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Susan D Reynolds

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio

    Collapse Research 
    Collapse research activities and funding
    R01HL075585     (REYNOLDS, SUSAN D)Jul 11, 2006 - Jun 30, 2012
    Wnt Regulation of Tracheobronchial Regeneration
    Role: Principal Investigator

    RC1HL099461     (REYNOLDS, SUSAN D)Sep 30, 2009 - Aug 31, 2012
    Cell Based Therapy for Lung Disease
    Role: Principal Investigator

    R21HL113961     (REYNOLDS, SUSAN D)Jul 1, 2013 - Jun 30, 2015
    Identification of Tracheobronchial Basal Cell-Specific Genes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ghosh M, Ahmad S, White CW, Reynolds SD. Transplantation of Airway Epithelial Stem/Progenitor Cells: A Future for Cell-Based Therapy. Am J Respir Cell Mol Biol. 2017 01; 56(1):1-10. PMID: 27632244.
      View in: PubMed
    2. Hayes D, Reynolds SD, Tumin D. Outcomes of lung transplantation for primary ciliary dyskinesia and Kartagener syndrome. J Heart Lung Transplant. 2016 Nov; 35(11):1377-1378. PMID: 27746084.
      View in: PubMed
    3. Reynolds SD, Rios C, Wesolowska-Andersen A, Zhuang Y, Pinter M, Happoldt C, Hill CL, Lallier SW, Cosgrove GP, Solomon GM, Nichols DP, Seibold MA. Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome. Am J Respir Cell Mol Biol. 2016 09; 55(3):323-36. PMID: 27144410.
      View in: PubMed
    4. Hayes D, Kopp BT, Kirkby SE, Reynolds SD, Mansour HM, Tobias JD, Tumin D. Impact of Donor Arterial Partial Pressure of Oxygen on Outcomes After Lung Transplantation in Adult Cystic Fibrosis Recipients. Lung. 2016 08; 194(4):547-53. PMID: 27272653.
      View in: PubMed
    5. Hayes D, Joy BF, Reynolds SD, Tobias JD, Tumin D. Influence of graft ischemic time and geographic distance between donor and recipient on survival in children after lung transplantation. J Heart Lung Transplant. 2016 10; 35(10):1220-1226. PMID: 27373823.
      View in: PubMed
    6. Burke MC, Li FQ, Cyge B, Arashiro T, Brechbuhl HM, Chen X, Siller SS, Weiss MA, O'Connell CB, Love D, Westlake CJ, Reynolds SD, Kuriyama R, Takemaru K. Chibby promotes ciliary vesicle formation and basal body docking during airway cell differentiation. J Cell Biol. 2014 Oct 13; 207(1):123-37. PMID: 25313408; PMCID: PMC4195830.
    7. Brechbuhl HM, Li B, Smith RW, Reynolds SD. Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15; 307(10):L800-10. PMID: 25217659; PMCID: PMC4233294.
    8. Kutten JC, McGovern D, Hobson CM, Luffy SA, Nieponice A, Tobita K, Francis RJ, Reynolds SD, Isenberg JS, Gilbert TW. Decellularized tracheal extracellular matrix supports epithelial migration, differentiation, and function. Tissue Eng Part A. 2015 Jan; 21(1-2):75-84. PMID: 24980864; PMCID: PMC4293134.
    9. Ghosh M, Ahmad S, Jian A, Li B, Smith RW, Helm KM, Seibold MA, Groshong SD, White CW, Reynolds SD. Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1127-34. PMID: 23927678; PMCID: PMC3931114.
    10. Ghosh M, Smith RW, Runkle CM, Hicks DA, Helm KM, Reynolds SD. Regulation of trachebronchial tissue-specific stem cell pool size. Stem Cells. 2013 Dec; 31(12):2767-78. PMID: 23712882; PMCID: PMC3844014.
    11. Saunders CJ, Reynolds SD, Finger TE. Chemosensory brush cells of the trachea. A stable population in a dynamic epithelium. Am J Respir Cell Mol Biol. 2013 Aug; 49(2):190-6. PMID: 23526223; PMCID: PMC3824035.
    12. Seibold MA, Smith RW, Urbanek C, Groshong SD, Cosgrove GP, Brown KK, Schwarz MI, Schwartz DA, Reynolds SD. The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS One. 2013; 8(3):e58658. PMID: 23527003; PMCID: PMC3603941.
    13. Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):94-104. PMID: 23065128; PMCID: PMC3547080.
    14. Reynolds SD, Brechbuhl HM, Smith MK, Smith RW, Ghosh M. Lung epithelial healing: a modified seed and soil concept. Proc Am Thorac Soc. 2012 May; 9(2):27-37. PMID: 22550238.
      View in: PubMed
    15. Smith MK, Koch PJ, Reynolds SD. Direct and indirect roles for ß-catenin in facultative basal progenitor cell differentiation. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L580-94. PMID: 22227204; PMCID: PMC3311526.
    16. Smith RW, Hicks DA, Reynolds SD. Roles for ß-catenin and doxycycline in the regulation of respiratory epithelial cell frequency and function. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):115-24. PMID: 21852686; PMCID: PMC3262653.
    17. Zemans RL, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, De Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, Downey GP. Neutrophil transmigration triggers repair of the lung epithelium via beta-catenin signaling. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15990-5. PMID: 21880956; PMCID: PMC3179042.
    18. Weiss DJ, Bertoncello I, Borok Z, Kim C, Panoskaltsis-Mortari A, Reynolds S, Rojas M, Stripp B, Warburton D, Prockop DJ. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc. 2011 Jun; 8(3):223-72. PMID: 21653527; PMCID: PMC3132784.
    19. Lukinskiene L, Liu Y, Reynolds SD, Steele C, Stripp BR, Leikauf GD, Kolls JK, Di YP. Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. J Immunol. 2011 Jul 01; 187(1):382-90. PMID: 21632717; PMCID: PMC3119743.
    20. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Proc Am Thorac Soc. 2011 Jun; 8(3):215-22. PMID: 21653526; PMCID: PMC3132783.
    21. Brechbuhl HM, Ghosh M, Smith MK, Smith RW, Li B, Hicks DA, Cole BB, Reynolds PR, Reynolds SD. ß-catenin dosage is a critical determinant of tracheal basal cell fate determination. Am J Pathol. 2011 Jul; 179(1):367-79. PMID: 21703416; PMCID: PMC3123883.
    22. Berry KA, Li B, Reynolds SD, Barkley RM, Gijón MA, Hankin JA, Henson PM, Murphy RC. MALDI imaging MS of phospholipids in the mouse lung. J Lipid Res. 2011 Aug; 52(8):1551-60. PMID: 21508254; PMCID: PMC3137021.
    23. Ghosh M, Brechbuhl HM, Smith RW, Li B, Hicks DA, Titchner T, Runkle CM, Reynolds SD. Context-dependent differentiation of multipotential keratin 14-expressing tracheal basal cells. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):403-10. PMID: 21131447; PMCID: PMC3175566.
    24. Ghosh M, Helm KM, Smith RW, Giordanengo MS, Li B, Shen H, Reynolds SD. A single cell functions as a tissue-specific stem cell and the in vitro niche-forming cell. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):459-69. PMID: 21131442; PMCID: PMC3175586.
    25. Cole BB, Smith RW, Jenkins KM, Graham BB, Reynolds PR, Reynolds SD. Tracheal Basal cells: a facultative progenitor cell pool. Am J Pathol. 2010 Jul; 177(1):362-76. PMID: 20522644; PMCID: PMC2893679.
    26. Reynolds SD, Malkinson AM. Clara cell: progenitor for the bronchiolar epithelium. Int J Biochem Cell Biol. 2010 Jan; 42(1):1-4. PMID: 19747565; PMCID: PMC2787899.
    27. Kinnamon SC, Reynolds SD. Cell biology. Using taste to clear the air(ways). Science. 2009 Aug 28; 325(5944):1081-2. PMID: 19713515.
      View in: PubMed
    28. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86. PMID: 19633071; PMCID: PMC2770781.
    29. Snyder JC, Reynolds SD, Hollingsworth JW, Li Z, Kaminski N, Stripp BR. Clara cells attenuate the inflammatory response through regulation of macrophage behavior. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):161-71. PMID: 19423773; PMCID: PMC2822978.
    30. Zemke AC, Teisanu RM, Giangreco A, Drake JA, Brockway BL, Reynolds SD, Stripp BR. beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium. Am J Respir Cell Mol Biol. 2009 Nov; 41(5):535-43. PMID: 19213872; PMCID: PMC2778160.
    31. Gilbert TW, Gilbert S, Madden M, Reynolds SD, Badylak SF. Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model. Ann Thorac Surg. 2008 Sep; 86(3):967-74; discussion 967-74. PMID: 18721593.
      View in: PubMed
    32. Zemke AC, Snyder JC, Brockway BL, Drake JA, Reynolds SD, Kaminski N, Stripp BR. Molecular staging of epithelial maturation using secretory cell-specific genes as markers. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):340-8. PMID: 18757308; PMCID: PMC2645532.
    33. Stripp BR, Reynolds SD. Maintenance and repair of the bronchiolar epithelium. Proc Am Thorac Soc. 2008 Apr 15; 5(3):328-33. PMID: 18403328; PMCID: PMC2645243.
    34. De Langhe SP, Reynolds SD. Wnt signaling in lung organogenesis. Organogenesis. 2008 Apr; 4(2):100-8. PMID: 19279721; PMCID: PMC2634255.
    35. Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR. Conditional stabilization of beta-catenin expands the pool of lung stem cells. Stem Cells. 2008 May; 26(5):1337-46. PMID: 18356571; PMCID: PMC2773682.
    36. Reynolds SD, Reynolds PR, Snyder JC, Whyte F, Paavola KJ, Stripp BR. CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. Am J Physiol Lung Cell Mol Physiol. 2007 Jul; 293(1):L114-23. PMID: 17384087.
      View in: PubMed
    37. Reynolds SD, Shen H, Reynolds PR, Betsuyaku T, Pilewski JM, Gambelli F, Di Giuseppe M, DeGuiseppe M, Ortiz LA, Stripp BR. Molecular and functional properties of lung SP cells. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L972-83. PMID: 17142352.
      View in: PubMed
    38. Stripp BR, Reynolds SD. Bioengineered lung epithelium: implications for basic and applied studies in lung tissue regeneration. Am J Respir Cell Mol Biol. 2005 Feb; 32(2):85-6. PMID: 15657173.
      View in: PubMed
    39. Yoshikawa S, Miyahara T, Reynolds SD, Stripp BR, Anghelescu M, Eyal FG, Parker JC. Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice. J Appl Physiol (1985). 2005 Apr; 98(4):1264-71. PMID: 15608088.
      View in: PubMed
    40. Reynolds SD, Giangreco A, Hong KU, McGrath KE, Ortiz LA, Stripp BR. Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1256-65. PMID: 15298853.
      View in: PubMed
    41. Evans CM, Williams OW, Tuvim MJ, Nigam R, Mixides GP, Blackburn MR, DeMayo FJ, Burns AR, Smith C, Reynolds SD, Stripp BR, Dickey BF. Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):382-94. PMID: 15191915.
      View in: PubMed
    42. Yoshikawa S, King JA, Reynolds SD, Stripp BR, Parker JC. Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L604-12. PMID: 14761872.
      View in: PubMed
    43. Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol. 2004 Feb; 164(2):577-88. PMID: 14742263; PMCID: PMC1602270.
    44. Giangreco A, Shen H, Reynolds SD, Stripp BR. Molecular phenotype of airway side population cells. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L624-30. PMID: 12909587.
      View in: PubMed
    45. Hong KU, Reynolds SD, Watkins S, Fuchs E, Stripp BR. In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L643-9. PMID: 12871857.
      View in: PubMed
    46. Reynolds SD, Reynolds PR, Pryhuber GS, Finder JD, Stripp BR. Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. Am J Respir Crit Care Med. 2002 Dec 01; 166(11):1498-509. PMID: 12406855.
      View in: PubMed
    47. Stripp BR, Reynolds SD, Boe IM, Lund J, Power JH, Coppens JT, Wong V, Reynolds PR, Plopper CG. Clara cell secretory protein deficiency alters clara cell secretory apparatus and the protein composition of airway lining fluid. Am J Respir Cell Mol Biol. 2002 Aug; 27(2):170-8. PMID: 12151308.
      View in: PubMed
    48. Giangreco A, Reynolds SD, Stripp BR. Terminal bronchioles harbor a unique airway stem cell population that localizes to the bronchoalveolar duct junction. Am J Pathol. 2002 Jul; 161(1):173-82. PMID: 12107102; PMCID: PMC1850682.
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