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Xiaojun Ren

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Denver Campus
DepartmentCLAS-Chemistry
Phone303/315-7641

    Collapse Research 
    Collapse research activities and funding
    R03CA191443     (REN, XIAOJUN)Dec 8, 2015 - Nov 30, 2018
    NIH
    Molecular Mechanisms of Chromosomal Segregation by Epigenetic Regulators
    Role: Principal Investigator
    R01GM135286     (REN, XIAOJUN)Sep 18, 2019 - Aug 31, 2023
    NIH
    Spatial Organization of Epigenetic Complexes and Chromatin
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kent S, Brown K, Yang CH, Alsaihati N, Tian C, Wang H, Ren X. Phase-Separated Transcriptional Condensates Accelerate Target-Search Process Revealed by Live-Cell Single-Molecule Imaging. Cell Rep. 2020 10 13; 33(2):108248. PMID: 33053359.
      View in: PubMed
    2. Zhang Y, Bertulat B, Tencer AH, Ren X, Wright GM, Black J, Cardoso MC, Kutateladze TG. MORC3 Forms Nuclear Condensates through Phase Separation. iScience. 2019 Jul 26; 17:182-189. PMID: 31284181.
      View in: PubMed
    3. Tatavosian R, Kent S, Brown K, Yao T, Duc HN, Huynh TN, Zhen CY, Ma B, Wang H, Ren X. Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation. J Biol Chem. 2019 02 01; 294(5):1451-1463. PMID: 30514760.
      View in: PubMed
    4. Tatavosian R, Duc HN, Huynh TN, Fang D, Schmitt B, Shi X, Deng Y, Phiel C, Yao T, Zhang Z, Wang H, Ren X. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018 05 25; 9(1):2080. PMID: 29802243.
      View in: PubMed
    5. Tatavosian R, Ren X. Sm-ChIPi: Single-Molecule Chromatin Immunoprecipitation Imaging. Methods Mol Biol. 2018; 1689:113-126. PMID: 29027169.
      View in: PubMed
    6. Duc HN, Ren X. Labelling HaloTag Fusion Proteins with HaloTag Ligand in Living Cells. Bio Protoc. 2017 Sep 05; 7(17). PMID: 28966948.
      View in: PubMed
    7. Huynh TN, Ren X. Producing GST-Cbx7 Fusion Proteins from Escherichia coli. Bio Protoc. 2017 Jun 20; 7(12). PMID: 28966944.
      View in: PubMed
    8. Zhen CY, Tatavosian R, Huynh TN, Duc HN, Das R, Kokotovic M, Grimm JB, Lavis LD, Lee J, Mejia FJ, Li Y, Yao T, Ren X. Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. Elife. 2016 10 10; 5. PMID: 27723458.
      View in: PubMed
    9. Tatavosian R, Zhen CY, Duc HN, Balas MM, Johnson AM, Ren X. Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging. J Biol Chem. 2015 Nov 20; 290(47):28038-28054. PMID: 26381410.
      View in: PubMed
    10. Zhen CY, Duc HN, Kokotovic M, Phiel CJ, Ren X. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell. 2014 Nov 15; 25(23):3726-39. PMID: 25232004.
      View in: PubMed
    11. Bartman CM, Egelston J, Ren X, Das R, Phiel CJ. A simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine. Exp Cell Res. 2015 Jan 01; 330(1):178-85. PMID: 25102378.
      View in: PubMed
    12. Cheng B, Ren X, Kerppola TK. KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Mol Cell Biol. 2014 Jun; 34(11):2075-91. PMID: 24687849.
      View in: PubMed
    13. Ren X, Kerppola TK. REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements. Mol Cell Biol. 2011 May; 31(10):2100-10. PMID: 21402785.
      View in: PubMed
    14. Alves D, Li H, Codrington R, Orte A, Ren X, Klenerman D, Balasubramanian S. Single-molecule analysis of human telomerase monomer. Nat Chem Biol. 2008 May; 4(5):287-9. PMID: 18391947.
      View in: PubMed
    15. Ren X, Vincenz C, Kerppola TK. Changes in the distributions and dynamics of polycomb repressive complexes during embryonic stem cell differentiation. Mol Cell Biol. 2008 May; 28(9):2884-95. PMID: 18316406.
      View in: PubMed
    16. Ren X, Li H, Clarke RW, Alves DA, Ying L, Klenerman D, Balasubramanian S. Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy. J Am Chem Soc. 2006 Apr 19; 128(15):4992-5000. PMID: 16608333.
      View in: PubMed
    17. Dong Z, Liu J, Mao S, Huang X, Yang B, Ren X, Luo G, Shen J. Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2, 2'-ditellurobis(2-deoxy-beta-cyclodextrin). J Am Chem Soc. 2004 Dec 22; 126(50):16395-404. PMID: 15600341.
      View in: PubMed
    18. Li H, Ying L, Ren X, Balasubramanian S, Klenerman D. Fluorescence studies of single biomolecules. Biochem Soc Trans. 2004 Nov; 32(Pt 5):753-6. PMID: 15494006.
      View in: PubMed
    19. Li H, Ren X, Ying L, Balasubramanian S, Klenerman D. Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14425-30. PMID: 15452356.
      View in: PubMed
    20. Ren X, Gavory G, Li H, Ying L, Klenerman D, Balasubramanian S. Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. Nucleic Acids Res. 2003 Nov 15; 31(22):6509-15. PMID: 14602909.
      View in: PubMed
    21. You D, Ren X, Xue Y, Luo G, Yang T, Shen J. A selenium-containing single-chain abzyme with potent antioxidant activity. Eur J Biochem. 2003 Nov; 270(21):4326-31. PMID: 14622297.
      View in: PubMed
    22. Luo GM, Ren XJ, Liu JQ, Mu Y, Shen JC. Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly. Curr Med Chem. 2003 Jul; 10(13):1151-83. PMID: 12678808.
      View in: PubMed
    23. Mu Y, Lv S, Ren X, Jin G, Liu J, Yan G, Li W, Shen J, Luo G. UV-B induced keratinocyte apoptosis is blocked by 2-selenium-bridged beta-cyclodextrin, a GPX mimic. J Photochem Photobiol B. 2003 Jan; 69(1):7-12. PMID: 12547491.
      View in: PubMed
    24. Ren X, Jemth P, Board PG, Luo G, Mannervik B, Liu J, Zhang K, Shen J. A semisynthetic glutathione peroxidase with high catalytic efficiency. Selenoglutathione transferase. Chem Biol. 2002 Jul; 9(7):789-94. PMID: 12144922.
      View in: PubMed
    25. Ren X, Xue Y, Liu J, Zhang K, Zheng J, Luo G, Guo C, Mu Y, Shen J. A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity. Chembiochem. 2002 Apr 02; 3(4):356-63. PMID: 11933237.
      View in: PubMed
    26. Su D, Ren X, You D, Li D, Mu Y, Yan G, Zhang Y, Luo Y, Xue Y, Shen J, Liu Z, Luo G. Generation of three selenium-containing catalytic antibodies with high catalytic efficiency using a novel hapten design method. Arch Biochem Biophys. 2001 Nov 15; 395(2):177-84. PMID: 11697854.
      View in: PubMed
    27. Ren X, Xue Y, Zhang K, Liu J, Luo G, Zheng J, Mu Y, Shen J. A novel dicyclodextrinyl ditelluride compound with antioxidant activity. FEBS Lett. 2001 Nov 02; 507(3):377-80. PMID: 11696375.
      View in: PubMed
    28. Ren X, Gao S, You D, Huang H, Liu Z, Mu Y, Liu J, Zhang Y, Yan G, Luo G, Yang T, Shen J. Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency. Biochem J. 2001 Oct 15; 359(Pt 2):369-74. PMID: 11583583.
      View in: PubMed
    29. Su D, You D, Ren X, Luo G, Mu Y, Yan G, Xue Y, Shen J. Kinetics study of a selenium-containing ScFv catalytic antibody that mimics glutathione peroxidase. Biochem Biophys Res Commun. 2001 Aug 10; 286(1):189-94. PMID: 11485327.
      View in: PubMed
    30. Ren X, Yang L, Liu J, Su D, You D, Liu C, Zhang K, Luo G, Mu Y, Yan G, Shen J. A novel glutathione peroxidase mimic with antioxidant activity. Arch Biochem Biophys. 2001 Mar 15; 387(2):250-6. PMID: 11370848.
      View in: PubMed
    31. Liu J, Luo G, Ren X, Mu Y, Bai Y, Shen J. A bis-cyclodextrin diselenide with glutathione peroxidase-like activity. Biochim Biophys Acta. 2000 Sep 29; 1481(2):222-8. PMID: 11018712.
      View in: PubMed
    32. Ren X, Liu J, Luo G, Zhang Y, Luo Y, Yan G, Shen J. A novel selenocystine-beta-cyclodextrin conjugate that acts as a glutathione peroxidase mimic. Bioconjug Chem. 2000 Sep-Oct; 11(5):682-7. PMID: 10995212.
      View in: PubMed
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