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James R Hagman

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/398-1398
    Other Positions
    TitleAffiliate - NJH
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-IMM MICRO GENERAL OPER

    TitleElectronic Research Admin
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-IMM MICRO GENERAL OPER


    Collapse Research 
    Collapse research activities and funding
    R03AI139822     (HAGMAN, JAMES R.)Nov 15, 2018 - Oct 31, 2021
    NIH
    Chd3 Conditional Knockout Mice: A New Tool for Studies of Lymphocyte Epigenetics
    Role: Principal Investigator
    R21AI138029     (HAGMAN, JAMES R.)May 15, 2018 - Apr 30, 2021
    NIH
    Regulation of Humoral Immunity by SR Protein Kinase 3
    Role: Principal Investigator
    R21AI115696     (HAGMAN, JAMES R.)Jun 15, 2015 - May 31, 2017
    NIH
    Regulation of V(D)J Recombination by Arginine Methylation
    Role: Principal Investigator
    R01AI098417     (HAGMAN, JAMES R.)Jul 3, 2012 - Jun 30, 2017
    NIH
    Regulation of B Cell Development and Function by Zfp521
    Role: Principal Investigator
    R01AI081878     (HAGMAN, JAMES R.)Feb 1, 2010 - Jan 31, 2015
    NIH
    Regulation of B Cell Identity and Lineage Progression
    Role: Principal Investigator
    R21CA107478     (HAGMAN, JAMES R)Apr 1, 2004 - Mar 31, 2006
    NIH
    Regulation of the Pax-5 Proto-Oncogen by Redox Mec,
    Role: Principal Investigator
    R01AI056322     (HAGMAN, JAMES R)Sep 1, 2003 - Dec 31, 2008
    NIH
    Transcriptional Control and Lineage Commitment by Pax-5
    Role: Principal Investigator
    R01AI054661     (HAGMAN, JAMES R)Apr 1, 2003 - Apr 30, 2012
    NIH
    Function and Regulation of Early B Cell Factor (EBF)
    Role: Principal Investigator
    R01AI037574     (HAGMAN, JAMES R)Mar 1, 1997 - Feb 28, 2003
    NIH
    REGULATION OF B CELL DIFFERENTIATION IN VITRO
    Role: Principal Investigator
    R21AI037574     (HAGMAN, JAMES R)Sep 1, 1996 - Aug 31, 1997
    NIH
    REGULATION OF B CELL DIFFERENTIATION IN VITRO
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hagman JR, Arends T, Laborda C, Knapp JR, Harmacek L, O'Connor BP. Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination. Immunol Rev. 2022 01; 305(1):29-42. PMID: 34927255.
      View in: PubMed
    2. Somasundaram R, Jensen CT, Tingvall-Gustafsson J, ?hsberg J, Okuyama K, Prasad M, Hagman JR, Wang X, Soneji S, Strid T, Ungerb?ck J, Sigvardsson M. EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. Blood. 2021 06 03; 137(22):3037-3049. PMID: 33619557.
      View in: PubMed
    3. Li Y, Gao J, Kamran M, Harmacek L, Danhorn T, Leach SM, O'Connor BP, Hagman JR, Huang H. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nat Commun. 2021 01 21; 12(1):494. PMID: 33479210.
      View in: PubMed
    4. Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 03; 105(3):585-597. PMID: 31101752.
      View in: PubMed
    5. Arends T, Dege C, Bortnick A, Danhorn T, Knapp JR, Jia H, Harmacek L, Fleenor CJ, Straign D, Walton K, Leach SM, Feeney AJ, Murre C, O'Connor BP, Hagman JR. CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10927-10936. PMID: 31085655.
      View in: PubMed
    6. Fleenor CJ, Arends T, Lei H, ?hsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, Hagman JR. Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment. Mol Cell Biol. 2018 09 01; 38(17). PMID: 29915154.
      View in: PubMed
    7. Liu H, Wang C, Lee S, Ning F, Wang Y, Zhang Q, Chen Z, Zang J, Nix J, Dai S, Marrack P, Hagman J, Kappler J, Zhang G. Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep. 2018 02 19; 8(1):3275. PMID: 29459673.
      View in: PubMed
    8. Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 10; 142(4):1173-1184. PMID: 29277702.
      View in: PubMed
    9. Hagman J. Critical Functions of IRF4 in B and T Lymphocytes. J Immunol. 2017 12 01; 199(11):3715-3716. PMID: 29158346.
      View in: PubMed
    10. Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7717-E7726. PMID: 28847961.
      View in: PubMed
    11. Hagman J. Editorial overview: Lymphocyte development and activation: Lymphoid cell differentiation: choosing paths to traverse the immune landscape. Curr Opin Immunol. 2016 Apr; 39:v-vii. PMID: 26923180.
      View in: PubMed
    12. Hayashi M, Jin Y, Yorgov D, Santorico SA, Hagman J, Ferrara TM, Jones KL, Cavalli G, Dinarello CA, Spritz RA. Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1357-62. PMID: 26787886.
      View in: PubMed
    13. Prasad MA, Ungerb?ck J, ?hsberg J, Somasundaram R, Strid T, Larsson M, M?nsson R, De Paepe A, Lilljebj?rn H, Fioretos T, Hagman J, Sigvardsson M. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency. Blood. 2015 Jun 25; 125(26):4052-9. PMID: 25838350.
      View in: PubMed
    14. Dege C, Hagman J. Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function. Immunol Rev. 2014 Sep; 261(1):126-40. PMID: 25123281.
      View in: PubMed
    15. Hagman J, Lukin K. Plasma cells for hire: prior experience required. Immunity. 2013 Jul 25; 39(1):89-91. PMID: 23890066.
      View in: PubMed
    16. Wang M, Ramirez J, Han J, Jia Y, Domenico J, Seibold MA, Hagman JR, Gelfand EW. The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis. J Allergy Clin Immunol. 2013 Nov; 132(5):1174-1183.e8. PMID: 23870673.
      View in: PubMed
    17. Dege C, Hagman J. Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res. 2013 Mar; 55(1-3):155-61. PMID: 22956488.
      View in: PubMed
    18. Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW. Ikaros promotes rearrangement of TCR a genes in an Ikaros null thymoma cell line. Eur J Immunol. 2013 Feb; 43(2):521-32. PMID: 23172374.
      View in: PubMed
    19. Ram?rez J, Dege C, Kutateladze TG, Hagman J. MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes. Mol Cell Biol. 2012 Dec; 32(24):5078-88. PMID: 23071088.
      View in: PubMed
    20. Musselman CA, Ram?rez J, Sims JK, Mansfield RE, Oliver SS, Denu JM, Mackay JP, Wade PA, Hagman J, Kutateladze TG. Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):787-92. PMID: 22215588.
      View in: PubMed
    21. Hagman J, Ram?rez J, Lukin K. B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1. Curr Top Microbiol Immunol. 2012; 356:17-38. PMID: 21735360.
      View in: PubMed
    22. Lukin K, Fields S, Guerrettaz L, Straign D, Rodriguez V, Zandi S, M?nsson R, Cambier JC, Sigvardsson M, Hagman J. A dose-dependent role for EBF1 in repressing non-B-cell-specific genes. Eur J Immunol. 2011 Jun; 41(6):1787-93. PMID: 21469119.
      View in: PubMed
    23. Hong X, Zang J, White J, Wang C, Pan CH, Zhao R, Murphy RC, Dai S, Henson P, Kappler JW, Hagman J, Zhang G. Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14568-72. PMID: 20679243.
      View in: PubMed
    24. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. PMID: 20543837.
      View in: PubMed
    25. Lukin K, Fields S, Lopez D, Cherrier M, Ternyak K, Ram?rez J, Feeney AJ, Hagman J. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7869-74. PMID: 20385820.
      View in: PubMed
    26. Ram?rez J, Lukin K, Hagman J. From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment. Curr Opin Immunol. 2010 Apr; 22(2):177-84. PMID: 20207529.
      View in: PubMed
    27. Ram?rez J, Hagman J. The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer. Epigenetics. 2009 Nov 16; 4(8):532-6. PMID: 19923891.
      View in: PubMed
    28. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 06; 284(45):31236-48. PMID: 19759004.
      View in: PubMed
    29. Hagman J. Conveying the message: identification of Ig-alpha and Ig-beta as components of the B cell receptor complex. J Immunol. 2009 Aug 01; 183(3):1503-4. PMID: 19620315.
      View in: PubMed
    30. Fitzsimmons D, Lukin K, Lutz R, Garvie CW, Wolberger C, Hagman J. Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5. J Mol Biol. 2009 Sep 18; 392(2):452-64. PMID: 19616560.
      View in: PubMed
    31. Gao H, Lukin K, Ram?rez J, Fields S, Lopez D, Hagman J. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11258-63. PMID: 19549820.
      View in: PubMed
    32. Thal MA, Carvalho TL, He T, Kim HG, Gao H, Hagman J, Klug CA. Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):552-7. PMID: 19122139.
      View in: PubMed
    33. Lukin K, Fields S, Hartley J, Hagman J. Early B cell factor: Regulator of B lineage specification and commitment. Semin Immunol. 2008 Aug; 20(4):221-7. PMID: 18722139.
      View in: PubMed
    34. Fields S, Ternyak K, Gao H, Ostraat R, Akerlund J, Hagman J. The 'zinc knuckle' motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes. Mol Immunol. 2008 Aug; 45(14):3786-96. PMID: 18606452.
      View in: PubMed
    35. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug; 27(2):281-95. PMID: 17723218.
      View in: PubMed
    36. Hagman J, Lukin K. "Hands-on" regulation of B cell development by the transcription factor Pax5. Immunity. 2007 Jul; 27(1):8-10. PMID: 17663980.
      View in: PubMed
    37. Matsuda JL, George TC, Hagman J, Gapin L. Temporal dissection of T-bet functions. J Immunol. 2007 Mar 15; 178(6):3457-65. PMID: 17339440.
      View in: PubMed
    38. Sawyer RT, Fontenot AP, Barnes TA, Parsons CE, Tooker BC, Maier LA, Gillespie MM, Gottschall EB, Silveira L, Hagman J, Newman LS. Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):191-200. PMID: 16980557.
      View in: PubMed
    39. Zhang Z, Espinoza CR, Yu Z, Stephan R, He T, Williams GS, Burrows PD, Hagman J, Feeney AJ, Cooper MD. Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes. Nat Immunol. 2006 Jun; 7(6):616-24. PMID: 16680144.
      View in: PubMed
    40. Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 2006 May 19; 125(4):691-702. PMID: 16677698.
      View in: PubMed
    41. Hagman J, Lukin K. Transcription factors drive B cell development. Curr Opin Immunol. 2006 Apr; 18(2):127-34. PMID: 16464566.
      View in: PubMed
    42. Hagman J, Lukin K. Early B-cell factor 'pioneers' the way for B-cell development. Trends Immunol. 2005 Sep; 26(9):455-61. PMID: 16027038.
      View in: PubMed
    43. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004 Oct; 5(10):1069-77. PMID: 15361869.
      View in: PubMed
    44. Steinke JW, Barekzi E, Hagman J, Borish L. Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1. J Immunol. 2004 Sep 01; 173(5):3215-22. PMID: 15322183.
      View in: PubMed
    45. Maier H, Ostraat R, Parenti S, Fitzsimmons D, Abraham LJ, Garvie CW, Hagman J. Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP). Nucleic Acids Res. 2003 Oct 01; 31(19):5483-9. PMID: 14500810.
      View in: PubMed
    46. Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J. Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol Cell Biol. 2003 Mar; 23(6):1946-60. PMID: 12612069.
      View in: PubMed
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