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Robert O Poyton

TitleSr Research Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-3823

    Collapse Research 
    Collapse research activities and funding
    R01GM030228     (POYTON, ROBERT OLIVER)Jul 1, 1981 - Jul 31, 2011
    NIH
    Mitochondria-Nuclear Crosstalk in Hypoxic Gene Induction
    Role: Principal Investigator

    R01GM034827     (POYTON, ROBERT OLIVER)Sep 12, 1985 - Aug 31, 1989
    NIH
    LEADER PEPTIDES--SUBUNITS OF MEMBRANE PROTEIN OLIGOMERS
    Role: Principal Investigator

    R01GM039324     (POYTON, ROBERT OLIVER)Apr 1, 1991 - Nov 30, 1995
    NIH
    FUNCTION OF SUBUNIT ISOFORMS IN CYTOCHROME C OXIDASE
    Role: Principal Investigator

    R01HL063324     (POYTON, ROBERT OLIVER)Jul 1, 1999 - May 31, 2004
    NIH
    OXYGEN SENSING AND REGULATION OF YEAST GENES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ball KA, Nelson AW, Foster DG, Poyton RO. Nitric oxide produced by cytochrome c oxidase helps stabilize HIF-1a in hypoxic mammalian cells. Biochem Biophys Res Commun. 2012 Apr 20; 420(4):727-32. PMID: 22450315.
      View in: PubMed
    2. Li B, Skinner C, Castello PR, Kato M, Easlon E, Xie L, Li T, Lu SP, Wang C, Tsang F, Poyton RO, Lin SJ. Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels. J Aging Res. 2011 Mar 31; 2011:673185. PMID: 21584246.
      View in: PubMed
    3. Poyton RO, Ball KA. Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase. Discov Med. 2011 Feb; 11(57):154-9. PMID: 21356170.
      View in: PubMed
    4. Ball KA, Castello PR, Poyton RO. Low intensity light stimulates nitrite-dependent nitric oxide synthesis but not oxygen consumption by cytochrome c oxidase: Implications for phototherapy. J Photochem Photobiol B. 2011 Mar 02; 102(3):182-91. PMID: 21237670.
      View in: PubMed
    5. Poyton RO, Castello PR, Ball KA, Woo DK, Pan N. Mitochondria and hypoxic signaling: a new view. Ann N Y Acad Sci. 2009 Oct; 1177:48-56. PMID: 19845606.
      View in: PubMed
    6. Poyton RO, Ball KA, Castello PR. Mitochondrial generation of free radicals and hypoxic signaling. Trends Endocrinol Metab. 2009 Sep; 20(7):332-40. PMID: 19733481.
      View in: PubMed
    7. Woo DK, Poyton RO. The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation. Exp Gerontol. 2009 Jun-Jul; 44(6-7):390-7. PMID: 19285548.
      View in: PubMed
    8. Woo DK, Phang TL, Trawick JD, Poyton RO. Multiple pathways of mitochondrial-nuclear communication in yeast: intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation. Biochim Biophys Acta. 2009 Feb; 1789(2):135-45. PMID: 18977319.
      View in: PubMed
    9. Castello PR, Woo DK, Ball K, Wojcik J, Liu L, Poyton RO. Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8203-8. PMID: 18388202.
      View in: PubMed
    10. Castello PR, David PS, McClure T, Crook Z, Poyton RO. Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Cell Metab. 2006 Apr; 3(4):277-87. PMID: 16581005.
      View in: PubMed
    11. David PS, Poyton RO. Effects of a transition from normoxia to anoxia on yeast cytochrome c oxidase and the mitochondrial respiratory chain: implications for hypoxic gene induction. Biochim Biophys Acta. 2005 Sep 05; 1709(2):169-80. PMID: 16084486.
      View in: PubMed
    12. Cassanova N, O'Brien KM, Stahl BT, McClure T, Poyton RO. Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome on its intracellular level and distribution. J Biol Chem. 2005 Mar 04; 280(9):7645-53. PMID: 15611069.
      View in: PubMed
    13. Church C, Goehring B, Forsha D, Wazny P, Poyton RO. A role for Pet100p in the assembly of yeast cytochrome c oxidase: interaction with a subassembly that accumulates in a pet100 mutant. J Biol Chem. 2005 Jan 21; 280(3):1854-63. PMID: 15507444.
      View in: PubMed
    14. O'Brien KM, Dirmeier R, Engle M, Poyton RO. Mitochondrial protein oxidation in yeast mutants lacking manganese-(MnSOD) or copper- and zinc-containing superoxide dismutase (CuZnSOD): evidence that MnSOD and CuZnSOD have both unique and overlapping functions in protecting mitochondrial proteins from oxidative damage. J Biol Chem. 2004 Dec 10; 279(50):51817-27. PMID: 15385544.
      View in: PubMed
    15. Dirmeier R, O'Brien K, Engle M, Dodd A, Spears E, Poyton RO. Measurement of oxidative stress in cells exposed to hypoxia and other changes in oxygen concentration. Methods Enzymol. 2004; 381:589-603. PMID: 15063700.
      View in: PubMed
    16. Poyton RO, Dirmeier R, O'Brien K, David P, Dodd A. Experimental strategies for analyzing oxygen sensing in yeast. Methods Enzymol. 2004; 381:644-62. PMID: 15063704.
      View in: PubMed
    17. Hon T, Dodd A, Dirmeier R, Gorman N, Sinclair PR, Zhang L, Poyton RO. A mechanism of oxygen sensing in yeast. Multiple oxygen-responsive steps in the heme biosynthetic pathway affect Hap1 activity. J Biol Chem. 2003 Dec 12; 278(50):50771-80. PMID: 14512429.
      View in: PubMed
    18. Dirmeier R, O'Brien KM, Engle M, Dodd A, Spears E, Poyton RO. Exposure of yeast cells to anoxia induces transient oxidative stress. Implications for the induction of hypoxic genes. J Biol Chem. 2002 Sep 20; 277(38):34773-84. PMID: 12089150.
      View in: PubMed
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