Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Lorna Grindlay Moore

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN BRS
Phone3037247474

    Collapse Biography 
    Collapse awards and honors
    2010Fran Boas Distinguished Achievement Award, Human Biology Association
    2013Grover Prize, American Thoracic Society

    Collapse Overview 
    Collapse overview
    My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.


    Collapse Research 
    Collapse research activities and funding
    K04HD000681     (MOORE, LORNA G.)Aug 1, 1985 - Jul 31, 1990
    NIH/NICHD
    MATERNAL VENTILATORY ADAPTATION TO PREGNANCY
    Role: Principal Investigator

    R01HL060131     (MOORE, LORNA G.)Jan 1, 1999 - Dec 31, 2004
    NIH/NHLBI
    CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION &GROWTH
    Role: Principal Investigator

    R03TW001188     (MOORE, LORNA G.)Sep 30, 1999 - Aug 31, 2003
    NIH/FIC
    INTRAUTERINE GROWTH RESTRICTION AT HIGH ALTITUDES
    Role: Principal Investigator

    R13HD042450     (MOORE, LORNA G.)Jul 1, 2002 - Jun 30, 2003
    NIH/NICHD
    Human Biology Association 2002 Annual Meeting
    Role: Principal Investigator

    R01HL079647     (MOORE, LORNA G.)Feb 1, 2005 - Jan 31, 2011
    NIH/NHLBI
    Genetic Regulation of Hypoxia-Induced IUGR
    Role: Principal Investigator

    R03TW007957     (MOORE, LORNA G.)Apr 8, 2009 - Mar 31, 2012
    NIH/FIC
    Perinatal Origins of Chronic Mountain Sickness
    Role: Principal Investigator

    R01HD088590     (MOORE, LORNA G.)Aug 1, 2016 - May 31, 2021
    NIH/NICHD
    Chronic hypoxia, AMPK activation and uterine artery blood flow
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Julian CG, Pedersen BS, Salmon CS, Yang IV, Gonzales M, Vargas E, Moore LG, Schwartz DA. Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy. Clin Transl Sci. 2015 Dec; 8(6):740-5. PMID: 26546417.
      View in: PubMed
    2. Skeffington KL, Higgins JS, Mahmoud AD, Evans AM, Sferruzzi-Perri AN, Fowden AL, Yung HW, Burton GJ, Giussani DA, Moore LG. Hypoxia, AMPK activation and uterine artery vasoreactivity. J Physiol. 2016 Mar 01; 594(5):1357-69. PMID: 26110512.
      View in: PubMed
    3. Julian CG, Gonzales M, Rodriguez A, Bellido D, Salmon CS, Ladenburger A, Reardon L, Vargas E, Moore LG. Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction. Am J Physiol Heart Circ Physiol. 2015 Aug 15; 309(4):H565-73. PMID: 26092986.
      View in: PubMed
    4. Browne VA, Julian CG, Toledo-Jaldin L, Cioffi-Ragan D, Vargas E, Moore LG. Uterine artery blood flow, fetal hypoxia and fetal growth. Philos Trans R Soc Lond B Biol Sci. 2015 Mar 05; 370(1663):20140068. PMID: 25602072.
      View in: PubMed
    5. Niermeyer S, Andrade-M MP, Vargas E, Moore LG. Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitude (2013 Grover Conference series). Pulm Circ. 2015 Mar; 5(1):48-62. PMID: 25992270.
      View in: PubMed
    6. Charles SM, Julian CG, Vargas E, Moore LG. Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity. J Clin Endocrinol Metab. 2014 Aug; 99(8):2908-16. PMID: 24684460.
      View in: PubMed
    7. Julian CG, Yang IV, Browne VA, Vargas E, Rodriguez C, Pedersen BS, Moore LG, Schwartz DA. Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth. FASEB J. 2014 Mar; 28(3):1268-79. PMID: 24307415.
      View in: PubMed
    8. Schwartz J, Cioffi-Ragan D, Wilson MJ, Julian CG, Beatty B, Moore LG, Galan HL. Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation. Am J Hum Biol. 2013 Jul-Aug; 25(4):544-9. PMID: 23754523.
      View in: PubMed
    9. Gabory A, Roseboom TJ, Moore T, Moore LG, Junien C. Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. Biol Sex Differ. 2013 Mar 21; 4(1):5. PMID: 23514128.
      View in: PubMed
    10. Julian CG, Vargas E, Gonzales M, Dávila RD, Ladenburger A, Reardon L, Schoo C, Powers RW, Lee-Chiong T, Moore LG. Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis). Respir Physiol Neurobiol. 2013 Apr 01; 186(2):188-96. PMID: 23380170.
      View in: PubMed
    11. Bigham AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD. Andean and Tibetan patterns of adaptation to high altitude. Am J Hum Biol. 2013 Mar-Apr; 25(2):190-7. PMID: 23348729.
      View in: PubMed
    12. Eckman DM, Gupta R, Rosenfeld CR, Morgan TM, Charles SM, Mertz H, Moore LG. Pregnancy increases myometrial artery myogenic tone via NOS- or COX-independent mechanisms. Am J Physiol Regul Integr Comp Physiol. 2012 Aug 15; 303(4):R368-75. PMID: 22739352.
      View in: PubMed
    13. Jean D, Moore LG. Travel to high altitude during pregnancy: frequently asked questions and recommendations for clinicians. High Alt Med Biol. 2012 Jun; 13(2):73-81. PMID: 22724609.
      View in: PubMed
    14. Ji F, Sharpley MS, Derbeneva O, Alves LS, Qian P, Wang Y, Chalkia D, Lvova M, Xu J, Yao W, Simon M, Platt J, Xu S, Angelin A, Davila A, Huang T, Wang PH, Chuang LM, Moore LG, Qian G, Wallace DC. Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7391-6. PMID: 22517755.
      View in: PubMed
    15. Galanter JM, Fernandez-Lopez JC, Gignoux CR, Barnholtz-Sloan J, Fernandez-Rozadilla C, Via M, Hidalgo-Miranda A, Contreras AV, Figueroa LU, Raska P, Jimenez-Sanchez G, Zolezzi IS, Torres M, Ponte CR, Ruiz Y, Salas A, Nguyen E, Eng C, Borjas L, Zabala W, Barreto G, González FR, Ibarra A, Taboada P, Porras L, Moreno F, Bigham A, Gutierrez G, Brutsaert T, León-Velarde F, Moore LG, Vargas E, Cruz M, Escobedo J, Rodriguez-Santana J, Rodriguez-Cintrón W, Chapela R, Ford JG, Bustamante C, Seminara D, Shriver M, Ziv E, Burchard EG, Haile R, Parra E, Carracedo A. Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas. PLoS Genet. 2012; 8(3):e1002554. PMID: 22412386.
      View in: PubMed
    16. Dávila RD, Julian CG, Browne VA, Toledo-Jaldin L, Wilson MJ, Rodriguez A, Vargas E, Moore LG. Role of cytokines in altitude-associated preeclampsia. Pregnancy Hypertens. 2012 Jan; 2(1):65-70. PMID: 22247821.
      View in: PubMed
    17. Julian CG, Vargas E, Browne VA, Wilson MJ, Bigham AW, Rodriguez C, McCord JM, Moore LG. Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA. J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1233-40. PMID: 22082238.
      View in: PubMed
    18. Julian CG, Hageman JL, Wilson MJ, Vargas E, Moore LG. Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight. Am J Hum Biol. 2011 Jul-Aug; 23(4):509-16. PMID: 21538651.
      View in: PubMed
    19. Moore LG, Charles SM, Julian CG. Humans at high altitude: hypoxia and fetal growth. Respir Physiol Neurobiol. 2011 Aug 31; 178(1):181-90. PMID: 21536153.
      View in: PubMed
    20. Pulgar VM, Yamashiro H, Rose JC, Moore LG. Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation. J Renin Angiotensin Aldosterone Syst. 2011 Sep; 12(3):176-83. PMID: 21421654.
      View in: PubMed
    21. Browne VA, Toledo-Jaldin L, Davila RD, Lopez LP, Yamashiro H, Cioffi-Ragan D, Julian CG, Wilson MJ, Bigham AW, Shriver MD, Honigman B, Vargas E, Roach R, Moore LG. High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude. Am J Physiol Regul Integr Comp Physiol. 2011 May; 300(5):R1221-9. PMID: 21325643.
      View in: PubMed
    22. Dávila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG. Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude? Reprod Sci. 2011 Jan; 18(1):79-87. PMID: 20841404.
      View in: PubMed
    23. Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, López Herráez D, Brutsaert T, Parra EJ, Moore LG, Shriver MD. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 2010 Sep 09; 6(9):e1001116. PMID: 20838600.
      View in: PubMed
    24. Dávila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG. Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry? Reprod Sci. 2010 Sep; 17(9):861-70. PMID: 20601535.
      View in: PubMed
    25. Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG, Shriver MD. Identifying positive selection candidate loci for high-altitude adaptation in Andean populations. Hum Genomics. 2009 Dec; 4(2):79-90. PMID: 20038496.
      View in: PubMed
    26. Julian CG, Wilson MJ, Moore LG. Evolutionary adaptation to high altitude: a view from in utero. Am J Hum Biol. 2009 Sep-Oct; 21(5):614-22. PMID: 19367578.
      View in: PubMed
    27. Julian CG, Wilson MJ, Lopez M, Yamashiro H, Tellez W, Rodriguez A, Bigham AW, Shriver MD, Rodriguez C, Vargas E, Moore LG. Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1564-75. PMID: 19244584.
      View in: PubMed
    28. Bennett A, Sain SR, Vargas E, Moore LG. Evidence that parent-of-origin affects birth-weight reductions at high altitude. Am J Hum Biol. 2008 Sep-Oct; 20(5):592-7. PMID: 18449923.
      View in: PubMed
    29. Julian CG, Galan HL, Wilson MJ, Desilva W, Cioffi-Ragan D, Schwartz J, Moore LG. Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude. Am J Physiol Regul Integr Comp Physiol. 2008 Sep; 295(3):R906-15. PMID: 18579652.
      View in: PubMed
    30. Moore LG, Niermeyer S, Vargas E. Does chronic mountain sickness (CMS) have perinatal origins? Respir Physiol Neurobiol. 2007 Sep 30; 158(2-3):180-9. PMID: 17706469.
      View in: PubMed
    31. Vargas M, Vargas E, Julian CG, Armaza JF, Rodriguez A, Tellez W, Niermeyer S, Wilson M, Parra E, Shriver M, Moore LG. Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1303-12. PMID: 17609312.
      View in: PubMed
    32. Wilson MJ, Lopez M, Vargas M, Julian C, Tellez W, Rodriguez A, Bigham A, Armaza JF, Niermeyer S, Shriver M, Vargas E, Moore LG. Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1313-24. PMID: 17581833.
      View in: PubMed
    33. Mao X, Bigham AW, Mei R, Gutierrez G, Weiss KM, Brutsaert TD, Leon-Velarde F, Moore LG, Vargas E, McKeigue PM, Shriver MD, Parra EJ. A genomewide admixture mapping panel for Hispanic/Latino populations. Am J Hum Genet. 2007 Jun; 80(6):1171-8. PMID: 17503334.
      View in: PubMed
    34. Julian CG, Vargas E, Armaza JF, Wilson MJ, Niermeyer S, Moore LG. High-altitude ancestry protects against hypoxia-associated reductions in fetal growth. Arch Dis Child Fetal Neonatal Ed. 2007 Sep; 92(5):F372-7. PMID: 17329275.
      View in: PubMed
    35. Mateev SN, Mouser R, Young DA, Mecham RP, Moore LG. Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy. J Appl Physiol (1985). 2006 Jun; 100(6):1842-50. PMID: 16714414.
      View in: PubMed
    36. Shriver MD, Mei R, Bigham A, Mao X, Brutsaert TD, Parra EJ, Moore LG. Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping. Adv Exp Med Biol. 2006; 588:89-100. PMID: 17089882.
      View in: PubMed
    37. Moore LG, Shriver M, Bemis L, Vargas E. An evolutionary model for identifying genetic adaptation to high altitude. Adv Exp Med Biol. 2006; 588:101-18. PMID: 17089883.
      View in: PubMed
    38. Rockwell LC, Dempsey EC, Moore LG. Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro. High Alt Med Biol. 2006; 7(3):237-44. PMID: 16978136.
      View in: PubMed
    39. Moore LG, Grover RF. Jack Reeves and his science. Respir Physiol Neurobiol. 2006 Apr 28; 151(2-3):96-108. PMID: 16386471.
      View in: PubMed
    40. León-Velarde F, Maggiorini M, Reeves JT, Aldashev A, Asmus I, Bernardi L, Ge RL, Hackett P, Kobayashi T, Moore LG, Penaloza D, Richalet JP, Roach R, Wu T, Vargas E, Zubieta-Castillo G, Zubieta-Calleja G. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol. 2005; 6(2):147-57. PMID: 16060849.
      View in: PubMed
    41. Jean D, Leal C, Kriemler S, Meijer H, Moore LG. Medical recommendations for women going to altitude. High Alt Med Biol. 2005; 6(1):22-31. PMID: 15772497.
      View in: PubMed
    42. Moore LG, Shriver M, Bemis L, Hickler B, Wilson M, Brutsaert T, Parra E, Vargas E. Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review. Placenta. 2004 Apr; 25 Suppl A:S60-71. PMID: 15033310.
      View in: PubMed
    43. Mazzeo RS, Dubay A, Kirsch J, Braun B, Butterfield GE, Rock PB, Wolfel EE, Zamudio S, Moore LG. Influence of alpha-adrenergic blockade on the catecholamine response to exercise at 4,300 meters. Metabolism. 2003 Nov; 52(11):1471-7. PMID: 14624409.
      View in: PubMed
    44. Rockwell LC, Vargas E, Moore LG. Human physiological adaptation to pregnancy: inter- and intraspecific perspectives. Am J Hum Biol. 2003 May-Jun; 15(3):330-41. PMID: 12704709.
      View in: PubMed
    45. Keyes LE, Armaza JF, Niermeyer S, Vargas E, Young DA, Moore LG. Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia. Pediatr Res. 2003 Jul; 54(1):20-5. PMID: 12700368.
      View in: PubMed
    46. Moore LG. Fetal growth restriction and maternal oxygen transport during high altitude pregnancy. High Alt Med Biol. 2003; 4(2):141-56. PMID: 12855048.
      View in: PubMed
    47. Moore LG. The quest for riches, or how mining silver in Bolivia has enriched our knowledge of the mechanisms underlying reproductive success. High Alt Med Biol. 2003; 4(2):105-9. PMID: 12877152.
      View in: PubMed
    48. Mateev S, Sillau AH, Mouser R, McCullough RE, White MM, Young DA, Moore LG. Chronic hypoxia opposes pregnancy-induced increase in uterine artery vasodilator response to flow. Am J Physiol Heart Circ Physiol. 2003 Mar; 284(3):H820-9. PMID: 12433660.
      View in: PubMed
    49. Coussons-Read ME, Mazzeo RS, Whitford MH, Schmitt M, Moore LG, Zamudio S. High altitude residence during pregnancy alters cytokine and catecholamine levels. Am J Reprod Immunol. 2002 Nov; 48(5):344-54. PMID: 12516658.
      View in: PubMed
    50. Cymerman A, Lieberman P, Hochstadt J, Rock PB, Butterfield GE, Moore LG. Speech motor control and acute mountain sickness. Aviat Space Environ Med. 2002 Aug; 73(8):766-72. PMID: 12182216.
      View in: PubMed
    51. Sillau AH, McCullough RE, Dyckes R, White MM, Moore LG. Chronic hypoxia increases MCA contractile response to U-46619 by reducing NO production and/or activity. J Appl Physiol (1985). 2002 May; 92(5):1859-64. PMID: 11960934.
      View in: PubMed
    52. Moore LG, Zamudio S, Zhuang J, Droma T, Shohet RV. Analysis of the myoglobin gene in Tibetans living at high altitude. High Alt Med Biol. 2002; 3(1):39-47. PMID: 12006163.
      View in: PubMed
    53. Zamudio S, Douglas M, Mazzeo RS, Wolfel EE, Young DA, Rock PB, Braun B, Muza SR, Butterfield GE, Moore LG. Women at altitude: forearm hemodynamics during acclimatization to 4,300 m with alpha(1)-adrenergic blockade. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2636-44. PMID: 11709433.
      View in: PubMed
    54. Fulco CS, Rock PB, Muza SR, Wolfel EE, Moore LG, Cymerman A. Circulatory responses to orthostasis during alpha1-adrenergic receptor blockade at high altitude. Aviat Space Environ Med. 2001 Dec; 72(12):1075-80. PMID: 11763107.
      View in: PubMed
    55. Reeves JT, Zamudio S, Dahms TE, Asmus I, Braun B, Butterfield GE, McCullough RG, Muza SR, Rock PB, Moore LG. Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase. J Appl Physiol (1985). 2001 Dec; 91(6):2579-86. PMID: 11717222.
      View in: PubMed
    56. Mazzeo RS, Donovan D, Fleshner M, Butterfield GE, Zamudio S, Wolfel EE, Moore LG. Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade. J Appl Physiol (1985). 2001 Nov; 91(5):2143-9. PMID: 11641355.
      View in: PubMed
    57. Muza SR, Rock PB, Fulco CS, Zamudio S, Braun B, Cymerman A, Butterfield GE, Moore LG. Women at altitude: ventilatory acclimatization at 4,300 m. J Appl Physiol (1985). 2001 Oct; 91(4):1791-9. PMID: 11568164.
      View in: PubMed
    58. Moore LG, Young D, McCullough RE, Droma T, Zamudio S. Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude. Am J Hum Biol. 2001 Sep-Oct; 13(5):635-44. PMID: 11505472.
      View in: PubMed
    59. Braun B, Rock PB, Zamudio S, Wolfel GE, Mazzeo RS, Muza SR, Fulco CS, Moore LG, Butterfield GE. Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity. J Appl Physiol (1985). 2001 Aug; 91(2):623-31. PMID: 11457773.
      View in: PubMed
    60. Fulco CS, Rock PB, Muza SR, Lammi E, Braun B, Cymerman A, Moore LG, Lewis SF. Gender alters impact of hypobaric hypoxia on adductor pollicis muscle performance. J Appl Physiol (1985). 2001 Jul; 91(1):100-8. PMID: 11408419.
      View in: PubMed
    61. Mazzeo RS, Carroll JD, Butterfield GE, Braun B, Rock PB, Wolfel EE, Zamudio S, Moore LG. Catecholamine responses to alpha-adrenergic blockade during exercise in women acutely exposed to altitude. J Appl Physiol (1985). 2001 Jan; 90(1):121-6. PMID: 11133901.
      View in: PubMed
    62. Moore LG. Human genetic adaptation to high altitude. High Alt Med Biol. 2001; 2(2):257-79. PMID: 11443005.
      View in: PubMed
    63. Moore LG, Zamudio S, Zhuang J, Sun S, Droma T. Oxygen transport in tibetan women during pregnancy at 3,658 m. Am J Phys Anthropol. 2001 Jan; 114(1):42-53. PMID: 11150051.
      View in: PubMed
    64. Cymerman A, Rock PB, Muza SR, Lyons TP, Fulco CS, Mazzeo RS, Butterfield G, Moore LG. Intraocular pressure and acclimatization to 4300 M altitude. Aviat Space Environ Med. 2000 Oct; 71(10):1045-50. PMID: 11051312.
      View in: PubMed
    65. Moore LG. Comparative human ventilatory adaptation to high altitude. Respir Physiol. 2000 Jul; 121(2-3):257-76. PMID: 10963780.
      View in: PubMed
    66. Zamudio S, Moore LG. Altitude and fetal growth: current knowledge and future directions. Ultrasound Obstet Gynecol. 2000 Jul; 16(1):6-8. PMID: 11084958.
      View in: PubMed
    67. White MM, McCullough RE, Dyckes R, Robertson AD, Moore LG. Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H2069-75. PMID: 10843906.
      View in: PubMed
    68. Rockwell LC, Keyes LE, Moore LG. Chronic hypoxia diminishes pregnancy-associated DNA synthesis in guinea pig uteroplacental arteries. Placenta. 2000 May; 21(4):313-9. PMID: 10833365.
      View in: PubMed
    69. Mawson JT, Braun B, Rock PB, Moore LG, Mazzeo R, Butterfield GE. Women at altitude: energy requirement at 4,300 m. J Appl Physiol (1985). 2000 Jan; 88(1):272-81. PMID: 10642390.
      View in: PubMed
    70. Braun B, Mawson JT, Muza SR, Dominick SB, Brooks GA, Horning MA, Rock PB, Moore LG, Mazzeo RS, Ezeji-Okoye SC, Butterfield GE. Women at altitude: carbohydrate utilization during exercise at 4,300 m. J Appl Physiol (1985). 2000 Jan; 88(1):246-56. PMID: 10642387.
      View in: PubMed
    71. Moore LG, Armaza F, Villena M, Vargas E. Comparative aspects of high-altitude adaptation in human populations. Adv Exp Med Biol. 2000; 475:45-62. PMID: 10849648.
      View in: PubMed
    72. Fulco CS, Rock PB, Muza SR, Lammi E, Cymerman A, Butterfield G, Moore LG, Braun B, Lewis SF. Slower fatigue and faster recovery of the adductor pollicis muscle in women matched for strength with men. Acta Physiol Scand. 1999 Nov; 167(3):233-9. PMID: 10606825.
      View in: PubMed
    73. Palmer SK, Moore LG, Young D, Cregger B, Berman JC, Zamudio S. Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado. Am J Obstet Gynecol. 1999 May; 180(5):1161-8. PMID: 10329872.
      View in: PubMed
    74. White MM, McCullough RE, Dyckes R, Robertson AD, Moore LG. Effects of pregnancy and chronic hypoxia on contractile responsiveness to alpha1-adrenergic stimulation. J Appl Physiol (1985). 1998 Dec; 85(6):2322-9. PMID: 9843559.
      View in: PubMed
    75. Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D, Johnson A, Osorio F, Goldberg C, Moore LG, Dahms T, Schrier RW. Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int. 1998 Dec; 54(6):2056-63. PMID: 9853271.
      View in: PubMed
    76. Braun B, Butterfield GE, Dominick SB, Zamudio S, McCullough RG, Rock PB, Moore LG. Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle. J Appl Physiol (1985). 1998 Nov; 85(5):1966-73. PMID: 9804605.
      View in: PubMed
    77. Niermeyer S, Moore LG. Hypoxic responses in infants. No known mechanism links hypoxia and sudden infant death syndrome. BMJ. 1998 Sep 05; 317(7159):675-6; author reply 677-8. PMID: 9758493.
      View in: PubMed
    78. Keyes L, Rodman DM, Curran-Everett D, Morris K, Moore LG. Effect of K+ATP channel inhibition on total and regional vascular resistance in guinea pig pregnancy. Am J Physiol. 1998 Aug; 275(2 Pt 2):H680-8. PMID: 9683458.
      View in: PubMed
    79. Halperin BD, Sun S, Zhuang J, Droma T, Moore LG. ECG observations in Tibetan and Han residents of Lhasa. J Electrocardiol. 1998 Jul; 31(3):237-43. PMID: 9682900.
      View in: PubMed
    80. Mazzeo RS, Child A, Butterfield GE, Mawson JT, Zamudio S, Moore LG. Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women. J Appl Physiol (1985). 1998 Apr; 84(4):1151-7. PMID: 9516178.
      View in: PubMed
    81. Moore LG, Niermeyer S, Zamudio S. Human adaptation to high altitude: regional and life-cycle perspectives. Am J Phys Anthropol. 1998; Suppl 27:25-64. PMID: 9881522.
      View in: PubMed
    82. Curran LS, Zhuang J, Droma T, Moore LG. Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m. Am J Phys Anthropol. 1998 Jan; 105(1):21-31. PMID: 9537925.
      View in: PubMed
    83. Curran LS, Zhuang J, Sun SF, Moore LG. Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m. J Appl Physiol (1985). 1997 Dec; 83(6):2098-104. PMID: 9390987.
      View in: PubMed
    84. Tatsumi K, Pickett CK, Jacoby CR, Weil JV, Moore LG. Role of endogenous female hormones in hypoxic chemosensitivity. J Appl Physiol (1985). 1997 Nov; 83(5):1706-10. PMID: 9375342.
      View in: PubMed
    85. Chapman AB, Zamudio S, Woodmansee W, Merouani A, Osorio F, Johnson A, Moore LG, Dahms T, Coffin C, Abraham WT, Schrier RW. Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol. 1997 Nov; 273(5 Pt 2):F777-82. PMID: 9374841.
      View in: PubMed
    Moore's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)