Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

Tobias Neff

TitleElectronic Research Admin
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse awards and honors
    2013ASCI Council's 2013 Young Physician-Scientist Awards, American Society for Clinical Investigation
    1993Elected Member, National German Merit Foundation (Studienstiftung des deutschen Volkes)

    Collapse Research 
    Collapse research activities and funding
    K08CA154777     (NEFF, TOBIAS)Jul 1, 2011 - Jun 30, 2016
    Ezh2 in MLL-AF9 mediated acute myeloid leukemia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P. MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 2017 Jun 12; 31(6):755-770.e6. PMID: 28609655.
      View in: PubMed
    2. Bernt KM, Hunger SP, Neff T. The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities. Front Pediatr. 2016; 4:49. PMID: 27242978; PMCID: PMC4870860.
    3. Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. J Clin Invest. 2016 Apr 01; 126(4):1438-50. PMID: 26927674; PMCID: PMC4811120.
    4. Danis E, Yamauchi T, Echanique K, Zhang X, Haladyna JN, Riedel SS, Zhu N, Xie H, Orkin SH, Armstrong SA, Bernt KM, Neff T. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia. Cell Rep. 2016 Mar 01; 14(8):1953-65. PMID: 26904942; PMCID: PMC4790111.
    5. Riedel SS, Neff T, Bernt KM. Histone profiles in cancer. Pharmacol Ther. 2015 Oct; 154:87-109. PMID: 26210403.
      View in: PubMed
    6. Haladyna JN, Yamauchi T, Neff T, Bernt KM. Epigenetic modifiers in normal and malignant hematopoiesis. Epigenomics. 2015; 7(2):301-20. PMID: 25942537.
      View in: PubMed
    7. Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Neff T, Zou K, Yuan GC, Orkin SH. Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell. 2013 Oct 03; 13(4):492-505. PMID: 24035353; PMCID: PMC3845089.
    8. Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct; 9(10):643-50. PMID: 23974116; PMCID: PMC3778130.
    9. Neff T, Armstrong SA. Recent progress toward epigenetic therapies: the example of mixed lineage leukemia. Blood. 2013 Jun 13; 121(24):4847-53. PMID: 23649466; PMCID: PMC3682337.
    10. Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis D, Lane SW, Armstrong SA. Genetic and pharmacologic inhibition of ß-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell. 2012 Apr 06; 10(4):412-24. PMID: 22482506; PMCID: PMC3339412.
    11. Neff T, Sinha AU, Kluk MJ, Zhu N, Khattab MH, Stein L, Xie H, Orkin SH, Armstrong SA. Polycomb repressive complex 2 is required for MLL-AF9 leukemia. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5028-33. PMID: 22396593; PMCID: PMC3324004.
    12. Beard BC, Sud R, Keyser KA, Ironside C, Neff T, Gerull S, Trobridge GD, Kiem HP. Long-term polyclonal and multilineage engraftment of methylguanine methyltransferase P140K gene-modified dog hematopoietic cells in primary and secondary recipients. Blood. 2009 May 21; 113(21):5094-103. PMID: 19336761; PMCID: PMC2686180.
    13. Neff T, Beard BC, Kiem HP. Survival of the fittest: in vivo selection and stem cell gene therapy. Blood. 2006 Mar 01; 107(5):1751-60. PMID: 16269617; PMCID: PMC1895696.
    14. Neff T, Beard BC, Peterson LJ, Anandakumar P, Thompson J, Kiem HP. Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood. 2005 Feb 01; 105(3):997-1002. PMID: 15494421.
      View in: PubMed
    15. Neff T, Peterson LJ, Morris JC, Thompson J, Zhang X, Horn PA, Thomasson BM, Kiem HP. Efficient gene transfer to hematopoietic repopulating cells using concentrated RD114-pseudotype vectors produced by human packaging cells. Mol Ther. 2004 Feb; 9(2):157-9. PMID: 14759799.
      View in: PubMed
    16. Horn PA, Keyser KA, Peterson LJ, Neff T, Thomasson BM, Thompson J, Kiem HP. Efficient lentiviral gene transfer to canine repopulating cells using an overnight transduction protocol. Blood. 2004 May 15; 103(10):3710-6. PMID: 14739227.
      View in: PubMed
    Neff's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)