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Michael Hillel Handler

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NS General Operations

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kushner JK, Hoffman PB, Brzezinski CR, Svalina MN, O'Neill BR, Hankinson TC, Wilkinson CC, Handler MH, Baca SM, Huntsman MM, Alexander AL. Characterizing the Diversity of Layer 2/3 Human Neocortical Neurons in Pediatric Epilepsy. eNeuro. 2025 May; 12(5). PMID: 40246555.
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    2. de Sousa GR, Calzadilla AJ, Grimaldo E, Donson AM, Sobral LM, Jones KM, Liu T, Amani V, Venkataraman S, Dahl NA, Levy JMM, Phang T, Vibhakar R, Hankinson T, Handler M, Valera ET, Foreman NK, Griesinger AM. Loss of LDOC1 by chromatin compaction in mesenchymal tumor cells is required for PFA1 ependymoma growth. Neuro Oncol. 2025 Feb 04. PMID: 39901723.
      View in: PubMed
    3. Pazniokas J, Harris W, Alshareef M, Alexander AL, Hankinson TC, Handler MH, Wilkinson CC, Samples DC. Bedside transfontanelle drain placement reduces the need for operative intervention in infants with subdural fluid collections. Childs Nerv Syst. 2024 Dec 16; 41(1):55. PMID: 39680149.
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    4. Voeller J, Katzenstein HM, Naranjo A, Tenney SC, Chen L, London WB, Handler MH, Schmidt ML, Shimada H, Hogarty MD, Gastier-Foster J, Park JR, Cohn SL, Maris JM, Bagatell R, Twist CJ. Outcomes of patients with intermediate-risk neuroblastoma presenting with motor deficits relating to intraspinal tumor extension: A report from the Children's Oncology Group study ANBL0531. Pediatr Blood Cancer. 2025 Jan; 72(1):e31407. PMID: 39502014.
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    5. Barr EK, Naranjo A, Twist CJ, Tenney SC, Schmidt ML, London WB, Gastier-Foster J, Adkins ES, Mattei P, Handler MH, Matthay KK, Park JR, Maris JM, Desai AV, Cohn SL. Long-term follow-up of patients with intermediate-risk neuroblastoma treated with response- and biology-based therapy: A report from the Children's Oncology Group study ANBL0531. Pediatr Blood Cancer. 2024 Aug; 71(8):e31089. PMID: 38822537.
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    6. Griesinger AM, Calzadilla AJ, Grimaldo E, Donson AM, Amani V, Pierce AM, Steiner J, Kargar S, Serkova NJ, Bertrand KC, Wright KD, Vibhakar R, Hankinson T, Handler M, Lindsay HB, Foreman NK, Dorris K. Development of Chromosome 1q+ Specific Treatment for Highest Risk Pediatric Posterior Fossa Ependymoma. Clin Cancer Res. 2024 Apr 15; 30(8):1544-1554. PMID: 38334950.
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    7. Zahedi S, Riemondy K, Griesinger AM, Donson AM, Fu R, Crespo M, DeSisto J, Groat MM, Bratbak E, Green A, Hankinson TC, Handler M, Vibhakar R, Willard N, Foreman NK, Levy JM. Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations. bioRxiv. 2024 Apr 10. PMID: 38645202.
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    8. Raybin JL, Donson A, Foreman NK, Vibhakar R, Handler MH, Liu AK. Maintaining Survival While Improving Quality of Life: An Advanced Practitioner-Led Pilot Feasibility Study to Reduce Radiation Dose in Children With Brain Tumors. J Adv Pract Oncol. 2024 Jan; 15(1):28-35. PMID: 39055368.
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    9. Grob ST, Miller KR, Sanford B, Donson AM, Jones K, Griesinger AM, Amani V, Foreman NK, Liu A, Handler M, Hankinson TC, Milgrom S, Levy JMM. Genetic predictors of neurocognitive outcomes in survivors of pediatric brain tumors. J Neurooncol. 2023 Oct; 165(1):161-169. PMID: 37878192.
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    10. Grob ST, Miller KR, Sanford B, Donson AM, Jones K, Griesinger AM, Amani V, Foreman NK, Liu A, Handler M, Hankinson TC, Milgrom S, Levy JM. Genetic Predictors of Neurocognitive Outcomes in Survivors of Pediatric Brain Tumors. Res Sq. 2023 Aug 07. PMID: 37609195.
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    11. Bsat S, Alshareef M, Pazniokas J, Handler MH. Technical evolution of pediatric neurosurgery: the evolution of intraoperative imaging. Childs Nerv Syst. 2023 10; 39(10):2605-2611. PMID: 37518061.
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    12. Arocho-Quinones EV, Lew SM, Handler MH, Tovar-Spinoza Z, Smyth MD, Bollo RJ, Donahue D, Perry MS, Levy M, Gonda D, Mangano FT, Kennedy BC, Storm PB, Price AV, Couture DE, Oluigbo C, Duhaime AC, Barnett GH, Muh CR, Sather MD, Fallah A, Wang AC, Bhatia S, Eastwood D, Tarima S, Graber S, Huckins S, Hafez D, Rumalla K, Bailey L, Shandley S, Roach A, Alexander E, Jenkins W, Tsering D, Price G, Meola A, Evanoff W, Thompson EM, Brandmeir N. Magnetic resonance imaging-guided stereotactic laser ablation therapy for the treatment of pediatric epilepsy: a retrospective multiinstitutional study. J Neurosurg Pediatr. 2023 Mar 03; 1-14. PMID: 36883640.
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    13. Vaughn AE, Louiselle AE, Tong S, Niemiec SM, Ahmad S, Zaretsky M, Galan HL, Behrendt N, Wilkinson CC, O'Neill B, Handler M, Derderian SC, Mirsky DM, Liechty KW. Early outcomes of a myofascial repair technique for fetal myelomeningocele. J Pediatr Surg. 2023 Jan; 58(1):20-26. PMID: 36289034.
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    14. Finneran MM, Graber S, Poppleton K, Alexander AL, Wilkinson CC, O'Neill BR, Hankinson TC, Handler MH. Postoperative general medical ward admission following Chiari malformation decompression. J Neurosurg Pediatr. 2022 12 01; 30(6):602-608. PMID: 36115060.
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    15. Malik N, Samples DC, Finneran MM, Graber S, Dorris K, Norris G, Foreman NK, Hankinson TC, Handler MH. Pediatric pineal region masses: a single-center experience over 25?years. Childs Nerv Syst. 2023 09; 39(9):2307-2316. PMID: 35831712.
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    16. Steinbok P, Cheong A, Dix DB, Bhatia S, Handler MH, Limbrick DD, Niazi T, Price AV, Ragheb J, Souweidane M, Tamber MS, Sandberg DI. Nonoperative Management of Childhood Calvarial Langerhans-Cell Histiocytosis. N Engl J Med. 2022 06 30; 386(26):2532-2534. PMID: 35767446.
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    17. Riemondy KA, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger AM, Amani V, Mitra S, Hankinson TC, Handler MH, Sill M, Ocasio J, Weir SJ, Malawsky DS, Gershon TR, Garancher A, Wechsler-Reya RJ, Hesselberth JR, Foreman NK, Donson AM, Vibhakar R. Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma. Neuro Oncol. 2022 02 01; 24(2):273-286. PMID: 34077540.
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    18. DeSisto J, Lucas JT, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Sch?ller U, Venkataraman S, Hoffman LM, Dorris K, Mulcahy Levy JM, Hankinson TC, Handler M, Liu AK, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma. Nat Commun. 2021 09 20; 12(1):5531. PMID: 34545084.
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    19. Svokos K, Batista-Silverman L, Graber SJ, O'Neill BR, Handler MH. International survey on the management of lumbosacral cutaneous stigmata in infants with suspected occult spinal dysraphism. J Neurosurg Pediatr. 2021 11 01; 28(5):592-599. PMID: 34479200.
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    20. Prince EW, Whelan R, Mirsky DM, Stence N, Staulcup S, Klimo P, Anderson RCE, Niazi TN, Grant G, Souweidane M, Johnston JM, Jackson EM, Limbrick DD, Smith A, Drapeau A, Chern JJ, Kilburn L, Ginn K, Naftel R, Dudley R, Tyler-Kabara E, Jallo G, Handler MH, Jones K, Donson AM, Foreman NK, Hankinson TC. Robust deep learning classification of adamantinomatous craniopharyngioma from limited preoperative radiographic images. Sci Rep. 2020 10 09; 10(1):16885. PMID: 33037266.
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    21. Grob ST, Nobre L, Campbell KR, Davies KD, Ryall S, Aisner DL, Hoffman L, Zahedi S, Morin A, Crespo M, Nellan A, Green AL, Foreman N, Vibhakar R, Hankinson TC, Handler MH, Hawkins C, Tabori U, Kleinschmidt-DeMasters BK, Mulcahy Levy JM. Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa103. PMID: 33063010.
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    22. Gillen AE, Riemondy KA, Amani V, Griesinger AM, Gilani A, Venkataraman S, Madhavan K, Prince E, Sanford B, Hankinson TC, Handler MH, Vibhakar R, Jones KL, Mitra S, Hesselberth JR, Foreman NK, Donson AM. Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology. Cell Rep. 2020 08 11; 32(6):108023. PMID: 32783945.
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    23. Prince E, Whelan R, Donson A, Staulcup S, Hengartner A, Vijmasi T, Agwu C, Lillehei KO, Foreman NK, Johnston JM, Massimi L, Anderson RCE, Souweidane MM, Naftel RP, Limbrick DD, Grant G, Niazi TN, Dudley R, Kilburn L, Jackson EM, Jallo GI, Ginn K, Smith A, Chern JJ, Lee A, Drapeau A, Krieger MD, Handler MH, Hankinson TC. Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets. Acta Neuropathol Commun. 2020 05 13; 8(1):68. PMID: 32404202.
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    24. Arocho-Quinones EV, Lew SM, Handler MH, Tovar-Spinoza Z, Smyth M, Bollo R, Donahue D, Perry MS, Levy ML, Gonda D, Mangano FT, Storm PB, Price AV, Couture DE, Oluigbo C, Duhaime AC, Barnett GH, Muh CR, Sather MD, Fallah A, Wang AC, Bhatia S, Patel K, Tarima S, Graber S, Huckins S, Hafez DM, Rumalla K, Bailey L, Shandley S, Roach A, Alexander E, Jenkins W, Tsering D, Price G, Meola A, Evanoff W, Thompson EM, Brandmeir N. Magnetic resonance-guided stereotactic laser ablation therapy for the treatment of pediatric brain tumors: a multiinstitutional retrospective study. J Neurosurg Pediatr. 2020 07 01; 26(1):13-21. PMID: 32217793.
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    25. Green AL, Flannery P, Hankinson TC, O'Neill B, Amani V, DeSisto J, Knox A, Chatwin H, Lemma R, Hoffman LM, Mulcahy Levy J, Raybin J, Hemenway M, Gilani A, Koschmann C, Dahl N, Handler M, Pierce A, Venkataraman S, Foreman N, Vibhakar R, Wempe MF, Dorris K. Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa021. PMID: 32642682.
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    26. Pierce AM, Witt DA, Donson AM, Gilani A, Sanford B, Sill M, Van Court B, Oweida A, Prince EW, Steiner J, Danis E, Dorris K, Hankinson T, Handler MH, Jones KL, Karam SD, Serkova NJ, Vibhakar R, Foreman NK, Griesinger AM. Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro Oncol. 2019 12 17; 21(12):1540-1551. PMID: 31276586.
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    27. Derderian SC, Greenan K, Mirsky DM, Stence NV, Graber S, Hankinson TC, Hubbell N, Alexander A, O'Neill BR, Wilkinson CC, Handler MH. The utility of magnetic resonance imaging in pediatric trauma patients suspected of having cervical spine injuries. J Trauma Acute Care Surg. 2019 12; 87(6):1328-1335. PMID: 31764482.
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    28. Twist CJ, Schmidt ML, Naranjo A, London WB, Tenney SC, Marachelian A, Shimada H, Collins MH, Esiashvili N, Adkins ES, Mattei P, Handler M, Katzenstein H, Attiyeh E, Hogarty MD, Gastier-Foster J, Wagner E, Matthay KK, Park JR, Maris JM, Cohn SL. Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531. J Clin Oncol. 2019 12 01; 37(34):3243-3255. PMID: 31386611.
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    29. Hilton SA, Hodges MM, Dewberry LC, Handler M, Galan HL, Zaretsky MV, Behrendt N, Marwan AI, Liechty KW. MOMS Plus: Single-Institution Review of Outcomes for Extended BMI Criteria for Open Fetal Repair of Myelomeningocele. Fetal Diagn Ther. 2019; 46(6):411-414. PMID: 31048584.
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    30. Norris GA, Garcia J, Hankinson TC, Handler M, Foreman N, Mirsky D, Stence N, Dorris K, Green AL. Diagnostic accuracy of neuroimaging in pediatric optic chiasm/sellar/suprasellar tumors. Pediatr Blood Cancer. 2019 06; 66(6):e27680. PMID: 30848081.
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    31. Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V. Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma. J Clin Oncol. 2019 04 20; 37(12):974-983. PMID: 30811284.
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    32. Gupta N, Goumnerova LC, Manley P, Chi SN, Neuberg D, Puligandla M, Fangusaro J, Goldman S, Tomita T, Alden T, DiPatri A, Rubin JB, Gauvain K, Limbrick D, Leonard J, Geyer JR, Leary S, Browd S, Wang Z, Sood S, Bendel A, Nagib M, Gardner S, Karajannis MA, Harter D, Ayyanar K, Gump W, Bowers DC, Weprin B, MacDonald TJ, Aguilera D, Brahma B, Robison NJ, Kiehna E, Krieger M, Sandler E, Aldana P, Khatib Z, Ragheb J, Bhatia S, Mueller S, Banerjee A, Bredlau AL, Gururangan S, Fuchs H, Cohen KJ, Jallo G, Dorris K, Handler M, Comito M, Dias M, Nazemi K, Baird L, Murray J, Lindeman N, Hornick JL, Malkin H, Sinai C, Greenspan L, Wright KD, Prados M, Bandopadhayay P, Ligon KL, Kieran MW. Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol. 2018 10 09; 20(11):1547-1555. PMID: 29741745.
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    33. Donson AM, Amani V, Warner EA, Griesinger AM, Witt DA, Levy JMM, Hoffman LM, Hankinson TC, Handler MH, Vibhakar R, Dorris K, Foreman NK. Identification of FDA-Approved Oncology Drugs with Selective Potency in High-Risk Childhood Ependymoma. Mol Cancer Ther. 2018 09; 17(9):1984-1994. PMID: 29925527.
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    34. Schur S, Allen V, White A, Mirsky D, Stence N, O'Neill B, Handler M, Dudley R, Laoprasert P. Significance of FDG-PET Hypermetabolism in Children with Intractable Focal Epilepsy. Pediatr Neurosurg. 2018; 53(3):153-162. PMID: 29672310.
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    35. Dudley RWR, Torok MR, Randall S, B?land B, Handler MH, Mulcahy-Levy JM, Liu AK, Hankinson TC. Pediatric versus adult meningioma: comparison of epidemiology, treatments, and outcomes using the Surveillance, Epidemiology, and End Results database. J Neurooncol. 2018 May; 137(3):621-629. PMID: 29520612.
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    36. Witt DA, Donson AM, Amani V, Moreira DC, Sanford B, Hoffman LM, Handler MH, Levy JMM, Jones KL, Nellan A, Foreman NK, Griesinger AM. Specific expression of PD-L1 in RELA-fusion supratentorial ependymoma: Implications for PD-1-targeted therapy. Pediatr Blood Cancer. 2018 05; 65(5):e26960. PMID: 29350470.
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    37. Yang MJ, Whelan R, Madden J, Mulcahy Levy JM, Kleinschmidt-DeMasters BK, Hankinson TC, Foreman NK, Handler MH. Intracranial Ewing sarcoma: four pediatric examples. Childs Nerv Syst. 2018 03; 34(3):441-448. PMID: 29285586.
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    38. Griesinger AM, Witt DA, Grob ST, Georgio Westover SR, Donson AM, Sanford B, Mulcahy Levy JM, Wong R, Moreira DC, DeSisto JA, Balakrishnan I, Hoffman LM, Handler MH, Jones KL, Vibhakar R, Venkataraman S, Foreman NK. NF-?B upregulation through epigenetic silencing of LDOC1 drives tumor biology and specific immunophenotype in Group A ependymoma. Neuro Oncol. 2017 Oct 01; 19(10):1350-1360. PMID: 28510691.
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    39. Oushy S, Parker JJ, Campbell K, Palmer C, Wilkinson C, Stence NV, Handler MH, Mirsky DM. Frontal and occipital horn ratio is associated with multifocal intraparenchymal hemorrhages in neonatal shunted hydrocephalus. J Neurosurg Pediatr. 2017 Nov; 20(5):432-438. PMID: 28885094.
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    40. Zaretsky MV, Liechty KW, Galan HL, Behrendt NJ, Reeves S, Marwan AI, Wilkinson C, Handler M, Lagueux M, Crombleholme TM. Modified Hysterotomy Closure Technique for Open Fetal Surgery. Fetal Diagn Ther. 2018; 44(2):105-111. PMID: 28873371.
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    41. Donson AM, Apps J, Griesinger AM, Amani V, Witt DA, Anderson RCE, Niazi TN, Grant G, Souweidane M, Johnston JM, Jackson EM, Kleinschmidt-DeMasters BK, Handler MH, Tan AC, Gore L, Virasami A, Gonzalez-Meljem JM, Jacques TS, Martinez-Barbera JP, Foreman NK, Hankinson TC. Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma. J Neuropathol Exp Neurol. 2017 Sep 01; 76(9):779-788. PMID: 28859336.
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    42. Amani V, Donson AM, Lummus SC, Prince EW, Griesinger AM, Witt DA, Hankinson TC, Handler MH, Dorris K, Vibhakar R, Foreman NK, Hoffman LM. Characterization of 2 Novel Ependymoma Cell Lines With Chromosome 1q Gain Derived From Posterior Fossa Tumors of Childhood. J Neuropathol Exp Neurol. 2017 Jul 01; 76(7):595-604. PMID: 28863455.
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    43. Dahl NA, Luebbert T, Loi M, Neuberger I, Handler MH, Kleinschmidt-DeMasters BK, Mulcahy Levy JM. Chordoma Occurs in Young Children With Tuberous Sclerosis. J Neuropathol Exp Neurol. 2017 Jun 01; 76(6):418-423. PMID: 28498973.
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    44. Laoprasert P, Ojemann JG, Handler MH. Insular epilepsy surgery. Epilepsia. 2017 04; 58 Suppl 1:35-45. PMID: 28386920.
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    45. Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors. Elife. 2017 01 17; 6. PMID: 28094001.
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    46. O'Neill BR, Gallegos D, Herron A, Palmer C, Stence NV, Hankinson TC, Corbett Wilkinson C, Handler MH. Use of magnetic resonance imaging to detect occult spinal dysraphism in infants. J Neurosurg Pediatr. 2017 Feb; 19(2):217-226. PMID: 27911245.
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    47. Amani V, Prince EW, Alimova I, Balakrishnan I, Birks D, Donson AM, Harris P, Levy JM, Handler M, Foreman NK, Venkataraman S, Vibhakar R. Polo-like Kinase?1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma. BMC Cancer. 2016 08 18; 16:647. PMID: 27538997.
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    48. Prince EW, Balakrishnan I, Shah M, Mulcahy Levy JM, Griesinger AM, Alimova I, Harris PS, Birks DK, Donson AM, Davidson N, Remke M, Taylor MD, Handler MH, Foreman NK, Venkataraman S, Vibhakar R. Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma. Oncotarget. 2016 Aug 16; 7(33):53881-53894. PMID: 27449089.
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    49. Dudley RW, Torok MR, Hoffman L, Levy JM, Handler MH, Liu AK, Hankinson TC. Response to Journal Club: Pediatric Low-Grade Ganglioglioma: Epidemiology, Treatments, and Outcome Analysis of 348 Children From the Surveillance, Epidemiology, and End Results Database. Neurosurgery. 2016 08; 79(2):309. PMID: 27428632.
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    50. Kruse CA, Pardo CA, Hartman AL, Jallo G, Vining EP, Voros J, Gaillard WD, Liu J, Oluigbo C, Malone S, Bleasel AF, Dexter M, Micati A, Velasco TR, Machado HR, Martino AM, Huang A, Wheatley BM, Grant GA, Granata T, Freri E, Garbelli R, Koh S, Nordli DR, Campos AR, O'Neill B, Handler MH, Chapman KE, Wilfong AA, Curry DJ, Yaun A, Madsen JR, Smyth MD, Mercer D, Bingaman W, Harvey AS, Leventer RJ, Lockhart PJ, Gillies G, Pope K, Giller CA, Park YD, Rojiani AM, Sharma SJ, Jenkins P, Tung S, Huynh MN, Chirwa TW, Cepeda C, Levine MS, Chang JW, Owens GC, Vinters HV, Mathern GW. Rasmussen encephalitis tissue transfer program. Epilepsia. 2016 06; 57(6):1005-7. PMID: 27286752.
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    51. Handler M, Dotan I, Klausner JM, Yanai H, Neeman E, Tulchinsky H. Clinical recurrence and re-resection rates after extensive vs. segmental colectomy in Crohn's colitis: a retrospective cohort study. Tech Coloproctol. 2016 May; 20(5):287-292. PMID: 26886936.
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    52. Poonia S, Graber S, Corbett Wilkinson C, O'neill BR, Handler MH, Hankinson TC. Outcome of hospital discharge on postoperative Day 1 following uncomplicated tethered spinal cord release. J Neurosurg Pediatr. 2016 Jun; 17(6):651-6. PMID: 26849810.
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    53. Cantey PT, Weeks J, Edwards M, Rao S, Ostovar GA, Dehority W, Alzona M, Swoboda S, Christiaens B, Ballan W, Hartley J, Terranella A, Weatherhead J, Dunn JJ, Marx DP, Hicks MJ, Rauch RA, Smith C, Dishop MK, Handler MH, Dudley RW, Chundu K, Hobohm D, Feiz-Erfan I, Hakes J, Berry RS, Stepensaski S, Greenfield B, Shroeder L, Bishop H, de Almeida M, Mathison B, Eberhard M. The Emergence of Zoonotic Onchocerca lupi Infection in the United States--A Case-Series. Clin Infect Dis. 2016 Mar 15; 62(6):778-83. PMID: 26611778.
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    54. Hankinson TC, Dudley RW, Torok MR, Patibandla MR, Dorris K, Poonia S, Wilkinson CC, Bruny JL, Handler MH, Liu AK. Short-term mortality following surgical procedures for the diagnosis of pediatric brain tumors: outcome analysis in 5533 children from SEER, 2004-2011. J Neurosurg Pediatr. 2016 Mar; 17(3):289-97. PMID: 26588456.
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    55. Hankinson TC, Patibandla MR, Green A, Hemenway M, Foreman N, Handler M, Liu AK. Hypofractionated Radiotherapy for Children With Diffuse Intrinsic Pontine Gliomas. Pediatr Blood Cancer. 2016 Apr; 63(4):716-8. PMID: 26544789.
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    56. Richardson MD, Palmeri NO, Williams SA, Torok MR, O'Neill BR, Handler MH, Hankinson TC. Routine perioperative ketorolac administration is not associated with hemorrhage in pediatric neurosurgery patients. J Neurosurg Pediatr. 2016 Jan; 17(1):107-15. PMID: 26451718.
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    57. Patibandla MR, Ridder T, Dorris K, Torok MR, Liu AK, Handler MH, Stence NV, Fenton LZ, Hankinson TC. Atypical pediatric ganglioglioma is common and associated with a less favorable clinical course. J Neurosurg Pediatr. 2016 Jan; 17(1):41-8. PMID: 26431248.
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    58. Kumar RM, Koh S, Knupp K, Handler MH, O'Neill BR. Surgery for infants with catastrophic epilepsy: an analysis of complications and efficacy. Childs Nerv Syst. 2015 Sep; 31(9):1479-91. PMID: 26022500.
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    59. Gump JM, Donson AM, Birks DK, Amani VM, Rao KK, Griesinger AM, Kleinschmidt-DeMasters BK, Johnston JM, Anderson RC, Rosenfeld A, Handler M, Gore L, Foreman N, Hankinson TC. Identification of targets for rational pharmacological therapy in childhood craniopharyngioma. Acta Neuropathol Commun. 2015 May 21; 3:30. PMID: 25990246.
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    60. Griesinger AM, Josephson RJ, Donson AM, Mulcahy Levy JM, Amani V, Birks DK, Hoffman LM, Furtek SL, Reigan P, Handler MH, Vibhakar R, Foreman NK. Interleukin-6/STAT3 Pathway Signaling Drives an Inflammatory Phenotype in Group A Ependymoma. Cancer Immunol Res. 2015 Oct; 3(10):1165-74. PMID: 25968456.
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    61. O'Neill BR, Handler MH, Tong S, Chapman KE. Incidence of seizures on continuous EEG monitoring following traumatic brain injury in children. J Neurosurg Pediatr. 2015 Aug; 16(2):167-76. PMID: 25955809.
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    62. Dudley RWR, Smith C, Dishop M, Mirsky D, Handler MH, Rao S. A cervical spine mass caused by Onchocerca lupi. Lancet. 2015 Oct 03; 386(10001):1372. PMID: 25843892.
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    63. Dudley RW, Torok MR, Gallegos DR, Mulcahy-Levy JM, Hoffman LM, Liu AK, Handler MH, Hankinson TC. Pediatric low-grade ganglioglioma: epidemiology, treatments, and outcome analysis on 348 children from the surveillance, epidemiology, and end results database. Neurosurgery. 2015 Mar; 76(3):313-9; discussion 319; quiz 319-20. PMID: 25603107.
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    64. Dudley RW, Torok MR, Gallegos D, Liu AK, Handler MH, Hankinson TC. Pediatric choroid plexus tumors: epidemiology, treatments, and outcome analysis on 202 children from the SEER database. J Neurooncol. 2015 Jan; 121(1):201-7. PMID: 25297498.
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    65. Venkataraman S, Alimova I, Balakrishnan I, Harris P, Birks DK, Griesinger A, Amani V, Cristiano B, Remke M, Taylor MD, Handler M, Foreman NK, Vibhakar R. Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15; 5(9):2355-71. PMID: 24796395.
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    66. Levy JM, Thompson JC, Griesinger AM, Amani V, Donson AM, Birks DK, Morgan MJ, Mirsky DM, Handler MH, Foreman NK, Thorburn A. Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. Cancer Discov. 2014 Jul; 4(7):773-80. PMID: 24823863.
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    67. Hankinson TC, Palmeri NO, Williams SA, Torok MR, Serrano CA, Foreman NK, Handler MH, Liu AK. Patterns of care for craniopharyngioma: survey of members of the american association of neurological surgeons. Pediatr Neurosurg. 2013; 49(3):131-6. PMID: 24577430.
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    68. Hoffman LM, Plimpton SR, Foreman NK, Stence NV, Hankinson TC, Handler MH, Hemenway MS, Vibhakar R, Liu AK. Fractionated stereotactic radiosurgery for recurrent ependymoma in children. J Neurooncol. 2014 Jan; 116(1):107-11. PMID: 24078173.
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    69. Donson AM, Kleinschmidt-DeMasters BK, Aisner DL, Bemis LT, Birks DK, Levy JM, Smith AA, Handler MH, Foreman NK, Rush SZ. Pediatric brainstem gangliogliomas show BRAF(V600E) mutation in a high percentage of cases. Brain Pathol. 2014 Mar; 24(2):173-83. PMID: 24238153.
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    70. Hoffman LM, Donson AM, Nakachi I, Griesinger AM, Birks DK, Amani V, Hemenway MS, Liu AK, Wang M, Hankinson TC, Handler MH, Foreman NK. Molecular sub-group-specific immunophenotypic changes are associated with outcome in recurrent posterior fossa ependymoma. Acta Neuropathol. 2014 May; 127(5):731-45. PMID: 24240813.
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    71. Griesinger AM, Birks DK, Donson AM, Amani V, Hoffman LM, Waziri A, Wang M, Handler MH, Foreman NK. Characterization of distinct immunophenotypes across pediatric brain tumor types. J Immunol. 2013 Nov 01; 191(9):4880-8. PMID: 24078694.
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    72. Richardson MD, Handler MH. Minimally invasive technique for insertion of ventriculopleural shunt catheters. J Neurosurg Pediatr. 2013 Nov; 12(5):501-4. PMID: 24011369.
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    73. Barton VN, Donson AM, Birks DK, Kleinschmidt-DeMasters BK, Handler MH, Foreman NK, Rush SZ. Insulin-like growth factor 2 mRNA binding protein 3 expression is an independent prognostic factor in pediatric pilocytic and pilomyxoid astrocytoma. J Neuropathol Exp Neurol. 2013 May; 72(5):442-9. PMID: 23584203.
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    74. Birks DK, Donson AM, Patel PR, Sufit A, Algar EM, Dunham C, Kleinschmidt-DeMasters BK, Handler MH, Vibhakar R, Foreman NK. Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes. Pediatr Blood Cancer. 2013 Jul; 60(7):1095-102. PMID: 23382118.
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    75. Zhou Z, Luther N, Ibrahim GM, Hawkins C, Vibhakar R, Handler MH, Souweidane MM. B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma. J Neurooncol. 2013 Feb; 111(3):257-64. PMID: 23232807.
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    76. Venkataraman S, Birks DK, Balakrishnan I, Alimova I, Harris PS, Patel PR, Handler MH, Dubuc A, Taylor MD, Foreman NK, Vibhakar R. MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma. J Biol Chem. 2013 Jan 18; 288(3):1918-28. PMID: 23212916.
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    77. Dunn W, Zeng Z, O'Neil M, Zhao J, Whitener M, Yu-Jui Wan Y, Mitchell EK, Handler M, Weinman SA. The interaction of rs738409, obesity, and alcohol: a population-based autopsy study. Am J Gastroenterol. 2012 Nov; 107(11):1668-74. PMID: 23032985.
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    78. Hankinson TC, Fields EC, Torok MR, Beaty BL, Handler MH, Foreman NK, O'neill BR, Liu AK. Limited utility despite accuracy of the national SEER dataset for the study of craniopharyngioma. J Neurooncol. 2012 Nov; 110(2):271-8. PMID: 22915191.
      View in: PubMed
    79. Donson AM, Birks DK, Schittone SA, Kleinschmidt-DeMasters BK, Sun DY, Hemenway MF, Handler MH, Waziri AE, Wang M, Foreman NK. Increased immune gene expression and immune cell infiltration in high-grade astrocytoma distinguish long-term from short-term survivors. J Immunol. 2012 Aug 15; 189(4):1920-7. PMID: 22802421.
      View in: PubMed
    80. Sufit A, Donson AM, Birks DK, Knipstein JA, Fenton LZ, Jedlicka P, Hankinson TC, Handler MH, Foreman NK. Diffuse intrinsic pontine tumors: a study of primitive neuroectodermal tumors versus the more common diffuse intrinsic pontine gliomas. J Neurosurg Pediatr. 2012 Aug; 10(2):81-8. PMID: 22747092.
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    81. Macy ME, Birks DK, Barton VN, Chan MH, Donson AM, Kleinschmidt-Demasters BK, Bemis LT, Handler MH, Foreman NK. Clinical and molecular characteristics of congenital glioblastoma. Neuro Oncol. 2012 Jul; 14(7):931-41. PMID: 22711608.
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    82. Harris PS, Venkataraman S, Alimova I, Birks DK, Donson AM, Knipstein J, Dubuc A, Taylor MD, Handler MH, Foreman NK, Vibhakar R. Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells. BMC Cancer. 2012 Mar 05; 12:80. PMID: 22390279.
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    83. Oluigbo CO, Wilkinson CC, Stence NV, Fenton LZ, McNatt SA, Handler MH. Comparison of outcomes following decompressive craniectomy in children with accidental and nonaccidental blunt cranial trauma. J Neurosurg Pediatr. 2012 Feb; 9(2):125-32. PMID: 22295915.
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    84. Visanji NP, Wong JC, Wang SX, Cappel B, Kleinschmidt-Demasters BK, Handler MH, Ochi A, Otsubo H, Rutka JT, Go C, Weiss S, Vinters HV, Hawkins CE, Desouza LV, Siu KW, Hazrati LN. A proteomic analysis of pediatric seizure cases associated with astrocytic inclusions. Epilepsia. 2012 Mar; 53(3):e50-4. PMID: 22220588.
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    85. Birks DK, Donson AM, Patel PR, Dunham C, Muscat A, Algar EM, Ashley DM, Kleinschmidt-Demasters BK, Vibhakar R, Handler MH, Foreman NK. High expression of BMP pathway genes distinguishes a subset of atypical teratoid/rhabdoid tumors associated with shorter survival. Neuro Oncol. 2011 Dec; 13(12):1296-307. PMID: 21946044.
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    86. Parsley L, Bellus G, Handler M, Tsai AC. Identical twin sisters with Rubinstein-Taybi syndrome associated with Chiari malformations and syrinx. Am J Med Genet A. 2011 Nov; 155A(11):2766-70. PMID: 21932317.
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    87. Hankinson TC, Campagna EJ, Foreman NK, Handler MH. Interpretation of magnetic resonance images in diffuse intrinsic pontine glioma: a survey of pediatric neurosurgeons. J Neurosurg Pediatr. 2011 Jul; 8(1):97-102. PMID: 21721895.
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    88. Birks DK, Barton VN, Donson AM, Handler MH, Vibhakar R, Foreman NK. Survey of MicroRNA expression in pediatric brain tumors. Pediatr Blood Cancer. 2011 Feb; 56(2):211-6. PMID: 21157891.
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    89. Barton VN, Foreman NK, Donson AM, Birks DK, Handler MH, Vibhakar R. Aurora kinase A as a rational target for therapy in glioblastoma. J Neurosurg Pediatr. 2010 Jul; 6(1):98-105. PMID: 20593995.
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    90. Katz JS, Oluigbo CO, Wilkinson CC, McNatt S, Handler MH. Prevalence of cervical spine injury in infants with head trauma. J Neurosurg Pediatr. 2010 May; 5(5):470-3. PMID: 20433260.
      View in: PubMed
    91. Handler MH, Foreman NK. Pontine gliomas. J Neurosurg Pediatr. 2010 Jan; 5(1):140-1; author reply 141-2. PMID: 20043750.
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    92. Donson AM, Birks DK, Barton VN, Wei Q, Kleinschmidt-Demasters BK, Handler MH, Waziri AE, Wang M, Foreman NK. Immune gene and cell enrichment is associated with a good prognosis in ependymoma. J Immunol. 2009 Dec 01; 183(11):7428-40. PMID: 19917695.
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    93. Barton VN, Donson AM, Kleinschmidt-DeMasters BK, Birks DK, Handler MH, Foreman NK. Unique molecular characteristics of pediatric myxopapillary ependymoma. Brain Pathol. 2010 May; 20(3):560-70. PMID: 19793339.
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    94. Madden JR, Dobyns E, Handler M, Foreman NK. Experience with electrolyte levels after craniotomy for pediatric brain tumors. J Pediatr Oncol Nurs. 2010 Jan-Feb; 27(1):21-3. PMID: 19687467.
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    95. Gault J, Awad IA, Recksiek P, Shenkar R, Breeze R, Handler M, Kleinschmidt-DeMasters BK. Cerebral cavernous malformations: somatic mutations in vascular endothelial cells. Neurosurgery. 2009 Jul; 65(1):138-44; discussion 144-5. PMID: 19574835.
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    96. Liu AK, Foreman NK, Gaspar LE, Trinidad E, Handler MH. Maximally safe resection followed by hypofractionated re-irradiation for locally recurrent ependymoma in children. Pediatr Blood Cancer. 2009 Jul; 52(7):804-7. PMID: 19260098.
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    97. Birks DK, Kleinschmidt-DeMasters BK, Donson AM, Barton VN, McNatt SA, Foreman NK, Handler MH. Claudin 6 is a positive marker for atypical teratoid/rhabdoid tumors. Brain Pathol. 2010 Jan; 20(1):140-50. PMID: 19220299.
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    98. Liu AK, Bagrosky B, Fenton LZ, Gaspar LE, Handler MH, McNatt SA, Foreman NK. Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy. Pediatr Blood Cancer. 2009 Feb; 52(2):227-30. PMID: 18937328.
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    99. Handler MH, Callahan B. Laparoscopic placement of distal ventriculoperitoneal shunt catheters. J Neurosurg Pediatr. 2008 Oct; 2(4):282-5. PMID: 18831665.
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    100. Hazrati LN, Kleinschmidt-DeMasters BK, Handler MH, Smith ML, Ochi A, Otsubo H, Rutka JT, Go C, Weiss S, Hawkins CE. Astrocytic inclusions in epilepsy: expanding the spectrum of filaminopathies. J Neuropathol Exp Neurol. 2008 Jul; 67(7):669-76. PMID: 18596546.
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    101. Bernard TJ, Mull BR, Handler MH, Harned RK, Filley CM, Kumpe DA, Tseng BS. An 18-year-old man with fenestrated vertebral arteries, recurrent stroke and successful angiographic coiling. J Neurol Sci. 2007 Sep 15; 260(1-2):279-82. PMID: 17568613.
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    102. Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK. MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr Blood Cancer. 2007 Apr; 48(4):403-7. PMID: 16609952.
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    103. Jorgenson L, Reiter PD, Freeman JE, Winston KR, Fish D, McBride LA, Handler MH. Vancomycin disposition and penetration into ventricular fluid of the central nervous system following intravenous therapy in patients with cerebrospinal devices. Pediatr Neurosurg. 2007; 43(6):449-55. PMID: 17992031.
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    104. Sowar K, Straessle J, Donson AM, Handler M, Foreman NK. Predicting which children are at risk for ependymoma relapse. J Neurooncol. 2006 May; 78(1):41-6. PMID: 16575538.
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    105. Townsend N, Handler M, Fleitz J, Foreman N. Intramedullary spinal cord astrocytomas in children. Pediatr Blood Cancer. 2004 Nov; 43(6):629-32. PMID: 15390309.
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    106. Smith AA, Weng E, Handler M, Foreman NK. Intracranial germ cell tumors: a single institution experience and review of the literature. J Neurooncol. 2004 Jun; 68(2):153-9. PMID: 15218952.
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    107. Gore L, Greffe BS, Rothenberg SS, Erickson M, Schreiber DP, Handler MH. Long-term survival after intralesional resection and multi-modal therapy of thoracic spine osteosarcoma. Med Pediatr Oncol. 2003 Jun; 40(6):400-2. PMID: 12692814.
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    108. McDowell BC, Morton BE, Janik JS, Gerow RK, Handler MH, Lowenstein AD, Cochran JH, Coughlin P, Youtz T, Conlan S. Separation of conjoined pygopagus twins. Plast Reconstr Surg. 2003 May; 111(6):1998-2002. PMID: 12711962.
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    109. Eule JM, Erickson MA, O'Brien MF, Handler M. Chiari I malformation associated with syringomyelia and scoliosis: a twenty-year review of surgical and nonsurgical treatment in a pediatric population. Spine (Phila Pa 1976). 2002 Jul 01; 27(13):1451-5. PMID: 12131745.
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    110. Orr LC, Fleitz J, McGavran L, Wyatt-Ashmead J, Handler M, Foreman NK. Cytogenetics in pediatric low-grade astrocytomas. Med Pediatr Oncol. 2002 Mar; 38(3):173-7. PMID: 11836716.
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    111. Fenton LZ, Sirotnak AP, Handler MH. Parietal pseudofracture and spontaneous intracranial hemorrhage suggesting nonaccidental trauma: report of 2 cases. Pediatr Neurosurg. 2000 Dec; 33(6):318-22. PMID: 11182643.
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    112. Disabato JA, Handler MH, Strain JD, Fleitz JM, Foreman NK. Successful use of intracavitary bleomycin for low-grade astrocytoma tumor cyst. Pediatr Neurosurg. 1999 Nov; 31(5):246-50. PMID: 10681679.
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    113. Sharma B, Handler M, Eichstetter I, Whitelock JM, Nugent MA, Iozzo RV. Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo. J Clin Invest. 1998 Oct 15; 102(8):1599-608. PMID: 9788974.
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    114. Weinberg JS, Freed DL, Sadock J, Handler M, Wisoff JH, Epstein FJ. Headache and Chiari I malformation in the pediatric population. Pediatr Neurosurg. 1998 Jul; 29(1):14-8. PMID: 9755306.
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    115. Foreman NK, Hay TC, Handler M. Chemotherapy for spinal cord astrocytoma. Med Pediatr Oncol. 1998 May; 30(5):311-2. PMID: 9544231.
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    116. Handler MH. A complication in removing a retained ventricular catheter using electrocautery. Pediatr Neurosurg. 1996 Nov; 25(5):276. PMID: 9309794.
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    117. Handler MH, Abbott R, Lee M. A near-fatal complication of endoscopic third ventriculostomy: case report. Neurosurgery. 1994 Sep; 35(3):525-7; discussion 527-8. PMID: 7800147.
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    118. Bridges N, Rifkinson-Mann S, Handler M, Epstein F. Planning ventriculoperitoneal shunts in infants and small children. Pediatr Neurosci. 1988; 14(4):191-5. PMID: 3269539.
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    119. Rosenblum B, Overby C, Levine M, Handler M, Sprecher S. Monostotic fibrous dysplasia of the thoracic spine. Spine (Phila Pa 1976). 1987 Nov; 12(9):939-42. PMID: 3327174.
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