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This is a "connection" page, showing publications co-authored by Douglas Seals and Zachary Clayton.

Connection Strength
  1. Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment. Hypertension. 2023 10; 80(10):2072-2087.
    View in: PubMed
    Score: 0.954
  2. Clayton ZS, Gioscia-Ryan RA, Justice JN, Lubieniecki KL, Hutton DA, Rossman MJ, Zigler MC, Seals DR. Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation. Exp Gerontol. 2022 01; 157:111632.
    View in: PubMed
    Score: 0.846
  3. Clayton ZS, Hutton DA, Mahoney SA, Seals DR. Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging. Aging Cancer. 2021 Jun; 2(1-2):45-69.
    View in: PubMed
    Score: 0.822
  4. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196.
    View in: PubMed
    Score: 0.820
  5. Clayton ZS, Brunt VE, Hutton DA, Casso AG, Ziemba BP, Melov S, Campisi J, Seals DR. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension. 2021 05 05; 77(5):1581-1590.
    View in: PubMed
    Score: 0.806
  6. Clayton ZS, Brunt VE, Hutton DA, VanDongen NS, D'Alessandro A, Reisz JA, Ziemba BP, Seals DR. Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment. JACC CardioOncol. 2020 Sep; 2(3):475-488.
    View in: PubMed
    Score: 0.779
  7. Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 Jan 24.
    View in: PubMed
    Score: 0.246
  8. Mahoney SA, Venkatasubramanian R, Darrah MA, Ludwig KR, VanDongen NS, Greenberg NT, Longtine AG, Hutton DA, Brunt VE, Campisi J, Melov S, Seals DR, Rossman MJ, Clayton ZS. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence. Aging Cell. 2024 Mar; 23(3):e14060.
    View in: PubMed
    Score: 0.244
  9. Moreau KL, Clayton ZS, DuBose LE, Rosenberry R, Seals DR. Effects of regular exercise on vascular function with aging: Does sex matter? Am J Physiol Heart Circ Physiol. 2024 Jan 01; 326(1):H123-H137.
    View in: PubMed
    Score: 0.242
  10. Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Female C57BL/6N mice are a viable model of aortic aging in women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H893-H904.
    View in: PubMed
    Score: 0.233
  11. Murray KO, Mahoney SA, Venkatasubramanian R, Seals DR, Clayton ZS. Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions. Exp Gerontol. 2023 03; 173:112105.
    View in: PubMed
    Score: 0.230
  12. Clayton ZS, Craighead DH, Darvish S, Coppock M, Ludwig KR, Brunt VE, Seals DR, Rossman MJ. Promoting healthy cardiovascular aging: emerging topics. J Cardiovasc Aging. 2022; 2.
    View in: PubMed
    Score: 0.222
  13. Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension. 2021 08; 78(2):499-511.
    View in: PubMed
    Score: 0.204
  14. Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, Battson ML, Ziemba BP, Hutton DA, VanDongen NS, Seals DR. Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice. J Physiol. 2021 02; 599(3):911-925.
    View in: PubMed
    Score: 0.196
  15. Rossman MJ, Gioscia-Ryan RA, Clayton ZS, Murphy MP, Seals DR. Targeting mitochondrial fitness as a strategy for healthy vascular aging. Clin Sci (Lond). 2020 06 26; 134(12):1491-1519.
    View in: PubMed
    Score: 0.192
  16. Gioscia-Ryan RA, Clayton ZS, Fleenor BS, Eng JS, Johnson LC, Rossman MJ, Zigler MC, Evans TD, Seals DR. Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening. Geroscience. 2021 02; 43(1):423-432.
    View in: PubMed
    Score: 0.191
  17. Cavalier AN, Clayton ZS, Wahl D, Hutton DA, McEntee CM, Seals DR, LaRocca TJ. Protective effects of apigenin on the brain transcriptome with aging. Mech Ageing Dev. 2024 Feb; 217:111889.
    View in: PubMed
    Score: 0.061
  18. Casso AG, VanDongen NS, Gioscia-Ryan RA, Clayton ZS, Greenberg NT, Ziemba BP, Hutton DA, Neilson AP, Davy KP, Seals DR, Brunt VE. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol. 2022 11; 600(21):4633-4651.
    View in: PubMed
    Score: 0.056
  19. Limbad C, Doi R, McGirr J, Ciotlos S, Perez K, Clayton ZS, Daya R, Seals DR, Campisi J, Melov S. Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. iScience. 2022 Feb 18; 25(2):103848.
    View in: PubMed
    Score: 0.054
  20. Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451.
    View in: PubMed
    Score: 0.051
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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