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Thomas Blumenthal

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/492-7533
ORCID ORCID Icon0000-0002-9411-0424 Additional info
    Other Positions
    TitleProfessor
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-BioChem&Molecular Genetics


    Collapse Research 
    Collapse research activities and funding
    T32GM007227     (BLUMENTHAL, THOMAS)Jul 1, 1975 - Jun 30, 1996
    NIH/NIGMS
    TRAINING IN MOLECULAR AND CELLULAR BIOLOGY
    Role: Principal Investigator

    R01GM030870     (BLUMENTHAL, THOMAS)Sep 1, 1982 - Aug 31, 1997
    NIH/NIGMS
    REGULATION OF C ELEGANS VITELLOGENIN GENES
    Role: Principal Investigator

    S15GM041200     (BLUMENTHAL, THOMAS)Jun 1, 1988 - May 31, 1989
    NIH/NIGMS
    SEQUENCE ANALYSIS COMPUTER SYSTEM
    Role: Principal Investigator

    R56GM042432     (BLUMENTHAL, THOMAS)May 1, 1992 - Jun 30, 2008
    NIH/NIGMS
    Trans-splicing in C. Elegans
    Role: Principal Investigator

    R01GM042432     (BLUMENTHAL, THOMAS)May 1, 1992 - Aug 31, 2013
    NIH/NIGMS
    Trans-splicing in C. Elegans
    Role: Principal Investigator

    R13RR010706     (BLUMENTHAL, THOMAS)Jun 1, 1995 - May 31, 1998
    NIH/NCRR
    INTERNATIONAL C ELEGANS MEETING
    Role: Principal Investigator

    R01GM059027     (BLUMENTHAL, THOMAS)Mar 1, 2000 - Feb 29, 2004
    NIH/NIGMS
    U2AF AND SPLICE SITE RECOGNITION IN C ELEGANS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Itani OA, Flibotte S, Dumas KJ, Guo C, Blumenthal T, Hu PJ. N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo. G3 (Bethesda). 2016 Jun 01; 6(6):1751-6. PMID: 27172199; PMCID: PMC4889670.
    2. Garrido-Lecca A, Saldi T, Blumenthal T. Localization of RNAPII and 3' end formation factor CstF subunits on C. elegans genes and operons. Transcription. 2016 May 26; 7(3):96-110. PMID: 27124504; PMCID: PMC4984680 [Available on 04/28/17].
    3. Blumenthal T, Davis P, Garrido-Lecca A. Operon and non-operon gene clusters in the C. elegans genome. WormBook. 2015 Apr 28; 1-20. PMID: 25936768; PMCID: PMC4781206.
    4. Saldi TK, Ash PE, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD. TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. EMBO J. 2014 Dec 17; 33(24):2947-66. PMID: 25391662; PMCID: PMC4282642.
    5. Saito TL, Hashimoto S, Gu SG, Morton JJ, Stadler M, Blumenthal T, Fire A, Morishita S. The transcription start site landscape of C. elegans. Genome Res. 2013 Aug; 23(8):1348-61. PMID: 23636945; PMCID: PMC3730108.
    6. Blumenthal T. Trans-splicing and operons in C. elegans. WormBook. 2012 Nov 20; 1-11. PMID: 23175478.
      View in: PubMed
    7. Blumenthal T. Split genes: another surprise from Giardia. Curr Biol. 2011 Feb 22; 21(4):R162-3. PMID: 21334298.
      View in: PubMed
    8. Lasda EL, Kuersten S, Blumenthal T. SL trans-splicing in a Caenorhabditis elegans in vitro extract. Cold Spring Harb Protoc. 2011 Feb 01; 2011(2):pdb.prot5574. PMID: 21285274; PMCID: PMC3137266.
    9. Lasda EL, Blumenthal T. Trans-splicing. Wiley Interdiscip Rev RNA. 2011 May-Jun; 2(3):417-34. PMID: 21957027.
      View in: PubMed
    10. Morton JJ, Blumenthal T. RNA processing in C. elegans. Methods Cell Biol. 2011; 106:187-217. PMID: 22118278.
      View in: PubMed
    11. Allen MA, Hillier LW, Waterston RH, Blumenthal T. A global analysis of C. elegans trans-splicing. Genome Res. 2011 Feb; 21(2):255-64. PMID: 21177958; PMCID: PMC3032929.
    12. Morton JJ, Blumenthal T. Identification of transcription start sites of trans-spliced genes: uncovering unusual operon arrangements. RNA. 2011 Feb; 17(2):327-37. PMID: 21156961; PMCID: PMC3022281.
    13. Lasda EL, Allen MA, Blumenthal T. Polycistronic pre-mRNA processing in vitro: snRNP and pre-mRNA role reversal in trans-splicing. Genes Dev. 2010 Aug 01; 24(15):1645-58. PMID: 20624853; PMCID: PMC2912562.
    14. Garrido-Lecca A, Blumenthal T. RNA polymerase II C-terminal domain phosphorylation patterns in Caenorhabditis elegans operons, polycistronic gene clusters with only one promoter. Mol Cell Biol. 2010 Aug; 30(15):3887-93. PMID: 20498277; PMCID: PMC2916409.
    15. Rowley JD, Blumenthal T. Medicine. The cart before the horse. Science. 2008 Sep 05; 321(5894):1302-4. PMID: 18772424.
      View in: PubMed
    16. Graber JH, Salisbury J, Hutchins LN, Blumenthal T. C. elegans sequences that control trans-splicing and operon pre-mRNA processing. RNA. 2007 Sep; 13(9):1409-26. PMID: 17630324; PMCID: PMC1950753.
    17. Saldi T, Wilusz C, MacMorris M, Blumenthal T. Functional redundancy of worm spliceosomal proteins U1A and U2B''. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9753-7. PMID: 17535930; PMCID: PMC1887542.
    18. MacMorris M, Kumar M, Lasda E, Larsen A, Kraemer B, Blumenthal T. A novel family of C. elegans snRNPs contains proteins associated with trans-splicing. RNA. 2007 Apr; 13(4):511-20. PMID: 17283210; PMCID: PMC1831854.
    19. Blumenthal T. Trans-splicing and operons. WormBook. 2005 Jun 25; 1-9. PMID: 18050426.
      View in: PubMed
    20. Hollins C, Zorio DA, MacMorris M, Blumenthal T. U2AF binding selects for the high conservation of the C. elegans 3' splice site. RNA. 2005 Mar; 11(3):248-53. PMID: 15661845; PMCID: PMC1370714.
    21. Blumenthal T. Operons in eukaryotes. Brief Funct Genomic Proteomic. 2004 Nov; 3(3):199-211. PMID: 15642184.
      View in: PubMed
    22. Zhao R, Shen J, Green MR, MacMorris M, Blumenthal T. Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export. Structure. 2004 Aug; 12(8):1373-81. PMID: 15296731.
      View in: PubMed
    23. Stein LD, Bao Z, Blasiar D, Blumenthal T, Brent MR, Chen N, Chinwalla A, Clarke L, Clee C, Coghlan A, Coulson A, D'Eustachio P, Fitch DH, Fulton LA, Fulton RE, Griffiths-Jones S, Harris TW, Hillier LW, Kamath R, Kuwabara PE, Mardis ER, Marra MA, Miner TL, Minx P, Mullikin JC, Plumb RW, Rogers J, Schein JE, Sohrmann M, Spieth J, Stajich JE, Wei C, Willey D, Wilson RK, Durbin R, Waterston RH. The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol. 2003 Nov; 1(2):E45. PMID: 14624247; PMCID: PMC261899.
    24. MacMorris M, Brocker C, Blumenthal T. UAP56 levels affect viability and mRNA export in Caenorhabditis elegans. RNA. 2003 Jul; 9(7):847-57. PMID: 12810918; PMCID: PMC1370451.
    25. Liu Y, Kuersten S, Huang T, Larsen A, MacMorris M, Blumenthal T. An uncapped RNA suggests a model for Caenorhabditis elegans polycistronic pre-mRNA processing. RNA. 2003 Jun; 9(6):677-87. PMID: 12756326; PMCID: PMC1370435.
    26. Lercher MJ, Blumenthal T, Hurst LD. Coexpression of neighboring genes in Caenorhabditis elegans is mostly due to operons and duplicate genes. Genome Res. 2003 Feb; 13(2):238-43. PMID: 12566401; PMCID: PMC420373.
    27. Blumenthal T, Gleason KS. Caenorhabditis elegans operons: form and function. Nat Rev Genet. 2003 Feb; 4(2):112-20. PMID: 12560808.
      View in: PubMed
    28. Blumenthal T, Evans D, Link CD, Guffanti A, Lawson D, Thierry-Mieg J, Thierry-Mieg D, Chiu WL, Duke K, Kiraly M, Kim SK. A global analysis of Caenorhabditis elegans operons. Nature. 2002 Jun 20; 417(6891):851-4. PMID: 12075352.
      View in: PubMed
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