Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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John Clifford Cambier

TitleDistinguished Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology
Phone303/724-8663
    Other Positions
    TitleChair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-Immunology Microbiology


    Collapse Research 
    Collapse research activities and funding
    R01AI020519     (CAMBIER, JOHN C.)May 1, 1983 - Feb 28, 2009
    NIH/NIAID
    Molecular Biology of B Cell Tolerance and Activation
    Role: Principal Investigator

    R01AI021768     (CAMBIER, JOHN C.)Dec 1, 1984 - May 31, 1996
    NIH/NIAID
    SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    Role: Principal Investigator

    R01AG013983     (CAMBIER, JOHN C.)Dec 1, 1984 - Aug 31, 2011
    NIH/NIA
    B Cells and Autoimmunity
    Role: Principal Investigator

    P01AI022295     (MARRACK, PHILIPPA C.)Jul 1, 1985 - Jul 31, 2014
    NIH/NIAID
    Antigen Recognition by Lymphocytes
    Role: Co-Principal Investigator

    P01AI029903     (CAMBIER, JOHN C.)Apr 1, 1990 - Mar 31, 1995
    NIH/NIAID
    MOLECULAR BASIS OF HIV INDUCED IMMUNE SUPPRESSION
    Role: Principal Investigator

    R01DK047121     (CAMBIER, JOHN C.)May 1, 1993 - Nov 30, 2005
    NIH/NIDDK
    INHIBITORY RECEPTORS AND THEIR MODE OF ACTION
    Role: Principal Investigator

    R56AI074444     (CAMBIER, JOHN C.)May 1, 1993 - Sep 29, 2009
    NIH/NIAID
    Inhibitory receptors and their mode of action
    Role: Principal Investigator

    R21AI036676     (CAMBIER, JOHN C.)Jun 1, 1995 - Sep 29, 2002
    NIH/NIAID
    HIV GP120 Desensitization of TCell Receptor Function
    Role: Principal Investigator

    R01AI036676     (CAMBIER, JOHN C.)Jun 1, 1995 - Jan 31, 2006
    NIH/NIAID
    HIV GP120 Desensitization of T Cell Receptor Function
    Role: Principal Investigator

    R01AI039773     (CAMBIER, JOHN C.)Jan 1, 1997 - Dec 31, 2002
    NIH/NIAID
    IGC REGULATION OF IGE-MEDIATED BASOPHIL DEGRANULATION
    Role: Principal Investigator

    R13CA096580     (CAMBIER, JOHN C.)Aug 1, 2002 - Jul 31, 2003
    NIH/NCI
    Conference Proposal: IMMUNORECEPTORS
    Role: Principal Investigator

    R13AI066860     (CAMBIER, JOHN C.)Jun 1, 2005 - May 31, 2006
    NIH/NIAID
    FASEB Conference-Immunoreceptors
    Role: Principal Investigator

    R01AI062739     (CAMBIER, JOHN C.)Jun 1, 2005 - Sep 30, 2011
    NIH/NIAID
    NKIP signaling and functions
    Role: Principal Investigator

    R13AG029058     (CAMBIER, JOHN C.)Aug 15, 2006 - Aug 31, 2007
    NIH/NIA
    Aging Research in Immunology: Satellite to 2006 European Congress of Immunology
    Role: Principal Investigator

    R21AI069894     (CAMBIER, JOHN C.)Aug 15, 2006 - Jul 31, 2009
    NIH/NIAID
    Characterization of anergic human B cells
    Role: Principal Investigator

    T32AI074491     (CAMBIER, JOHN C.)Jul 1, 2007 - Jun 30, 2019
    NIH/NIAID
    Molecular Mechanisms of Immune Tolerance
    Role: Principal Investigator

    R21AI078207     (CAMBIER, JOHN C.)Jul 1, 2009 - Jun 30, 2012
    NIH/NIAID
    B Cell Development in Aging
    Role: Principal Investigator

    R01AI077597     (CAMBIER, JOHN C.)Dec 1, 2009 - Nov 30, 2015
    NIH/NIAID
    Infectious Agents and B Cell Anergy
    Role: Principal Investigator

    S10RR027331     (CAMBIER, JOHN C.)Dec 10, 2009 - Dec 9, 2011
    NIH/NCRR
    iCyt Reflection High Speed Cell Sorter
    Role: Principal Investigator

    R21AI099346     (CAMBIER, JOHN C.)Aug 1, 2012 - Jul 31, 2014
    NIH/NIAID
    Mouse modeling of a human STING gene variant for infectious disease
    Role: Principal Investigator

    R01DK096492     (CAMBIER, JOHN C.)Aug 20, 2012 - Jun 30, 2017
    NIH/NIDDK
    B Cells and Type 1 Diabetes
    Role: Principal Investigator

    R21AI124488     (CAMBIER, JOHN C.)Feb 16, 2016 - Jan 31, 2018
    NIH/NIAID
    Perturbation of B cell anergy in T1D
    Role: Principal Investigator

    R01AI124487     (CAMBIER, JOHN C.)Mar 1, 2016 - Feb 28, 2021
    NIH/NIAID
    Autoimmunity risk alleles compromising B cell anergy
    Role: Principal Investigator

    DP3DK110845     (MICHELS, AARON W)Aug 1, 2016 - Jul 31, 2019
    NIH/NIDDK
    Insulin Specific T and B cells in Type 1 Diabetes
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Getahun A, Wemlinger SM, Rudra P, Santiago ML, van Dyk LF, Cambier JC. Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway. J Exp Med. 2017 Apr 03; 214(4):931-941. PMID: 28341640.
      View in: PubMed
    2. Smith MJ, Packard TA, O'Neill SK, Hinman RM, Rihanek M, Gottlieb PA, Cambier JC. Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function. J Vis Exp. 2017 Feb 16; (120). PMID: 28287549.
      View in: PubMed
    3. Seay HR, Yusko E, Rothweiler SJ, Zhang L, Posgai AL, Campbell-Thompson M, Vignali M, Emerson RO, Kaddis JS, Ko D, Nakayama M, Smith MJ, Cambier JC, Pugliese A, Atkinson MA, Robins HS, Brusko TM. Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes. JCI Insight. 2016 Dec 08; 1(20):e88242. PMID: 27942583.
      View in: PubMed
    4. Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC. B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes. J Clin Med. 2016 Nov 08; 5(11). PMID: 27834793.
      View in: PubMed
    5. Franks SE, Getahun A, Hogarth PM, Cambier JC. Targeting B cells in treatment of autoimmunity. Curr Opin Immunol. 2016 Dec; 43:39-45. PMID: 27718447.
      View in: PubMed
    6. Noges LE, White J, Cambier JC, Kappler JW, Marrack P. Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines. J Immunol. 2016 Aug 15; 197(4):1221-30. PMID: 27357147; PMCID: PMC4974487.
    7. Getahun A, Beavers NA, Larson SR, Shlomchik MJ, Cambier JC. Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med. 2016 May 02; 213(5):751-69. PMID: 27114609; PMCID: PMC4854724 [Available on 11/02/16].
    8. Cambier J. Preview of Immunological Reviews for 2016. Immunol Rev. 2016 Jan; 269(1):5-6. PMID: 26683140.
      View in: PubMed
    9. Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 01; 196(1):217-31. PMID: 26582947; PMCID: PMC4684964 [Available on 01/01/17].
    10. Getahun A, Cambier JC. Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling. Immunol Rev. 2015 Nov; 268(1):66-73. PMID: 26497513; PMCID: PMC4621791 [Available on 11/01/16].
    11. Chen Z, Getahun A, Chen X, Dollin Y, Cambier JC, Wang JH. Imbalanced PTEN and PI3K Signaling Impairs Class Switch Recombination. J Immunol. 2015 Dec 01; 195(11):5461-71. PMID: 26500350; PMCID: PMC4655169 [Available on 12/01/16].
    12. Akerlund J, Getahun A, Cambier JC. B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens. J Autoimmun. 2015 Aug; 62:45-54. PMID: 26152931; PMCID: PMC4529775.
    13. Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E39-48. PMID: 25535377; PMCID: PMC4291655.
    14. White MJ, McArthur K, Metcalf D, Lane RM, Cambier JC, Herold MJ, van Delft MF, Bedoui S, Lessene G, Ritchie ME, Huang DC, Kile BT. Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production. Cell. 2014 Dec 18; 159(7):1549-62. PMID: 25525874; PMCID: PMC4520319.
    15. Smith MJ, Packard TA, O'Neill SK, Henry Dunand CJ, Huang M, Fitzgerald-Miller L, Stowell D, Hinman RM, Wilson PC, Gottlieb PA, Cambier JC. Loss of anergic B cells in prediabetic and new-onset type 1 diabetic patients. Diabetes. 2015 May; 64(5):1703-12. PMID: 25524915; PMCID: PMC4407867.
    16. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356; PMCID: PMC4440340.
    17. Luo W, Mayeux J, Gutierrez T, Russell L, Getahun A, Müller J, Tedder T, Parnes J, Rickert R, Nitschke L, Cambier J, Satterthwaite AB, Garrett-Sinha LA. A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. J Immunol. 2014 Jul 15; 193(2):909-20. PMID: 24929000; PMCID: PMC4082765.
    18. Hinman RM, Smith MJ, Cambier JC. B cells and type 1 diabetes ...in mice and men. Immunol Lett. 2014 Aug; 160(2):128-32. PMID: 24472603.
      View in: PubMed
    19. Hardy IR, Anceriz N, Rousseau F, Seefeldt MB, Hatterer E, Irla M, Buatois V, Chatel LE, Getahun A, Fletcher A, Cons L, Pontini G, Hertzberg NA, Magistrelli G, Malinge P, Smith MJ, Reith W, Kosco-Vilbois MH, Ferlin WG, Cambier JC. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. J Immunol. 2014 Feb 15; 192(4):1641-50. PMID: 24442438; PMCID: PMC3941979.
    20. Hinman RM, Cambier JC. Role of B lymphocytes in the pathogenesis of type 1 diabetes. Curr Diab Rep. 2014; 14(11):543. PMID: 25189436.
      View in: PubMed
    21. Packard TA, Cambier JC. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation. F1000Prime Rep. 2013 Oct 01; 5:40. PMID: 24167721; PMCID: PMC3790562.
    22. Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C. Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. EMBO Rep. 2013 Oct; 14(10):900-6. PMID: 24008845; PMCID: PMC3807221.
    23. Bounab Y, Getahun A, Cambier JC, Daëron M. Phosphatase regulation of immunoreceptor signaling in T cells, B cells and mast cells. Curr Opin Immunol. 2013 Jun; 25(3):313-20. PMID: 23684445; PMCID: PMC3732051.
    24. Cambier JC. Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways. J Clin Invest. 2013 May; 123(5):1928-31. PMID: 23619359; PMCID: PMC3635745.
    25. Slansky JE, Cohen JJ, Cambier JC. Integrated immunology in Colorado. Immunol Res. 2013 Mar; 55(1-3):1-2. PMID: 22975788.
      View in: PubMed
    26. Packard TA, Li QZ, Cosgrove GP, Bowler RP, Cambier JC. COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype. Immunol Res. 2013 Mar; 55(1-3):48-57. PMID: 22941590; PMCID: PMC3919062.
    27. Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. J Immunol. 2013 Mar 15; 190(6):2835-43. PMID: 23378430; PMCID: PMC3593745.
    28. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108; PMCID: PMC3478644.
    29. Getahun A, Smith MJ, Kogut I, van Dyk LF, Cambier JC. Retention of anergy and inhibition of antibody responses during acute ? herpesvirus 68 infection. J Immunol. 2012 Sep 15; 189(6):2965-74. PMID: 22904300; PMCID: PMC3436999.
    30. Jin L, Cambier JC. SMIP-016 in action: CD37 as a death receptor. Cancer Cell. 2012 May 15; 21(5):597-8. PMID: 22624709; PMCID: PMC4363110.
    31. Kogut I, Scholz JL, Cancro MP, Cambier JC. B cell maintenance and function in aging. Semin Immunol. 2012 Oct; 24(5):342-9. PMID: 22560930.
      View in: PubMed
    32. Khalil AM, Cambier JC, Shlomchik MJ. B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity. Science. 2012 Jun 01; 336(6085):1178-81. PMID: 22555432; PMCID: PMC3777391.
    33. Waterman PM, Marschner S, Brandl E, Cambier JC. The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling. Immunol Lett. 2012 Mar 30; 143(1):122-30. PMID: 22370159; PMCID: PMC3314150.
    34. O'Brien RL, Chain JL, Aydintug MK, Bohrer-Kunter D, Huang Y, Hardy IR, Cambier JC, Lahmers K, Nuhsbaum T, Davidson R, Sun D, Born WK. aß TCR? T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking ?d T cells. Invest Ophthalmol Vis Sci. 2012 Jan 25; 53(1):301-8. PMID: 22199243; PMCID: PMC3292366.
    35. Xu LG, Jin L, Zhang BC, Akerlund LJ, Shu HB, Cambier JC. VISA is required for B cell expression of TLR7. J Immunol. 2012 Jan 01; 188(1):248-58. PMID: 22105994; PMCID: PMC3244560.
    36. O'Neill SK, Getahun A, Gauld SB, Merrell KT, Tamir I, Smith MJ, Dal Porto JM, Li QZ, Cambier JC. Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity. 2011 Nov 23; 35(5):746-56. PMID: 22078222; PMCID: PMC3232011.
    37. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. J Immunol. 2011 Sep 01; 187(5):2595-601. PMID: 21813776; PMCID: PMC3159690.
    38. Grubeck-Loebenstein B, Cambier J. Immune senescence. Editorial overview. Curr Opin Immunol. 2011 Aug; 23(4):509-11. PMID: 21782404.
      View in: PubMed
    39. Yarkoni Y, Cambier JC. Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude. Mol Immunol. 2011 Sep; 48(15-16):1851-8. PMID: 21663969; PMCID: PMC3163766.
    40. Lukin K, Fields S, Guerrettaz L, Straign D, Rodriguez V, Zandi S, Månsson R, Cambier JC, Sigvardsson M, Hagman J. A dose-dependent role for EBF1 in repressing non-B-cell-specific genes. Eur J Immunol. 2011 Jun; 41(6):1787-93. PMID: 21469119; PMCID: PMC3127254.
    41. Van Den Broeck A, Cambier J. B cells talk to their progenitors. Blood. 2011 Mar 17; 117(11):2985-6. PMID: 21415272.
      View in: PubMed
    42. Jin L, Xu LG, Yang IV, Davidson EJ, Schwartz DA, Wurfel MM, Cambier JC. Identification and characterization of a loss-of-function human MPYS variant. Genes Immun. 2011 Jun; 12(4):263-9. PMID: 21248775; PMCID: PMC3107388.
    43. Dhirapong A, Lleo A, Yang GX, Tsuneyama K, Dunn R, Kehry M, Packard TA, Cambier JC, Liu FT, Lindor K, Coppel RL, Ansari AA, Gershwin ME. B cell depletion therapy exacerbates murine primary biliary cirrhosis. Hepatology. 2011 Feb; 53(2):527-35. PMID: 21274873; PMCID: PMC3058242.
    44. Jin L, Lenz LL, Cambier JC. Cellular reactive oxygen species inhibit MPYS induction of IFNß. PLoS One. 2010 Dec 10; 5(12):e15142. PMID: 21170271; PMCID: PMC3000824.
    45. Chan MA, Gigliotti NM, Matangkasombut P, Gauld SB, Cambier JC, Rosenwasser LJ. CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage. Clin Immunol. 2010 Dec; 137(3):330-6. PMID: 20805040.
      View in: PubMed
    46. Waterman PM, Cambier JC. The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms. FEBS Lett. 2010 Dec 15; 584(24):4878-82. PMID: 20875413; PMCID: PMC2998577.
    47. Yarkoni Y, Getahun A, Cambier JC. Molecular underpinning of B-cell anergy. Immunol Rev. 2010 Sep; 237(1):249-63. PMID: 20727040; PMCID: PMC2968701.
    48. Cady CT, Powell MS, Harbeck RJ, Giclas PC, Murphy JR, Katial RK, Weber RW, Hogarth PM, Johnson S, Bonvini E, Koenig S, Cambier JC. IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB. Immunol Lett. 2010 May 04; 130(1-2):57-65. PMID: 20004689; PMCID: PMC2849848.
    49. Getahun A, O'Neill SK, Cambier JC. Establishing anergy as a bona fide in vivo mechanism of B cell tolerance. J Immunol. 2009 Nov 01; 183(9):5439-41. PMID: 19843930; PMCID: PMC2968702.
    50. Cambier JC, Getahun A. B cell activation versus anergy; the antigen receptor as a molecular switch. Immunol Lett. 2010 Jan 18; 128(1):6-7. PMID: 19808046; PMCID: PMC2815188.
    51. O'Neill SK, Liu E, Cambier JC. Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2009 Aug; 16(4):293-8. PMID: 19502979; PMCID: PMC2968699.
    52. Jackson L, Cady CT, Cambier JC. TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23. J Immunol. 2009 Aug 15; 183(4):2585-92. PMID: 19635918; PMCID: PMC2914506.
    53. O'Neill SK, Veselits ML, Zhang M, Labno C, Cao Y, Finnegan A, Uccellini M, Alegre ML, Cambier JC, Clark MR. Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6262-7. PMID: 19332776; PMCID: PMC2662959.
    54. Decoté-Ricardo D, Chagas KK, Rocha JD, Redner P, Lopes UG, Cambier JC, Barros de Arruda L, Peçanha LM. Modulation of in vitro murine B-lymphocyte response by curcumin. Phytomedicine. 2009 Oct; 16(10):982-8. PMID: 19303754; PMCID: PMC2908300.
    55. Crowley JE, Stadanlick JE, Cambier JC, Cancro MP. FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. Blood. 2009 Feb 12; 113(7):1464-73. PMID: 18791164; PMCID: PMC2644074.
    56. Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, Cohen PL, Eisenberg RA. B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol. 2008 Sep 01; 181(5):2961-72. PMID: 18713966; PMCID: PMC2865432.
    57. Guerrettaz LM, Johnson SA, Cambier JC. Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11898-902. PMID: 18697924; PMCID: PMC2515225.
    58. Cady CT, Rice JS, Ott VL, Cambier JC. Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors. Immunol Rev. 2008 Aug; 224:44-57. PMID: 18759919; PMCID: PMC2968700.
    59. Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol. 2008 Aug; 28(16):5014-26. PMID: 18559423; PMCID: PMC2519703.
    60. Jin L, Stolpa JC, Young RM, Pugh-Bernard AE, Refaeli Y, Cambier JC. MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death. Immunol Lett. 2008 Mar 15; 116(2):184-94. PMID: 18194817; PMCID: PMC2424217.
    61. Rider DA, Havenith CE, de Ridder R, Schuurman J, Favre C, Cooper JC, Walker S, Baadsgaard O, Marschner S, vandeWinkel JG, Cambier J, Parren PW, Alexander DR. A human CD4 monoclonal antibody for the treatment of T-cell lymphoma combines inhibition of T-cell signaling by a dual mechanism with potent Fc-dependent effector activity. Cancer Res. 2007 Oct 15; 67(20):9945-53. PMID: 17942927.
      View in: PubMed
    62. Conrad FJ, Rice JS, Cambier JC. Multiple paths to loss of anergy and gain of autoimmunity. Autoimmunity. 2007 Sep; 40(6):418-24. PMID: 17729035.
      View in: PubMed
    63. Lyubchenko T, Dal Porto JM, Holers VM, Cambier JC. Cutting edge: Complement (C3d)-linked antigens break B cell anergy. J Immunol. 2007 Sep 01; 179(5):2695-9. PMID: 17709481.
      View in: PubMed
    64. Cambier JC, Gauld SB, Merrell KT, Vilen BJ. B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol. 2007 Aug; 7(8):633-43. PMID: 17641666; PMCID: PMC3714009.
    65. Velez MG, Kane M, Liu S, Gauld SB, Cambier JC, Torres RM, Pelanda R. Ig allotypic inclusion does not prevent B cell development or response. J Immunol. 2007 Jul 15; 179(2):1049-57. PMID: 17617597.
      View in: PubMed
    66. Brauweiler A, Merrell K, Gauld SB, Cambier JC. Cutting Edge: Acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness. J Immunol. 2007 Mar 15; 178(6):3353-7. PMID: 17339427.
      View in: PubMed
    67. Mills DM, Stolpa JC, Cambier JC. Modulation of MHC class II signal transduction by CD19. Adv Exp Med Biol. 2007; 596:139-48. PMID: 17338182.
      View in: PubMed
    68. Merrell KT, Benschop RJ, Gauld SB, Aviszus K, Decote-Ricardo D, Wysocki LJ, Cambier JC. Identification of anergic B cells within a wild-type repertoire. Immunity. 2006 Dec; 25(6):953-62. PMID: 17174121.
      View in: PubMed
    69. Pugh-Bernard AE, Cambier JC. B cell receptor signaling in human systemic lupus erythematosus. Curr Opin Rheumatol. 2006 Sep; 18(5):451-5. PMID: 16896281.
      View in: PubMed
    70. Powell MS, Barnes NC, Bradford TM, Musgrave IF, Wines BD, Cambier JC, Hogarth PM. Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding. J Immunol. 2006 Jun 15; 176(12):7489-94. PMID: 16751395.
      View in: PubMed
    71. Gauld SB, Merrell KT, Cambier JC. Silencing of autoreactive B cells by anergy: a fresh perspective. Curr Opin Immunol. 2006 Jun; 18(3):292-7. PMID: 16616480.
      View in: PubMed
    72. Gauld SB, Benschop RJ, Merrell KT, Cambier JC. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat Immunol. 2005 Nov; 6(11):1160-7. PMID: 16200069.
      View in: PubMed
    73. Cambier J. Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling. Immunol Rev. 2005 Jun; 205:5-6. PMID: 15882340.
      View in: PubMed
    74. Lyubchenko T, dal Porto J, Cambier JC, Holers VM. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway. J Immunol. 2005 Mar 15; 174(6):3264-72. PMID: 15749857.
      View in: PubMed
    75. Gauld SB, Cambier JC. Src-family kinases in B-cell development and signaling. Oncogene. 2004 Oct 18; 23(48):8001-6. PMID: 15489917.
      View in: PubMed
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    162. André P, Cambier JC, Wade TK, Raetz T, Wade WF. Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules. J Exp Med. 1994 Feb 01; 179(2):763-8. PMID: 8294884; PMCID: PMC2191390.
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    170. Friedrich RJ, Campbell KS, Cambier JC. The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene. J Immunol. 1993 Apr 01; 150(7):2814-22. PMID: 8454858.
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    174. Cambier JC, Campbell KS. Membrane immunoglobulin and its accomplices: new lessons from an old receptor. FASEB J. 1992 Oct; 6(13):3207-17. PMID: 1397843.
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    177. Wysocki LJ, Creadon G, Lehmann KR, Cambier JC. B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro. Immunology. 1992 Jan; 75(1):116-21. PMID: 1537587; PMCID: PMC1384812.
    178. Campbell KS, Hager EJ, Cambier JC. Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J Immunol. 1991 Sep 01; 147(5):1575-80. PMID: 1880417.
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    179. Blackman MA, Finkel TH, Kappler J, Cambier J, Marrack P. Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice. Proc Natl Acad Sci U S A. 1991 Aug 01; 88(15):6682-6. PMID: 1907374; PMCID: PMC52152.
    180. Hauschildt S, Lückhoff A, Langhorne J, Wiesmüller KH, Jung G, Bessler W, Cambier JC. Increase in the intracellular free calcium concentration is not an obligatory early event in lipopeptide-induced B-cell activation. Immunology. 1991 Jul; 73(3):366-8. PMID: 1879881; PMCID: PMC1384557.
    181. Justement LB, Campbell KS, Chien NC, Cambier JC. Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science. 1991 Jun 28; 252(5014):1839-42. PMID: 1648262.
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    182. Reth M, Hombach J, Wienands J, Campbell KS, Chien N, Justement LB, Cambier JC. The B-cell antigen receptor complex. Immunol Today. 1991 Jun; 12(6):196-201. PMID: 1878135.
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    183. Campbell KS, Hager EJ, Friedrich RJ, Cambier JC. IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3982-6. PMID: 2023945; PMCID: PMC51577.
    184. Cambier JC, Morrison DC, Chien MM, Lehmann KR. Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking. J Immunol. 1991 Apr 01; 146(7):2075-82. PMID: 1848577.
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    185. Fisher CL, Ghysdael J, Cambier JC. Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1. J Immunol. 1991 Mar 15; 146(6):1743-9. PMID: 1900874.
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    186. Finkel TH, Kubo RT, Cambier JC. T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor. Immunol Today. 1991 Feb; 12(2):79-85. PMID: 1829360.
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    187. Cambier JC. Capturing antigen receptor components. Curr Biol. 1991 Feb; 1(1):25-7. PMID: 15336198.
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    188. Rijkers GT, Griffioen AW, Zegers BJ, Cambier JC. Ligation of membrane immunoglobulin leads to inactivation of the signal-transducing ability of membrane immunoglobulin, CD19, CD21, and B-cell gp95. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8766-70. PMID: 1701054; PMCID: PMC55040.
    189. Cambier JC, Fisher CL, Pickles H, Morrison DC. Dual molecular mechanisms mediate ligand-induced membrane Ig desensitization. J Immunol. 1990 Jul 01; 145(1):13-9. PMID: 2113552.
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    190. Chien MM, Cambier JC. Divalent cation regulation of phosphoinositide metabolism. Naturally occurring B lymphoblasts contain a Mg2(+)-regulated phosphatidylinositol-specific phospholipase C. J Biol Chem. 1990 Jun 05; 265(16):9201-7. PMID: 2160965.
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    191. Gallagher RB, Cambier JC. Signal transmission pathways and lymphocyte function. Immunol Today. 1990 Jun; 11(6):187-9. PMID: 2162179.
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    192. Justement LB, Wienands J, Hombach J, Reth M, Cambier JC. Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells. J Immunol. 1990 May 01; 144(9):3272-80. PMID: 2109774.
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    193. Cambier JC, Campbell KS. Signal transduction by B lymphocyte receptors: structure-function relationships of membrane immunoglobulins and associated molecules. Semin Immunol. 1990 Mar; 2(2):139-49. PMID: 1966612.
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    194. Campbell KS, Cambier JC. B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J. 1990 Feb; 9(2):441-8. PMID: 2154371; PMCID: PMC551685.
    195. Cross D, Cambier JC. Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression. J Immunol. 1990 Jan 15; 144(2):432-9. PMID: 1688578.
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    196. Finkel TH, Cambier JC, Kubo RT, Born WK, Marrack P, Kappler JW. The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell. 1989 Sep 22; 58(6):1047-54. PMID: 2673539.
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    197. Cambier JC. Transmembrane signaling in T lymphocyte dependent B lymphocyte activation. Semin Immunol. 1989 Sep; 1(1):43-54. PMID: 15630958.
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    198. Cambier JC, Lehmann KR. Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J Exp Med. 1989 Sep 01; 170(3):877-86. PMID: 2788709; PMCID: PMC2189451.
    199. Wade WF, Chen ZZ, Maki R, McKercher S, Palmer E, Cambier JC, Freed JH. Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6297-301. PMID: 2503831; PMCID: PMC297825.
    200. Klemsz MJ, Justement LB, Palmer E, Cambier JC. Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands. J Immunol. 1989 Aug 01; 143(3):1032-9. PMID: 2787345.
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    201. Justement LB, Kreiger J, Cambier JC. Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig. J Immunol. 1989 Aug 01; 143(3):881-9. PMID: 2663989.
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    202. Finkel TH, Marrack P, Kappler JW, Kubo RT, Cambier JC. Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance. J Immunol. 1989 May 01; 142(9):3006-12. PMID: 2523422.
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    203. Marrack P, Blackman M, Burgert HG, McCormack JM, Cambier J, Finkel TH, Kappler J. T-cell repertoire and thymus. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:105-10. PMID: 2639749.
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    204. Chien MM, Cambier JC. Measurement of phosphoinositide hydrolysis in isolated cell membrane preparations. Methods Enzymol. 1989; 168:338-47. PMID: 2542728.
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    205. Cambier J. Lymphocyte subsets and activation. Curr Opin Immunol. 1988 Dec; 1(2):220-7. PMID: 2978539.
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    206. Caldwell KK, Newell MK, Cambier JC, Prasad KN, Masserano JM, Schlegel W, Cooper DM. Evaluation of methods for the isolation of plasma membranes displaying guanosine 5'-triphosphate-dependence for the regulation of adenylate cyclase activity: potential application to the study of other guanosine 5'-triphosphate-dependent transduction systems. Anal Biochem. 1988 Nov 15; 175(1):177-90. PMID: 3245566.
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    207. Cambier J, Chen ZZ, Pasternak J, Ransom J, Sandoval V, Pickles H. Ligand-induced desensitization of B-cell membrane immunoglobulin-mediated Ca2+ mobilization and protein kinase C translocation. Proc Natl Acad Sci U S A. 1988 Sep; 85(17):6493-7. PMID: 3045817; PMCID: PMC281999.
    208. Ransom JT, Chen M, Sandoval VM, Pasternak JA, Digiusto D, Cambier JC. Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis. J Immunol. 1988 May 01; 140(9):3150-5. PMID: 2834453.
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    209. Cambier JC, Julius MH. Early changes in quiescent B cell physiology subsequent to cognate and bystander interaction with helper T cells. Scand J Immunol. 1988 Jan; 27(1):59-71. PMID: 2963373.
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    210. Ransom JT, Cambier JC. The dynamics and relationship of K+ efflux and Ca++ influx in B lymphocytes after antigen-receptor cross-linking. Soc Gen Physiol Ser. 1988; 43:241-51. PMID: 3269025.
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    211. Finkel TH, McDuffie M, Kappler JW, Marrack P, Cambier JC. Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature. 1987 Nov 12-18; 330(6144):179-81. PMID: 3499573.
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    212. Harris LK, Cambier JC. B lymphocyte activation. Transmembrane signal transduction by membrane immunoglobulin in isolated cell membranes. J Immunol. 1987 Aug 01; 139(3):963-70. PMID: 3036948.
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    213. Cambier JC, Newell MK, Justement LB, McGuire JC, Leach KL, Chen ZZ. Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature. 1987 Jun 18-24; 327(6123):629-32. PMID: 3037375.
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    214. Chen ZZ, McGuire JC, Leach KL, Cambier JC. Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction. J Immunol. 1987 Apr 01; 138(7):2345-52. PMID: 3494063.
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    215. Cambier JC, Justement LB, Newell MK, Chen ZZ, Harris LK, Sandoval VM, Klemsz MJ, Ransom JT. Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation. Immunol Rev. 1987 Feb; 95:37-57. PMID: 2437013.
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    216. Julius MH, Paige CJ, Leanderson T, Cambier JC. Neither interleukin 2 nor gamma interferon directly promote growth or differentiation of mouse B cells. Scand J Immunol. 1987 Feb; 25(2):195-202. PMID: 3103206.
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    217. Ransom JT, DiGiusto DL, Cambier J. Flow cytometric analysis of intracellular calcium mobilization. Methods Enzymol. 1987; 141:53-63. PMID: 3496517.
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    218. Cambier JC, Ransom JT, Harris LK, Coggeshall KM, Chen ZZ, Newell MK, Justement LB. Coupling of B cell surface Ig, Ia and BSF1 receptors to intracellular "second messengers". Adv Exp Med Biol. 1987; 213:195-205. PMID: 2820209.
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    219. Cambier JC, Ransom JT. Molecular mechanisms of transmembrane signaling in B lymphocytes. Annu Rev Immunol. 1987; 5:175-99. PMID: 2439102.
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    220. Cambier JC, Chen ZZ, Ransom JT, Coggeshall KM, Klemsz MJ, Harris LK, Sandoval VM, Newell MK. Differential transmembrane signaling in B lymphocyte activation. Ann N Y Acad Sci. 1987; 494:52-64. PMID: 3037967.
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    221. Justement L, Chen Z, Harris L, Ransom J, Sandoval V, Smith C, Rennick D, Roehm N, Cambier J. BSF1 induces membrane protein phosphorylation but not phosphoinositide metabolism, Ca2+ mobilization, protein kinase C translocation, or membrane depolarization in resting murine B lymphocytes. J Immunol. 1986 Dec 01; 137(11):3664-70. PMID: 3023486.
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    222. Ransom JT, Harris LK, Cambier JC. Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes. J Immunol. 1986 Jul 15; 137(2):708-14. PMID: 3014002.
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    223. Cambier JC, Heusser CH, Julius MH. Abortive activation of B lymphocytes by monoclonal anti-immunoglobulin antibodies. J Immunol. 1986 May 01; 136(9):3140-6. PMID: 3485681.
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    224. Carotenuto P, Pontesilli O, Cambier JC, Hayward AR. Desferoxamine blocks IL 2 receptor expression on human T lymphocytes. J Immunol. 1986 Apr 01; 136(7):2342-7. PMID: 3005409.
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    225. Chen ZZ, Coggeshall KM, Cambier JC. Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J Immunol. 1986 Mar 15; 136(6):2300-4. PMID: 3005408.
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    226. Leclercq L, Cambier JC, Mishal Z, Julius MH, Theze J. Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis, and progression through cell cycle. J Immunol. 1986 Jan; 136(2):539-45. PMID: 2416811.
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    227. Ransom JT, Cambier JC. B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression. J Immunol. 1986 Jan; 136(1):66-72. PMID: 3079612.
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    228. Ransom JT, DiGiusto DL, Cambier JC. Single cell analysis of calcium mobilization in anti-immunoglobulin-stimulated B lymphocytes. J Immunol. 1986 Jan; 136(1):54-7. PMID: 2415629.
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    229. Jakoi ER, Cambier J, Saslow S. Transepithelial transport of maternal antibody: purification of IgG receptor from newborn rat intestine. J Immunol. 1985 Nov; 135(5):3360-4. PMID: 2931482.
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    230. Butler JE, Cambier JC, Klobasa F. Identification and characterization of a hapten-modifiable TEPC 15 cross-reactive idiotype in swine. Mol Immunol. 1985 Oct; 22(10):1159-68. PMID: 2417108.
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    231. Cambier JC, Monroe JG, Mark Coggeshall K, Ransom JT. The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin. Immunol Today. 1985 Jul; 6(7):218-22. PMID: 25290184.
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    232. Monroe JG, Cambier JC, Mody EA, Pisetsky DS. Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. Clin Immunol Immunopathol. 1985 Jan; 34(1):124-9. PMID: 3871181.
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    233. Coggeshall KM, Cambier JC. B cell activation. VI. Effects of exogenous diglyceride and modulators of phospholipid metabolism suggest a central role for diacylglycerol generation in transmembrane signaling by mIg. J Immunol. 1985 Jan; 134(1):101-7. PMID: 2981089.
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    234. Coggeshall KM, Cambier JC. B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis. J Immunol. 1984 Dec; 133(6):3382-6. PMID: 6092473.
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    235. Roehm NW, Leibson HJ, Zlotnik A, Kappler J, Marrack P, Cambier JC. Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med. 1984 Sep 01; 160(3):679-94. PMID: 6432933; PMCID: PMC2187406.
    236. Roehm N, Herron L, Cambier J, DiGuisto D, Haskins K, Kappler J, Marrack P. The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells. Cell. 1984 Sep; 38(2):577-84. PMID: 6331891.
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    237. Cambier JC, Monroe JG. B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies. J Immunol. 1984 Aug; 133(2):576-81. PMID: 6610706.
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    238. Havran WL, DiGiusto DL, Cambier JC. mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10-fold on most splenic B cells. J Immunol. 1984 Apr; 132(4):1712-6. PMID: 6421926.
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    239. Monroe JG, Niedel JE, Cambier JC. B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. J Immunol. 1984 Mar; 132(3):1472-8. PMID: 6229582.
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    240. Monroe JG, Cambier JC. B cell activation. II. Receptor cross-linking by thymus-independent and thymus-dependent antigens induces a rapid decrease in the plasma membrane potential of antigen-binding B lymphocytes. J Immunol. 1983 Dec; 131(6):2641-4. PMID: 6196393.
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    241. Monroe JG, Cambier JC. B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled. J Exp Med. 1983 Nov 01; 158(5):1589-99. PMID: 6415207; PMCID: PMC2187138.
    242. Monroe JG, Cambier JC. Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle. J Immunol Methods. 1983 Sep 30; 63(1):45-56. PMID: 6604756.
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    243. Monroe JG, Cambier JC. B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes. J Exp Med. 1983 Jun 01; 157(6):2073-86. PMID: 6602204; PMCID: PMC2187028.
    244. Elkins K, Cambier JC. Constitutive production of a factor supporting B lymphocyte differentiation by a T cell hybridoma. J Immunol. 1983 Mar; 130(3):1247-51. PMID: 6337214.
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    245. Monroe JG, Havran WL, Cambier JC. B lymphocyte activation: entry into cell cycle is accompanied by decreased expression of IgD but not IgM. Eur J Immunol. 1983 Mar; 13(3):208-13. PMID: 6601015.
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    246. Monroe JG, Cambier JC. Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. J Immunol. 1983 Feb; 130(2):626-31. PMID: 6600247.
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    247. Cambier JC, Monroe JG. Flow cytometry as an analytic and preparative tool for studies of neuroendocrine function. Methods Enzymol. 1983; 103:227-45. PMID: 6199646.
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    248. Elkins K, Cambier J. Nonspecific lymphokines derived from monoclonal T cell lines in primary B cell immune responses. Lymphokine Res. 1983; 2(4):119-25. PMID: 6332247.
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    249. Cambier JC, Monroe JG, Neale MJ. Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells. J Exp Med. 1982 Dec 01; 156(6):1635-49. PMID: 6184434; PMCID: PMC2186872.
    250. Monroe JG, Havran WL, Cambier JC. Enrichment of viable lymphocytes in defined cycle phases by sorting on the basis of pulse width of axial light extinction. Cytometry. 1982 Jul; 3(1):24-7. PMID: 6180872.
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    251. Cambier JC, Neale MJ. Isolated phosphorylcholine binding lymphocytes. I. Use of a cleavable crosslinking reagent for solid-phase adsorbent isolation of functional antigen binding cells. J Immunol Methods. 1982 Jun 11; 51(2):209-21. PMID: 6809832.
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    252. Monroe JG, Cambier JC. Cell cycle dependence for expression of membrane associated IgD, IgM and Ia antigen on mitogen-stimulated murine B-lymphocytes. Ann N Y Acad Sci. 1982; 399:238-54. PMID: 6984607.
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    253. Cambier JC, Havran WL, Fernández de Albornoz T, Corley RB. Identification of a brain theta-positive, secretory cell from hematopoietic tissues. J Immunol. 1981 Oct; 127(4):1685-91. PMID: 7196931.
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    254. Cambier JC, Corley RB. The effect of second signals on the induction of B cell tolerance: failure of helper T cells to block tolerance induction. Eur J Immunol. 1981 Jul; 11(7):550-6. PMID: 6169534.
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    255. Cambier JC, Neale MJ. Induction of clonally restricted thymus-dependent antibody responses in vitro using phosphorylcholine derivatized sheep erythrocytes. J Immunol Methods. 1980; 38(3-4):231-8. PMID: 7003017.
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    256. Kettman JR, Cambier JC, Uhr JW, Ligler F, Vitetta ES. The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells. Immunol Rev. 1979; 43:69-95. PMID: 83290.
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    257. Ligler FS, Cambier JC, Vitetta ES, Kettman JR, Uhr JW. Inactivation of antigen-responsive clones with antisera specific for IgM or IgD. J Immunol. 1978 Apr; 120(4):1139-42. PMID: 305934.
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    258. Cambier JC, Ligler FS, Uhr JW, Kettman JR, Vitetta ES. Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD. Proc Natl Acad Sci U S A. 1978 Jan; 75(1):432-5. PMID: 305047; PMCID: PMC411263.
    259. Vitetta ES, Cambier JC, Ligler FS, Kettman JR, Uhr JW. B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells. J Exp Med. 1977 Dec 01; 146(6):1804-8. PMID: 303688; PMCID: PMC2181918.
    260. Cambier JC, Uhr JW, Kettman JR, Vitetta ES. B cell tolerance. I. Analysis of hapten-specific unresponsiveness induced in vitro in adult and neonatal murine spleen cell populations. J Immunol. 1977 Dec; 119(6):2054-9. PMID: 72117.
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    261. Cambier JC, Vitetta ES, Kettman JR, Wetzel GM, Uhr JW. B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells. J Exp Med. 1977 Jul 01; 146(1):107-17. PMID: 68987; PMCID: PMC2180726.
    262. Cambier JC, Vitetta ES, Uhr JW, Kettman JR. B-cell tolerance. II. Trinitrophenyl human gamma globulin-induced tolerance in adult and neonatal murine B cells responsive to thymus-dependent and independent forms of the same hapten. J Exp Med. 1977 Mar 01; 145(3):778-83. PMID: 95788; PMCID: PMC2180712.
    263. Vitetta ES, Cambier J, Forman J, Kettman JR, Yuan D, Uhr JW. Immunoglobulin receptors on murine B lymphocytes. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:185-91. PMID: 302188.
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    264. Cambier JC, Kettman JR, Vitetta ES, Uhr JW. Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance. J Exp Med. 1976 Jul 01; 144(1):293-7. PMID: 1084409; PMCID: PMC2190369.
    265. Cambier JC, Butler JE. Two immunochemically and physicochemically distinct secretory components from rat exocrine secretion. J Immunol. 1976 Apr; 116(4):994-9. PMID: 815439.
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