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Andrew Paul Fontenot

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionClinical Immunology


    Collapse Research 
    Collapse research activities and funding
    K08HL003982     (FONTENOT, ANDREW P)Jul 1, 1998 - Jun 30, 2003
    NIH
    PATHOGENIC T CELLS IN BERYLLIUM-INDUCED LUNG DISEASE
    Role: Principal Investigator
    R01HL062410     (FONTENOT, ANDREW P.)Jul 15, 1998 - Jan 31, 2019
    NIH
    Pathogenic T cells in chronic beryllium disease
    Role: Principal Investigator
    R21HL077591     (FONTENOT, ANDREW P)Sep 1, 2004 - Jun 30, 2007
    NIH
    Identifying T cell ligands in sarcoidosis
    Role: Principal Investigator
    R01HL092997     (FONTENOT, ANDREW P.)Apr 10, 2009 - Aug 11, 2009
    NIH
    T Cells in Beryllium Sensitization and Disease
    Role: Principal Investigator
    U01HL098996     (FONTENOT, ANDREW P.)Sep 23, 2009 - Jul 31, 2015
    NIH
    Alterations in Lung Microbiome in Acute and Chronic HIV infection
    Role: Principal Investigator
    K24HL102245     (FONTENOT, ANDREW P.)Apr 1, 2010 - Dec 31, 2020
    NIH
    Patient-Oriented Research in Immunologic Lung Disease.
    Role: Principal Investigator
    R21HL111760     (FONTENOT, ANDREW P.)Jan 1, 2012 - Dec 31, 2014
    NIH
    Development of an HLA-DP2 Transgenic Murine Model of Chronic Beryllium Disease
    Role: Principal Investigator
    U01HL121816     (FONTENOT, ANDREW P.)Sep 26, 2013 - Jul 31, 2019
    NIH
    Interactions of smoking, PD-1 and IL-10 in HIV-associated lung disease
    Role: Principal Investigator
    R01ES025534     (FONTENOT, ANDREW P.)Jan 1, 2016 - Dec 31, 2020
    NIH
    Interactions between antigen-specific effector and regulatory T cells in beryllium-induced disease
    Role: Principal Investigator
    R01HL136137     (FONTENOT, ANDREW P.)Jul 5, 2017 - Jun 30, 2025
    NIH
    T cell Epitope Discovery in Sarcoidosis
    Role: Principal Investigator
    R01HL152756     (FONTENOT, ANDREW P.)Apr 1, 2020 - Mar 31, 2024
    NIH
    Role of Chemokines in Innate and Adaptive Immunity in the Lung
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Atif SM, Fontenot AP. T Follicular Helper-like Cells in Sarcoidosis: Lending a Helping Hand. Am J Respir Crit Care Med. 2021 Oct 28. PMID: 34710337.
      View in: PubMed
    2. Greaves SA, Ravindran A, Santos RG, Chen L, Falta MT, Wang Y, Mitchell AM, Atif SM, Mack DG, Tinega AN, Maier LA, Dai S, Pinilla C, Grunewald J, Fontenot AP. CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope. J Exp Med. 2021 10 04; 218(10). PMID: 34410304.
      View in: PubMed
    3. Liao SY, Atif SM, Mould K, Konigsberg IR, Fu R, Davidson E, Li L, Fontenot AP, Maier LA, Yang IV. Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases. Eur Respir J. 2021 06; 57(6). PMID: 33602861.
      View in: PubMed
    4. Falta MT, Crawford JC, Tinega AN, Landry LG, Crawford F, Mack DG, Martin AK, Atif SM, Li L, Santos RG, Nakayama M, Kappler JW, Maier LA, Thomas PG, Pinilla C, Fontenot AP. Beryllium-specific CD4+ T cells induced by chemokine neoantigens perpetuate inflammation. J Clin Invest. 2021 05 03; 131(9). PMID: 33630763.
      View in: PubMed
    5. Shotland AM, Fontenot AP, McKee AS. Pulmonary Macrophage Cell Death in Lung Health and Disease. Am J Respir Cell Mol Biol. 2021 05; 64(5):547-556. PMID: 33332993.
      View in: PubMed
    6. Neff CP, Atif SM, Logue EC, Siebert J, Görg C, Lavelle J, Fiorillo S, Twigg H, Campbell TB, Fontenot AP, Palmer BE. HIV Infection Is Associated with Loss of Anti-Inflammatory Alveolar Macrophages. J Immunol. 2020 11 01; 205(9):2447-2455. PMID: 32929038.
      View in: PubMed
    7. Collins MK, Shotland AM, Wade MF, Atif SM, Richards DK, Torres-Llompart M, Mack DG, Martin AK, Fontenot AP, McKee AS. A role for TNF-a in alveolar macrophage damage-associated molecular pattern release. JCI Insight. 2020 05 07; 5(9). PMID: 32255768.
      View in: PubMed
    8. Armstrong AJS, Shaffer M, Nusbacher NM, Griesmer C, Fiorillo S, Schneider JM, Neff CP, Li SX, Fontenot AP, Campbell T, Palmer BE, Lozupone CA. Correction to: An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men. Microbiome. 2020 04 06; 8(1):50. PMID: 32252810.
      View in: PubMed
    9. Greaves SA, Atif SM, Fontenot AP. Adaptive Immunity in Pulmonary Sarcoidosis and Chronic Beryllium Disease. Front Immunol. 2020; 11:474. PMID: 32256501.
      View in: PubMed
    10. Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB. Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension. J Am Heart Assoc. 2019 08 06; 8(15):e013111. PMID: 31339057.
      View in: PubMed
    11. Atif SM, Mack DG, McKee AS, Rangel-Moreno J, Martin AK, Getahun A, Maier LA, Cambier JC, Tuder R, Fontenot AP. Protective role of B cells in sterile particulate-induced lung injury. JCI Insight. 2019 05 16; 5. PMID: 31094704.
      View in: PubMed
    12. Anderson K, Carey B, Martin A, Roark C, Chalk C, Nowell-Bostic M, Freed B, Aubrey M, Trapnell B, Fontenot A. Pulmonary alveolar proteinosis: An autoimmune disease lacking an HLA association. PLoS One. 2019; 14(3):e0213179. PMID: 30845238.
      View in: PubMed
    13. Logue EC, Neff CP, Mack DG, Martin AK, Fiorillo S, Lavelle J, Vandivier RW, Campbell TB, Palmer BE, Fontenot AP. Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers. J Immunol. 2019 03 01; 202(5):1363-1372. PMID: 30665939.
      View in: PubMed
    14. Armstrong AJS, Shaffer M, Nusbacher NM, Griesmer C, Fiorillo S, Schneider JM, Preston Neff C, Li SX, Fontenot AP, Campbell T, Palmer BE, Lozupone CA. An exploration of Prevotella-rich microbiomes in HIV and men who have sex with men. Microbiome. 2018 11 05; 6(1):198. PMID: 30396369.
      View in: PubMed
    15. Wade MF, Collins MK, Richards D, Mack DG, Martin AK, Dinarello CA, Fontenot AP, McKee AS. TLR9 and IL-1R1 Promote Mobilization of Pulmonary Dendritic Cells during Beryllium Sensitization. J Immunol. 2018 10 15; 201(8):2232-2243. PMID: 30185516.
      View in: PubMed
    16. Fontenot AP. Immunologic Effects of Beryllium Exposure. Ann Am Thorac Soc. 2018 04; 15(Suppl 2):S81-S85. PMID: 29676647.
      View in: PubMed
    17. Moller DR, Rybicki BA, Hamzeh NY, Montgomery CG, Chen ES, Drake W, Fontenot AP. Genetic, Immunologic, and Environmental Basis of Sarcoidosis. Ann Am Thorac Soc. 2017 Dec; 14(Supplement_6):S429-S436. PMID: 29073364.
      View in: PubMed
    18. Mitchell AM, Kaiser Y, Falta MT, Munson DJ, Landry LG, Eklund A, Nakayama M, Slansky JE, Grunewald J, Fontenot AP. Shared aß TCR Usage in Lungs of Sarcoidosis Patients with Löfgren's Syndrome. J Immunol. 2017 10 01; 199(7):2279-2290. PMID: 28827283.
      View in: PubMed
    19. Presti RM, Flores SC, Palmer BE, Atkinson JJ, Lesko CR, Lau B, Fontenot AP, Roman J, McDyer JF, Twigg HL. Mechanisms Underlying HIV-Associated Noninfectious Lung Disease. Chest. 2017 11; 152(5):1053-1060. PMID: 28427967.
      View in: PubMed
    20. Munson DJ, Egelston CA, Chiotti KE, Parra ZE, Bruno TC, Moore BL, Nakano TA, Simons DL, Jimenez G, Yim JH, Rozanov DV, Falta MT, Fontenot AP, Reynolds PR, Leach SM, Borges VF, Kappler JW, Spellman PT, Lee PP, Slansky JE. Identification of shared TCR sequences from T cells in human breast cancer using emulsion RT-PCR. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8272-7. PMID: 27307436.
      View in: PubMed
    21. McKee AS, Fontenot AP. Interplay of innate and adaptive immunity in metal-induced hypersensitivity. Curr Opin Immunol. 2016 10; 42:25-30. PMID: 27228132.
      View in: PubMed
    22. Cribbs SK, Fontenot AP. The Impact of Antiretroviral Therapy on Lung Immunology. Semin Respir Crit Care Med. 2016 Apr; 37(2):157-65. PMID: 26974295.
      View in: PubMed
    23. Fontenot AP, Falta MT, Kappler JW, Dai S, McKee AS. Beryllium-Induced Hypersensitivity: Genetic Susceptibility and Neoantigen Generation. J Immunol. 2016 Jan 01; 196(1):22-7. PMID: 26685315.
      View in: PubMed
    24. Beck JM, Schloss PD, Venkataraman A, Twigg H, Jablonski KA, Bushman FD, Campbell TB, Charlson ES, Collman RG, Crothers K, Curtis JL, Drews KL, Flores SC, Fontenot AP, Foulkes MA, Frank I, Ghedin E, Huang L, Lynch SV, Morris A, Palmer BE, Schmidt TM, Sodergren E, Weinstock GM, Young VB. Multicenter Comparison of Lung and Oral Microbiomes of HIV-infected and HIV-uninfected Individuals. Am J Respir Crit Care Med. 2015 Dec 01; 192(11):1335-44. PMID: 26247840.
      View in: PubMed
    25. Falta MT, Tinega AN, Mack DG, Bowerman NA, Crawford F, Kappler JW, Pinilla C, Fontenot AP. Metal-specific CD4+ T-cell responses induced by beryllium exposure in HLA-DP2 transgenic mice. Mucosal Immunol. 2016 Jan; 9(1):218-28. PMID: 26129650.
      View in: PubMed
    26. McKee AS, Mack DG, Crawford F, Fontenot AP. MyD88 dependence of beryllium-induced dendritic cell trafficking and CD4? T-cell priming. Mucosal Immunol. 2015 Nov; 8(6):1237-47. PMID: 25760420.
      View in: PubMed
    27. Neff CP, Chain JL, MaWhinney S, Martin AK, Linderman DJ, Flores SC, Campbell TB, Palmer BE, Fontenot AP. Lymphocytic alveolitis is associated with the accumulation of functionally impaired HIV-specific T cells in the lung of antiretroviral therapy-naive subjects. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):464-73. PMID: 25536276.
      View in: PubMed
    28. Balmes JR, Abraham JL, Dweik RA, Fireman E, Fontenot AP, Maier LA, Muller-Quernheim J, Ostiguy G, Pepper LD, Saltini C, Schuler CR, Takaro TK, Wambach PF. An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med. 2014 Nov 15; 190(10):e34-59. PMID: 25398119.
      View in: PubMed
    29. Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell. 2014 Jul 03; 158(1):132-42. PMID: 24995984.
      View in: PubMed
    30. Lozupone CA, Rhodes ME, Neff CP, Fontenot AP, Campbell TB, Palmer BE. HIV-induced alteration in gut microbiota: driving factors, consequences, and effects of antiretroviral therapy. Gut Microbes. 2014 Jul 01; 5(4):562-70. PMID: 25078714.
      View in: PubMed
    31. Mack DG, Falta MT, McKee AS, Martin AK, Simonian PL, Crawford F, Gordon T, Mercer RR, Hoover MD, Marrack P, Kappler JW, Tuder RM, Fontenot AP. Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8553-8. PMID: 24912188.
      View in: PubMed
    32. Bowerman NA, Falta MT, Mack DG, Wehrmann F, Crawford F, Mroz MM, Maier LA, Kappler JW, Fontenot AP. Identification of multiple public TCR repertoires in chronic beryllium disease. J Immunol. 2014 May 15; 192(10):4571-80. PMID: 24719461.
      View in: PubMed
    33. Fontenot AP, Peebles RS. Allergy and hypersensitivity. Curr Opin Immunol. 2013 Dec; 25(6):736-7. PMID: 24183163.
      View in: PubMed
    34. Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, Knight R, Fontenot AP, Palmer BE. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013 Sep 11; 14(3):329-39. PMID: 24034618.
      View in: PubMed
    35. Dai S, Falta MT, Bowerman NA, McKee AS, Fontenot AP. T cell recognition of beryllium. Curr Opin Immunol. 2013 Dec; 25(6):775-80. PMID: 23978481.
      View in: PubMed
    36. Chain JL, Martin AK, Mack DG, Maier LA, Palmer BE, Fontenot AP. Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation. J Immunol. 2013 Aug 15; 191(4):1648-56. PMID: 23851684.
      View in: PubMed
    37. Twigg HL, Morris A, Ghedin E, Curtis JL, Huffnagle GB, Crothers K, Campbell TB, Flores SC, Fontenot AP, Beck JM, Huang L, Lynch S, Knox KS, Weinstock G. Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med. 2013 Jul; 1(5):354-6. PMID: 24429191.
      View in: PubMed
    38. Falta MT, Pinilla C, Mack DG, Tinega AN, Crawford F, Giulianotti M, Santos R, Clayton GM, Wang Y, Zhang X, Maier LA, Marrack P, Kappler JW, Fontenot AP. Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease. J Exp Med. 2013 Jul 01; 210(7):1403-18. PMID: 23797096.
      View in: PubMed
    39. Morris A, Beck JM, Schloss PD, Campbell TB, Crothers K, Curtis JL, Flores SC, Fontenot AP, Ghedin E, Huang L, Jablonski K, Kleerup E, Lynch SV, Sodergren E, Twigg H, Young VB, Bassis CM, Venkataraman A, Schmidt TM, Weinstock GM. Comparison of the respiratory microbiome in healthy nonsmokers and smokers. Am J Respir Crit Care Med. 2013 May 15; 187(10):1067-75. PMID: 23491408.
      View in: PubMed
    40. Lozupone C, Cota-Gomez A, Palmer BE, Linderman DJ, Charlson ES, Sodergren E, Mitreva M, Abubucker S, Martin J, Yao G, Campbell TB, Flores SC, Ackerman G, Stombaugh J, Ursell L, Beck JM, Curtis JL, Young VB, Lynch SV, Huang L, Weinstock GM, Knox KS, Twigg H, Morris A, Ghedin E, Bushman FD, Collman RG, Knight R, Fontenot AP. Widespread colonization of the lung by Tropheryma whipplei in HIV infection. Am J Respir Crit Care Med. 2013 May 15; 187(10):1110-7. PMID: 23392441.
      View in: PubMed
    41. Palmer BE, Neff CP, Lecureux J, Ehler A, Dsouza M, Remling-Mulder L, Korman AJ, Fontenot AP, Akkina R. In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice. J Immunol. 2013 Jan 01; 190(1):211-9. PMID: 23209326.
      View in: PubMed
    42. Silveira LJ, McCanlies EC, Fingerlin TE, Van Dyke MV, Mroz MM, Strand M, Fontenot AP, Bowerman N, Dabelea DM, Schuler CR, Weston A, Maier LA. Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove. J Immunol. 2012 Oct 15; 189(8):4014-23. PMID: 22972925.
      View in: PubMed
    43. Maier LA, Barkes BQ, Mroz M, Rossman MD, Barnard J, Gillespie M, Martin A, Mack DG, Silveira L, Sawyer RT, Newman LS, Fontenot AP. Infliximab therapy modulates an antigen-specific immune response in chronic beryllium disease. Respir Med. 2012 Dec; 106(12):1810-3. PMID: 22974830.
      View in: PubMed
    44. Menezes CA, Sullivan AK, Falta MT, Mack DG, Freed BM, Rocha MO, Gollob KJ, Fontenot AP, Dutra WO. Highly conserved CDR3 region in circulating CD4(+)Vß5(+) T cells may be associated with cytotoxic activity in Chagas disease. Clin Exp Immunol. 2012 Aug; 169(2):109-18. PMID: 22774985.
      View in: PubMed
    45. Brindley SM, Lanham AM, Karrer FM, Tucker RM, Fontenot AP, Mack CL. Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells. Hepatology. 2012 Apr; 55(4):1130-8. PMID: 22105891.
      View in: PubMed
    46. Atamas SP, Fontenot AP. Regulatory T cells and lung fibrosis: a good cell gone bad. Am J Respir Crit Care Med. 2011 Dec 01; 184(11):1224-6. PMID: 22162882.
      View in: PubMed
    47. Martin AK, Mack DG, Falta MT, Mroz MM, Newman LS, Maier LA, Fontenot AP. Beryllium-specific CD4+ T cells in blood as a biomarker of disease progression. J Allergy Clin Immunol. 2011 Nov; 128(5):1100-6.e1-5. PMID: 21943943.
      View in: PubMed
    48. Bowerman NA, Falta MT, Mack DG, Kappler JW, Fontenot AP. Mutagenesis of beryllium-specific TCRs suggests an unusual binding topology for antigen recognition. J Immunol. 2011 Oct 01; 187(7):3694-703. PMID: 21873524.
      View in: PubMed
    49. Goldstein JI, Kominsky DJ, Jacobson N, Bowers B, Regalia K, Austin GL, Yousefi M, Falta MT, Fontenot AP, Gerich ME, Golden-Mason L, Colgan SP. Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease. Gastroenterology. 2011 Jul; 141(1):208-16. PMID: 21557945.
      View in: PubMed
    50. Hanaoka M, Nicolls MR, Fontenot AP, Kraskauskas D, Mack DG, Kratzer A, Salys J, Kraskauskiene V, Burns N, Voelkel NF, Taraseviciene-Stewart L. Immunomodulatory strategies prevent the development of autoimmune emphysema. Respir Res. 2010 Dec 16; 11:179. PMID: 21162738.
      View in: PubMed
    51. Risbano MG, Meadows CA, Coldren CD, Jenkins TJ, Edwards MG, Collier D, Huber W, Mack DG, Fontenot AP, Geraci MW, Bull TM. Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension. Clin Transl Sci. 2010 Oct; 3(5):210-8. PMID: 20973920.
      View in: PubMed
    52. Simonian PL, Wehrmann F, Roark CL, Born WK, O'Brien RL, Fontenot AP. ?d T cells protect against lung fibrosis via IL-22. J Exp Med. 2010 Sep 27; 207(10):2239-53. PMID: 20855496.
      View in: PubMed
    53. Kassu A, Marcus RA, D'Souza MB, Kelly-McKnight EA, Golden-Mason L, Akkina R, Fontenot AP, Wilson CC, Palmer BE. Regulation of virus-specific CD4+ T cell function by multiple costimulatory receptors during chronic HIV infection. J Immunol. 2010 Sep 01; 185(5):3007-18. PMID: 20656923.
      View in: PubMed
    54. Falta MT, Bowerman NA, Dai S, Kappler JW, Fontenot AP. Linking genetic susceptibility and T cell activation in beryllium-induced disease. Proc Am Thorac Soc. 2010 May; 7(2):126-9. PMID: 20427584.
      View in: PubMed
    55. Dai S, Murphy GA, Crawford F, Mack DG, Falta MT, Marrack P, Kappler JW, Fontenot AP. Crystal structure of HLA-DP2 and implications for chronic beryllium disease. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7425-30. PMID: 20356827.
      View in: PubMed
    56. Mack DG, Lanham AM, Falta MT, Palmer BE, Maier LA, Fontenot AP. Deficient and dysfunctional regulatory T cells in the lungs of chronic beryllium disease subjects. Am J Respir Crit Care Med. 2010 Jun 01; 181(11):1241-9. PMID: 20299529.
      View in: PubMed
    57. Born WK, Roark CL, Jin N, Wands JM, Kemal Aydintug M, Huang Y, Chain JL, Hahn YS, Simonian PL, Fontenot AP, O'Brien RL. Role of ?d T Cells in Lung Inflammation. Open Immunol J. 2009; 2:143-150. PMID: 26550059.
      View in: PubMed
    58. Simonian PL, Roark CL, Born WK, O'Brien RL, Fontenot AP. Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis. Transl Res. 2009 Nov; 154(5):222-7. PMID: 19840763.
      View in: PubMed
    59. Mack DG, Lanham AM, Palmer BE, Maier LA, Fontenot AP. CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung. J Immunol. 2009 Jun 01; 182(11):7317-24. PMID: 19454729.
      View in: PubMed
    60. Simonian PL, Roark CL, Wehrmann F, Lanham AM, Born WK, O'Brien RL, Fontenot AP. IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis. J Immunol. 2009 May 15; 182(10):6540-9. PMID: 19414809.
      View in: PubMed
    61. Kassu A, D'Souza M, O'Connor BP, Kelly-McKnight E, Akkina R, Fontenot AP, Palmer BE. Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production. Clin Immunol. 2009 Aug; 132(2):234-45. PMID: 19406689.
      View in: PubMed
    62. Fontenot AP, Amicosante M. Metal-induced diffuse lung disease. Semin Respir Crit Care Med. 2008 Dec; 29(6):662-9. PMID: 19221964.
      View in: PubMed
    63. Simonian PL, Roark CL, Wehrmann F, Lanham AK, Diaz del Valle F, Born WK, O'Brien RL, Fontenot AP. Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis. J Immunol. 2009 Jan 01; 182(1):657-65. PMID: 19109199.
      View in: PubMed
    64. Mack DG, Lanham AK, Palmer BE, Maier LA, Watts TH, Fontenot AP. 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. J Immunol. 2008 Sep 15; 181(6):4381-8. PMID: 18768897.
      View in: PubMed
    65. Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL. gammadelta T cells: an important source of IL-17. Curr Opin Immunol. 2008 Jun; 20(3):353-7. PMID: 18439808.
      View in: PubMed
    66. Palmer BE, Mack DG, Martin AK, Gillespie M, Mroz MM, Maier LA, Fontenot AP. Up-regulation of programmed death-1 expression on beryllium-specific CD4+ T cells in chronic beryllium disease. J Immunol. 2008 Feb 15; 180(4):2704-12. PMID: 18250483.
      View in: PubMed
    67. D'Souza M, Fontenot AP, Mack DG, Lozupone C, Dillon S, Meditz A, Wilson CC, Connick E, Palmer BE. Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J Immunol. 2007 Aug 01; 179(3):1979-87. PMID: 17641065.
      View in: PubMed
    68. Mack CL, Falta MT, Sullivan AK, Karrer F, Sokol RJ, Freed BM, Fontenot AP. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology. 2007 Jul; 133(1):278-87. PMID: 17631149.
      View in: PubMed
    69. Palmer BE, Mack DG, Martin AK, Maier LA, Fontenot AP. CD57 expression correlates with alveolitis severity in subjects with beryllium-induced disease. J Allergy Clin Immunol. 2007 Jul; 120(1):184-91. PMID: 17416406.
      View in: PubMed
    70. Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, Gill RG. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 2006 Nov; 44(5):1231-9. PMID: 17058262.
      View in: PubMed
    71. Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O'Brien RL, Fontenot AP. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J Immunol. 2006 Oct 01; 177(7):4436-43. PMID: 16982878.
      View in: PubMed
    72. Fontenot AP, Keizer TS, McCleskey M, Mack DG, Meza-Romero R, Huan J, Edwards DM, Chou YK, Vandenbark AA, Scott B, Burrows GG. Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells. J Immunol. 2006 Sep 15; 177(6):3874-83. PMID: 16951350.
      View in: PubMed
    73. Sawyer RT, Fontenot AP, Barnes TA, Parsons CE, Tooker BC, Maier LA, Gillespie MM, Gottschall EB, Silveira L, Hagman J, Newman LS. Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):191-200. PMID: 16980557.
      View in: PubMed
    74. Sullivan AK, Simonian PL, Falta MT, Cosgrove GP, Brown KK, Kotzin BL, Voelkel NF, Fontenot AP. Activated oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Proc Am Thorac Soc. 2006 Aug; 3(6):486. PMID: 16921120.
      View in: PubMed
    75. Amicosante M, Fontenot AP. T cell recognition in chronic beryllium disease. Clin Immunol. 2006 Nov; 121(2):134-43. PMID: 16697706.
      View in: PubMed
    76. Fontenot AP, Edwards DM, Chou YK, Mack DG, LaTocha D, Vandenbark AA, Burrows GG. Self-presentation of beryllium by BAL CD4+ T cells: T cell-T cell interactions and their potential role in chronic beryllium disease. Eur J Immunol. 2006 Apr; 36(4):930-9. PMID: 16552706.
      View in: PubMed
    77. Palmer BE, Blyveis N, Fontenot AP, Wilson CC. Functional and phenotypic characterization of CD57+CD4+ T cells and their association with HIV-1-induced T cell dysfunction. J Immunol. 2005 Dec 15; 175(12):8415-23. PMID: 16339584.
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    78. Bill JR, Mack DG, Falta MT, Maier LA, Sullivan AK, Joslin FG, Martin AK, Freed BM, Kotzin BL, Fontenot AP. Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain. J Immunol. 2005 Nov 15; 175(10):7029-37. PMID: 16272364.
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    79. Fontenot AP, Maier LA. Genetic susceptibility and immune-mediated destruction in beryllium-induced disease. Trends Immunol. 2005 Oct; 26(10):543-9. PMID: 16099719.
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    80. Fontenot AP, Palmer BE, Sullivan AK, Joslin FG, Wilson CC, Maier LA, Newman LS, Kotzin BL. Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response. J Clin Invest. 2005 Oct; 115(10):2886-93. PMID: 16151531.
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    81. Lynes MA, Fontenot AP, Lawrence DA, Rosenspire AJ, Pollard KM. Gene expression influences on metal immunomodulation. Toxicol Appl Pharmacol. 2006 Jan 01; 210(1-2):9-16. PMID: 15993910.
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    82. Sullivan AK, Simonian PL, Falta MT, Mitchell JD, Cosgrove GP, Brown KK, Kotzin BL, Voelkel NF, Fontenot AP. Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema. Am J Respir Crit Care Med. 2005 Sep 01; 172(5):590-6. PMID: 15937291.
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    83. Falta MT, Fontenot AP, Rosloniec EF, Crawford F, Roark CL, Bill J, Marrack P, Kappler J, Kotzin BL. Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen. Arthritis Rheum. 2005 Jun; 52(6):1885-96. PMID: 15934080.
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    84. Pott GB, Palmer BE, Sullivan AK, Silviera L, Maier LA, Newman LS, Kotzin BL, Fontenot AP. Frequency of beryllium-specific, TH1-type cytokine-expressing CD4+ T cells in patients with beryllium-induced disease. J Allergy Clin Immunol. 2005 May; 115(5):1036-42. PMID: 15867863.
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    85. Sawyer RT, Dobis DR, Goldstein M, Velsor L, Maier LA, Fontenot AP, Silveira L, Newman LS, Day BJ. Beryllium-stimulated reactive oxygen species and macrophage apoptosis. Free Radic Biol Med. 2005 Apr 01; 38(7):928-37. PMID: 15749389.
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    86. Chou YK, Edwards DM, Weinberg AD, Vandenbark AA, Kotzin BL, Fontenot AP, Burrows GG. Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis. J Immunol. 2005 Apr 01; 174(7):4316-24. PMID: 15778396.
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    87. Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M, Sullivan A, Nicolls MR, Fontenot AP, Tuder RM, Voelkel NF. An animal model of autoimmune emphysema. Am J Respir Crit Care Med. 2005 Apr 01; 171(7):734-42. PMID: 15563631.
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    88. Sawyer RT, Day BJ, Fadok VA, Chiarappa-Zucca M, Maier LA, Fontenot AP, Silveira L, Newman LS. Beryllium-ferritin: lymphocyte proliferation and macrophage apoptosis in chronic beryllium disease. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):470-7. PMID: 15256386.
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    89. Schwarz MI, Fontenot AP. Drug-induced diffuse alveolar hemorrhage syndromes and vasculitis. Clin Chest Med. 2004 Mar; 25(1):133-40. PMID: 15062605.
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    90. Sawyer RT, Parsons CE, Fontenot AP, Maier LA, Gillespie MM, Gottschall EB, Silveira L, Newman LS. Beryllium-induced tumor necrosis factor-alpha production by CD4+ T cells is mediated by HLA-DP. Am J Respir Cell Mol Biol. 2004 Jul; 31(1):122-30. PMID: 14975942.
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    91. Maier LA, McGrath DS, Sato H, Lympany P, Welsh K, Du Bois R, Silveira L, Fontenot AP, Sawyer RT, Wilcox E, Newman LS. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. J Immunol. 2003 Dec 15; 171(12):6910-8. PMID: 14662898.
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    92. Fontenot AP, Kotzin BL. Chronic beryllium disease: immune-mediated destruction with implications for organ-specific autoimmunity. Tissue Antigens. 2003 Dec; 62(6):449-58. PMID: 14617028.
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    93. Fontenot AP, Gharavi L, Bennett SR, Canavera SJ, Newman LS, Kotzin BL. CD28 costimulation independence of target organ versus circulating memory antigen-specific CD4+ T cells. J Clin Invest. 2003 Sep; 112(5):776-84. PMID: 12952926.
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    94. Fontenot AP, Canavera SJ, Gharavi L, Newman LS, Kotzin BL. Target organ localization of memory CD4(+) T cells in patients with chronic beryllium disease. J Clin Invest. 2002 Nov; 110(10):1473-82. PMID: 12438445.
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    95. Fontenot AP, Pelak VS. Development of neurologic symptoms in a 26-year-old woman following recovery from methanol intoxication. Chest. 2002 Oct; 122(4):1436-9. PMID: 12377876.
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    96. Fontenot AP, Maier LA, Canavera SJ, Hendry-Hofer TB, Boguniewicz M, Barker EA, Newman LS, Kotzin BL. Beryllium skin patch testing to analyze T cell stimulation and granulomatous inflammation in the lung. J Immunol. 2002 Apr 01; 168(7):3627-34. PMID: 11907128.
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    97. Fouty BW, Lynch DA, Fontenot AP, Schwarz MI. Hypoxemia explained 36 years later. Chest. 2001 Nov; 120(5):1739-40. PMID: 11713163.
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    98. Fontenot AP, Newman LS, Kotzin BL. Chronic beryllium disease: T cell recognition of a metal presented by HLA-DP. Clin Immunol. 2001 Jul; 100(1):4-14. PMID: 11414740.
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    99. Fontenot AP, Torres M, Marshall WH, Newman LS, Kotzin BL. Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12717-22. PMID: 11050177.
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    100. Fontenot AP, Falta MT, Freed BM, Newman LS, Kotzin BL. Identification of pathogenic T cells in patients with beryllium-induced lung disease. J Immunol. 1999 Jul 15; 163(2):1019-26. PMID: 10395700.
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    101. Fontenot AP, Kotzin BL, Comment CE, Newman LS. Expansions of T-cell subsets expressing particular T-cell receptor variable regions in chronic beryllium disease. Am J Respir Cell Mol Biol. 1998 Apr; 18(4):581-9. PMID: 9533947.
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    102. Fontenot A, Jennings C, King TE. Pulmonary opacities and glomerulonephritis in a 15-year-old boy. Chest. 1998 Feb; 113(2):525-7. PMID: 9498976.
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