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Jeffrey Benjamin Kaplan

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology
Phone720/848-4453

    Collapse Research 
    Collapse research activities and funding
    F32AI007281     (KAPLAN, JEFFREY B)Mar 23, 1986
    NIH/NIAID
    REGULATION OF DIFFERENTIATION IN CAULOBACTER
    Role: Principal Investigator

    R01DE015124     (KAPLAN, JEFFREY B)Jul 1, 2004 - Mar 31, 2008
    NIH/NIDCR
    Biofilm growth and detachment of an oral pathogen
    Role: Principal Investigator

    R21AI082392     (KAPLAN, JEFFREY B)Jul 22, 2009 - Jun 30, 2012
    NIH/NIAID
    Anti-staphylococcal activities of A. actinomycetemcomitans dispersin B
    Role: Principal Investigator

    R01AI097182     (KAPLAN, JEFFREY B)Apr 1, 2012 - Mar 31, 2015
    NIH/NIAID
    Biofilm matrix-degrading enzymes for the treatment and prevention of S. aureus-as
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kaplan JB, Sampathkumar V, Bendaoud M, Giannakakis AK, Lally ET, Balashova NV. In vitro characterization of biofilms formed by Kingella kingae. Mol Oral Microbiol. 2017 Aug; 32(4):341-353. PMID: 27714987.
      View in: PubMed
    2. Mlynek KD, Callahan MT, Shimkevitch AV, Farmer JT, Endres JL, Marchand M, Bayles KW, Horswill AR, Kaplan JB. Effects of Low-Dose Amoxicillin on Staphylococcus aureus USA300 Biofilms. Antimicrob Agents Chemother. 2016 May; 60(5):2639-51. PMID: 26856828; PMCID: PMC4862544 [Available on 11/01/16].
    3. Boniface MM, Wani SB, Schefter TE, Koo PJ, Meguid C, Leong S, Kaplan JB, Wingrove LJ, McCarter MD. Multidisciplinary management for esophageal and gastric cancer. Cancer Manag Res. 2016; 8:39-44. PMID: 27217796; PMCID: PMC4853141.
    4. Shanmugam M, Gopal P, El Abbar F, Schreiner HC, Kaplan JB, Fine DH, Ramasubbu N. Role of exopolysaccharide in Aggregatibacter actinomycetemcomitans-induced bone resorption in a rat model for periodontal disease. PLoS One. 2015; 10(2):e0117487. PMID: 25706999; PMCID: PMC4338281.
    5. Nait Chabane Y, Marti S, Rihouey C, Alexandre S, Hardouin J, Lesouhaitier O, Vila J, Kaplan JB, Jouenne T, Dé E. Characterisation of pellicles formed by Acinetobacter baumannii at the air-liquid interface. PLoS One. 2014; 9(10):e111660. PMID: 25360550; PMCID: PMC4216135.
    6. Song EK, Tai WM, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Pitts TM, Wang G, Blatchford P, Yahn R, Kaplan J, Tan AC, Atreya CE, Eckhardt G, Kelley RK, Venook A, Kwak EL, Ryan D, Arcaroli JJ. Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model. Int J Cancer. 2015 Apr 15; 136(8):1967-75. PMID: 25242168; PMCID: PMC4323738.
    7. Farmer JT, Shimkevitch AV, Reilly PS, Mlynek KD, Jensen KS, Callahan MT, Bushaw-Newton KL, Kaplan JB. Environmental bacteria produce abundant and diverse antibiofilm compounds. J Appl Microbiol. 2014 Dec; 117(6):1663-73. PMID: 25179003.
      View in: PubMed
    8. Kaplan JB. Biofilm matrix-degrading enzymes. Methods Mol Biol. 2014; 1147:203-13. PMID: 24664835.
      View in: PubMed
    9. Ng M, Epstein SB, Callahan MT, Piotrowski BO, Simon GL, Roberts AD, Keiser JF, Kaplan JB. Induction of MRSA Biofilm by Low-Dose ß-Lactam Antibiotics: Specificity, Prevalence and Dose-Response Effects. Dose Response. 2014 Jan; 12(1):152-61. PMID: 24659939; PMCID: PMC3960960.
    10. Banerjee A, Kaplan JB, Soherwardy A, Nudell Y, Mackenzie GA, Johnson S, Balashova NV. Characterization of TEM-1 ß-Lactamase-Producing Kingella kingae Clinical Isolates. Antimicrob Agents Chemother. 2013 Sep; 57(9):4300-4306. PMID: 23796935.
      View in: PubMed
    11. Karwacki MT, Kadouri DE, Bendaoud M, Izano EA, Sampathkumar V, Inzana TJ, Kaplan JB. Antibiofilm activity of Actinobacillus pleuropneumoniae serotype 5 capsular polysaccharide. PLoS One. 2013; 8(5):e63844. PMID: 23691104; PMCID: PMC3653790.
    12. Pavlukhina SV, Kaplan JB, Xu L, Chang W, Yu X, Madhyastha S, Yakandawala N, Mentbayeva A, Khan B, Sukhishvili SA. Noneluting enzymatic antibiofilm coatings. ACS Appl Mater Interfaces. 2012 Sep 26; 4(9):4708-16. PMID: 22909396; PMCID: PMC3459334.
    13. Kaplan JB, Izano EA, Gopal P, Karwacki MT, Kim S, Bose JL, Bayles KW, Horswill AR. Low levels of ß-lactam antibiotics induce extracellular DNA release and biofilm formation in Staphylococcus aureus. MBio. 2012; 3(4):e00198-12. PMID: 22851659; PMCID: PMC3419523.
    14. Rendueles O, Kaplan JB, Ghigo JM. Antibiofilm polysaccharides. Environ Microbiol. 2013 Feb; 15(2):334-46. PMID: 22730907; PMCID: PMC3502681.
    15. Kaplan JB, Lo C, Xie G, Johnson SL, Chain PS, Donnelly R, Kachlany SC, Balashova NV. Genome sequence of Kingella kingae septic arthritis isolate PYKK081. J Bacteriol. 2012 Jun; 194(11):3017. PMID: 22582375; PMCID: PMC3370631.
    16. Kaplan JB, LoVetri K, Cardona ST, Madhyastha S, Sadovskaya I, Jabbouri S, Izano EA. Recombinant human DNase I decreases biofilm and increases antimicrobial susceptibility in staphylococci. J Antibiot (Tokyo). 2012 Feb; 65(2):73-7. PMID: 22167157; PMCID: PMC3288126.
    17. Kaplan JB. Antibiotic-induced biofilm formation. Int J Artif Organs. 2011 Sep; 34(9):737-51. PMID: 22094552.
      View in: PubMed
    18. Bendaoud M, Vinogradov E, Balashova NV, Kadouri DE, Kachlany SC, Kaplan JB. Broad-spectrum biofilm inhibition by Kingella kingae exopolysaccharide. J Bacteriol. 2011 Aug; 193(15):3879-86. PMID: 21602333; PMCID: PMC3147541.
    19. Kaplan JB, Jabbouri S, Sadovskaya I. Extracellular DNA-dependent biofilm formation by Staphylococcus epidermidis RP62A in response to subminimal inhibitory concentrations of antibiotics. Res Microbiol. 2011 Jun; 162(5):535-41. PMID: 21402153; PMCID: PMC3109171.
    20. Lee JH, Wang H, Kaplan JB, Lee WY. Microfluidic approach to create three-dimensional tissue models for biofilm-related infection of orthopaedic implants. Tissue Eng Part C Methods. 2011 Jan; 17(1):39-48. PMID: 20618080.
      View in: PubMed
    21. Fine DH, Kaplan JB, Furgang D, Karched M, Velliyagounder K, Yue G. Mapping the epithelial-cell-binding domain of the Aggregatibacter actinomycetemcomitans autotransporter adhesin Aae. Microbiology. 2010 Nov; 156(Pt 11):3412-20. PMID: 20688817; PMCID: PMC3090143.
    22. Lee JH, Wang H, Kaplan JB, Lee WY. Effects of Staphylococcus epidermidis on osteoblast cell adhesion and viability on a Ti alloy surface in a microfluidic co-culture environment. Acta Biomater. 2010 Nov; 6(11):4422-9. PMID: 20573556.
      View in: PubMed
    23. Kaplan JB. Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses. J Dent Res. 2010 Mar; 89(3):205-18. PMID: 20139339; PMCID: PMC3318030.
    24. Ra SH, Kaplan JB, Lassman CR. Focal nodular hyperplasia after orthotopic liver transplantation. Liver Transpl. 2010 Jan; 16(1):98-103. PMID: 19866450.
      View in: PubMed
    25. Kaplan JB. Therapeutic potential of biofilm-dispersing enzymes. Int J Artif Organs. 2009 Sep; 32(9):545-54. PMID: 19851978.
      View in: PubMed
    26. Yakandawala N, Gawande PV, LoVetri K, Romeo T, Kaplan JB, Madhyastha S. Enhanced expression of engineered ACA-less beta-1, 6-N-acetylglucosaminidase (dispersin B) in Escherichia coli. J Ind Microbiol Biotechnol. 2009 Oct; 36(10):1297-305. PMID: 19597857.
      View in: PubMed
    27. Di Bonaventura MP, DeSalle R, Pop M, Nagarajan N, Figurski DH, Fine DH, Kaplan JB, Planet PJ. Complete genome sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700. J Bacteriol. 2009 Jul; 191(14):4693-4. PMID: 19447908; PMCID: PMC2704734.
    28. Izano EA, Shah SM, Kaplan JB. Intercellular adhesion and biocide resistance in nontypeable Haemophilus influenzae biofilms. Microb Pathog. 2009 Apr; 46(4):207-13. PMID: 19490830; PMCID: PMC2691864.
    29. Ganeshnarayan K, Shah SM, Libera MR, Santostefano A, Kaplan JB. Poly-N-acetylglucosamine matrix polysaccharide impedes fluid convection and transport of the cationic surfactant cetylpyridinium chloride through bacterial biofilms. Appl Environ Microbiol. 2009 Mar; 75(5):1308-14. PMID: 19114520; PMCID: PMC2648167.
    30. Kerrigan JE, Ragunath C, Kandra L, Gyémánt G, Lipták A, Jánossy L, Kaplan JB, Ramasubbu N. Modeling and biochemical analysis of the activity of antibiofilm agent Dispersin B. Acta Biol Hung. 2008 Dec; 59(4):439-51. PMID: 19133500.
      View in: PubMed
    31. Krsko P, Kaplan JB, Libera M. Spatially controlled bacterial adhesion using surface-patterned poly(ethylene glycol) hydrogels. Acta Biomater. 2009 Feb; 5(2):589-96. PMID: 18842467.
      View in: PubMed
    32. Lee JH, Kaplan JB, Lee WY. Microfluidic devices for studying growth and detachment of Staphylococcus epidermidis biofilms. Biomed Microdevices. 2008 Aug; 10(4):489-98. PMID: 18204904.
      View in: PubMed
    33. Isaza MP, Duncan MS, Kaplan JB, Kachlany SC. Screen for leukotoxin mutants in Aggregatibacter actinomycetemcomitans: genes of the phosphotransferase system are required for leukotoxin biosynthesis. Infect Immun. 2008 Aug; 76(8):3561-8. PMID: 18541661; PMCID: PMC2493242.
    34. Venketaraman V, Lin AK, Le A, Kachlany SC, Connell ND, Kaplan JB. Both leukotoxin and poly-N-acetylglucosamine surface polysaccharide protect Aggregatibacter actinomycetemcomitans cells from macrophage killing. Microb Pathog. 2008 Sep; 45(3):173-80. PMID: 18573331; PMCID: PMC2586082.
    35. Rupani D, Izano EA, Schreiner HC, Fine DH, Kaplan JB. Aggregatibacter actinomycetemcomitans serotype f O-polysaccharide mediates coaggregation with Fusobacterium nucleatum. Oral Microbiol Immunol. 2008 Apr; 23(2):127-30. PMID: 18279180.
      View in: PubMed
    36. Izano EA, Amarante MA, Kher WB, Kaplan JB. Differential roles of poly-N-acetylglucosamine surface polysaccharide and extracellular DNA in Staphylococcus aureus and Staphylococcus epidermidis biofilms. Appl Environ Microbiol. 2008 Jan; 74(2):470-6. PMID: 18039822; PMCID: PMC2223269.
    37. Manuel SG, Ragunath C, Sait HB, Izano EA, Kaplan JB, Ramasubbu N. Role of active-site residues of dispersin B, a biofilm-releasing beta-hexosaminidase from a periodontal pathogen, in substrate hydrolysis. FEBS J. 2007 Nov; 274(22):5987-99. PMID: 17949435.
      View in: PubMed
    38. Izano EA, Sadovskaya I, Wang H, Vinogradov E, Ragunath C, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB. Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance in Aggregatibacter actinomycetemcomitans. Microb Pathog. 2008 Jan; 44(1):52-60. PMID: 17851029; PMCID: PMC2253675.
    39. Yue G, Kaplan JB, Furgang D, Mansfield KG, Fine DH. A second Aggregatibacter actinomycetemcomitans autotransporter adhesin exhibits specificity for buccal epithelial cells in humans and Old World primates. Infect Immun. 2007 Sep; 75(9):4440-8. PMID: 17620359; PMCID: PMC1951147.
    40. Izano EA, Wang H, Ragunath C, Ramasubbu N, Kaplan JB. Detachment and killing of Aggregatibacter actinomycetemcomitans biofilms by dispersin B and SDS. J Dent Res. 2007 Jul; 86(7):618-22. PMID: 17586707.
      View in: PubMed
    41. Donelli G, Francolini I, Romoli D, Guaglianone E, Piozzi A, Ragunath C, Kaplan JB. Synergistic activity of dispersin B and cefamandole nafate in inhibition of staphylococcal biofilm growth on polyurethanes. Antimicrob Agents Chemother. 2007 Aug; 51(8):2733-40. PMID: 17548491; PMCID: PMC1932551.
    42. Izano EA, Sadovskaya I, Vinogradov E, Mulks MH, Velliyagounder K, Ragunath C, Kher WB, Ramasubbu N, Jabbouri S, Perry MB, Kaplan JB. Poly-N-acetylglucosamine mediates biofilm formation and antibiotic resistance in Actinobacillus pleuropneumoniae. Microb Pathog. 2007 Jul; 43(1):1-9. PMID: 17412552; PMCID: PMC1950449.
    43. Chaignon P, Sadovskaya I, Ragunah Ch, Ramasubbu N, Kaplan JB, Jabbouri S. Susceptibility of staphylococcal biofilms to enzymatic treatments depends on their chemical composition. Appl Microbiol Biotechnol. 2007 May; 75(1):125-32. PMID: 17221196.
      View in: PubMed
    44. Rohde H, Burandt EC, Siemssen N, Frommelt L, Burdelski C, Wurster S, Scherpe S, Davies AP, Harris LG, Horstkotte MA, Knobloch JK, Ragunath C, Kaplan JB, Mack D. Polysaccharide intercellular adhesin or protein factors in biofilm accumulation of Staphylococcus epidermidis and Staphylococcus aureus isolated from prosthetic hip and knee joint infections. Biomaterials. 2007 Mar; 28(9):1711-20. PMID: 17187854.
      View in: PubMed
    45. Akman HO, Karadimas C, Gyftodimou Y, Grigoriadou M, Kokotas H, Konstantinidou A, Anninos H, Patsouris E, Thaker HM, Kaplan JB, Besharat I, Hatzikonstantinou K, Fotopoulos S, Dimauro S, Petersen MB. Prenatal diagnosis of glycogen storage disease type IV. Prenat Diagn. 2006 Oct; 26(10):951-5. PMID: 16874838.
      View in: PubMed
    46. Fine DH, Kaplan JB, Kachlany SC, Schreiner HC. How we got attached to Actinobacillus actinomycetemcomitans: A model for infectious diseases. Periodontol 2000. 2006; 42:114-57. PMID: 16930309.
      View in: PubMed
    47. Ramasubbu N, Thomas LM, Ragunath C, Kaplan JB. Structural analysis of dispersin B, a biofilm-releasing glycoside hydrolase from the periodontopathogen Actinobacillus actinomycetemcomitans. J Mol Biol. 2005 Jun 10; 349(3):475-86. PMID: 15878175.
      View in: PubMed
    48. Kaplan JB, Mulks MH. Biofilm formation is prevalent among field isolates of Actinobacillus pleuropneumoniae. Vet Microbiol. 2005 Jun 15; 108(1-2):89-94. PMID: 15917136.
      View in: PubMed
    49. Fine DH, Velliyagounder K, Furgang D, Kaplan JB. The Actinobacillus actinomycetemcomitans autotransporter adhesin Aae exhibits specificity for buccal epithelial cells from humans and old world primates. Infect Immun. 2005 Apr; 73(4):1947-53. PMID: 15784534; PMCID: PMC1087452.
    50. Kaplan JB, Velliyagounder K, Ragunath C, Rohde H, Mack D, Knobloch JK, Ramasubbu N. Genes involved in the synthesis and degradation of matrix polysaccharide in Actinobacillus actinomycetemcomitans and Actinobacillus pleuropneumoniae biofilms. J Bacteriol. 2004 Dec; 186(24):8213-20. PMID: 15576769; PMCID: PMC532409.
    51. Kaplan JB, Ragunath C, Velliyagounder K, Fine DH, Ramasubbu N. Enzymatic detachment of Staphylococcus epidermidis biofilms. Antimicrob Agents Chemother. 2004 Jul; 48(7):2633-6. PMID: 15215120; PMCID: PMC434209.
    52. Velliyagounder K, Kaplan JB, Furgang D, Legarda D, Diamond G, Parkin RE, Fine DH. One of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis. Infect Immun. 2003 Nov; 71(11):6141-7. PMID: 14573629; PMCID: PMC219577.
    53. Kaplan JB, Ragunath C, Ramasubbu N, Fine DH. Detachment of Actinobacillus actinomycetemcomitans biofilm cells by an endogenous beta-hexosaminidase activity. J Bacteriol. 2003 Aug; 185(16):4693-8. PMID: 12896987; PMCID: PMC166467.
    54. Schreiner HC, Sinatra K, Kaplan JB, Furgang D, Kachlany SC, Planet PJ, Perez BA, Figurski DH, Fine DH. Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7295-300. PMID: 12756291; PMCID: PMC165869.
    55. Kaplan JB, Meyenhofer MF, Fine DH. Biofilm growth and detachment of Actinobacillus actinomycetemcomitans. J Bacteriol. 2003 Feb; 185(4):1399-404. PMID: 12562811; PMCID: PMC142852.
    56. Kaplan JB, Kokeguchi S, Murayama Y, Fine DH. Sequence diversity in the major fimbrial subunit gene (flp-1) of Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol. 2002 Dec; 17(6):354-9. PMID: 12485326.
      View in: PubMed
    57. Kaplan JB, Fine DH. Biofilm dispersal of Neisseria subflava and other phylogenetically diverse oral bacteria. Appl Environ Microbiol. 2002 Oct; 68(10):4943-50. PMID: 12324342; PMCID: PMC126399.
    58. Kaplan JB, Schreiner HC, Furgang D, Fine DH. Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. J Clin Microbiol. 2002 Apr; 40(4):1181-7. PMID: 11923328; PMCID: PMC140340.
    59. Kaplan JB, Perry MB, MacLean LL, Furgang D, Wilson ME, Fine DH. Structural and genetic analyses of O polysaccharide from Actinobacillus actinomycetemcomitans serotype f. Infect Immun. 2001 Sep; 69(9):5375-84. PMID: 11500407; PMCID: PMC98647.
    60. Kachlany SC, Planet PJ, Desalle R, Fine DH, Figurski DH, Kaplan JB. flp-1, the first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans. Mol Microbiol. 2001 May; 40(3):542-54. PMID: 11359562.
      View in: PubMed
    61. Kaplan JB, Fine DH. Codon usage in Actinobacillus actinomycetemcomitans. FEMS Microbiol Lett. 1998 Jun 01; 163(1):31-6. PMID: 9631542.
      View in: PubMed
    62. Kaplan JB, Dingwall A, Bryan R, Champer R, Shapiro L. Temporal regulation and overlap organization of two Caulobacter flagellar genes. J Mol Biol. 1989 Jan 05; 205(1):71-83. PMID: 2648000.
      View in: PubMed
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