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Changwei Liu

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Research 
    Collapse research activities and funding
    R01NS072397     (LIU, CHANGWEI)Sep 1, 2010 - Jul 31, 2015
    Cellular regulation by protein ubiquitination/deubiquitination
    Role: Principal Investigator

    U01CA222958     (LIU, CHANGWEI)Jul 5, 2018 - Jun 30, 2023
    Validating and targeting USP35 for anticancer drug development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Westrich JA, Warren CJ, Klausner MJ, Guo K, Liu CW, Santiago ML, Pyeon D. Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. J Virol. 2018 04 01; 92(7). PMID: 29367246.
      View in: PubMed
    2. Han KJ, Foster D, Harhaj EW, Dzieciatkowska M, Hansen K, Liu CW. Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity. Hum Mol Genet. 2016 Apr 01; 25(7):1392-405. PMID: 26908624.
      View in: PubMed
    3. Jacobson AD, MacFadden A, Wu Z, Peng J, Liu CW. Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell. 2014 Jun 15; 25(12):1824-35. PMID: 24743594.
      View in: PubMed
    4. Liu CW, Jacobson AD. Functions of the 19S complex in proteasomal degradation. Trends Biochem Sci. 2013 Feb; 38(2):103-10. PMID: 23290100.
      View in: PubMed
    5. Han KJ, Foster DG, Zhang NY, Kanisha K, Dzieciatkowska M, Sclafani RA, Hansen KC, Peng J, Liu CW. Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron. J Biol Chem. 2012 Dec 21; 287(52):43741-52. PMID: 23112048.
      View in: PubMed
    6. Zhang NY, Jacobson AD, Macfadden A, Liu CW. Ubiquitin chain trimming recycles the substrate binding sites of the 26 S proteasome and promotes degradation of lysine 48-linked polyubiquitin conjugates. J Biol Chem. 2011 Jul 22; 286(29):25540-6. PMID: 21632534.
      View in: PubMed
    7. Jacobson AD, Zhang NY, Xu P, Han KJ, Noone S, Peng J, Liu CW. The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome. J Biol Chem. 2009 Dec 18; 284(51):35485-94. PMID: 19858201.
      View in: PubMed
    8. Zhao M, Zhang NY, Zurawel A, Hansen KC, Liu CW. Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates. J Biol Chem. 2010 Feb 12; 285(7):4771-80. PMID: 20007692.
      View in: PubMed
    9. Zhang NY, Tang Z, Liu CW. alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis. J Biol Chem. 2008 Jul 18; 283(29):20288-98. PMID: 18502751.
      View in: PubMed
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