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William Allen Sather

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology
Phone303/724-3130

    Collapse Research 
    Collapse research activities and funding
    F32NS008562     (SATHER, WILLIAM A)Feb 1, 1990
    NIH/NINDS
    QUISQUALATE-ACTIVATED CONDUCTANCE CHANGE MEDIATED BY IP3
    Role: Principal Investigator

    R01NS035245     (SATHER, WILLIAM A)Jun 1, 1996 - Mar 31, 2007
    NIH/NINDS
    Structural Basis of Ion Selectivity in Calciumn Channels
    Role: Principal Investigator

    R01HL088548     (SATHER, WILLIAM A)Aug 27, 2007 - Jul 31, 2013
    NIH/NHLBI
    Reciprocal Control of Ca2+ Channels by Anchored Protein Kinase A and Calcineurin
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA. STIM1 Ca2+ Sensor Control of L-type Ca2+-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep. 2017 Apr 11; 19(2):321-334. PMID: 28402855.
      View in: PubMed
    2. Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14. PMID: 27158117; PMCID: PMC5024723 [Available on 08/05/17].
    3. Murphy JG, Sanderson JL, Gorski JA, Scott JD, Catterall WA, Sather WA, Dell'Acqua ML. AKAP-anchored PKA maintains neuronal L-type calcium channel activity and NFAT transcriptional signaling. Cell Rep. 2014 Jun 12; 7(5):1577-88. PMID: 24835999; PMCID: PMC4136445.
    4. Dittmer PJ, Dell'Acqua ML, Sather WA. Ca2+/calcineurin-dependent inactivation of neuronal L-type Ca2+ channels requires priming by AKAP-anchored protein kinase A. Cell Rep. 2014 Jun 12; 7(5):1410-6. PMID: 24835998; PMCID: PMC4164350.
    5. Youn DH, Gerber G, Sather WA. Ionotropic glutamate receptors and voltage-gated Ca²? channels in long-term potentiation of spinal dorsal horn synapses and pain hypersensitivity. Neural Plast. 2013; 2013:654257. PMID: 24224102; PMCID: PMC3808892.
    6. Oliveria SF, Dittmer PJ, Youn DH, Dell'Acqua ML, Sather WA. Localized calcineurin confers Ca2+-dependent inactivation on neuronal L-type Ca2+ channels. J Neurosci. 2012 Oct 31; 32(44):15328-37. PMID: 23115171; PMCID: PMC3593728.
    7. Oliveria SF, Dell'Acqua ML, Sather WA. AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling. Neuron. 2007 Jul 19; 55(2):261-75. PMID: 17640527; PMCID: PMC2698451.
    8. Lai M, Wang F, Rohan JG, Maeno-Hikichi Y, Chen Y, Zhou Y, Gao G, Sather WA, Zhang JF. A tctex1-Ca2+ channel complex for selective surface expression of Ca2+ channels in neurons. Nat Neurosci. 2005 Apr; 8(4):435-42. PMID: 15768038.
      View in: PubMed
    9. Cibulsky SM, Sather WA. Control of ion conduction in L-type Ca2+ channels by the concerted action of S5-6 regions. Biophys J. 2003 Mar; 84(3):1709-19. PMID: 12609873; PMCID: PMC1302740.
    10. Cloues RK, Sather WA. Afterhyperpolarization regulates firing rate in neurons of the suprachiasmatic nucleus. J Neurosci. 2003 Mar 01; 23(5):1593-604. PMID: 12629163.
      View in: PubMed
    11. Sather WA, McCleskey EW. Permeation and selectivity in calcium channels. Annu Rev Physiol. 2003; 65:133-59. PMID: 12471162.
      View in: PubMed
    12. Wu XS, Edwards HD, Sather WA. Side chain orientation in the selectivity filter of a voltage-gated Ca2+ channel. J Biol Chem. 2000 Oct 13; 275(41):31778-85. PMID: 10934200.
      View in: PubMed
    13. Cloues RK, Cibulsky SM, Sather WA. Ion interactions in the high-affinity binding locus of a voltage-gated Ca(2+) channel. J Gen Physiol. 2000 Oct; 116(4):569-86. PMID: 11004206; PMCID: PMC2230626.
    14. Cibulsky SM, Sather WA. The EEEE locus is the sole high-affinity Ca(2+) binding structure in the pore of a voltage-gated Ca(2+) channel: block by ca(2+) entering from the intracellular pore entrance. J Gen Physiol. 2000 Sep; 116(3):349-62. PMID: 10962013; PMCID: PMC2233694.
    15. Cloues RK, Sather WA. Permeant ion binding affinity in subconductance states of an L-type Ca2+ channel expressed in Xenopus laevis oocytes. J Physiol. 2000 Apr 01; 524 Pt 1:19-36. PMID: 10747181; PMCID: PMC2269845.
    16. Snell LD, Claffey DJ, Ruth JA, Valenzuela CF, Cardoso R, Wang Z, Levinson SR, Sather WA, Williamson AV, Ingersoll NC, Ovchinnikova L, Bhave SV, Hoffman PL, Tabakoff B. Novel structure having antagonist actions at both the glycine site of the N-methyl-D-aspartate receptor and neuronal voltage-sensitive sodium channels: biochemical, electrophysiological, and behavioral characterization. J Pharmacol Exp Ther. 2000 Jan; 292(1):215-27. PMID: 10604951.
      View in: PubMed
    17. Williamson AV, Sather WA. Nonglutamate pore residues in ion selection and conduction in voltage-gated Ca2+ channels. Biophys J. 1999 Nov; 77(5):2575-89. PMID: 10545358.
      View in: PubMed
    18. Cibulsky SM, Sather WA. Block by ruthenium red of cloned neuronal voltage-gated calcium channels. J Pharmacol Exp Ther. 1999 Jun; 289(3):1447-53. PMID: 10336538.
      View in: PubMed
    19. Ellinor PT, Yang J, Sather WA, Zhang JF, Tsien RW. Ca2+ channel selectivity at a single locus for high-affinity Ca2+ interactions. Neuron. 1995 Nov; 15(5):1121-32. PMID: 7576655.
      View in: PubMed
    20. Wheeler DB, Randall A, Sather WA, Tsien RW. Neuronal calcium channels encoded by the alpha 1A subunit and their contribution to excitatory synaptic transmission in the CNS. Prog Brain Res. 1995; 105:65-78. PMID: 7568898.
      View in: PubMed
    21. Sather WA, Tanabe T, Zhang JF, Tsien RW. Biophysical and pharmacological characterization of a class A calcium channel. Ann N Y Acad Sci. 1994 Dec 15; 747:294-301. PMID: 7847678.
      View in: PubMed
    22. Sather WA, Yang J, Tsien RW. Structural basis of ion channel permeation and selectivity. Curr Opin Neurobiol. 1994 Jun; 4(3):313-23. PMID: 7522675.
      View in: PubMed
    23. Wheeler DB, Sather WA, Randall A, Tsien RW. Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system. Adv Second Messenger Phosphoprotein Res. 1994; 29:155-71. PMID: 7848709.
      View in: PubMed
    24. Yang J, Ellinor PT, Sather WA, Zhang JF, Tsien RW. Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels. Nature. 1993 Nov 11; 366(6451):158-61. PMID: 8232554.
      View in: PubMed
    25. Zhang JF, Randall AD, Ellinor PT, Horne WA, Sather WA, Tanabe T, Schwarz TL, Tsien RW. Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology. 1993 Nov; 32(11):1075-88. PMID: 8107963.
      View in: PubMed
    26. Sather WA, Tanabe T, Zhang JF, Mori Y, Adams ME, Tsien RW. Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Neuron. 1993 Aug; 11(2):291-303. PMID: 8394721.
      View in: PubMed
    27. Rispoli G, Sather WA, Detwiler PB. Visual transduction in dialysed detached rod outer segments from lizard retina. J Physiol. 1993 Jun; 465:513-37. PMID: 8229848; PMCID: PMC1175444.
    28. Dorville A, McCort-Tranchepain I, Vichard D, Sather W, Maroun R, Ascher P, Roques BP. Preferred antagonist binding state of the NMDA receptor: synthesis, pharmacology, and computer modeling of (phosphonomethyl)phenylalanine derivatives. J Med Chem. 1992 Jul 10; 35(14):2551-62. PMID: 1386112.
      View in: PubMed
    29. Sather W, Dieudonné S, MacDonald JF, Ascher P. Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones. J Physiol. 1992 May; 450:643-72. PMID: 1359126; PMCID: PMC1176143.
    30. Ascher P, Dieudonné S, Macdonald J, Sather W. Kinetics of activation, deactivation and desensitization of the "NMDA" glutamate receptor. C R Acad Sci III. 1992; 314(9 Suppl):75-7. PMID: 1422912.
      View in: PubMed
    31. Sather W, Johnson JW, Henderson G, Ascher P. Glycine-insensitive desensitization of NMDA responses in cultured mouse embryonic neurons. Neuron. 1990 May; 4(5):725-31. PMID: 2160836.
      View in: PubMed
    32. Sather WA, Detwiler PB. Intracellular biochemical manipulation of phototransduction in detached rod outer segments. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):9290-4. PMID: 2827176; PMCID: PMC299739.
    33. Sather WA, Bodoia RD, Detwiler PB. Does the plasma membrane of the rod outer segment contain more than one type of ion channel? Neurosci Res Suppl. 1985; 2:S89-99. PMID: 2417176.
      View in: PubMed
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