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Donna L Bratton

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    R01AI058228     (BRATTON, DONNA L)Dec 15, 2003 - Nov 30, 2009
    Defective PS Exposure in Neutrophil Apoptosis in CGD
    Role: Principal Investigator

    R56AI058228     (BRATTON, DONNA L)Aug 17, 2011 - Jul 31, 2013
    Macrophage PPARg signaling, efferocytosis, and exaggerated inflammation in CGD
    Role: Principal Investigator

    R01AI110408     (BRATTON, DONNA L)Feb 15, 2014 - Jan 31, 2019
    Reversal of Inflammatory Processes in CGD
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gibbings SL, Thomas SM, Atif SM, McCubbrey AL, Desch AN, Danhorn T, Leach SM, Bratton DL, Henson PM, Janssen WJ, Jakubzick CV. Three Unique Interstitial Macrophages in the Murine Lung at Steady State. Am J Respir Cell Mol Biol. 2017 Jul; 57(1):66-76. PMID: 28257233.
      View in: PubMed
    2. Jayaraman D, Bratton DL, Harbeck RJ, Wolf M, Rabinovitch N. A case of recurrent facial angioedema associated with elevated tree pollen counts. J Allergy Clin Immunol Pract. 2017 May 11. PMID: 28506423.
      View in: PubMed
    3. Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV. Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes. Am J Respir Crit Care Med. 2016 Mar 15; 193(6):614-26. PMID: 26551758; PMCID: PMC4824940 [Available on 03/15/17].
    4. Gibbings SL, Goyal R, Desch AN, Leach SM, Prabagar M, Atif SM, Bratton DL, Janssen W, Jakubzick CV. Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages. Blood. 2015 Sep 10; 126(11):1357-66. PMID: 26232173; PMCID: PMC4566811.
    5. Fernandez-Boyanapalli RF, Frasch SC, Thomas SM, Malcolm KC, Nicks M, Harbeck RJ, Jakubzick CV, Nemenoff R, Henson PM, Holland SM, Bratton DL. Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in chronic granulomatous disease. J Allergy Clin Immunol. 2015 Feb; 135(2):517-527.e12. PMID: 25498313; PMCID: PMC4331116.
    6. Eltzschig HK, Bratton DL, Colgan SP. Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases. Nat Rev Drug Discov. 2014 Nov; 13(11):852-69. PMID: 25359381; PMCID: PMC4259899.
    7. Caceres SM, Malcolm KC, Taylor-Cousar JL, Nichols DP, Saavedra MT, Bratton DL, Moskowitz SM, Burns JL, Nick JA. Enhanced in vitro formation and antibiotic resistance of nonattached Pseudomonas aeruginosa aggregates through incorporation of neutrophil products. Antimicrob Agents Chemother. 2014 Nov; 58(11):6851-60. PMID: 25182651; PMCID: PMC4249413.
    8. Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37. PMID: 24325577; PMCID: PMC4068926.
    9. Janssen WJ, Yunt ZX, Muldrow A, Kearns MT, Kloepfer A, Barthel L, Bratton DL, Bowler RP, Henson PM. Circulating hematopoietic progenitor cells are decreased in COPD. COPD. 2014 Jun; 11(3):277-89. PMID: 24182349; PMCID: PMC4112029.
    10. Xiong W, Frasch SC, Thomas SM, Bratton DL, Henson PM. Induction of TGF-ß1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36. PLoS One. 2013; 8(8):e72772. PMID: 23936544; PMCID: PMC3732218.
    11. Suram S, Silveira LJ, Mahaffey S, Brown GD, Bonventre JV, Williams DL, Gow NA, Bratton DL, Murphy RC, Leslie CC. Cytosolic phospholipase A(2)a and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One. 2013; 8(7):e69002. PMID: 23950842; PMCID: PMC3742295.
    12. Henson PM, Bratton DL. Antiinflammatory effects of apoptotic cells. J Clin Invest. 2013 Jul; 123(7):2773-4. PMID: 23863635; PMCID: PMC3696541.
    13. Malcolm KC, Nichols EM, Caceres SM, Kret JE, Martiniano SL, Sagel SD, Chan ED, Caverly L, Solomon GM, Reynolds P, Bratton DL, Taylor-Cousar JL, Nichols DP, Saavedra MT, Nick JA. Mycobacterium abscessus induces a limited pattern of neutrophil activation that promotes pathogen survival. PLoS One. 2013; 8(2):e57402. PMID: 23451220; PMCID: PMC3581440.
    14. Henson PM, Bratton DL. Allergy: airway epithelial Rac1 suppresses allergic inflammation. Curr Biol. 2013 Feb 04; 23(3):R104-6. PMID: 23391381.
      View in: PubMed
    15. Frasch SC, Fernandez-Boyanapalli RF, Berry KA, Murphy RC, Leslie CC, Nick JA, Henson PM, Bratton DL. Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine. J Biol Chem. 2013 Feb 15; 288(7):4583-93. PMID: 23293064; PMCID: PMC3576064.
    16. Fernandez-Boyanapalli R, Goleva E, Kolakowski C, Min E, Day B, Leung DY, Riches DW, Bratton DL, Sutherland ER. Obesity impairs apoptotic cell clearance in asthma. J Allergy Clin Immunol. 2013 Apr; 131(4):1041-7, 1047.e1-3. PMID: 23154082; PMCID: PMC4190068.
    17. Frasch SC, Bratton DL. Emerging roles for lysophosphatidylserine in resolution of inflammation. Prog Lipid Res. 2012 Jul; 51(3):199-207. PMID: 22465125; PMCID: PMC3365616.
    18. Kearns MT, Dalal S, Horstmann SA, Richens TR, Tanaka T, Doe JM, Boe DM, Voelkel NF, Taraseviciene-Stewart L, Janssen WJ, Lee CG, Elias JA, Bratton D, Tuder RM, Henson PM, Vandivier RW. Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 01; 302(7):L711-8. PMID: 22307908; PMCID: PMC3330764.
    19. Korns D, Frasch SC, Fernandez-Boyanapalli R, Henson PM, Bratton DL. Modulation of macrophage efferocytosis in inflammation. Front Immunol. 2011; 2:57. PMID: 22566847; PMCID: PMC3342042.
    20. Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM. IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol. 2011 Sep 01; 187(5):2101-11. PMID: 21813769; PMCID: PMC3159788.
    21. Bratton DL, Henson PM. Neutrophil clearance: when the party is over, clean-up begins. Trends Immunol. 2011 Aug; 32(8):350-7. PMID: 21782511; PMCID: PMC3151332.
    22. Gally F, Di YP, Smith SK, Minor MN, Liu Y, Bratton DL, Frasch SC, Michels NM, Case SR, Chu HW. SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. Am J Pathol. 2011 May; 178(5):2159-67. PMID: 21514430; PMCID: PMC3081195.
    23. Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC, Bonventre JV, Murphy RC, Henson PM, Bratton DL. Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity. J Biol Chem. 2011 Apr 08; 286(14):12108-22. PMID: 21297111; PMCID: PMC3069415.
    24. Tollefson AK, Oberley-Deegan RE, Butterfield KT, Nicks ME, Weaver MR, Remigio LK, Decsesznak J, Chu HW, Bratton DL, Riches DW, Bowler RP. Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress. Free Radic Biol Med. 2010 Dec 15; 49(12):1937-46. PMID: 20887783; PMCID: PMC3780970.
    25. Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010 Oct 01; 185(7):4030-41. PMID: 20805415; PMCID: PMC4346245.
    26. Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL. PPAR? activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood. 2010 Nov 25; 116(22):4512-22. PMID: 20693431; PMCID: PMC2996113.
    27. Carel K, Bratton DL, Miyazawa N, Gyorkos E, Kelsay K, Bender B, Strand M, Atkins D, Gelfand EW, Klinnert MD. The Atopic Dermatitis Quickscore (ADQ): validation of a new parent-administered atopic dermatitis scoring tool. Ann Allergy Asthma Immunol. 2008 Nov; 101(5):500-7. PMID: 19055204.
      View in: PubMed
    28. Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009 Feb 26; 113(9):2047-55. PMID: 18952895; PMCID: PMC2651016.
    29. Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin HS, Leslie C, Henson PM, Murphy RC, Bratton DL. NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem. 2008 Nov 28; 283(48):33736-49. PMID: 18824544; PMCID: PMC2586279.
    30. Xiao YQ, Freire-de-Lima CG, Schiemann WP, Bratton DL, Vandivier RW, Henson PM. Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol. 2008 Sep 01; 181(5):3575-85. PMID: 18714031; PMCID: PMC2583327.
    31. Rothenberg SS, Bratton D. The effects of laparoscopic Nissen fundoplication to enhance pulmonary function in the treatment of a patient with severe asthma and gastroesophageal reflux disease. J Allergy Clin Immunol. 2008 Apr; 121(4):1069-70. PMID: 18395555.
      View in: PubMed
    32. Bratton DL, Henson PM. Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? Curr Biol. 2008 Jan 22; 18(2):R76-9. PMID: 18211846.
      View in: PubMed
    33. McPhillips K, Janssen WJ, Ghosh M, Byrne A, Gardai S, Remigio L, Bratton DL, Kang JL, Henson P. TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms. J Immunol. 2007 Jun 15; 178(12):8117-26. PMID: 17548650.
      View in: PubMed
    34. Frasch SC, Zemski-Berry K, Murphy RC, Borregaard N, Henson PM, Bratton DL. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. J Immunol. 2007 May 15; 178(10):6540-8. PMID: 17475884.
      View in: PubMed
    35. Freire-de-Lima CG, Xiao YQ, Gardai SJ, Bratton DL, Schiemann WP, Henson PM. Apoptotic cells, through transforming growth factor-beta, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in murine macrophages. J Biol Chem. 2006 Dec 15; 281(50):38376-84. PMID: 17056601.
      View in: PubMed
    36. Gardai SJ, Bratton DL, Ogden CA, Henson PM. Recognition ligands on apoptotic cells: a perspective. J Leukoc Biol. 2006 May; 79(5):896-903. PMID: 16641135.
      View in: PubMed
    37. Xiao YQ, Freire-de-Lima CG, Janssen WJ, Morimoto K, Lyu D, Bratton DL, Henson PM. Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production. J Immunol. 2006 Jan 15; 176(2):1209-17. PMID: 16394011.
      View in: PubMed
    38. Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell. 2005 Oct 21; 123(2):321-34. PMID: 16239148.
      View in: PubMed
    39. Bratton DL, Henson PM. Autoimmunity and apoptosis: refusing to go quietly. Nat Med. 2005 Jan; 11(1):26-7. PMID: 15635442.
      View in: PubMed
    40. Davies GM, Dasbach EJ, Santanello NC, Knorr BA, Bratton DL. The effect of montelukast versus usual care on health care resource utilization in children aged 2 to 5 years with asthma. Clin Ther. 2004 Nov; 26(11):1895-904. PMID: 15639701.
      View in: PubMed
    41. Duez C, Dakhama A, Tomkinson A, Marquillies P, Balhorn A, Tonnel AB, Bratton DL, Gelfand EW. Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge. J Allergy Clin Immunol. 2004 Oct; 114(4):820-5. PMID: 15480321.
      View in: PubMed
    42. Fessler MB, Arndt PG, Frasch SC, Lieber JG, Johnson CA, Murphy RC, Nick JA, Bratton DL, Malcolm KC, Worthen GS. Lipid rafts regulate lipopolysaccharide-induced activation of Cdc42 and inflammatory functions of the human neutrophil. J Biol Chem. 2004 Sep 17; 279(38):39989-98. PMID: 15262974.
      View in: PubMed
    43. Silkoff PE, Bates CA, Meiser JB, Bratton DL. Single-breath exhaled nitric oxide in preschool children facilitated by a servo-controlled device maintaining constant flow. Pediatr Pulmonol. 2004 Jun; 37(6):554-8. PMID: 15114557.
      View in: PubMed
    44. Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL, Henson PM. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem. 2004 May 14; 279(20):21085-95. PMID: 14766748.
      View in: PubMed
    45. Frasch SC, Henson PM, Nagaosa K, Fessler MB, Borregaard N, Bratton DL. Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. J Biol Chem. 2004 Apr 23; 279(17):17625-33. PMID: 14766753.
      View in: PubMed
    46. Gardai SJ, Hoontrakoon R, Goddard CD, Day BJ, Chang LY, Henson PM, Bratton DL. Oxidant-mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte-macrophage colony-stimulating factor. J Immunol. 2003 Jan 01; 170(1):556-66. PMID: 12496443.
      View in: PubMed
    47. Bukstein DA, Bratton DL, Firriolo KM, Estojak J, Bird SR, Hustad CM, Edelman JM. Evaluation of parental preference for the treatment of asthmatic children aged 6 to 11 years with oral montelukast or inhaled cromolyn: a randomized, open-label, crossover study. J Asthma. 2003; 40(5):475-85. PMID: 14529097.
      View in: PubMed
    48. Price MR, Bratton DL, Klinnert MD. Caregiver negative affect is a primary determinant of caregiver report of pediatric asthma quality of life. Ann Allergy Asthma Immunol. 2002 Dec; 89(6):572-7. PMID: 12487222.
      View in: PubMed
    49. Hoontrakoon R, Chu HW, Gardai SJ, Wenzel SE, McDonald P, Fadok VA, Henson PM, Bratton DL. Interleukin-15 inhibits spontaneous apoptosis in human eosinophils via autocrine production of granulocyte macrophage-colony stimulating factor and nuclear factor-kappaB activation. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):404-12. PMID: 11919076.
      View in: PubMed
    50. Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002 Mar; 109(5):661-70. PMID: 11877474; PMCID: PMC150889.
    51. Xiao YQ, Malcolm K, Worthen GS, Gardai S, Schiemann WP, Fadok VA, Bratton DL, Henson PM. Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta. J Biol Chem. 2002 Apr 26; 277(17):14884-93. PMID: 11842088.
      View in: PubMed
    52. Gardai S, Whitlock BB, Helgason C, Ambruso D, Fadok V, Bratton D, Henson PM. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. J Biol Chem. 2002 Feb 15; 277(7):5236-46. PMID: 11724799.
      View in: PubMed
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