    56. Kranz DM, Saito H, Disteche CM, Swisshelm K, Pravtcheva D, Ruddle FH, Eisen HN, Tonegawa S. Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene. Science. 1985 Feb 22; 227(4689):941-5. PMID: 3918347.
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    57. Disteche CM, Swisshelm K, Forbes S, Pagon RA. X-inactivation patterns in lymphocytes and skin fibroblasts of three cases of X-autosome translocations with abnormal phenotypes. Hum Genet. 1984; 66(1):71-6. PMID: 6698557.
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    58. Swisshelm K, Rodriguez ML, Luthy D, Salk D, Norwood T. Antenatal diagnosis of mosaic trisomy 8 confirmed in fetal tissues. Clin Genet. 1981 Oct; 20(4):276-80. PMID: 7333020.
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