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Laura D Brown

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    R01HD079404     (BROWN, LAURA DAVIDSON)Apr 1, 2015 - Jan 31, 2021
    NIH
    Regulation of fetal skeletal muscle growth in IUGR
    Role: Principal Investigator

    S10OD023553     (BROWN, LAURA DAVIDSON)Mar 3, 2017 - Mar 2, 2018
    NIH
    UV-visible HPLC with PCX Pinnacle post column reaction module
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2021 Oct 05. PMID: 34611848.
      View in: PubMed
    2. Steller JG, Gumina D, Driver C, Palmer C, Brown LD, Reeves S, Hobbins JC, Galan HL. 3D Fractional Limb Volume Identifies Reduced Subcutaneous and Lean Mass in Fetal Growth Restriction. J Ultrasound Med. 2021 Sep 28. PMID: 34580892.
      View in: PubMed
    3. Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 Sep; 9(18):e15033. PMID: 34558219.
      View in: PubMed
    4. Rozance PJ, Wesolowski SR, Jonker SS, Brown LD. Anemic hypoxemia reduces myoblast proliferation and muscle growth in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2021 09 01; 321(3):R352-R363. PMID: 34287074.
      View in: PubMed
    5. Cilvik SN, Wesolowski SR, Anthony RV, Brown LD, Rozance PJ. Late gestation fetal hyperglucagonaemia impairs placental function and results in diminished fetal protein accretion and decreased fetal growth. J Physiol. 2021 07; 599(13):3403-3427. PMID: 33878802.
      View in: PubMed
    6. White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2021 06 01; 320(6):E1138-E1147. PMID: 33938236.
      View in: PubMed
    7. Boehmer BH, Wesolowski SR, Brown LD, Rozance PJ. Chronic Fetal Leucine Infusion Does Not Potentiate Glucose-Stimulated Insulin Secretion or Affect Pancreatic Islet Development in Late-Gestation Growth-Restricted Fetal Sheep. J Nutr. 2021 02 01; 151(2):312-319. PMID: 33326574.
      View in: PubMed
    8. Tang M, Weaver NE, Berman LM, Brown LD, Hendricks AE, Krebs NF. Different Blood Metabolomics Profiles in Infants Consuming a Meat- or Dairy-Based Complementary Diet. Nutrients. 2021 Jan 27; 13(2). PMID: 33513734.
      View in: PubMed
    9. Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 03 01; 320(3):E527-E538. PMID: 33427051.
      View in: PubMed
    10. Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 04; 40:101827. PMID: 33485059.
      View in: PubMed
    11. Schinkel ER, Nelson ER, Young BE, Bernstein RM, Taylor SN, Brown LD, Hay WW, Brown KJ, Prenni J. Concentrating human milk: an innovative point-of-care device designed to increase human milk feeding options for preterm infants. J Perinatol. 2021 03; 41(3):582-589. PMID: 33060780.
      View in: PubMed
    12. Boehmer BH, Baker PR, Brown LD, Wesolowski SR, Rozance PJ. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. J Endocrinol. 2020 10; 247(1):115-126. PMID: 32756000.
      View in: PubMed
    13. Rozance PJ, Jones AK, Bourque SL, D'Alessandro A, Hay WW, Brown LD, Wesolowski SR. Effects of chronic hyperinsulinemia on metabolic pathways and insulin signaling in the fetal liver. Am J Physiol Endocrinol Metab. 2020 10 01; 319(4):E721-E733. PMID: 32830555.
      View in: PubMed
    14. Boehmer BH, Brown LD, Wesolowski SR, Hay WW, Rozance PJ. A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and ß Cells in Late-Gestation Sheep. J Nutr. 2020 08 01; 150(8):2061-2069. PMID: 32470982.
      View in: PubMed
    15. Stremming J, Jansson T, Powell TL, Rozance PJ, Brown LD. Reduced Na+ K+ -ATPase activity may reduce amino acid uptake in intrauterine growth restricted fetal sheep muscle despite unchanged ex vivo amino acid transporter activity. J Physiol. 2020 04; 598(8):1625-1639. PMID: 31909825.
      View in: PubMed
    16. Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 12 19; 244(2):339-352. PMID: 31751294.
      View in: PubMed
    17. Chang EI, Wesolowski SR, Gilje EA, Baker PR, Reisz JA, D'Alessandro A, Hay WW, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 11 01; 317(5):R615-R629. PMID: 31483682.
      View in: PubMed
    18. Jones AK, Rozance PJ, Brown LD, Goldstrohm DA, Hay WW, Limesand SW, Wesolowski SR. Sustained hypoxemia in late gestation potentiates hepatic gluconeogenic gene expression but does not activate glucose production in the ovine fetus. Am J Physiol Endocrinol Metab. 2019 07 01; 317(1):E1-E10. PMID: 30964701.
      View in: PubMed
    19. Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 05 01; 316(5):R427-R440. PMID: 30758974.
      View in: PubMed
    20. Jonker SS, Kamna D, LoTurco D, Kailey J, Brown LD. IUGR impairs cardiomyocyte growth and maturation in fetal sheep. J Endocrinol. 2018 11 01; 239(2):253-265. PMID: 30143557.
      View in: PubMed
    21. Wai SG, Rozance PJ, Wesolowski SR, Hay WW, Brown LD. Prolonged amino acid infusion into intrauterine growth-restricted fetal sheep increases leucine oxidation rates. Am J Physiol Endocrinol Metab. 2018 12 01; 315(6):E1143-E1153. PMID: 30205012.
      View in: PubMed
    22. Stremming JE, Wright CJ, Brown LD. Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants? Acta Paediatr. 2018 10; 107(10):1836. PMID: 29873417.
      View in: PubMed
    23. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 01 01; 596(1):67-82. PMID: 28940557.
      View in: PubMed
    24. Brown LD, Kohn JR, Rozance PJ, Hay WW, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 05 01; 312(5):R654-R663. PMID: 28179229.
      View in: PubMed
    25. Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 04 01; 312(4):R492-R500. PMID: 28100476.
      View in: PubMed
    26. Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 03; 232(3):475-491. PMID: 28053000.
      View in: PubMed
    27. Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct; 157(10):3788-3799. PMID: 27501184.
      View in: PubMed
    28. Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R200-8. PMID: 27170658.
      View in: PubMed
    29. Hay WW, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug; 105(8):881-9. PMID: 27028695.
      View in: PubMed
    30. Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 06; 157(6):2447-60. PMID: 27049667.
      View in: PubMed
    31. Brown LD, Hay WW. Impact of placental insufficiency on fetal skeletal muscle growth. Mol Cell Endocrinol. 2016 11 05; 435:69-77. PMID: 26994511.
      View in: PubMed
    32. Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 04; 241(8):839-47. PMID: 26873920.
      View in: PubMed
    33. Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar; 170:10-2. PMID: 26746122.
      View in: PubMed
    34. Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R920-8. PMID: 26224688.
      View in: PubMed
    35. Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan; 156(1):367-76. PMID: 25343274.
      View in: PubMed
    36. Houin SS, Rozance PJ, Brown LD, Hay WW, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E306-14. PMID: 25516551.
      View in: PubMed
    37. Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18; 2(6). PMID: 24944291.
      View in: PubMed
    38. Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014; 5(1):28. PMID: 24917928.
      View in: PubMed
    39. Brown LD. Endocrine regulation of fetal skeletal muscle growth: impact on future metabolic health. J Endocrinol. 2014 May; 221(2):R13-29. PMID: 24532817.
      View in: PubMed
    40. Brown LD, Hendrickson K, Masor ML, Hay WW. High-protein formulas: evidence for use in preterm infants. Clin Perinatol. 2014 Jun; 41(2):383-403. PMID: 24873839.
      View in: PubMed
    41. Hay WW, Brown LD, Denne SC. Energy requirements, protein-energy metabolism and balance, and carbohydrates in preterm infants. World Rev Nutr Diet. 2014; 110:64-81. PMID: 24751622.
      View in: PubMed
    42. Funk T, Prok L, Brown LD, Bruckner AL. Multifocal vascular tumors and fetal hydrops. J Pediatr. 2014 May; 164(5):1214-8. PMID: 24433827.
      View in: PubMed
    43. Brown LD, Hay WW. The nutritional dilemma for preterm infants: how to promote neurocognitive development and linear growth, but reduce the risk of obesity. J Pediatr. 2013 Dec; 163(6):1543-5. PMID: 24018016.
      View in: PubMed
    44. Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15; 304(4):E352-62. PMID: 23211516.
      View in: PubMed
    45. Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 01; 304(1):R50-8. PMID: 23135788.
      View in: PubMed
    46. Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15; 303(8):R861-9. PMID: 22933022.
      View in: PubMed
    47. Thorn SR, Brown LD, Rozance PJ, Hay WW, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan; 62(1):65-73. PMID: 22933111.
      View in: PubMed
    48. Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E352-64. PMID: 22649066.
      View in: PubMed
    49. Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1483-92. PMID: 22454287.
      View in: PubMed
    50. Thorn SR, Rozance PJ, Brown LD, Hay WW. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May; 29(3):225-36. PMID: 21710398.
      View in: PubMed
    51. Brown LD, Green AS, Limesand SW, Rozance PJ. Maternal amino acid supplementation for intrauterine growth restriction. Front Biosci (Schol Ed). 2011 Jan 01; 3:428-44. PMID: 21196387.
      View in: PubMed
    52. Arroyo JA, Brown LD, Galan HL. Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol. 2009 Dec; 201(6):616.e1-7. PMID: 19800600.
      View in: PubMed
    53. Rozance PJ, Crispo MM, Barry JS, O'Meara MC, Frost MS, Hansen KC, Hay WW, Brown LD. Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation. Am J Physiol Endocrinol Metab. 2009 Sep; 297(3):E638-46. PMID: 19602583.
      View in: PubMed
    54. Brown LD, Cheung A, Harwood JE, Battaglia FC. Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes. J Nutr. 2009 Sep; 139(9):1648-52. PMID: 19494026.
      View in: PubMed
    55. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452.
      View in: PubMed
    56. Limesand SW, Rozance PJ, Brown LD, Hay WW. Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep. Am J Physiol Endocrinol Metab. 2009 Apr; 296(4):E879-87. PMID: 19190258.
      View in: PubMed
    57. Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW. Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Pediatr Res. 2009 Jan; 65(1):72-8. PMID: 18704001.
      View in: PubMed
    58. Brown LD, Rozance PJ, Barry JS, Friedman JE, Hay WW. Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E56-63. PMID: 18940943.
      View in: PubMed
    59. Brown LD, Cavalli C, Harwood JE, Casadei A, Teng CC, Traggiai C, Serra G, Bevilacqua G, Battaglia FC. Plasma concentrations of carbohydrates and sugar alcohols in term newborns after milk feeding. Pediatr Res. 2008 Aug; 64(2):189-93. PMID: 18391836.
      View in: PubMed
    60. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E365-70. PMID: 18056789.
      View in: PubMed
    61. Brown LD, Hay WW. Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1333-40. PMID: 16868230.
      View in: PubMed
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