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Rahul Kumar

TitlePost-Doctoral Fellow
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    17POST33670045     (Rahull Kumar)Jul 1, 2017 - Jun 30, 2019
    Role of Thrombospondin-1 in TGF-beta1 Activation in Hypoxic Pulmonary Hypertension
    Role: Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kumar R, Deep G, Wempe MF, Surek J, Kumar A, Agarwal R, Agarwal C. Procyanidin B2 3,3?-di-O-gallate induces oxidative stress-mediated cell death in prostate cancer cells via inhibiting MAP kinase phosphatase activity and activating ERK1/2 and AMPK. Mol Carcinog. 2018 Jan; 57(1):57-69. PMID: 28876465.
      View in: PubMed
    2. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 05 30; 8:15494. PMID: 28555642.
      View in: PubMed
    3. Kohli S, Kumar R, Gupta M, Tyagi S, Pasha MA. Impact of interactions between risk alleles on clinical endpoints in hypertension. Heart Asia. 2016; 8(1):83-9. PMID: 27326240; PMCID: PMC4898629.
    4. Ali Z, Waseem M, Kumar R, Pandey P, Mohammad G, Qadar Pasha MA. Unveiling the interactions among BMPR-2, ALK-1 and 5-HTT genes in the pathophysiology of HAPE. Gene. 2016 Aug 22; 588(2):163-72. PMID: 27196063.
      View in: PubMed
    5. Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY. Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit. Cell Rep. 2015 Nov 03; 13(5):1016-32. PMID: 26565914; PMCID: PMC4644508.
    6. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556; PMCID: PMC4642207 [Available on 10/15/16].
    7. Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM. Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L435-40. PMID: 26115672; PMCID: PMC4556932.
    8. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713. PMID: 25825391; PMCID: PMC4459813.
    9. Kumar R, Kohli S, Ali Z, Duhan K, Ram R, Gupta M, Tyagi S, Mohammad G, Pasha MQ. CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes. Hypertens Res. 2015 Jul; 38(7):498-506. PMID: 25787042.
      View in: PubMed
    10. Graham BB, Kumar R. Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series). Pulm Circ. 2014 Sep; 4(3):353-62. PMID: 25621148; PMCID: PMC4278594.
    11. Kumar R, Kohli S, Mishra A, Garg R, Alam P, Stobdan T, Nejatizadeh A, Gupta M, Tyagi S, Pasha MA. Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension. Am J Hypertens. 2015 Feb; 28(2):239-47. PMID: 25159081.
      View in: PubMed
    12. Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014 Aug; 124(8):3514-28. PMID: 24960162; PMCID: PMC4109523.
    13. Gupta MD, Girish MP, Sikdar S, Ahuja R, Shah D, Kumar R, Rain M, Nejatizadeh A, Tyagi S, Pasha Q. ß-T594M epithelial sodium channel gene polymorphism and essential hypertension in individuals of Indo-Aryan ancestry in Northern India. Indian Heart J. 2014 Jul-Aug; 66(4):397-400. PMID: 25173196.
      View in: PubMed
    14. Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014 Jun; 4(2):289-99. PMID: 25006448; PMCID: PMC4070790.
    15. Gupta MD, Akkarappatty C, Girish MP, Kumar R, Rain M, Tyagi S, Qadar Pasha MA. Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the North Indian population. Coron Artery Dis. 2014 May; 25(3):192-7. PMID: 24525787.
      View in: PubMed
    16. Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM. Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):951-9. PMID: 23815102; PMCID: PMC3931110.
    17. Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB. Pathology of pulmonary hypertension. Clin Chest Med. 2013 Dec; 34(4):639-50. PMID: 24267295.
      View in: PubMed
    18. Kumar R, Kohli S, Alam P, Barkotoky R, Gupta M, Tyagi S, Jain SK, Pasha MA. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. PLoS One. 2013; 8(5):e63934. PMID: 23691120; PMCID: PMC3653800.
    19. Mishra A, Ali Z, Vibhuti A, Kumar R, Alam P, Ram R, Thinlas T, Mohammad G, Pasha MA. CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema. Clin Sci (Lond). 2012 Mar; 122(6):299-309. PMID: 21973220.
      View in: PubMed
    20. Kumar R, Nejatizadeh A, Gupta M, Markan A, Tyagi S, Jain SK, Pasha MA. The epistasis between vascular homeostasis genes is apparent in essential hypertension. Atherosclerosis. 2012 Feb; 220(2):418-24. PMID: 22134143.
      View in: PubMed
    21. Nejatizadeh A, Kumar R, Stobdan T, Pasha MQ. Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension. Genet Mol Biol. 2011 Oct; 34(4):553-6. PMID: 22215956; PMCID: PMC3229107.
    22. Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Tyagi S, Jain SK, Pasha MA. CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension. Clin Biochem. 2010 Jan; 43(1-2):136-41. PMID: 19786005.
      View in: PubMed
    23. Kumar R, Nejatizadeh A, Arif E, Akhtar S, Gupta M, Tyagi S, Goyal AK, Jain SK, Qadar Pasha MA. Multi-locus interactions of vascular homeostasis genes in essential hypertension: a gender-based study. Clin Chim Acta. 2009 Jul; 405(1-2):87-93. PMID: 19379721.
      View in: PubMed
    24. Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Javed S, Pasha MQ. Significance of angiotensinogen gene haplotypes and genotypes combinations in hypertension. J Hypertens. 2008 Jun; 26(6):1094-101. PMID: 18475146.
      View in: PubMed
    25. Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Sikdar S, Gupta M, Javed S, Pasha MA. Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension. Free Radic Biol Med. 2008 Jun 01; 44(11):1912-8. PMID: 18325347.
      View in: PubMed
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