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Changwei Liu

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3208

    Collapse Research 
    Collapse research activities and funding
    R01NS072397     (LIU, CHANGWEI)Sep 1, 2010 - Jul 31, 2015
    NIH/NINDS
    Cellular regulation by protein ubiquitination/deubiquitination
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Han KJ, Foster D, Harhaj EW, Dzieciatkowska M, Hansen K, Liu CW. Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity. Hum Mol Genet. 2016 Apr 01; 25(7):1392-405. PMID: 26908624; PMCID: PMC4787908 [Available on 04/01/17].
    2. Jacobson AD, MacFadden A, Wu Z, Peng J, Liu CW. Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell. 2014 Jun 15; 25(12):1824-35. PMID: 24743594; PMCID: PMC4055262.
    3. Liu CW, Jacobson AD. Functions of the 19S complex in proteasomal degradation. Trends Biochem Sci. 2013 Feb; 38(2):103-10. PMID: 23290100; PMCID: PMC3557657.
    4. Han KJ, Foster DG, Zhang NY, Kanisha K, Dzieciatkowska M, Sclafani RA, Hansen KC, Peng J, Liu CW. Ubiquitin-specific protease 9x deubiquitinates and stabilizes the spinal muscular atrophy protein-survival motor neuron. J Biol Chem. 2012 Dec 21; 287(52):43741-52. PMID: 23112048; PMCID: PMC3527959.
    5. Zhang NY, Jacobson AD, Macfadden A, Liu CW. Ubiquitin chain trimming recycles the substrate binding sites of the 26 S proteasome and promotes degradation of lysine 48-linked polyubiquitin conjugates. J Biol Chem. 2011 Jul 22; 286(29):25540-6. PMID: 21632534; PMCID: PMC3138263.
    6. Jacobson AD, Zhang NY, Xu P, Han KJ, Noone S, Peng J, Liu CW. The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome. J Biol Chem. 2009 Dec 18; 284(51):35485-94. PMID: 19858201; PMCID: PMC2790978.
    7. Zhao M, Zhang NY, Zurawel A, Hansen KC, Liu CW. Degradation of some polyubiquitinated proteins requires an intrinsic proteasomal binding element in the substrates. J Biol Chem. 2010 Feb 12; 285(7):4771-80. PMID: 20007692; PMCID: PMC2836082.
    8. Zhang NY, Tang Z, Liu CW. alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis. J Biol Chem. 2008 Jul 18; 283(29):20288-98. PMID: 18502751.
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