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Linda A Barbour

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-3954

    Collapse Research 
    Collapse research activities and funding
    K23RR017496     (BARBOUR, LINDA)Jul 1, 2002 - Jun 30, 2008
    NIH/NCRR
    Mentored Patient-Oriented Research Career Development Award
    Role: Principal Investigator

    R56DK078645     (BARBOUR, LINDA)Sep 15, 2007 - Feb 28, 2010
    NIH/NIDDK
    Regulation of Maternal Fuel Supply and Neonatal Adiposity
    Role: Principal Investigator

    R01DK078645     (BARBOUR, LINDA ANNE)Mar 15, 2010 - Feb 28, 2015
    NIH/NIDDK
    Regulation of Maternal Fuel Supply and Neonatal Adiposity
    Role: Principal Investigator

    R21DK088324     (BARBOUR, LINDA ANNE)Apr 20, 2010 - Mar 31, 2013
    NIH/NIDDK
    Role of Macronutrient Diet Composition on Maternal and Infant Metabolic Outcomes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Díaz P, Dimasuay KG, Koele-Schmidt L, Jang B, Barbour LA, Jansson T, Powell TL. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017 Sep; 57:52-59. PMID: 28864019.
      View in: PubMed
    2. Young BE, Patinkin Z, Palmer C, de la Houssaye B, Barbour LA, Hernandez T, Friedman JE, Krebs NF. Human milk insulin is related to maternal plasma insulin and BMI: but other components of human milk do not differ by BMI. Eur J Clin Nutr. 2017 Sep; 71(9):1094-1100. PMID: 28513622.
      View in: PubMed
    3. Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan; 105(1):234-236. PMID: 28049665.
      View in: PubMed
    4. Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS. Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI. Int J Obes (Lond). 2017 Apr; 41(4):510-517. PMID: 27876761.
      View in: PubMed
    5. Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE. Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project. PLoS One. 2016; 11(7):e0159575. PMID: 27414406; PMCID: PMC4944979.
    6. Moore GS, Allshouse AA, Fisher BM, Kahn BF, Hernandez TL, Reece MS, Reynolds RM, Lee W, Barbour LA, Galan HL. Can Fetal Limb Soft Tissue Measurements in the Third Trimester Predict Neonatal Adiposity? J Ultrasound Med. 2016 Sep; 35(9):1915-24. PMID: 27417735.
      View in: PubMed
    7. Shapiro AL, Kaar JL, Crume TL, Starling AP, Siega-Riz AM, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D. Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study. Int J Obes (Lond). 2016 Jul; 40(7):1056-62. PMID: 27133623.
      View in: PubMed
    8. Lemas DJ, Young BE, Baker PR, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr. 2016 May; 103(5):1291-300. PMID: 27140533; PMCID: PMC4841936 [Available on 05/01/17].
    9. Soderborg TK, Borengasser SJ, Barbour LA, Friedman JE. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia. 2016 May; 59(5):895-906. PMID: 26843076; PMCID: PMC4829383 [Available on 05/01/17].
    10. Klingensmith GJ, Pyle L, Nadeau KJ, Barbour LA, Goland RS, Willi SM, Linder B, White NH. Pregnancy Outcomes in Youth With Type 2 Diabetes: The TODAY Study Experience. Diabetes Care. 2016 Jan; 39(1):122-9. PMID: 26628417; PMCID: PMC4686849 [Available on 01/01/17].
    11. McIntyre HD, Sacks DA, Barbour LA, Feig DS, Catalano PM, Damm P, McElduff A. Issues With the Diagnosis and Classification of Hyperglycemia in Early Pregnancy. Diabetes Care. 2016 Jan; 39(1):53-4. PMID: 26519336.
      View in: PubMed
    12. Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA. Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study. Diabetes Care. 2016 Jan; 39(1):39-42. PMID: 26223240; PMCID: PMC4686845 [Available on 01/01/17].
    13. Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE. Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life. Pediatr Obes. 2016 08; 11(4):264-71. PMID: 26198967; PMCID: PMC4762753 [Available on 08/01/17].
    14. Nicklas JM, Barbour LA. Optimizing Weight for Maternal and Infant Health - Tenable, or Too Late? Expert Rev Endocrinol Metab. 2015; 10(2):227-242. PMID: 26442123.
      View in: PubMed
    15. Boyle KE, Hwang H, Janssen RC, DeVente JM, Barbour LA, Hernandez TL, Mandarino LJ, Lappas M, Friedman JE. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One. 2014; 9(9):e106872. PMID: 25216282; PMCID: PMC4162568.
    16. Barbour LA. Changing perspectives in pre-existing diabetes and obesity in pregnancy: maternal and infant short- and long-term outcomes. Curr Opin Endocrinol Diabetes Obes. 2014 Aug; 21(4):257-63. PMID: 24937039.
      View in: PubMed
    17. Barbour LA. Unresolved controversies in gestational diabetes: implications on maternal and infant health. Curr Opin Endocrinol Diabetes Obes. 2014 Aug; 21(4):264-70. PMID: 24937040.
      View in: PubMed
    18. Hernandez TL, Van Pelt RE, Anderson MA, Daniels LJ, West NA, Donahoo WT, Friedman JE, Barbour LA. A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: a randomized crossover study. Diabetes Care. 2014; 37(5):1254-62. PMID: 24595632; PMCID: PMC3994935.
    19. Hernandez TL, Anderson MA, Chartier-Logan C, Friedman JE, Barbour LA. Strategies in the nutritional management of gestational diabetes. Clin Obstet Gynecol. 2013 Dec; 56(4):803-15. PMID: 24047934; PMCID: PMC3921177.
    20. Hernandez TL, Barbour LA. A standard approach to continuous glucose monitor data in pregnancy for the study of fetal growth and infant outcomes. Diabetes Technol Ther. 2013 Feb; 15(2):172-9. PMID: 23268584; PMCID: PMC3558676.
    21. Brumbaugh DE, Tearse P, Cree-Green M, Fenton LZ, Brown M, Scherzinger A, Reynolds R, Alston M, Hoffman C, Pan Z, Friedman JE, Barbour LA. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr. 2013 May; 162(5):930-6.e1. PMID: 23260099; PMCID: PMC3610780.
    22. De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ, Mestman J, Rovet J, Sullivan S. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012 Aug; 97(8):2543-65. PMID: 22869843.
      View in: PubMed
    23. Barbour LA. Weight gain in pregnancy: is less truly more for mother and infant? Obstet Med. 2012 Jun; 5(2):58-64. PMID: 27579137; PMCID: PMC4989622.
    24. Barbour LA, Van Pelt RE, Brumbaugh DE, Hernandez TL, Friedman JE. Comment on: Rowan et al. Metformin in Gestational diabetes: The Offspring Follow-Up (MiG TOFU): body composition at 2 years of age. Diabetes Care 2011;34:2279-2284. Diabetes Care. 2012 Mar; 35(3):e28; author reply e30. PMID: 22355031; PMCID: PMC3322686.
    25. Harmon KA, Gerard L, Jensen DR, Kealey EH, Hernandez TL, Reece MS, Barbour LA, Bessesen DH. Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet: metabolic determinants of fetal growth. Diabetes Care. 2011 Oct; 34(10):2198-204. PMID: 21775754; PMCID: PMC3177740.
    26. Hernandez TL, Friedman JE, Van Pelt RE, Barbour LA. Patterns of glycemia in normal pregnancy: should the current therapeutic targets be challenged? Diabetes Care. 2011 Jul; 34(7):1660-8. PMID: 21709299; PMCID: PMC3120213.
    27. Barbour LA, McCurdy CE, Hernandez TL, Friedman JE. Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum. J Clin Endocrinol Metab. 2011 May; 96(5):1431-41. PMID: 21289241; PMCID: PMC3085211.
    28. Heerwagen MJ, Miller MR, Barbour LA, Friedman JE. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3):R711-22. PMID: 20631295; PMCID: PMC2944425.
    29. Diamond JR, Finlayson CA, Thienelt C, Kabos P, Hardesty L, Barbour L, Klein CE, Rabinovitch R, Elias A, Borges VF. Early-stage BRCA2-linked breast cancer diagnosed in the first trimester of pregnancy associated with a hypercoagulable state. Oncology (Williston Park). 2009 Aug; 23(9):784-91. PMID: 19777765.
      View in: PubMed
    30. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ, Stagnaro-Green A. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2007 Aug; 92(8 Suppl):S1-47. PMID: 17948378.
      View in: PubMed
    31. Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007 Jul; 30 Suppl 2:S112-9. PMID: 17596458.
      View in: PubMed
    32. del Rincon JP, Iida K, Gaylinn BD, McCurdy CE, Leitner JW, Barbour LA, Kopchick JJ, Friedman JE, Draznin B, Thorner MO. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance. Diabetes. 2007 Jun; 56(6):1638-46. PMID: 17363744.
      View in: PubMed
    33. Kahn BF, Davies JK, Lynch AM, Reynolds RM, Barbour LA. Predictors of glyburide failure in the treatment of gestational diabetes. Obstet Gynecol. 2006 Jun; 107(6):1303-9. PMID: 16738156.
      View in: PubMed
    34. Barbour LA, Mizanoor Rahman S, Gurevich I, Leitner JW, Fischer SJ, Roper MD, Knotts TA, Vo Y, McCurdy CE, Yakar S, Leroith D, Kahn CR, Cantley LC, Friedman JE, Draznin B. Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. J Biol Chem. 2005 Nov 11; 280(45):37489-94. PMID: 16166093.
      View in: PubMed
    35. Barbour LA, Oja JL, Schultz LK. A prospective trial that demonstrates that dalteparin requirements increase in pregnancy to maintain therapeutic levels of anticoagulation. Am J Obstet Gynecol. 2004 Sep; 191(3):1024-9. PMID: 15467584.
      View in: PubMed
    36. Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. 2004 Mar; 145(3):1144-50. PMID: 14633976.
      View in: PubMed
    37. Barbour LA. New concepts in insulin resistance of pregnancy and gestational diabetes: long-term implications for mother and offspring. J Obstet Gynaecol. 2003 Sep; 23(5):545-9. PMID: 12963518.
      View in: PubMed
    38. Barbour LA, Shao J, Qiao L, Pulawa LK, Jensen DR, Bartke A, Garrity M, Draznin B, Friedman JE. Human placental growth hormone causes severe insulin resistance in transgenic mice. Am J Obstet Gynecol. 2002 Mar; 186(3):512-7. PMID: 11904616.
      View in: PubMed
    39. Barbour LA. ACOG practice bulletin. Thrombembolism in pregnancy. Int J Gynaecol Obstet. 2001 Nov; 75(2):203-12. PMID: 11724031.
      View in: PubMed
    40. Powrie RO, Larson L, Rosene-Montella K, Abarca M, Barbour L, Trujillo N. Alveolar-arterial oxygen gradient in acute pulmonary embolism in pregnancy. Am J Obstet Gynecol. 1998 Feb; 178(2):394-6. PMID: 9500505.
      View in: PubMed
    41. Barbour LA. Current concepts of anticoagulant therapy in pregnancy. Obstet Gynecol Clin North Am. 1997 Sep; 24(3):499-521. PMID: 9266575.
      View in: PubMed
    42. Lefkowitz JB, Clarke SH, Barbour LA. Comparison of protein S functional and antigenic assays in normal pregnancy. Am J Obstet Gynecol. 1996 Sep; 175(3 Pt 1):657-60. PMID: 8828430.
      View in: PubMed
    43. Barbour LA, Smith JM, Marlar RA. Heparin levels to guide thromboembolism prophylaxis during pregnancy. Am J Obstet Gynecol. 1995 Dec; 173(6):1869-73. PMID: 8610778.
      View in: PubMed
    44. Barbour LA, Pickard J. Controversies in thromboembolic disease during pregnancy: a critical review. Obstet Gynecol. 1995 Oct; 86(4 Pt 1):621-33. PMID: 7675391.
      View in: PubMed
    45. Barbour LA, Kick SD, Steiner JF, LoVerde ME, Heddleston LN, Lear JL, Barón AE, Barton PL. A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry. Am J Obstet Gynecol. 1994 Mar; 170(3):862-9. PMID: 8141217.
      View in: PubMed
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