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Laura D Brown

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    R01HD079404     (BROWN, LAURA DAVIDSON)Apr 1, 2015 - Jan 31, 2020
    Regulation of fetal skeletal muscle growth in IUGR
    Role: Principal Investigator

    S10OD023553     (BROWN, LAURA DAVIDSON)Mar 3, 2017 - Mar 2, 2018
    UV-visible HPLC with PCX Pinnacle post column reaction module
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW, Friedman JE, Wesolowski SR. Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver. Am J Physiol Regul Integr Comp Physiol. 2019 Feb 13. PMID: 30758974.
      View in: PubMed
    2. Jonker SS, Kamna D, Loturco D, Kailey J, Brown LD. IUGR impairs cardiomyocyte growth and maturation in fetal sheep. J Endocrinol. 2018 Aug 24. PMID: 30143557.
      View in: PubMed
    3. Stremming JE, Wright CJ, Brown LD. Is paracetamol as effective as indomethacin or ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants? Acta Paediatr. 2018 Oct; 107(10):1836. PMID: 29873417.
      View in: PubMed
    4. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth-restricted fetal sheep. J Physiol. 2018 Jan 01; 596(1):67-82. PMID: 28940557.
      View in: PubMed
    5. Brown LD, Kohn JR, Rozance PJ, Hay WW, Wesolowski SR. Exogenous amino acids suppress glucose oxidation and potentiate hepatic glucose production in late gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 05 01; 312(5):R654-R663. PMID: 28179229.
      View in: PubMed
    6. Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 04 01; 312(4):R492-R500. PMID: 28100476.
      View in: PubMed
    7. Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW, Leinwand LA, Friedman JE, Brown LD. Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro. J Endocrinol. 2017 03; 232(3):475-491. PMID: 28053000.
      View in: PubMed
    8. Brown LD, Davis M, Wai S, Wesolowski SR, Hay WW, Limesand SW, Rozance PJ. Chronically Increased Amino Acids Improve Insulin Secretion, Pancreatic Vascularity, and Islet Size in Growth-Restricted Fetal Sheep. Endocrinology. 2016 Oct; 157(10):3788-3799. PMID: 27501184.
      View in: PubMed
    9. Culpepper C, Wesolowski SR, Benjamin J, Bruce JL, Brown LD, Jonker SS, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia increases plasma glucagon and hepatic PCK1 mRNA in late-gestation fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R200-8. PMID: 27170658.
      View in: PubMed
    10. Hay WW, Brown LD, Rozance PJ, Wesolowski SR, Limesand SW. Challenges in nourishing the intrauterine growth-restricted foetus - Lessons learned from studies in the intrauterine growth-restricted foetal sheep. Acta Paediatr. 2016 Aug; 105(8):881-9. PMID: 27028695.
      View in: PubMed
    11. Brown LD, Wesolowski SR, Kailey J, Bourque S, Wilson A, Andrews SE, Hay WW, Rozance PJ. Chronic Hyperinsulinemia Increases Myoblast Proliferation in Fetal Sheep Skeletal Muscle. Endocrinology. 2016 06; 157(6):2447-60. PMID: 27049667; PMCID: PMC4891788 [Available on 06/01/17].
    12. Brown LD, Hay WW. Impact of placental insufficiency on fetal skeletal muscle growth. Mol Cell Endocrinol. 2016 11 05; 435:69-77. PMID: 26994511.
      View in: PubMed
    13. Barry JS, Rozance PJ, Brown LD, Anthony RV, Thornburg KL, Hay WW. Increased fetal myocardial sensitivity to insulin-stimulated glucose metabolism during ovine fetal growth restriction. Exp Biol Med (Maywood). 2016 04; 241(8):839-47. PMID: 26873920.
      View in: PubMed
    14. Brown LD, Rozance PJ. A Sweet Addition for the Treatment of Neonatal Hypoglycemia. J Pediatr. 2016 Mar; 170:10-2. PMID: 26746122.
      View in: PubMed
    15. Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW, Wesolowski SR. Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15; 309(8):R920-8. PMID: 26224688; PMCID: PMC4666949 [Available on 10/15/16].
    16. Andrews SE, Brown LD, Thorn SR, Limesand SW, Davis M, Hay WW, Rozance PJ. Increased adrenergic signaling is responsible for decreased glucose-stimulated insulin secretion in the chronically hyperinsulinemic ovine fetus. Endocrinology. 2015 Jan; 156(1):367-76. PMID: 25343274; PMCID: PMC4272391.
    17. Houin SS, Rozance PJ, Brown LD, Hay WW, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E306-14. PMID: 25516551; PMCID: PMC4329495.
    18. Brown LD, Thorn SR, O'Meara MC, Lavezzi JR, Rozance PJ. A physiological increase in insulin suppresses muscle-specific ubiquitin ligase gene activation in fetal sheep with sustained hypoglycemia. Physiol Rep. 2014 Jun 18; 2(6). PMID: 24944291; PMCID: PMC4208658.
    19. Brown LD, Thorn SR, Cheung A, Lavezzi JR, Battaglia FC, Rozance PJ. Changes in fetal mannose and other carbohydrates induced by a maternal insulin infusion in pregnant sheep. J Anim Sci Biotechnol. 2014; 5(1):28. PMID: 24917928; PMCID: PMC4051387.
    20. Brown LD. Endocrine regulation of fetal skeletal muscle growth: impact on future metabolic health. J Endocrinol. 2014 May; 221(2):R13-29. PMID: 24532817; PMCID: PMC4004098.
    21. Brown LD, Hendrickson K, Masor ML, Hay WW. High-protein formulas: evidence for use in preterm infants. Clin Perinatol. 2014 Jun; 41(2):383-403. PMID: 24873839.
      View in: PubMed
    22. Hay WW, Brown LD, Denne SC. Energy requirements, protein-energy metabolism and balance, and carbohydrates in preterm infants. World Rev Nutr Diet. 2014; 110:64-81. PMID: 24751622.
      View in: PubMed
    23. Funk T, Prok L, Brown LD, Bruckner AL. Multifocal vascular tumors and fetal hydrops. J Pediatr. 2014 May; 164(5):1214-8. PMID: 24433827.
      View in: PubMed
    24. Brown LD, Hay WW. The nutritional dilemma for preterm infants: how to promote neurocognitive development and linear growth, but reduce the risk of obesity. J Pediatr. 2013 Dec; 163(6):1543-5. PMID: 24018016.
      View in: PubMed
    25. Gadhia MM, Maliszewski AM, O'Meara MC, Thorn SR, Lavezzi JR, Limesand SW, Hay WW, Brown LD, Rozance PJ. Increased amino acid supply potentiates glucose-stimulated insulin secretion but does not increase ß-cell mass in fetal sheep. Am J Physiol Endocrinol Metab. 2013 Feb 15; 304(4):E352-62. PMID: 23211516.
      View in: PubMed
    26. Lavezzi JR, Thorn SR, O'Meara MC, LoTurco D, Brown LD, Hay WW, Rozance PJ. Increased fetal insulin concentrations for one week fail to improve insulin secretion or ß-cell mass in fetal sheep with chronically reduced glucose supply. Am J Physiol Regul Integr Comp Physiol. 2013 Jan 01; 304(1):R50-8. PMID: 23135788.
      View in: PubMed
    27. Thorn SR, Sekar SM, Lavezzi JR, O'Meara MC, Brown LD, Hay WW, Rozance PJ. A physiological increase in insulin suppresses gluconeogenic gene activation in fetal sheep with sustained hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2012 Oct 15; 303(8):R861-9. PMID: 22933022; PMCID: PMC3469666.
    28. Thorn SR, Brown LD, Rozance PJ, Hay WW, Friedman JE. Increased hepatic glucose production in fetal sheep with intrauterine growth restriction is not suppressed by insulin. Diabetes. 2013 Jan; 62(1):65-73. PMID: 22933111; PMCID: PMC3526037.
    29. Brown LD, Rozance PJ, Thorn SR, Friedman JE, Hay WW. Acute supplementation of amino acids increases net protein accretion in IUGR fetal sheep. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E352-64. PMID: 22649066; PMCID: PMC3423121.
    30. Maliszewski AM, Gadhia MM, O'Meara MC, Thorn SR, Rozance PJ, Brown LD. Prolonged infusion of amino acids increases leucine oxidation in fetal sheep. Am J Physiol Endocrinol Metab. 2012 Jun 15; 302(12):E1483-92. PMID: 22454287; PMCID: PMC3378157.
    31. Thorn SR, Rozance PJ, Brown LD, Hay WW. The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med. 2011 May; 29(3):225-36. PMID: 21710398; PMCID: PMC3216466.
    32. Brown LD, Green AS, Limesand SW, Rozance PJ. Maternal amino acid supplementation for intrauterine growth restriction. Front Biosci (Schol Ed). 2011 Jan 01; 3:428-44. PMID: 21196387; PMCID: PMC3181118.
    33. Arroyo JA, Brown LD, Galan HL. Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol. 2009 Dec; 201(6):616.e1-7. PMID: 19800600; PMCID: PMC2789863.
    34. Rozance PJ, Crispo MM, Barry JS, O'Meara MC, Frost MS, Hansen KC, Hay WW, Brown LD. Prolonged maternal amino acid infusion in late-gestation pregnant sheep increases fetal amino acid oxidation. Am J Physiol Endocrinol Metab. 2009 Sep; 297(3):E638-46. PMID: 19602583; PMCID: PMC2739698.
    35. Brown LD, Cheung A, Harwood JE, Battaglia FC. Inositol and mannose utilization rates in term and late-preterm infants exceed nutritional intakes. J Nutr. 2009 Sep; 139(9):1648-52. PMID: 19494026; PMCID: PMC2728690.
    36. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452; PMCID: PMC2703533.
    37. Limesand SW, Rozance PJ, Brown LD, Hay WW. Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep. Am J Physiol Endocrinol Metab. 2009 Apr; 296(4):E879-87. PMID: 19190258; PMCID: PMC2670627.
    38. Rozance PJ, Limesand SW, Barry JS, Brown LD, Hay WW. Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction. Pediatr Res. 2009 Jan; 65(1):72-8. PMID: 18704001; PMCID: PMC2678008.
    39. Brown LD, Rozance PJ, Barry JS, Friedman JE, Hay WW. Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E56-63. PMID: 18940943; PMCID: PMC2636989.
    40. Brown LD, Cavalli C, Harwood JE, Casadei A, Teng CC, Traggiai C, Serra G, Bevilacqua G, Battaglia FC. Plasma concentrations of carbohydrates and sugar alcohols in term newborns after milk feeding. Pediatr Res. 2008 Aug; 64(2):189-93. PMID: 18391836; PMCID: PMC2903005.
    41. Rozance PJ, Limesand SW, Barry JS, Brown LD, Thorn SR, LoTurco D, Regnault TR, Friedman JE, Hay WW. Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep. Am J Physiol Endocrinol Metab. 2008 Feb; 294(2):E365-70. PMID: 18056789; PMCID: PMC3857025.
    42. Brown LD, Hay WW. Effect of hyperinsulinemia on amino acid utilization and oxidation independent of glucose metabolism in the ovine fetus. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1333-40. PMID: 16868230.
      View in: PubMed
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