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David C Thompson

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-2888

    Collapse Research 
    Collapse research activities and funding
    R01HL047101     (THOMPSON, DAVID C)Aug 1, 1991 - Jul 31, 1997
    NIH/NHLBI
    LOCAL REFLEXES IN THE AIRWAYS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Matsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson DC, Singh S, Smith C, Messersmith W, Vasiliou V. Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer. Br J Cancer. 2017 Sep 07. PMID: 28881356.
      View in: PubMed
    2. Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS. Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice. Behav Brain Res. 2017 Sep 15; 334:72-77. PMID: 28743602.
      View in: PubMed
    3. Charkoftaki G, Chen Y, Han M, Sandoval M, Yu X, Zhao H, Orlicky DJ, Thompson DC, Vasiliou V. Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function. Chem Biol Interact. 2017 Feb 28. PMID: 28254523.
      View in: PubMed
    4. Chen Y, Jester JV, Anderson DM, Marchitti SA, Schey KL, Thompson DC, Vasiliou V. Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry. Chem Biol Interact. 2016 Dec 27. PMID: 28038895.
      View in: PubMed
    5. Matsumoto A, Thompson DC, Chen Y, Kitagawa K, Vasiliou V. Roles of defective ALDH2 polymorphism on liver protection and cancer development. Environ Health Prev Med. 2016 Nov; 21(6):395-402. PMID: 27714678.
      View in: PubMed
    6. Heit C, Eriksson P, Thompson DC, Charkoftaki G, Fritz KS, Vasiliou V. Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS. Alcohol Clin Exp Res. 2016 Sep; 40(9):1825-31. PMID: 27501276; PMCID: PMC5008984 [Available on 09/01/17].
    7. Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V. Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. Sci Rep. 2016 Jul 12; 6:29743. PMID: 27403993; PMCID: PMC4940737.
    8. Nebert DW, Dong H, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Letter to the editor for "Update of the human and mouse Fanconi anemia genes". Hum Genomics. 2016 Jul 04; 10(1):25. PMID: 27377885; PMCID: PMC4932714.
    9. Koppaka V, Chen Y, Mehta G, Orlicky DJ, Thompson DC, Jester JV, Vasiliou V. ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis. PLoS One. 2016; 11(1):e0146433. PMID: 26751691; PMCID: PMC4708999.
    10. Singh S, Arcaroli JJ, Orlicky DJ, Chen Y, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Thompson DC, Vasiliou V. Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma. Pancreas. 2016 Jan; 45(1):117-22. PMID: 26566217.
      View in: PubMed
    11. Dong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V. Update of the human and mouse Fanconi anemia genes. Hum Genomics. 2015 Nov 24; 9:32. PMID: 26596371; PMCID: PMC4657327.
    12. Jackson BC, Thompson DC, Charkoftaki G, Vasiliou V. Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology. Expert Opin Drug Metab Toxicol. 2015; 11(12):1839-47. PMID: 26558415; PMCID: PMC4937717 [Available on 11/11/16].
    13. Singh S, Chen Y, Matsumoto A, Orlicky DJ, Dong H, Thompson DC, Vasiliou V. ALDH1B1 links alcohol consumption and diabetes. Biochem Biophys Res Commun. 2015 Aug 07; 463(4):768-773. PMID: 26086111; PMCID: PMC4517591.
    14. Singh S, Arcaroli J, Chen Y, Thompson DC, Messersmith W, Jimeno A, Vasiliou V. ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/ß-Catenin, Notch and PI3K/Akt Signaling Pathways. PLoS One. 2015; 10(5):e0121648. PMID: 25950950; PMCID: PMC4423958.
    15. Heit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V. Transgenic mouse models for alcohol metabolism, toxicity, and cancer. Adv Exp Med Biol. 2015; 815:375-87. PMID: 25427919; PMCID: PMC4323349.
    16. Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V. Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling. Pharm Res. 2015 May; 32(5):1648-62. PMID: 25413692; PMCID: PMC4382438.
    17. Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Hum Genomics. 2014 Sep 01; 8:16. PMID: 25181945; PMCID: PMC4445687.
    18. Jang JH, Bruse S, Liu Y, Duffy V, Zhang C, Oyamada N, Randell S, Matsumoto A, Thompson DC, Lin Y, Vasiliou V, Tesfaigzi Y, Nyunoya T. Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity. Free Radic Biol Med. 2014 Mar; 68:80-6. PMID: 24316006; PMCID: PMC3941192.
    19. Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V. Update of the human and mouse SERPIN gene superfamily. Hum Genomics. 2013 Oct 30; 7:22. PMID: 24172014; PMCID: PMC3880077.
    20. Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V. Glutathione defense mechanism in liver injury: insights from animal models. Food Chem Toxicol. 2013 Oct; 60:38-44. PMID: 23856494; PMCID: PMC3801188.
    21. Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC. ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1. Chem Biol Interact. 2013 Feb 25; 202(1-3):22-31. PMID: 23348497; PMCID: PMC3746320.
    22. Heit C, Dong H, Chen Y, Thompson DC, Deitrich RA, Vasiliou VK. The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system. Subcell Biochem. 2013; 67:235-47. PMID: 23400924; PMCID: PMC4314297.
    23. Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V. Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2. Chem Biol Interact. 2013 Feb 25; 202(1-3):11-21. PMID: 23247008; PMCID: PMC3687035.
    24. Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. Free Radic Biol Med. 2013 Mar; 56:89-101. PMID: 23195683; PMCID: PMC3631350.
    25. Vasiliou V, Thompson DC, Smith C, Fujita M, Chen Y. Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells. Chem Biol Interact. 2013 Feb 25; 202(1-3):2-10. PMID: 23159885; PMCID: PMC4128326.
    26. Thompson DC, Nuffer W, Brown K. Characteristics valued by the pharmacy practice community when hiring a recently graduated pharmacist. Am J Pharm Educ. 2012 Nov 12; 76(9):170. PMID: 23193334; PMCID: PMC3508484.
    27. Chen Y, Thompson DC, Koppaka V, Jester JV, Vasiliou V. Ocular aldehyde dehydrogenases: protection against ultraviolet damage and maintenance of transparency for vision. Prog Retin Eye Res. 2013 Mar; 33:28-39. PMID: 23098688; PMCID: PMC3570594.
    28. Luo Y, Dallaglio K, Chen Y, Robinson WA, Robinson SE, McCarter MD, Wang J, Gonzalez R, Thompson DC, Norris DA, Roop DR, Vasiliou V, Fujita M. ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets. Stem Cells. 2012 Oct; 30(10):2100-13. PMID: 22887839; PMCID: PMC3448863.
    29. Brocker C, Thompson DC, Vasiliou V. The role of hyperosmotic stress in inflammation and disease. Biomol Concepts. 2012 Aug; 3(4):345-364. PMID: 22977648.
      View in: PubMed
    30. Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacol Rev. 2012 Jul; 64(3):520-39. PMID: 22544865; PMCID: PMC3400832.
    31. Black W, Chen Y, Matsumoto A, Thompson DC, Lassen N, Pappa A, Vasiliou V. Molecular mechanisms of ALDH3A1-mediated cellular protection against 4-hydroxy-2-nonenal. Free Radic Biol Med. 2012 May 01; 52(9):1937-44. PMID: 22406320; PMCID: PMC3457646.
    32. Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Exp Hematol. 2012 Apr; 40(4):318-29.e2. PMID: 22198153.
      View in: PubMed
    33. Gibson DS, Rooney ME, Finnegan S, Qiu J, Thompson DC, Labaer J, Pennington SR, Duncan MW. Biomarkers in rheumatology, now and in the future. Rheumatology (Oxford). 2012 Mar; 51(3):423-33. PMID: 22179724.
      View in: PubMed
    34. Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. Hum Genomics. 2011 Oct; 5(6):691-702. PMID: 22155607; PMCID: PMC3251818.
    35. Marchitti SA, Chen Y, Thompson DC, Vasiliou V. Ultraviolet radiation: cellular antioxidant response and the role of ocular aldehyde dehydrogenase enzymes. Eye Contact Lens. 2011 Jul; 37(4):206-13. PMID: 21670692; PMCID: PMC3356694.
    36. Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Hum Genomics. 2011 May; 5(4):283-303. PMID: 21712190; PMCID: PMC3392178.
    37. Chen Y, Koppaka V, Thompson DC, Vasiliou V. Focus on molecules: ALDH1A1: from lens and corneal crystallin to stem cell marker. Exp Eye Res. 2012 Sep; 102:105-6. PMID: 21536030; PMCID: PMC3423494.
    38. Chen Y, Orlicky DJ, Matsumoto A, Singh S, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1 (ALDH1B1) is a potential biomarker for human colon cancer. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):173-9. PMID: 21216231; PMCID: PMC3112362.
    39. Stagos D, Chen Y, Brocker C, Donald E, Jackson BC, Orlicky DJ, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metab Dispos. 2010 Oct; 38(10):1679-87. PMID: 20616185; PMCID: PMC2957164.
    40. Dwyer-Nield LD, Srebernak MC, Barrett BS, Ahn J, Cosper P, Meyer AM, Kisley LR, Bauer AK, Thompson DC, Malkinson AM. Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines. Carcinogenesis. 2005 Jul; 26(7):1196-206. PMID: 15746162.
      View in: PubMed
    41. Kisley LR, Barrett BS, Bauer AK, Dwyer-Nield LD, Barthel B, Meyer AM, Thompson DC, Malkinson AM. Genetic ablation of inducible nitric oxide synthase decreases mouse lung tumorigenesis. Cancer Res. 2002 Dec 01; 62(23):6850-6. PMID: 12460898.
      View in: PubMed
    42. Kisley LR, Barrett BS, Dwyer-Nield LD, Bauer AK, Thompson DC, Malkinson AM. Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice. Carcinogenesis. 2002 Oct; 23(10):1653-60. PMID: 12376474.
      View in: PubMed
    43. Thompson DC, Porter SE, Bauer AK, Das KC, Ou B, Dwyer-Nield L, White CW, Malkinson AM. Cytokine-induced nitric oxide formation in normal but not in neoplastic murine lung epithelial cell lines. Am J Physiol. 1998 Jun; 274(6 Pt 1):L922-32. PMID: 9609731.
      View in: PubMed
    44. Thompson DC, Altiere RJ. Differential susceptibility of tracheal contraction to nonadrenergic noncholinergic relaxation. J Pharmacol Exp Ther. 1998 Jan; 284(1):19-24. PMID: 9435155.
      View in: PubMed
    45. Cibulsky SM, Thompson DC. Absence of tachykinin involvement in leukotriene D4 and antigen-induced contraction of guinea pig isolated bronchus. J Pharmacol Exp Ther. 1997 Dec; 283(3):1102-9. PMID: 9399982.
      View in: PubMed
    46. Lindsay G, Diamond L, Thompson DC, Cibulsky SM, Altiere RJ. Nitric oxide. Role as a relaxant agonist and transmitter of nonadrenergic noncholinergic inhibitory nerves in guinea pig trachea. Chest. 1995 Mar; 107(3 Suppl):125S. PMID: 7874990.
      View in: PubMed
    47. Altiere RJ, Travis DC, Thompson DC. Characterization of acetylcholinesterase in rabbit intrapulmonary arteries. Am J Physiol. 1994 Dec; 267(6 Pt 1):L745-52. PMID: 7810679.
      View in: PubMed
    48. Altiere RJ, Travis DC, Roberts J, Thompson DC. Pharmacological characterization of muscarinic receptors mediating acetylcholine-induced contraction and relaxation in rabbit intrapulmonary arteries. J Pharmacol Exp Ther. 1994 Jul; 270(1):269-76. PMID: 8035325.
      View in: PubMed
    49. Thompson DC, Diamond L, Altiere RJ. Atypical presynaptic alpha-adrenoceptor modulation of neurally-mediated cholinergic responses in guinea-pig tracheal smooth muscle. Pulm Pharmacol. 1992 Dec; 5(4):251-5. PMID: 1477481.
      View in: PubMed
    50. Altiere RJ, Thompson DC. Modulation of cholinergic responses by N omega-nitro-L-arginine in rabbit intrapulmonary arteries. Pulm Pharmacol. 1992 Jun; 5(2):149-51. PMID: 1611234.
      View in: PubMed
    51. Altiere RJ, Diamond L, Thompson DC. Omega-conotoxin-sensitive calcium channels modulate autonomic neurotransmission in guinea pig airways. J Pharmacol Exp Ther. 1992 Jan; 260(1):98-103. PMID: 1309883.
      View in: PubMed
    52. Thompson DC, Szarek JL, Altiere RJ, Diamond L. Nonadrenergic bronchodilation induced by high concentrations of sulfur dioxide. J Appl Physiol (1985). 1990 Nov; 69(5):1786-91. PMID: 2272972.
      View in: PubMed
    53. Thompson DC, Diamond L, Altiere RJ. Enzymatic modulation of vasoactive intestinal peptide and nonadrenergic noncholinergic inhibitory responses in guinea pig tracheae. Am Rev Respir Dis. 1990 Nov; 142(5):1119-23. PMID: 2240834.
      View in: PubMed
    54. Thompson DC, Diamond L, Altiere RJ. Presynaptic alpha adrenoceptor modulation of neurally mediated cholinergic excitatory and nonadrenergic noncholinergic inhibitory responses in guinea pig trachea. J Pharmacol Exp Ther. 1990 Jul; 254(1):306-11. PMID: 2164097.
      View in: PubMed
    55. Thompson DC, Altiere RJ, Diamond L. Nicotinic agonist modulation of feline bronchomotor tone. Clin Exp Pharmacol Physiol. 1990 Feb; 17(2):83-97. PMID: 2328544.
      View in: PubMed
    56. Altiere RJ, Thompson DC, Catravas JD. Dichotomous actions of endothelium-derived factors in modulating vasomotor tone in rabbit pulmonary arteries. Pulm Pharmacol. 1989; 2(1):55-8. PMID: 2520488.
      View in: PubMed
    57. Diamond L, Altiere RJ, Thompson DC. The airway nonadrenergic noncholinergic inhibitory nervous system. Chest. 1988 Jun; 93(6):1283-5. PMID: 3286146.
      View in: PubMed
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