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James R Hagman

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/398-1398
    Other Positions
    TitleElectronic Research Admin
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-IMM MICRO GENERAL OPER

    TitleAffiliate
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-IMM MICRO GENERAL OPER


    Collapse Research 
    Collapse research activities and funding
    R03AI139822     (HAGMAN, JAMES R.)Nov 15, 2018 - Oct 31, 2021
    NIH
    Chd3 Conditional Knockout Mice: A New Tool for Studies of Lymphocyte Epigenetics
    Role: Principal Investigator

    R21AI138029     (HAGMAN, JAMES R.)May 15, 2018 - Apr 30, 2021
    NIH
    Regulation of Humoral Immunity by SR Protein Kinase 3
    Role: Principal Investigator

    R21AI115696     (HAGMAN, JAMES R.)Jun 15, 2015 - May 31, 2017
    NIH
    Regulation of V(D)J Recombination by Arginine Methylation
    Role: Principal Investigator

    R01AI098417     (HAGMAN, JAMES R.)Jul 3, 2012 - Jun 30, 2017
    NIH
    Regulation of B Cell Development and Function by Zfp521
    Role: Principal Investigator

    R01AI081878     (HAGMAN, JAMES R.)Feb 1, 2010 - Jan 31, 2015
    NIH
    Regulation of B Cell Identity and Lineage Progression
    Role: Principal Investigator

    R21CA107478     (HAGMAN, JAMES R)Apr 1, 2004 - Mar 31, 2006
    NIH
    Regulation of the Pax-5 Proto-Oncogen by Redox Mec,
    Role: Principal Investigator

    R01AI056322     (HAGMAN, JAMES R)Sep 1, 2003 - Dec 31, 2008
    NIH
    Transcriptional Control and Lineage Commitment by Pax-5
    Role: Principal Investigator

    R01AI054661     (HAGMAN, JAMES R)Apr 1, 2003 - Apr 30, 2012
    NIH
    Function and Regulation of Early B Cell Factor (EBF)
    Role: Principal Investigator

    R01AI037574     (HAGMAN, JAMES R)Mar 1, 1997 - Feb 28, 2003
    NIH
    REGULATION OF B CELL DIFFERENTIATION IN VITRO
    Role: Principal Investigator

    R21AI037574     (HAGMAN, JAMES R)Sep 1, 1996 - Aug 31, 1997
    NIH
    REGULATION OF B CELL DIFFERENTIATION IN VITRO
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hagman JR, Arends T, Laborda C, Knapp JR, Harmacek L, O'Connor BP. Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination. Immunol Rev. 2022 01; 305(1):29-42. PMID: 34927255.
      View in: PubMed
    2. Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 03; 105(3):585-597. PMID: 31101752.
      View in: PubMed
    3. Arends T, Dege C, Bortnick A, Danhorn T, Knapp JR, Jia H, Harmacek L, Fleenor CJ, Straign D, Walton K, Leach SM, Feeney AJ, Murre C, O'Connor BP, Hagman JR. CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10927-10936. PMID: 31085655.
      View in: PubMed
    4. Fleenor CJ, Arends T, Lei H, Åhsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, Hagman JR. Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment. Mol Cell Biol. 2018 09 01; 38(17). PMID: 29915154.
      View in: PubMed
    5. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19616560.
      View in: PubMed
    6. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 17663980.
      View in: PubMed
    7. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18606452.
      View in: PubMed
    8. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33479210.
      View in: PubMed
    9. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 22215588.
      View in: PubMed
    10. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19620315.
      View in: PubMed
    11. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21469119.
      View in: PubMed
    12. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20679243.
      View in: PubMed
    13. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 23870673.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33619557.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16680144.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16980557.
      View in: PubMed
    17. Liu H, Wang C, Lee S, Ning F, Wang Y, Zhang Q, Chen Z, Zang J, Nix J, Dai S, Marrack P, Hagman J, Kappler J, Zhang G. Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep. 2018 02 19; 8(1):3275. PMID: 29459673.
      View in: PubMed
    18. Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 10; 142(4):1173-1184. PMID: 29277702.
      View in: PubMed
    19. Hagman J. Critical Functions of IRF4 in B and T Lymphocytes. J Immunol. 2017 12 01; 199(11):3715-3716. PMID: 29158346.
      View in: PubMed
    20. Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7717-E7726. PMID: 28847961.
      View in: PubMed
    21. Hagman J. Editorial overview: Lymphocyte development and activation: Lymphoid cell differentiation: choosing paths to traverse the immune landscape. Curr Opin Immunol. 2016 Apr; 39:v-vii. PMID: 26923180.
      View in: PubMed
    22. Hayashi M, Jin Y, Yorgov D, Santorico SA, Hagman J, Ferrara TM, Jones KL, Cavalli G, Dinarello CA, Spritz RA. Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1357-62. PMID: 26787886.
      View in: PubMed
    23. Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency. Blood. 2015 Jun 25; 125(26):4052-9. PMID: 25838350.
      View in: PubMed
    24. Dege C, Hagman J. Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function. Immunol Rev. 2014 Sep; 261(1):126-40. PMID: 25123281.
      View in: PubMed
    25. Hagman J, Lukin K. Plasma cells for hire: prior experience required. Immunity. 2013 Jul 25; 39(1):89-91. PMID: 23890066.
      View in: PubMed
    26. Dege C, Hagman J. Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res. 2013 Mar; 55(1-3):155-61. PMID: 22956488.
      View in: PubMed
    27. Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW. Ikaros promotes rearrangement of TCR a genes in an Ikaros null thymoma cell line. Eur J Immunol. 2013 Feb; 43(2):521-32. PMID: 23172374.
      View in: PubMed
    28. Ramírez J, Dege C, Kutateladze TG, Hagman J. MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes. Mol Cell Biol. 2012 Dec; 32(24):5078-88. PMID: 23071088.
      View in: PubMed
    29. Hagman J, Ramírez J, Lukin K. B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1. Curr Top Microbiol Immunol. 2012; 356:17-38. PMID: 21735360.
      View in: PubMed
    30. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. PMID: 20543837.
      View in: PubMed
    31. Lukin K, Fields S, Lopez D, Cherrier M, Ternyak K, Ramírez J, Feeney AJ, Hagman J. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7869-74. PMID: 20385820.
      View in: PubMed
    32. Ramírez J, Lukin K, Hagman J. From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment. Curr Opin Immunol. 2010 Apr; 22(2):177-84. PMID: 20207529.
      View in: PubMed
    33. Ramírez J, Hagman J. The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer. Epigenetics. 2009 Nov 16; 4(8):532-6. PMID: 19923891.
      View in: PubMed
    34. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 06; 284(45):31236-48. PMID: 19759004.
      View in: PubMed
    35. Gao H, Lukin K, Ramírez J, Fields S, Lopez D, Hagman J. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11258-63. PMID: 19549820.
      View in: PubMed
    36. Thal MA, Carvalho TL, He T, Kim HG, Gao H, Hagman J, Klug CA. Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):552-7. PMID: 19122139.
      View in: PubMed
    37. Lukin K, Fields S, Hartley J, Hagman J. Early B cell factor: Regulator of B lineage specification and commitment. Semin Immunol. 2008 Aug; 20(4):221-7. PMID: 18722139.
      View in: PubMed
    38. Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug; 27(2):281-95. PMID: 17723218.
      View in: PubMed
    39. Matsuda JL, George TC, Hagman J, Gapin L. Temporal dissection of T-bet functions. J Immunol. 2007 Mar 15; 178(6):3457-65. PMID: 17339440.
      View in: PubMed
    40. Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 2006 May 19; 125(4):691-702. PMID: 16677698.
      View in: PubMed
    41. Hagman J, Lukin K. Transcription factors drive B cell development. Curr Opin Immunol. 2006 Apr; 18(2):127-34. PMID: 16464566.
      View in: PubMed
    42. Hagman J, Lukin K. Early B-cell factor 'pioneers' the way for B-cell development. Trends Immunol. 2005 Sep; 26(9):455-61. PMID: 16027038.
      View in: PubMed
    43. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004 Oct; 5(10):1069-77. PMID: 15361869.
      View in: PubMed
    44. Steinke JW, Barekzi E, Hagman J, Borish L. Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1. J Immunol. 2004 Sep 01; 173(5):3215-22. PMID: 15322183.
      View in: PubMed
    45. Maier H, Ostraat R, Parenti S, Fitzsimmons D, Abraham LJ, Garvie CW, Hagman J. Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP). Nucleic Acids Res. 2003 Oct 01; 31(19):5483-9. PMID: 14500810.
      View in: PubMed
    46. Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J. Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol Cell Biol. 2003 Mar; 23(6):1946-60. PMID: 12612069.
      View in: PubMed
    47. Maier H, Hagman J. Roles of EBF and Pax-5 in B lineage commitment and development. Semin Immunol. 2002 Dec; 14(6):415-22. PMID: 12457614.
      View in: PubMed
    48. Sigvardsson M, Clark DR, Fitzsimmons D, Doyle M, Akerblad P, Breslin T, Bilke S, Li R, Yeamans C, Zhang G, Hagman J. Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter. Mol Cell Biol. 2002 Dec; 22(24):8539-51. PMID: 12446773.
      View in: PubMed
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