James R Hagman
Title | Affiliate |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-IMM MICRO GENERAL OPER |
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Phone | 303/398-1398 |
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Title | Affiliate - NJH |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-IMM MICRO GENERAL OPER |
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Title | Electronic Research Admin |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-IMM MICRO GENERAL OPER |
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Research R03AI139822 (HAGMAN, JAMES R.)Nov 15, 2018 - Oct 31, 2021 NIH Chd3 Conditional Knockout Mice: A New Tool for Studies of Lymphocyte Epigenetics Role: Principal Investigator |
| R21AI138029 (HAGMAN, JAMES R.)May 15, 2018 - Apr 30, 2021 NIH Regulation of Humoral Immunity by SR Protein Kinase 3 Role: Principal Investigator |
| R21AI115696 (HAGMAN, JAMES R.)Jun 15, 2015 - May 31, 2017 NIH Regulation of V(D)J Recombination by Arginine Methylation Role: Principal Investigator |
| R01AI098417 (HAGMAN, JAMES R.)Jul 3, 2012 - Jun 30, 2017 NIH Regulation of B Cell Development and Function by Zfp521 Role: Principal Investigator |
| R01AI081878 (HAGMAN, JAMES R.)Feb 1, 2010 - Jan 31, 2015 NIH Regulation of B Cell Identity and Lineage Progression Role: Principal Investigator |
| R21CA107478 (HAGMAN, JAMES R)Apr 1, 2004 - Mar 31, 2006 NIH Regulation of the Pax-5 Proto-Oncogen by Redox Mec, Role: Principal Investigator |
| R01AI056322 (HAGMAN, JAMES R)Sep 1, 2003 - Dec 31, 2008 NIH Transcriptional Control and Lineage Commitment by Pax-5 Role: Principal Investigator |
| R01AI054661 (HAGMAN, JAMES R)Apr 1, 2003 - Apr 30, 2012 NIH Function and Regulation of Early B Cell Factor (EBF) Role: Principal Investigator |
| R01AI037574 (HAGMAN, JAMES R)Mar 1, 1997 - Feb 28, 2003 NIH REGULATION OF B CELL DIFFERENTIATION IN VITRO Role: Principal Investigator |
| R21AI037574 (HAGMAN, JAMES R)Sep 1, 1996 - Aug 31, 1997 NIH REGULATION OF B CELL DIFFERENTIATION IN VITRO Role: Principal Investigator |
Bibliographic
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Hagman JR, Arends T, Laborda C, Knapp JR, Harmacek L, O'Connor BP. Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination. Immunol Rev. 2022 01; 305(1):29-42. PMID: 34927255.
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Somasundaram R, Jensen CT, Tingvall-Gustafsson J, ?hsberg J, Okuyama K, Prasad M, Hagman JR, Wang X, Soneji S, Strid T, Ungerb?ck J, Sigvardsson M. EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene. Blood. 2021 06 03; 137(22):3037-3049. PMID: 33619557.
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Li Y, Gao J, Kamran M, Harmacek L, Danhorn T, Leach SM, O'Connor BP, Hagman JR, Huang H. GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers. Nat Commun. 2021 01 21; 12(1):494. PMID: 33479210.
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Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 03; 105(3):585-597. PMID: 31101752.
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Arends T, Dege C, Bortnick A, Danhorn T, Knapp JR, Jia H, Harmacek L, Fleenor CJ, Straign D, Walton K, Leach SM, Feeney AJ, Murre C, O'Connor BP, Hagman JR. CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis. Proc Natl Acad Sci U S A. 2019 05 28; 116(22):10927-10936. PMID: 31085655.
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Fleenor CJ, Arends T, Lei H, ?hsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, Hagman JR. Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment. Mol Cell Biol. 2018 09 01; 38(17). PMID: 29915154.
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Liu H, Wang C, Lee S, Ning F, Wang Y, Zhang Q, Chen Z, Zang J, Nix J, Dai S, Marrack P, Hagman J, Kappler J, Zhang G. Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7. Sci Rep. 2018 02 19; 8(1):3275. PMID: 29459673.
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Li Y, Liu B, Harmacek L, Long Z, Liang J, Lukin K, Leach SM, O'Connor B, Gerber AN, Hagman J, Roers A, Finkelman FD, Huang H. The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis. J Allergy Clin Immunol. 2018 10; 142(4):1173-1184. PMID: 29277702.
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Hagman J. Critical Functions of IRF4 in B and T Lymphocytes. J Immunol. 2017 12 01; 199(11):3715-3716. PMID: 29158346.
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Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7717-E7726. PMID: 28847961.
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Hagman J. Editorial overview: Lymphocyte development and activation: Lymphoid cell differentiation: choosing paths to traverse the immune landscape. Curr Opin Immunol. 2016 Apr; 39:v-vii. PMID: 26923180.
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Hayashi M, Jin Y, Yorgov D, Santorico SA, Hagman J, Ferrara TM, Jones KL, Cavalli G, Dinarello CA, Spritz RA. Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):1357-62. PMID: 26787886.
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Prasad MA, Ungerb?ck J, ?hsberg J, Somasundaram R, Strid T, Larsson M, M?nsson R, De Paepe A, Lilljebj?rn H, Fioretos T, Hagman J, Sigvardsson M. Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency. Blood. 2015 Jun 25; 125(26):4052-9. PMID: 25838350.
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Dege C, Hagman J. Mi-2/NuRD chromatin remodeling complexes regulate B and T-lymphocyte development and function. Immunol Rev. 2014 Sep; 261(1):126-40. PMID: 25123281.
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Hagman J, Lukin K. Plasma cells for hire: prior experience required. Immunity. 2013 Jul 25; 39(1):89-91. PMID: 23890066.
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Wang M, Ramirez J, Han J, Jia Y, Domenico J, Seibold MA, Hagman JR, Gelfand EW. The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis. J Allergy Clin Immunol. 2013 Nov; 132(5):1174-1183.e8. PMID: 23870673.
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Dege C, Hagman J. Activation of Aicda gene transcription by Pax5 in plasmacytoma cells. Immunol Res. 2013 Mar; 55(1-3):155-61. PMID: 22956488.
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Collins B, Clambey ET, Scott-Browne J, White J, Marrack P, Hagman J, Kappler JW. Ikaros promotes rearrangement of TCR a genes in an Ikaros null thymoma cell line. Eur J Immunol. 2013 Feb; 43(2):521-32. PMID: 23172374.
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Ram?rez J, Dege C, Kutateladze TG, Hagman J. MBD2 and multiple domains of CHD4 are required for transcriptional repression by Mi-2/NuRD complexes. Mol Cell Biol. 2012 Dec; 32(24):5078-88. PMID: 23071088.
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Musselman CA, Ram?rez J, Sims JK, Mansfield RE, Oliver SS, Denu JM, Mackay JP, Wade PA, Hagman J, Kutateladze TG. Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):787-92. PMID: 22215588.
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Hagman J, Ram?rez J, Lukin K. B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1. Curr Top Microbiol Immunol. 2012; 356:17-38. PMID: 21735360.
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Lukin K, Fields S, Guerrettaz L, Straign D, Rodriguez V, Zandi S, M?nsson R, Cambier JC, Sigvardsson M, Hagman J. A dose-dependent role for EBF1 in repressing non-B-cell-specific genes. Eur J Immunol. 2011 Jun; 41(6):1787-93. PMID: 21469119.
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Hong X, Zang J, White J, Wang C, Pan CH, Zhao R, Murphy RC, Dai S, Henson P, Kappler JW, Hagman J, Zhang G. Interaction of JMJD6 with single-stranded RNA. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14568-72. PMID: 20679243.
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Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. PMID: 20543837.
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Lukin K, Fields S, Lopez D, Cherrier M, Ternyak K, Ram?rez J, Feeney AJ, Hagman J. Compound haploinsufficiencies of Ebf1 and Runx1 genes impede B cell lineage progression. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7869-74. PMID: 20385820.
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Ram?rez J, Lukin K, Hagman J. From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment. Curr Opin Immunol. 2010 Apr; 22(2):177-84. PMID: 20207529.
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Ram?rez J, Hagman J. The Mi-2/NuRD complex: a critical epigenetic regulator of hematopoietic development, differentiation and cancer. Epigenetics. 2009 Nov 16; 4(8):532-6. PMID: 19923891.
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Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 06; 284(45):31236-48. PMID: 19759004.
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Hagman J. Conveying the message: identification of Ig-alpha and Ig-beta as components of the B cell receptor complex. J Immunol. 2009 Aug 01; 183(3):1503-4. PMID: 19620315.
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Fitzsimmons D, Lukin K, Lutz R, Garvie CW, Wolberger C, Hagman J. Highly cooperative recruitment of Ets-1 and release of autoinhibition by Pax5. J Mol Biol. 2009 Sep 18; 392(2):452-64. PMID: 19616560.
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Gao H, Lukin K, Ram?rez J, Fields S, Lopez D, Hagman J. Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11258-63. PMID: 19549820.
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Thal MA, Carvalho TL, He T, Kim HG, Gao H, Hagman J, Klug CA. Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):552-7. PMID: 19122139.
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Lukin K, Fields S, Hartley J, Hagman J. Early B cell factor: Regulator of B lineage specification and commitment. Semin Immunol. 2008 Aug; 20(4):221-7. PMID: 18722139.
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Fields S, Ternyak K, Gao H, Ostraat R, Akerlund J, Hagman J. The 'zinc knuckle' motif of Early B cell Factor is required for transcriptional activation of B cell-specific genes. Mol Immunol. 2008 Aug; 45(14):3786-96. PMID: 18606452.
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Joshi NS, Cui W, Chandele A, Lee HK, Urso DR, Hagman J, Gapin L, Kaech SM. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity. 2007 Aug; 27(2):281-95. PMID: 17723218.
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Hagman J, Lukin K. "Hands-on" regulation of B cell development by the transcription factor Pax5. Immunity. 2007 Jul; 27(1):8-10. PMID: 17663980.
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Matsuda JL, George TC, Hagman J, Gapin L. Temporal dissection of T-bet functions. J Immunol. 2007 Mar 15; 178(6):3457-65. PMID: 17339440.
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Sawyer RT, Fontenot AP, Barnes TA, Parsons CE, Tooker BC, Maier LA, Gillespie MM, Gottschall EB, Silveira L, Hagman J, Newman LS. Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):191-200. PMID: 16980557.
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Zhang Z, Espinoza CR, Yu Z, Stephan R, He T, Williams GS, Burrows PD, Hagman J, Feeney AJ, Cooper MD. Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes. Nat Immunol. 2006 Jun; 7(6):616-24. PMID: 16680144.
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Chen Z, Zang J, Whetstine J, Hong X, Davrazou F, Kutateladze TG, Simpson M, Mao Q, Pan CH, Dai S, Hagman J, Hansen K, Shi Y, Zhang G. Structural insights into histone demethylation by JMJD2 family members. Cell. 2006 May 19; 125(4):691-702. PMID: 16677698.
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Hagman J, Lukin K. Transcription factors drive B cell development. Curr Opin Immunol. 2006 Apr; 18(2):127-34. PMID: 16464566.
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Hagman J, Lukin K. Early B-cell factor 'pioneers' the way for B-cell development. Trends Immunol. 2005 Sep; 26(9):455-61. PMID: 16027038.
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Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004 Oct; 5(10):1069-77. PMID: 15361869.
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Steinke JW, Barekzi E, Hagman J, Borish L. Functional analysis of -571 IL-10 promoter polymorphism reveals a repressor element controlled by sp1. J Immunol. 2004 Sep 01; 173(5):3215-22. PMID: 15322183.
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Maier H, Ostraat R, Parenti S, Fitzsimmons D, Abraham LJ, Garvie CW, Hagman J. Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP). Nucleic Acids Res. 2003 Oct 01; 31(19):5483-9. PMID: 14500810.
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Maier H, Colbert J, Fitzsimmons D, Clark DR, Hagman J. Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site. Mol Cell Biol. 2003 Mar; 23(6):1946-60. PMID: 12612069.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2003 | 2 | 2004 | 2 | 2005 | 1 | 2006 | 4 | 2007 | 3 | 2008 | 2 | 2009 | 6 | 2010 | 4 | 2011 | 1 | 2012 | 4 | 2013 | 3 | 2014 | 1 | 2015 | 1 | 2016 | 2 | 2017 | 3 | 2018 | 2 | 2019 | 2 | 2021 | 3 |
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