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Brianna J Klein

TitleResearch Associate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Klein BJ, Vann KR, Andrews FH, Wang WW, Zhang J, Zhang Y, Beloglazkina AA, Mi W, Li Y, Li H, Shi X, Kutateladze AG, Strahl BD, Liu WR, Kutateladze TG. Structural insights into the p-p-p stacking mechanism and DNA-binding activity of the YEATS domain. Nat Commun. 2018 Nov 01; 9(1):4574. PMID: 30385749.
      View in: PubMed
    2. Zhang Y, Xue Y, Shi J, Ahn J, Mi W, Ali M, Wang X, Klein BJ, Wen H, Li W, Shi X, Kutateladze TG. The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3. Nat Struct Mol Biol. 2018 Sep; 25(9):841-849. PMID: 30150647.
      View in: PubMed
    3. Klein BJ, Krajewski K, Restrepo S, Lewis PW, Strahl BD, Kutateladze TG. Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers. Epigenetics. 2018; 13(7):683-692. PMID: 30045670.
      View in: PubMed
    4. Klein BJ, Ahmad S, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Côté J, Kutateladze TG. Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain. Nucleic Acids Res. 2018 Jan 09; 46(1):421-430. PMID: 29145630.
      View in: PubMed
    5. Simithy J, Sidoli S, Yuan ZF, Coradin M, Bhanu NV, Marchione DM, Klein BJ, Bazilevsky GA, McCullough CE, Magin RS, Kutateladze TG, Snyder NW, Marmorstein R, Garcia BA. Characterization of histone acylations links chromatin modifications with metabolism. Nat Commun. 2017 10 26; 8(1):1141. PMID: 29070843.
      View in: PubMed
    6. Tencer AH, Gatchalian J, Klein BJ, Khan A, Zhang Y, Strahl BD, van Wely KHM, Kutateladze TG. A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO. Structure. 2017 10 03; 25(10):1530-1539.e3. PMID: 28919441.
      View in: PubMed
    7. Klein BJ, Simithy J, Wang X, Ahn J, Andrews FH, Zhang Y, Côté J, Shi X, Garcia BA, Kutateladze TG. Recognition of Histone H3K14 Acylation by MORF. Structure. 2017 04 04; 25(4):650-654.e2. PMID: 28286003.
      View in: PubMed
    8. Klein BJ, Wang X, Cui G, Yuan C, Botuyan MV, Lin K, Lu Y, Wang X, Zhao Y, Bruns CJ, Mer G, Shi X, Kutateladze TG. PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation. Cell Rep. 2016 10 18; 17(4):1158-1170. PMID: 27760318.
      View in: PubMed
    9. Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML. ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Cancer Discov. 2016 07; 6(7):770-83. PMID: 27154821; PMCID: PMC4930721 [Available on 07/01/17].
    10. Gatchalian J, Gallardo CM, Shinsky SA, Ospina RR, Liendo AM, Krajewski K, Klein BJ, Andrews FH, Strahl BD, M van Wely KH, Kutateladze TG. Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive. Nucleic Acids Res. 2016 07 27; 44(13):6102-12. PMID: 27016734.
      View in: PubMed
    11. Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X. G9a-mediated methylation of ERa links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nat Commun. 2016 Mar 10; 7:10810. PMID: 26960573; PMCID: PMC4792926.
    12. Klein BJ, Muthurajan UM, Lalonde ME, Gibson MD, Andrews FH, Hepler M, Machida S, Yan K, Kurumizaka H, Poirier MG, Côté J, Luger K, Kutateladze TG. Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation. Nucleic Acids Res. 2016 Jan 08; 44(1):472-84. PMID: 26626149; PMCID: PMC4705663.
    13. Tong Q, Mazur SJ, Rincon-Arano H, Rothbart SB, Kuznetsov DM, Cui G, Liu WH, Gete Y, Klein BJ, Jenkins L, Mer G, Kutateladze AG, Strahl BD, Groudine M, Appella E, Kutateladze TG. An acetyl-methyl switch drives a conformational change in p53. Structure. 2015 Feb 03; 23(2):322-31. PMID: 25651062; PMCID: PMC4317571.
    14. Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar MA, Peña PV, Mangan A, Bentley DL, Strahl BD, Groudine M, Li W, Shi X, Kutateladze TG. The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Rep. 2014 Jan 30; 6(2):325-35. PMID: 24412361; PMCID: PMC3918441.
    15. Klein BJ, Lalonde ME, Côté J, Yang XJ, Kutateladze TG. Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes. Epigenetics. 2014 Feb; 9(2):186-93. PMID: 24169304; PMCID: PMC3962528.
    16. Lalonde ME, Avvakumov N, Glass KC, Joncas FH, Saksouk N, Holliday M, Paquet E, Yan K, Tong Q, Klein BJ, Tan S, Yang XJ, Kutateladze TG, Côté J. Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity. Genes Dev. 2013 Sep 15; 27(18):2009-24. PMID: 24065767; PMCID: PMC3792477.
    17. Klein BJ, Bose D, Baker KJ, Yusoff ZM, Zhang X, Murakami KS. RNA polymerase and transcription elongation factor Spt4/5 complex structure. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):546-50. PMID: 21187417; PMCID: PMC3021056.
    18. Hirata A, Klein BJ, Murakami KS. The X-ray crystal structure of RNA polymerase from Archaea. Nature. 2008 Feb 14; 451(7180):851-4. PMID: 18235446; PMCID: PMC2805805.
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