Xiaojun Ren
Title | Associate Professor |
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Institution | University of Colorado Denver - Denver Campus |
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Department | CLAS-Chemistry |
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Phone | 303/315-7641 |
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Research R01GM135286 (REN, XIAOJUN)Sep 18, 2019 - Aug 31, 2023 NIH Spatial Organization of Epigenetic Complexes and Chromatin Role: Principal Investigator |
| R03CA191443 (REN, XIAOJUN)Dec 8, 2015 - Nov 30, 2018 NIH Molecular Mechanisms of Chromosomal Segregation by Epigenetic Regulators Role: Principal Investigator |
Bibliographic
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Ingersoll S, Brown K, Ma B, Ren X. Quantifying the Binding and Target-Search Kinetics of Transcriptional Regulatory Factors by Live-Cell Single-Molecule Tracking. Methods Mol Biol. 2023; 2599:141-162. PMID: 36427148.
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Brown K, Kent S, Ren X. Quantifying the global binding and target-search dynamics of epigenetic regulatory factors using live-cell single-molecule tracking. STAR Protoc. 2021 12 17; 2(4):100959. PMID: 34825219.
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Zhang Y, Brown K, Yu Y, Ibrahim Z, Zandian M, Xuan H, Ingersoll S, Lee T, Ebmeier CC, Liu J, Panne D, Shi X, Ren X, Kutateladze TG. Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity. Nat Commun. 2021 07 29; 12(1):4618. PMID: 34326347.
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Brown K, Andrianakos H, Ingersoll S, Ren X. Single-molecule imaging of epigenetic complexes in living cells: insights from studies on Polycomb group proteins. Nucleic Acids Res. 2021 07 09; 49(12):6621-6637. PMID: 34009336.
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Kent S, Brown K, Yang CH, Alsaihati N, Tian C, Wang H, Ren X. Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging. Cell Rep. 2020 10 13; 33(2):108248. PMID: 33053359.
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Zhang Y, Bertulat B, Tencer AH, Ren X, Wright GM, Black J, Cardoso MC, Kutateladze TG. MORC3 Forms Nuclear Condensates through Phase Separation. iScience. 2019 Jul 26; 17:182-189. PMID: 31284181.
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Tatavosian R, Kent S, Brown K, Yao T, Duc HN, Huynh TN, Zhen CY, Ma B, Wang H, Ren X. Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation. J Biol Chem. 2019 02 01; 294(5):1451-1463. PMID: 30514760.
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Tatavosian R, Duc HN, Huynh TN, Fang D, Schmitt B, Shi X, Deng Y, Phiel C, Yao T, Zhang Z, Wang H, Ren X. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018 05 25; 9(1):2080. PMID: 29802243.
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Tatavosian R, Ren X. Sm-ChIPi: Single-Molecule Chromatin Immunoprecipitation Imaging. Methods Mol Biol. 2018; 1689:113-126. PMID: 29027169.
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Duc HN, Ren X. Labelling HaloTag Fusion Proteins with HaloTag Ligand in Living Cells. Bio Protoc. 2017 Sep 05; 7(17). PMID: 28966948.
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Huynh TN, Ren X. Producing GST-Cbx7 Fusion Proteins from Escherichia coli. Bio Protoc. 2017 Jun 20; 7(12). PMID: 28966944.
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Zhen CY, Tatavosian R, Huynh TN, Duc HN, Das R, Kokotovic M, Grimm JB, Lavis LD, Lee J, Mejia FJ, Li Y, Yao T, Ren X. Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. Elife. 2016 10 10; 5. PMID: 27723458.
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Tatavosian R, Zhen CY, Duc HN, Balas MM, Johnson AM, Ren X. Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging. J Biol Chem. 2015 Nov 20; 290(47):28038-28054. PMID: 26381410.
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Zhen CY, Duc HN, Kokotovic M, Phiel CJ, Ren X. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell. 2014 Nov 15; 25(23):3726-39. PMID: 25232004.
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Bartman CM, Egelston J, Ren X, Das R, Phiel CJ. A simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine. Exp Cell Res. 2015 Jan 01; 330(1):178-85. PMID: 25102378.
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Cheng B, Ren X, Kerppola TK. KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Mol Cell Biol. 2014 Jun; 34(11):2075-91. PMID: 24687849.
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Ren X, Kerppola TK. REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements. Mol Cell Biol. 2011 May; 31(10):2100-10. PMID: 21402785.
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Alves D, Li H, Codrington R, Orte A, Ren X, Klenerman D, Balasubramanian S. Single-molecule analysis of human telomerase monomer. Nat Chem Biol. 2008 May; 4(5):287-9. PMID: 18391947.
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Ren X, Vincenz C, Kerppola TK. Changes in the distributions and dynamics of polycomb repressive complexes during embryonic stem cell differentiation. Mol Cell Biol. 2008 May; 28(9):2884-95. PMID: 18316406.
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Ren X, Li H, Clarke RW, Alves DA, Ying L, Klenerman D, Balasubramanian S. Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy. J Am Chem Soc. 2006 Apr 19; 128(15):4992-5000. PMID: 16608333.
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Dong Z, Liu J, Mao S, Huang X, Yang B, Ren X, Luo G, Shen J. Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2, 2'-ditellurobis(2-deoxy-beta-cyclodextrin). J Am Chem Soc. 2004 Dec 22; 126(50):16395-404. PMID: 15600341.
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Li H, Ying L, Ren X, Balasubramanian S, Klenerman D. Fluorescence studies of single biomolecules. Biochem Soc Trans. 2004 Nov; 32(Pt 5):753-6. PMID: 15494006.
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Li H, Ren X, Ying L, Balasubramanian S, Klenerman D. Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14425-30. PMID: 15452356.
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Ren X, Gavory G, Li H, Ying L, Klenerman D, Balasubramanian S. Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. Nucleic Acids Res. 2003 Nov 15; 31(22):6509-15. PMID: 14602909.
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You D, Ren X, Xue Y, Luo G, Yang T, Shen J. A selenium-containing single-chain abzyme with potent antioxidant activity. Eur J Biochem. 2003 Nov; 270(21):4326-31. PMID: 14622297.
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Luo GM, Ren XJ, Liu JQ, Mu Y, Shen JC. Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly. Curr Med Chem. 2003 Jul; 10(13):1151-83. PMID: 12678808.
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Mu Y, Lv S, Ren X, Jin G, Liu J, Yan G, Li W, Shen J, Luo G. UV-B induced keratinocyte apoptosis is blocked by 2-selenium-bridged beta-cyclodextrin, a GPX mimic. J Photochem Photobiol B. 2003 Jan; 69(1):7-12. PMID: 12547491.
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Ren X, Jemth P, Board PG, Luo G, Mannervik B, Liu J, Zhang K, Shen J. A semisynthetic glutathione peroxidase with high catalytic efficiency. Selenoglutathione transferase. Chem Biol. 2002 Jul; 9(7):789-94. PMID: 12144922.
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Ren X, Xue Y, Liu J, Zhang K, Zheng J, Luo G, Guo C, Mu Y, Shen J. A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity. Chembiochem. 2002 Apr 02; 3(4):356-63. PMID: 11933237.
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Su D, Ren X, You D, Li D, Mu Y, Yan G, Zhang Y, Luo Y, Xue Y, Shen J, Liu Z, Luo G. Generation of three selenium-containing catalytic antibodies with high catalytic efficiency using a novel hapten design method. Arch Biochem Biophys. 2001 Nov 15; 395(2):177-84. PMID: 11697854.
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Ren X, Xue Y, Zhang K, Liu J, Luo G, Zheng J, Mu Y, Shen J. A novel dicyclodextrinyl ditelluride compound with antioxidant activity. FEBS Lett. 2001 Nov 02; 507(3):377-80. PMID: 11696375.
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Ren X, Gao S, You D, Huang H, Liu Z, Mu Y, Liu J, Zhang Y, Yan G, Luo G, Yang T, Shen J. Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency. Biochem J. 2001 Oct 15; 359(Pt 2):369-74. PMID: 11583583.
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Su D, You D, Ren X, Luo G, Mu Y, Yan G, Xue Y, Shen J. Kinetics study of a selenium-containing ScFv catalytic antibody that mimics glutathione peroxidase. Biochem Biophys Res Commun. 2001 Aug 10; 286(1):189-94. PMID: 11485327.
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Ren X, Yang L, Liu J, Su D, You D, Liu C, Zhang K, Luo G, Mu Y, Yan G, Shen J. A novel glutathione peroxidase mimic with antioxidant activity. Arch Biochem Biophys. 2001 Mar 15; 387(2):250-6. PMID: 11370848.
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Liu J, Luo G, Ren X, Mu Y, Bai Y, Shen J. A bis-cyclodextrin diselenide with glutathione peroxidase-like activity. Biochim Biophys Acta. 2000 Sep 29; 1481(2):222-8. PMID: 11018712.
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Ren X, Liu J, Luo G, Zhang Y, Luo Y, Yan G, Shen J. A novel selenocystine-beta-cyclodextrin conjugate that acts as a glutathione peroxidase mimic. Bioconjug Chem. 2000 Sep-Oct; 11(5):682-7. PMID: 10995212.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2000 | 2 | 2001 | 5 | 2002 | 2 | 2003 | 4 | 2004 | 3 | 2006 | 1 | 2008 | 2 | 2011 | 1 | 2014 | 3 | 2015 | 1 | 2016 | 1 | 2017 | 2 | 2018 | 3 | 2019 | 1 | 2020 | 1 | 2021 | 3 | 2023 | 1 |
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