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Xiaojun Ren

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Denver Campus

    Collapse Research 
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    R03CA191443     (REN, XIAOJUN)Dec 8, 2015 - Nov 30, 2017
    Molecular Mechanisms of Chromosomal Segregation by Epigenetic Regulators
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tatavosian R, Kent S, Brown K, Yao T, Duc HN, Huynh TN, Zhen CY, Ma B, Wang H, Ren X. Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation. J Biol Chem. 2018 Dec 04. PMID: 30514760.
      View in: PubMed
    2. Tatavosian R, Duc HN, Huynh TN, Fang D, Schmitt B, Shi X, Deng Y, Phiel C, Yao T, Zhang Z, Wang H, Ren X. Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation. Nat Commun. 2018 05 25; 9(1):2080. PMID: 29802243.
      View in: PubMed
    3. Tatavosian R, Ren X. Sm-ChIPi: Single-Molecule Chromatin Immunoprecipitation Imaging. Methods Mol Biol. 2018; 1689:113-126. PMID: 29027169.
      View in: PubMed
    4. Duc HN, Ren X. Labelling HaloTag Fusion Proteins with HaloTag Ligand in Living Cells. Bio Protoc. 2017 Sep 05; 7(17). PMID: 28966948.
      View in: PubMed
    5. Huynh TN, Ren X. Producing GST-Cbx7 Fusion Proteins from Escherichia coli. Bio Protoc. 2017 Jun 20; 7(12). PMID: 28966944.
      View in: PubMed
    6. Zhen CY, Tatavosian R, Huynh TN, Duc HN, Das R, Kokotovic M, Grimm JB, Lavis LD, Lee J, Mejia FJ, Li Y, Yao T, Ren X. Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin. Elife. 2016 10 10; 5. PMID: 27723458.
      View in: PubMed
    7. Tatavosian R, Zhen CY, Duc HN, Balas MM, Johnson AM, Ren X. Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging. J Biol Chem. 2015 Nov 20; 290(47):28038-54. PMID: 26381410; PMCID: PMC4653664 [Available on 11/20/16].
    8. Zhen CY, Duc HN, Kokotovic M, Phiel CJ, Ren X. Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomes. Mol Biol Cell. 2014 Nov 15; 25(23):3726-39. PMID: 25232004; PMCID: PMC4230780.
    9. Bartman CM, Egelston J, Ren X, Das R, Phiel CJ. A simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine. Exp Cell Res. 2015 Jan 01; 330(1):178-85. PMID: 25102378; PMCID: PMC4268182.
    10. Cheng B, Ren X, Kerppola TK. KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genes. Mol Cell Biol. 2014 Jun; 34(11):2075-91. PMID: 24687849; PMCID: PMC4019052.
    11. Ren X, Kerppola TK. REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements. Mol Cell Biol. 2011 May; 31(10):2100-10. PMID: 21402785; PMCID: PMC3133345.
    12. Alves D, Li H, Codrington R, Orte A, Ren X, Klenerman D, Balasubramanian S. Single-molecule analysis of human telomerase monomer. Nat Chem Biol. 2008 May; 4(5):287-9. PMID: 18391947.
      View in: PubMed
    13. Ren X, Vincenz C, Kerppola TK. Changes in the distributions and dynamics of polycomb repressive complexes during embryonic stem cell differentiation. Mol Cell Biol. 2008 May; 28(9):2884-95. PMID: 18316406; PMCID: PMC2293085.
    14. Ren X, Li H, Clarke RW, Alves DA, Ying L, Klenerman D, Balasubramanian S. Analysis of human telomerase activity and function by two color single molecule coincidence fluorescence spectroscopy. J Am Chem Soc. 2006 Apr 19; 128(15):4992-5000. PMID: 16608333; PMCID: PMC2195889.
    15. Dong Z, Liu J, Mao S, Huang X, Yang B, Ren X, Luo G, Shen J. Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2, 2'-ditellurobis(2-deoxy-beta-cyclodextrin). J Am Chem Soc. 2004 Dec 22; 126(50):16395-404. PMID: 15600341.
      View in: PubMed
    16. Li H, Ying L, Ren X, Balasubramanian S, Klenerman D. Fluorescence studies of single biomolecules. Biochem Soc Trans. 2004 Nov; 32(Pt 5):753-6. PMID: 15494006.
      View in: PubMed
    17. Li H, Ren X, Ying L, Balasubramanian S, Klenerman D. Measuring single-molecule nucleic acid dynamics in solution by two-color filtered ratiometric fluorescence correlation spectroscopy. Proc Natl Acad Sci U S A. 2004 Oct 05; 101(40):14425-30. PMID: 15452356; PMCID: PMC521954.
    18. Ren X, Gavory G, Li H, Ying L, Klenerman D, Balasubramanian S. Identification of a new RNA.RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenita point mutation. Nucleic Acids Res. 2003 Nov 15; 31(22):6509-15. PMID: 14602909; PMCID: PMC275565.
    19. You D, Ren X, Xue Y, Luo G, Yang T, Shen J. A selenium-containing single-chain abzyme with potent antioxidant activity. Eur J Biochem. 2003 Nov; 270(21):4326-31. PMID: 14622297.
      View in: PubMed
    20. Luo GM, Ren XJ, Liu JQ, Mu Y, Shen JC. Towards more efficient glutathione peroxidase mimics: substrate recognition and catalytic group assembly. Curr Med Chem. 2003 Jul; 10(13):1151-83. PMID: 12678808.
      View in: PubMed
    21. Mu Y, Lv S, Ren X, Jin G, Liu J, Yan G, Li W, Shen J, Luo G. UV-B induced keratinocyte apoptosis is blocked by 2-selenium-bridged beta-cyclodextrin, a GPX mimic. J Photochem Photobiol B. 2003 Jan; 69(1):7-12. PMID: 12547491.
      View in: PubMed
    22. Ren X, Jemth P, Board PG, Luo G, Mannervik B, Liu J, Zhang K, Shen J. A semisynthetic glutathione peroxidase with high catalytic efficiency. Selenoglutathione transferase. Chem Biol. 2002 Jul; 9(7):789-94. PMID: 12144922.
      View in: PubMed
    23. Ren X, Xue Y, Liu J, Zhang K, Zheng J, Luo G, Guo C, Mu Y, Shen J. A novel cyclodextrin-derived tellurium compound with glutathione peroxidase activity. Chembiochem. 2002 Apr 02; 3(4):356-63. PMID: 11933237.
      View in: PubMed
    24. Su D, Ren X, You D, Li D, Mu Y, Yan G, Zhang Y, Luo Y, Xue Y, Shen J, Liu Z, Luo G. Generation of three selenium-containing catalytic antibodies with high catalytic efficiency using a novel hapten design method. Arch Biochem Biophys. 2001 Nov 15; 395(2):177-84. PMID: 11697854.
      View in: PubMed
    25. Ren X, Xue Y, Zhang K, Liu J, Luo G, Zheng J, Mu Y, Shen J. A novel dicyclodextrinyl ditelluride compound with antioxidant activity. FEBS Lett. 2001 Nov 02; 507(3):377-80. PMID: 11696375.
      View in: PubMed
    26. Ren X, Gao S, You D, Huang H, Liu Z, Mu Y, Liu J, Zhang Y, Yan G, Luo G, Yang T, Shen J. Cloning and expression of a single-chain catalytic antibody that acts as a glutathione peroxidase mimic with high catalytic efficiency. Biochem J. 2001 Oct 15; 359(Pt 2):369-74. PMID: 11583583; PMCID: PMC1222155.
    27. Su D, You D, Ren X, Luo G, Mu Y, Yan G, Xue Y, Shen J. Kinetics study of a selenium-containing ScFv catalytic antibody that mimics glutathione peroxidase. Biochem Biophys Res Commun. 2001 Aug 10; 286(1):189-94. PMID: 11485327.
      View in: PubMed
    28. Ren X, Yang L, Liu J, Su D, You D, Liu C, Zhang K, Luo G, Mu Y, Yan G, Shen J. A novel glutathione peroxidase mimic with antioxidant activity. Arch Biochem Biophys. 2001 Mar 15; 387(2):250-6. PMID: 11370848.
      View in: PubMed
    29. Liu J, Luo G, Ren X, Mu Y, Bai Y, Shen J. A bis-cyclodextrin diselenide with glutathione peroxidase-like activity. Biochim Biophys Acta. 2000 Sep 29; 1481(2):222-8. PMID: 11018712.
      View in: PubMed
    30. Ren X, Liu J, Luo G, Zhang Y, Luo Y, Yan G, Shen J. A novel selenocystine-beta-cyclodextrin conjugate that acts as a glutathione peroxidase mimic. Bioconjug Chem. 2000 Sep-Oct; 11(5):682-7. PMID: 10995212.
      View in: PubMed
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