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Michael E Yeager

TitleAssoc Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentCEDC-Bioengineering
Phone303/724-4191

    Collapse Research 
    Collapse research activities and funding
    R24HD105357     (YEAGER, MICHAEL E.)Sep 26, 2020 - Sep 25, 2024
    NIH
    RAT21: Generation and Characterization of Rat Models of Down Syndrome
    Role: Principal Investigator
    R21HL151256     (YEAGER, MICHAEL E.)Sep 15, 2019 - Aug 31, 2021
    NIH
    Bronchus-Associated Lymphoid Tissue & Lung Infection in Down Syndrome
    Role: Principal Investigator
    R01AI141662     (YEAGER, MICHAEL E.)Jun 1, 2019 - May 31, 2024
    NIH
    Persistent Post-Viral State of Bacterial Pneumonia Susceptibility and Severity in Down Syndrome
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Colvin KL, Elliott RJ, Goodman DM, Harral J, Barrett EG, Yeager ME. Increased lethality of respiratory infection by Streptococcus pneumoniae in the Dp16 mouse model of Down syndrome. FASEB Bioadv. 2023 Dec; 5(12):528-540. PMID: 38094158.
      View in: PubMed
    2. Colvin KL, Nguyen K, Boncella KL, Goodman DM, Elliott RJ, Harral JW, Bilodeaux J, Smith BJ, Yeager ME. Lung and Heart Biology of the Dp16 Mouse Model of down Syndrome: Implications for Studying Cardiopulmonary Disease. Genes (Basel). 2023 Sep 19; 14(9). PMID: 37761959.
      View in: PubMed
    3. Sch?fer M, Ivy DD, Nguyen K, Boncella K, Frank BS, Morgan GJ, Miller-Reed K, Truong U, Colvin K, Yeager ME. Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H242-H252. PMID: 34085841.
      View in: PubMed
    4. Waugh KA, Araya P, Pandey A, Jordan KR, Smith KP, Granrath RE, Khanal S, Butcher ET, Estrada BE, Rachubinski AL, McWilliams JA, Minter R, Dimasi T, Colvin KL, Baturin D, Pham AT, Galbraith MD, Bartsch KW, Yeager ME, Porter CC, Sullivan KD, Hsieh EW, Espinosa JM. Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome. Cell Rep. 2019 11 12; 29(7):1893-1908.e4. PMID: 31722205.
      View in: PubMed
    5. Sch?fer M, Barker AJ, Kheyfets V, Stenmark KR, Crapo J, Yeager ME, Truong U, Buckner JK, Fenster BE, Hunter KS. Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations. J Am Heart Assoc. 2017 Dec 20; 6(12). PMID: 29263034.
      View in: PubMed
    6. Gally F, Rao DM, Schmitz C, Colvin KL, Yeager ME, Perraud AL. The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome. Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):126-132. PMID: 28970008.
      View in: PubMed
    7. Colvin KL, Ivy DD, Yeager ME. Altered Peripheral Blood Myeloid Cell Subpopulations in Children With Down Syndrome and Pulmonary Hypertension. J Pediatr Hematol Oncol. 2017 03; 39(2):158-159. PMID: 28060127.
      View in: PubMed
    8. Colvin KL, Yeager ME. What people with Down Syndrome can teach us about cardiopulmonary disease. Eur Respir Rev. 2017 Jan; 26(143). PMID: 28223397.
      View in: PubMed
    9. Colvin KL, Yeager ME. Applying Biotechnology and Bioengineering to Pediatric Lung Disease: Emerging Paradigms and Platforms. Front Pediatr. 2015; 3:45. PMID: 26106589.
      View in: PubMed
    10. Lohani O, Colvin KL, Yeager ME. Biomarkers for pediatric pulmonary arterial hypertension: challenges and recommendations. Paediatr Respir Rev. 2015 Sep; 16(4):225-31. PMID: 26036720.
      View in: PubMed
    11. Colvin KL, Yeager ME. Proteomics of pulmonary hypertension: could personalized profiles lead to personalized medicine? Proteomics Clin Appl. 2015 Feb; 9(1-2):111-20. PMID: 25408474.
      View in: PubMed
    12. Colvin KL, Yeager ME. Animal Models of Pulmonary Hypertension: Matching Disease Mechanisms to Etiology of the Human Disease. J Pulm Respir Med. 2014 Aug 04; 4(4). PMID: 25705569.
      View in: PubMed
    13. Colvin KL, Dufva MJ, Delaney RP, Ivy DD, Stenmark KR, Yeager ME. Biomarkers for pediatric pulmonary arterial hypertension - a call to collaborate. Front Pediatr. 2014; 2:7. PMID: 24551834.
      View in: PubMed
    14. Williams SM, Golden-Mason L, Ferguson BS, Schuetze KB, Cavasin MA, Demos-Davies K, Yeager ME, Stenmark KR, McKinsey TA. Class I HDACs regulate angiotensin II-dependent cardiac fibrosis via fibroblasts and circulating fibrocytes. J Mol Cell Cardiol. 2014 Feb; 67:112-25. PMID: 24374140.
      View in: PubMed
    15. Colvin KL, Cripe PJ, Ivy DD, Stenmark KR, Yeager ME. Bronchus-associated lymphoid tissue in pulmonary hypertension produces pathologic autoantibodies. Am J Respir Crit Care Med. 2013 Nov 01; 188(9):1126-36. PMID: 24093638.
      View in: PubMed
    16. Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014 Jan 03; 114(1):67-78. PMID: 24122720.
      View in: PubMed
    17. Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E. Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal. 2013 May 10; 18(14):1753-64. PMID: 23240585.
      View in: PubMed
    18. Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013; 75:23-47. PMID: 23216413.
      View in: PubMed
    19. Yeager ME, Colvin KL, Everett AD, Stenmark KR, Ivy DD. Plasma proteomics of differential outcome to long-term therapy in children with idiopathic pulmonary arterial hypertension. Proteomics Clin Appl. 2012 Jun; 6(5-6):257-67. PMID: 22653875.
      View in: PubMed
    20. Yeager ME, Reddy MB, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Activation of the unfolded protein response is associated with pulmonary hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):229-40. PMID: 22837864.
      View in: PubMed
    21. Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 02; 110(5):739-48. PMID: 22282194.
      View in: PubMed
    22. Yeager ME, Belchenko DD, Nguyen CM, Colvin KL, Ivy DD, Stenmark KR. Endothelin-1, the unfolded protein response, and persistent inflammation: role of pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):14-22. PMID: 21778413.
      View in: PubMed
    23. Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Circulating myeloid-derived suppressor cells are increased and activated in pulmonary hypertension. Chest. 2012 Apr; 141(4):944-952. PMID: 21940769.
      View in: PubMed
    24. Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, Sokol RJ, Strassheim D, Meyrick B, Yeager ME, Flockton AR, McKeon BA, Lemon DD, Horn TR, Anwar A, Barajas C, Stenmark KR. Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol. 2011 Sep 01; 187(5):2711-22. PMID: 21813768.
      View in: PubMed
    25. Yeager ME, Nguyen CM, Belchenko DD, Colvin KL, Takatsuki S, Ivy DD, Stenmark KR. Circulating fibrocytes are increased in children and young adults with pulmonary hypertension. Eur Respir J. 2012 Jan; 39(1):104-11. PMID: 21700605.
      View in: PubMed
    26. Yeager ME, Frid MG, Stenmark KR. Progenitor cells in pulmonary vascular remodeling. Pulm Circ. 2011 Jan-Mar; 1(1):3-16. PMID: 22034593.
      View in: PubMed
    27. Ryu J, Vicencio AG, Yeager ME, Kashgarian M, Haddad GG, Eickelberg O. Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost. 2005 Jul; 94(1):175-83. PMID: 16113801.
      View in: PubMed
    28. Richter A, Yeager ME, Zaiman A, Cool CD, Voelkel NF, Tuder RM. Impaired transforming growth factor-beta signaling in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1340-8. PMID: 15361368.
      View in: PubMed
    29. Eickelberg O, Yeager ME, Grimminger F. The tantalizing triplet of pulmonary hypertension-BMP receptors, serotonin receptors, and angiopoietins. Cardiovasc Res. 2003 Dec 01; 60(3):465-7. PMID: 14659791.
      View in: PubMed
    30. Cool CD, Rai PR, Yeager ME, Hernandez-Saavedra D, Serls AE, Bull TM, Geraci MW, Brown KK, Routes JM, Tuder RM, Voelkel NF. Expression of human herpesvirus 8 in primary pulmonary hypertension. N Engl J Med. 2003 Sep 18; 349(12):1113-22. PMID: 13679525.
      View in: PubMed
    31. Voelkel NF, Cool C, Taraceviene-Stewart L, Geraci MW, Yeager M, Bull T, Kasper M, Tuder RM. Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension. Crit Care Med. 2002 May; 30(5 Suppl):S251-6. PMID: 12004244.
      View in: PubMed
    32. Geraci MW, Hoshikawa Y, Yeager M, Golpon H, Gesell T, Tuder RM, Voelkel NF. Gene expression profiles in pulmonary hypertension. Chest. 2002 Mar; 121(3 Suppl):104S-105S. PMID: 11893725.
      View in: PubMed
    33. Yeager ME, Golpon HA, Voelkel NF, Tuder RM. Microsatellite mutational analysis of endothelial cells within plexiform lesions from patients with familial, pediatric, and sporadic pulmonary hypertension. Chest. 2002 Mar; 121(3 Suppl):61S. PMID: 11893687.
      View in: PubMed
    34. Geraci MW, Moore M, Gesell T, Yeager ME, Alger L, Golpon H, Gao B, Loyd JE, Tuder RM, Voelkel NF. Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis. Circ Res. 2001 Mar 30; 88(6):555-62. PMID: 11282888.
      View in: PubMed
    35. Yeager ME, Halley GR, Golpon HA, Voelkel NF, Tuder RM. Microsatellite instability of endothelial cell growth and apoptosis genes within plexiform lesions in primary pulmonary hypertension. Circ Res. 2001 Jan 19; 88(1):E2-E11. PMID: 11139485.
      View in: PubMed
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