Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

John J Tentler

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
    Collapse research activities and funding
    F31AA005343     (TENTLER, JOHN J)Jan 30, 1993
    Role: Principal Investigator

    R43AI043238     (TENTLER, JOHN J)Sep 30, 1997 - Jun 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Couts KL, Bemis J, Turner JA, Bagby SM, Murphy D, Christiansen J, Hintzsche JD, Le A, Pitts TM, Wells K, Applegate A, Amato C, Multani P, Chow-Maneval E, Tentler JJ, Shellman YG, Rioth MJ, Tan AC, Gonzalez R, Medina T, Doebele RC, Robinson WA. ALK inhibitor response in melanomas expressing EML4-ALK fusions and alternate ALK isoforms. Mol Cancer Ther. 2017 Oct 20. PMID: 29054983.
      View in: PubMed
    2. Hintzsche JD, Gorden NT, Amato CM, Kim J, Wuensch KE, Robinson SE, Applegate AJ, Couts KL, Medina TM, Wells KR, Wisell JA, McCarter MD, Box NF, Shellman YG, Gonzalez RC, Lewis KD, Tentler JJ, Tan AC, Robinson WA. Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. Melanoma Res. 2017 Jun; 27(3):189-199. PMID: 28296713.
      View in: PubMed
    3. Ionkina AA, Tentler JJ, Kim J, Capasso A, Pitts TM, Ryall KA, Howison RR, Kabos P, Sartorius CA, Tan AC, Eckhardt SG, Diamond JR. Efficacy and Molecular Mechanisms of Differentiated Response to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Models of p53-Mutated Triple-Negative Breast Cancer. Front Oncol. 2017; 7:94. PMID: 28555173.
      View in: PubMed
    4. Turner J, Couts K, Sheren J, Saichaemchan S, Ariyawutyakorn W, Avolio I, Cabral E, Glogowska M, Amato C, Robinson S, Hintzsche J, Applegate A, Seelenfreund E, Gonzalez R, Wells K, Bagby S, Tentler J, Tan AC, Wisell J, Varella-Garcia M, Robinson W. Kinase gene fusions in defined subsets of melanoma. Pigment Cell Melanoma Res. 2017 Jan; 30(1):53-62. PMID: 27864876.
      View in: PubMed
    5. Wong KM, Micel LN, Selby HM, Tan AC, Pitts TM, Bagby SM, Spreafico A, Klauck PJ, Blakemore SJ, Smith PF, McDonald A, Berger A, Tentler JJ, Eckhardt SG. Targeting the protein ubiquitination machinery in melanoma by the NEDD8-activating enzyme inhibitor pevonedistat (MLN4924). Invest New Drugs. 2017 Feb; 35(1):11-25. PMID: 27783255.
      View in: PubMed
    6. Pitts TM, Bradshaw-Pierce EL, Bagby SM, Hyatt SL, Selby HM, Spreafico A, Tentler JJ, McPhillips K, Klauck PJ, Capasso A, Diamond JR, Davis SL, Tan AC, Arcaroli JJ, Purkey A, Messersmith WA, Ecsedy JA, Eckhardt SG. Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer. Oncotarget. 2016 Aug 02; 7(31):50290-50301. PMID: 27385211.
      View in: PubMed
    7. Hintzsche J, Kim J, Yadav V, Amato C, Robinson SE, Seelenfreund E, Shellman Y, Wisell J, Applegate A, McCarter M, Box N, Tentler J, De S, Robinson WA, Tan AC. IMPACT: a whole-exome sequencing analysis pipeline for integrating molecular profiles with actionable therapeutics in clinical samples. J Am Med Inform Assoc. 2016 Jul; 23(4):721-30. PMID: 27026619; PMCID: PMC4926746 [Available on 07/01/17].
    8. Ryall KA, Kim J, Klauck PJ, Shin J, Yoo M, Ionkina A, Pitts TM, Tentler JJ, Diamond JR, Eckhardt SG, Heasley LE, Kang J, Tan AC. An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer. BMC Genomics. 2015; 16 Suppl 12:S2. PMID: 26681397; PMCID: PMC4682411.
    9. Begg MD, Bennett LM, Cicutto L, Gadlin H, Moss M, Tentler J, Schoenbaum E. Graduate Education for the Future: New Models and Methods for the Clinical and Translational Workforce. Clin Transl Sci. 2015 Dec; 8(6):787-92. PMID: 26643714; PMCID: PMC4709034 [Available on 12/08/16].
    10. Lieu CH, Klauck PJ, Henthorn PK, Tentler JJ, Tan AC, Spreafico A, Selby HM, Britt BC, Bagby SM, Arcaroli JJ, Messersmith WA, Pitts TM, Eckhardt SG. Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts. Oncotarget. 2015 Oct 27; 6(33):34561-72. PMID: 26439693; PMCID: PMC4741473.
    11. Davis SL, Robertson KM, Pitts TM, Tentler JJ, Bradshaw-Pierce EL, Klauck PJ, Bagby SM, Hyatt SL, Selby HM, Spreafico A, Ecsedy JA, Arcaroli JJ, Messersmith WA, Tan AC, Eckhardt SG. Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models. Front Pharmacol. 2015; 6:120. PMID: 26136684; PMCID: PMC4468631.
    12. Tentler JJ, Ionkina AA, Tan AC, Newton TP, Pitts TM, Glogowska MJ, Kabos P, Sartorius CA, Sullivan KD, Espinosa JM, Eckhardt SG, Diamond JR. p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer. Mol Cancer Ther. 2015 May; 14(5):1117-29. PMID: 25758253; PMCID: PMC4425647.
    13. Pitts TM, Newton TP, Bradshaw-Pierce EL, Addison R, Arcaroli JJ, Klauck PJ, Bagby SM, Hyatt SL, Purkey A, Tentler JJ, Tan AC, Messersmith WA, Eckhardt SG, Leong S. Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer. PLoS One. 2014; 9(11):e113037. PMID: 25401499; PMCID: PMC4234626.
    14. Micel LN, Tentler JJ, Tan AC, Selby HM, Brunkow KL, Robertson KM, Davis SL, Klauck PJ, Pitts TM, Gangolli E, Fabrey R, O'Connell SM, Vincent PW, Eckhardt SG. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb; 14(2):317-25. PMID: 25376610; PMCID: PMC4671492.
    15. Davis SL, Eckhardt SG, Tentler JJ, Diamond JR. Triple-negative breast cancer: bridging the gap from cancer genomics to predictive biomarkers. Ther Adv Med Oncol. 2014 May; 6(3):88-100. PMID: 24790649; PMCID: PMC3987651.
    16. Flanigan SA, Pitts TM, Newton TP, Kulikowski GN, Tan AC, McManus MC, Spreafico A, Kachaeva MI, Selby HM, Tentler JJ, Eckhardt SG, Leong S. Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models. Clin Cancer Res. 2013 Nov 15; 19(22):6219-29. PMID: 24045180; PMCID: PMC3843359.
    17. Spreafico A, Tentler JJ, Pitts TM, Tan AC, Gregory MA, Arcaroli JJ, Klauck PJ, McManus MC, Hansen RJ, Kim J, Micel LN, Selby HM, Newton TP, McPhillips KL, Gustafson DL, Degregori JV, Messersmith WA, Winn RA, Eckhardt SG. Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer. Clin Cancer Res. 2013 Aug 01; 19(15):4149-62. PMID: 23757356; PMCID: PMC3905307.
    18. Schlegel J, Sambade MJ, Sather S, Moschos SJ, Tan AC, Winges A, DeRyckere D, Carson CC, Trembath DG, Tentler JJ, Eckhardt SG, Kuan PF, Hamilton RL, Duncan LM, Miller CR, Nikolaishvili-Feinberg N, Midkiff BR, Liu J, Zhang W, Yang C, Wang X, Frye SV, Earp HS, Shields JM, Graham DK. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest. 2013 May; 123(5):2257-67. PMID: 23585477; PMCID: PMC3639697.
    19. Pitts TM, Kulikowski GN, Tan AC, Murray BW, Arcaroli JJ, Tentler JJ, Spreafico A, Selby HM, Kachaeva MI, McPhillips KL, Britt BC, Bradshaw-Pierce EL, Messersmith WA, Varella-Garcia M, Eckhardt SG. Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models. Front Pharmacol. 2013; 4:35. PMID: 23543898; PMCID: PMC3610060.
    20. Micel LN, Tentler JJ, Smith PG, Eckhardt GS. Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies. J Clin Oncol. 2013 Mar 20; 31(9):1231-8. PMID: 23358974; PMCID: PMC3807137.
    21. Deng H, Liu J, Deng Y, Han G, Shellman YG, Robinson SE, Tentler JJ, Robinson WA, Norris DA, Wang XJ, Zhang Q. CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and Brca1. J Invest Dermatol. 2013 May; 133(5):1294-301. PMID: 23303449; PMCID: PMC3711675.
    22. Diamond JR, Eckhardt SG, Tan AC, Newton TP, Selby HM, Brunkow KL, Kachaeva MI, Varella-Garcia M, Pitts TM, Bray MR, Fletcher GC, Tentler JJ. Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models. Clin Cancer Res. 2013 Jan 01; 19(1):291-303. PMID: 23136197; PMCID: PMC3537923.
    23. Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol. 2012 Jul; 8(7):646-54. PMID: 22660439; PMCID: PMC3430605.
    24. Tentler JJ, Tan AC, Weekes CD, Jimeno A, Leong S, Pitts TM, Arcaroli JJ, Messersmith WA, Eckhardt SG. Patient-derived tumour xenografts as models for oncology drug development. Nat Rev Clin Oncol. 2012 Apr 17; 9(6):338-50. PMID: 22508028; PMCID: PMC3928688.
    25. Morelli MP, Tentler JJ, Kulikowski GN, Tan AC, Bradshaw-Pierce EL, Pitts TM, Brown AM, Nallapareddy S, Arcaroli JJ, Serkova NJ, Hidalgo M, Ciardiello F, Eckhardt SG. Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models. Clin Cancer Res. 2012 Feb 15; 18(4):1051-62. PMID: 22173548; PMCID: PMC3876277.
    26. Prescott JD, Poczobutt JM, Tentler JJ, Walker DM, Gutierrez-Hartmann A. Mapping of ESE-1 subdomains required to initiate mammary epithelial cell transformation via a cytoplasmic mechanism. Mol Cancer. 2011 Aug 28; 10:103. PMID: 21871131; PMCID: PMC3183030.
    27. Spratlin JL, Pitts TM, Kulikowski GN, Morelli MP, Tentler JJ, Serkova NJ, Eckhardt SG. Synergistic activity of histone deacetylase and proteasome inhibition against pancreatic and hepatocellular cancer cell lines. Anticancer Res. 2011 Apr; 31(4):1093-103. PMID: 21508352; PMCID: PMC3866806.
    28. Flanigan SA, Pitts TM, Eckhardt SG, Tentler JJ, Tan AC, Thorburn A, Leong S. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clin Cancer Res. 2010 Nov 15; 16(22):5436-46. PMID: 20943761; PMCID: PMC3119523.
    29. Tentler JJ, Nallapareddy S, Tan AC, Spreafico A, Pitts TM, Morelli MP, Selby HM, Kachaeva MI, Flanigan SA, Kulikowski GN, Leong S, Arcaroli JJ, Messersmith WA, Eckhardt SG. Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer. Mol Cancer Ther. 2010 Dec; 9(12):3351-62. PMID: 20923857; PMCID: PMC3931013.
    30. Poczobutt JM, Tentler J, Lu X, Schedin PJ, Gutierrez-Hartmann A. Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells. BMC Cancer. 2010 Jul 16; 10:373. PMID: 20637104; PMCID: PMC2913961.
    31. Pitts TM, Tan AC, Kulikowski GN, Tentler JJ, Brown AM, Flanigan SA, Leong S, Coldren CD, Hirsch FR, Varella-Garcia M, Korch C, Eckhardt SG. Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development. Clin Cancer Res. 2010 Jun 15; 16(12):3193-204. PMID: 20530704; PMCID: PMC2889230.
    32. Morelli MP, Brown AM, Pitts TM, Tentler JJ, Ciardiello F, Ryan A, Jürgensmeier JM, Eckhardt SG. Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines. Mol Cancer Ther. 2009 Sep; 8(9):2546-58. PMID: 19755510; PMCID: PMC2819052.
    33. Pitts TM, Morrow M, Kaufman SA, Tentler JJ, Eckhardt SG. Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models. Mol Cancer Ther. 2009 Feb; 8(2):342-9. PMID: 19174560; PMCID: PMC2813767.
    34. Farrow KN, Bradford AP, Tentler JJ, Gutierrez-Hartmann A. Structural and functional analysis of the differential effects of c-Jun and v-Jun on prolactin gene expression. Mol Endocrinol. 2004 Oct; 18(10):2479-90. PMID: 15231872.
      View in: PubMed
    35. Schedin PJ, Eckel-Mahan KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann A. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene. 2004 Mar 04; 23(9):1766-79. PMID: 14767472.
      View in: PubMed
    36. Tentler JJ, Bradford AP, Schweppe RE, Gutierrez-Hartmann A. Selective repression of rat prolactin gene by stable expression of dominant-negative Ets in GH4 pituitary cells. Endocrine. 2003 Feb-Mar; 20(1-2):3-12. PMID: 12668863.
      View in: PubMed
    37. Eckel KL, Tentler JJ, Cappetta GJ, Diamond SE, Gutierrez-Hartmann A. The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA Cell Biol. 2003 Feb; 22(2):79-94. PMID: 12713734.
      View in: PubMed
    38. Tentler JJ, Hadcock JR, Gutierrez-Hartmann A. Somatostatin acts by inhibiting the cyclic 3',5'-adenosine monophosphate (cAMP)/protein kinase A pathway, cAMP response element-binding protein (CREB) phosphorylation, and CREB transcription potency. Mol Endocrinol. 1997 Jun; 11(7):859-66. PMID: 9178746.
      View in: PubMed
    39. Tentler JJ, LaPaglia N, Steiner J, Williams D, Castelli M, Kelley MR, Emanuele NV, Emanuele MA. Ethanol, growth hormone and testosterone in peripubertal rats. J Endocrinol. 1997 Mar; 152(3):477-87. PMID: 9071969.
      View in: PubMed
    40. Halloran MM, Emanuele MA, Emanuele NV, Tentler JJ, Kelley MR. Further characterization of the impact of ethanol on ßLH: alterations in polyribosome association of ßLH mRNA. Endocrine. 1995 Jun; 3(6):469-73. PMID: 21153252.
      View in: PubMed
    41. Wilson DM, Tentler JJ, Carney JP, Wilson TM, Kelley MR. Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats. Alcohol Clin Exp Res. 1994 Oct; 18(5):1267-71. PMID: 7847618.
      View in: PubMed
    42. Emanuele MA, Halloran MM, Tentler JJ, Uddin S, Emanuele NV, Kelley MR. The effects of ethanol on pituitary function. Compr Ther. 1994; 20(6):326-30. PMID: 8062540.
      View in: PubMed
    43. Halloran MM, Emanuele MA, Draski L, Tentler JJ, Emanuele NV, Kelley MR. Failure of ethanol to induce changes in gonadotropin gene expression in selectively bred ethanol-sensitive rats. Endocr Res. 1993 Dec; 19(4):317-29. PMID: 8306944.
      View in: PubMed
    44. Kelley MR, Jurgens JK, Tentler J, Emanuele NV, Blutt SE, Emanuele MA. Coupled reverse transcription-polymerase chain reaction (RT-PCR) technique is comparative, quantitative, and rapid: uses in alcohol research involving low abundance mRNA species such as hypothalamic LHRH and GRF. Alcohol. 1993 May-Jun; 10(3):185-9. PMID: 7685170.
      View in: PubMed
    45. Emanuele MA, Tentler JJ, Kirsteins L, Emanuele NV, Lawrence A, Kelley MR. The effect of "binge" ethanol exposure on growth hormone and prolactin gene expression and secretion. Endocrinology. 1992 Nov; 131(5):2077-82. PMID: 1330488.
      View in: PubMed
    46. Emanuele MA, Tentler JJ, Halloran MM, Emanuele NV, Wallock L, Kelley MR. The effect of acute in vivo ethanol exposure on follicle stimulating hormone transcription and translation. Alcohol Clin Exp Res. 1992 Aug; 16(4):776-80. PMID: 1530142.
      View in: PubMed
    47. Emanuele NV, Jurgens JK, Halloran MM, Tentler JJ, Lawrence AM, Kelley MR. The rat prolactin gene is expressed in brain tissue: detection of normal and alternatively spliced prolactin messenger RNA. Mol Endocrinol. 1992 Jan; 6(1):35-42. PMID: 1738369.
      View in: PubMed
    48. Emanuele MA, Tentler J, Emanuele NV, Kelley MR. In vivo effects of acute EtOH on rat alpha and beta luteinizing hormone gene expression. Alcohol. 1991 Sep-Oct; 8(5):345-8. PMID: 1724604.
      View in: PubMed
    49. Azad N, Emanuele NV, Halloran MM, Tentler J, Kelley MR. Presence of luteinizing hormone-releasing hormone (LHRH) mRNA in rat spleen lymphocytes. Endocrinology. 1991 Mar; 128(3):1679-81. PMID: 1999181.
      View in: PubMed
    50. Emanuele NV, Emanuele MA, Tentler J, Kirsteins L, Azad N, Lawrence AM. Rat spleen lymphocytes contain an immunoactive and bioactive luteinizing hormone-releasing hormone. Endocrinology. 1990 May; 126(5):2482-6. PMID: 2184019.
      View in: PubMed
    51. Emanuele MA, Tentler J, Reda D, Kirsteins L, Emanuele NV, Lawrence AM. The effect of in vitro ethanol exposure on LHRH release from perifused rat hypothalami. Endocr Res. 1990; 16(3):313-21. PMID: 2292236.
      View in: PubMed
    52. Kelley MR, Emanuele MA, Tentler J, Emanuele NV. Cross-reaction of albumin with polyclonal LH antibody on western blots. Endocr Res. 1990; 16(4):477-91. PMID: 2102467.
      View in: PubMed
    53. Emanuele MA, Tentler J, Reda D, Kirsteins L, Emanuele NV, Lawrence AM. Failure of in vitro ethanol to inhibit LHRH release from the hypothalamus. Alcohol. 1989 Jul-Aug; 6(4):263-6. PMID: 2669840.
      View in: PubMed
    54. Emanuele MA, Tentler J, Reda D, Kirsteins L, Emanuele NV, Lawrence AM. In-vivo effect of ethanol on release of LH-releasing hormone and LH in rats. J Endocrinol. 1989 Apr; 121(1):37-41. PMID: 2654323.
      View in: PubMed
    55. Emanuele MA, Tentler J, Emanuele NV, Reda D, Kirsteins L, Lawrence AM. In vitro effect of ethanol exposure on basal and GnRH-stimulated LH secretion from pituitary cells. Endocr Res. 1989; 15(3):393-401. PMID: 2667970.
      View in: PubMed
    56. Azad N, Nayyar R, Tentler J, Cernius M, Emanuele NV, Kirsteins L, Lawrence AM. Anatomical and functional effects of estrogen-induced prolactinomas on the rat hypothalamus. J Exp Pathol. 1989; 4(4):237-49. PMID: 2614531.
      View in: PubMed
    57. Emanuele MA, Tentler J, Kirsteins L, Reda D, Emanuele NV, Lawrence AM. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov; 115(2):221-3. PMID: 3437247.
      View in: PubMed
    58. Emanuele NV, Metcalfe L, Wallock L, Tentler J, Hagen TC, Beer CT, Martinson D, Gout PW, Kirsteins L, Lawrence AM. Extrahypothalamic brain prolactin: characterization and evidence for independence from pituitary prolactin. Brain Res. 1987 Sep 22; 421(1-2):255-62. PMID: 3690272.
      View in: PubMed
    59. Emanuele NV, Metcalfe L, Wallock L, Tentler J, Hagen TC, Beer CT, Martinson D, Gout PW, Kirsteins L, Lawrence AM. Hypothalamic prolactin: characterization by radioimmunoassay and bioassay and response to hypophysectomy and restraint stress. Neuroendocrinology. 1986; 44(2):217-21. PMID: 3796795.
      View in: PubMed
    Tentler's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)