Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Carl W White

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    R01HL052732     (WHITE, CARL W)Sep 15, 1995 - Aug 31, 2003
    NIH/NHLBI
    ROLE OF HEXOKINASE IN LUNG ADAPTATION TO OXIDANT STRESS
    Role: Principal Investigator

    U10HL056263     (WHITE, CARL W)Sep 30, 1995 - Aug 31, 1999
    NIH/NHLBI
    CRITICAL TARGETS IN HYPEROXIC MITOCHONDRIAL INJURY
    Role: Principal Investigator

    U01HL056263     (WHITE, CARL W)Sep 30, 1995 - Aug 31, 2009
    NIH/NHLBI
    Hypoxia-inducible factors bronchopulmonary dysplasia-BPD
    Role: Principal Investigator

    R01ES014448     (WHITE, CARL W)Sep 23, 2005 - Jul 31, 2011
    NIH/NIEHS
    Lung epithelial cell survival signaling in ozone in cystic fibrosis and normals
    Role: Principal Investigator

    U54ES015678     (WHITE, CARL W)Sep 29, 2006 - May 31, 2016
    NIH/NIEHS
    Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Role: Principal Investigator

    RC1HL099461     (REYNOLDS, SUSAN D)Sep 30, 2009 - Aug 31, 2012
    NIH/NHLBI
    Cell Based Therapy for Lung Disease
    Role: Co-Principal Investigator

    U54ES027698     (WHITE, CARL W)Sep 30, 2016 - Aug 31, 2021
    NIH/NIEHS
    Development of antidotes for toxic gases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Summerhill EM, Hoyle GW, Jordt SE, Jugg BJ, Martin JG, Matalon S, Patterson SE, Prezant DJ, Sciuto AM, Svendsen ER, White CW, Veress LA. An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness. Ann Am Thorac Soc. 2017 Jun; 14(6):1060-1072. PMID: 28418689.
      View in: PubMed
    2. McGraw MD, Rioux JS, Garlick RB, Rancourt RC, White CW, Veress LA. Impaired Proliferation and Differentiation of the Conducting Airway Epithelium Associated with Bronchiolitis Obliterans after Sulfur Mustard Inhalation Injury in Rats. Toxicol Sci. 2017 Apr 11. PMID: 28402575.
      View in: PubMed
    3. Ghosh M, Ahmad S, White CW, Reynolds SD. Transplantation of Airway Epithelial Stem/Progenitor Cells: A Future for Cell-Based Therapy. Am J Respir Cell Mol Biol. 2017 Jan; 56(1):1-10. PMID: 27632244.
      View in: PubMed
    4. McElroy CS, Min E, Huang J, Loader JE, Hendry-Hofer TB, Garlick RB, Rioux JS, Veress LA, Smith R, Osborne C, Anderson DR, Holmes WW, Paradiso DC, White CW, Day BJ. From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicol Sci. 2016 Dec; 154(2):341-353. PMID: 27605419.
      View in: PubMed
    5. White CW, Rancourt RC, Veress LA. Sulfur mustard inhalation: mechanisms of injury, alteration of coagulation, and fibrinolytic therapy. Ann N Y Acad Sci. 2016 Aug; 1378(1):87-95. PMID: 27384912.
      View in: PubMed
    6. Gabehart K, Correll KA, Loader JE, White CW, Dakhama A. The lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4. Respir Res. 2015 Sep 26; 16:117. PMID: 26410792; PMCID: PMC4583721.
    7. Zaky A, Bradley WE, Lazrak A, Zafar I, Doran S, Ahmad A, White CW, Dell'Italia LJ, Matalon S, Ahmad S. Chlorine inhalation-induced myocardial depression and failure. Physiol Rep. 2015 Jun; 3(6). PMID: 26109193; PMCID: PMC4510636.
    8. Kumar D, Tewari-Singh N, Agarwal C, Jain AK, Inturi S, Kant R, White CW, Agarwal R. Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicol Lett. 2015 Jun 15; 235(3):161-71. PMID: 25891025; PMCID: PMC4430414.
    9. Ahmad S, Ahmad A, Hendry-Hofer TB, Loader JE, Claycomb WC, Mozziconacci O, Schöneich C, Reisdorph N, Powell RL, Chandler JD, Day BJ, Veress LA, White CW. Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity. Am J Respir Cell Mol Biol. 2015 Apr; 52(4):492-502. PMID: 25188881; PMCID: PMC4491118.
    10. Jain AK, Tewari-Singh N, Inturi S, Kumar D, Orlicky DJ, Agarwal C, White CW, Agarwal R. Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicol Appl Pharmacol. 2015 May 15; 285(1):71-8. PMID: 25791923; PMCID: PMC4410080.
    11. Goswami DG, Kumar D, Tewari-Singh N, Orlicky DJ, Jain AK, Kant R, Rancourt RC, Dhar D, Inturi S, Agarwal C, White CW, Agarwal R. Topical nitrogen mustard exposure causes systemic toxic effects in mice. Exp Toxicol Pathol. 2015 Feb; 67(2):161-70. PMID: 25481215; PMCID: PMC4308427.
    12. Veress LA, Anderson DR, Hendry-Hofer TB, Houin PR, Rioux JS, Garlick RB, Loader JE, Paradiso DC, Smith RW, Rancourt RC, Holmes WW, White CW. Airway tissue plasminogen activator prevents acute mortality due to lethal sulfur mustard inhalation. Toxicol Sci. 2015 Jan; 143(1):178-84. PMID: 25331496; PMCID: PMC4274387.
    13. Rancourt RC, Ahmad A, Veress LA, Rioux JS, Garlick RB, White CW. Antifibrinolytic mechanisms in acute airway injury after sulfur mustard analog inhalation. Am J Respir Cell Mol Biol. 2014 Oct; 51(4):559-67. PMID: 24796565; PMCID: PMC4189487.
    14. Tewari-Singh N, Inturi S, Jain AK, Agarwal C, Orlicky DJ, White CW, Agarwal R, Day BJ. Catalytic antioxidant AEOL 10150 treatment ameliorates sulfur mustard analog 2-chloroethyl ethyl sulfide-associated cutaneous toxic effects. Free Radic Biol Med. 2014 Jul; 72:285-95. PMID: 24815113; PMCID: PMC4080896.
    15. Ahmad S, Ahmad A, Neeves KB, Hendry-Hofer T, Loader JE, White CW, Veress L. In vitro cell culture model for toxic inhaled chemical testing. J Vis Exp. 2014 May 08; (87). PMID: 24837339; PMCID: PMC4047665.
    16. Inturi S, Tewari-Singh N, Agarwal C, White CW, Agarwal R. Activation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes. Mutat Res. 2014 May-Jun; 763-764:53-63. PMID: 24732344; PMCID: PMC4199943.
    17. Houin PR, Veress LA, Rancourt RC, Hendry-Hofer TB, Loader JE, Rioux JS, Garlick RB, White CW. Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatr Pulmonol. 2015 Feb; 50(2):118-26. PMID: 24692161; PMCID: PMC4182164.
    18. Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. Myeloperoxidase deficiency attenuates nitrogen mustard-induced skin injuries. Toxicology. 2014 Jun 05; 320:25-33. PMID: 24631667; PMCID: PMC4019690.
    19. Tewari-Singh N, Jain AK, Orlicky DJ, White CW, Agarwal R. Cutaneous injury-related structural changes and their progression following topical nitrogen mustard exposure in hairless and haired mice. PLoS One. 2014; 9(1):e85402. PMID: 24416404; PMCID: PMC3885697.
    20. Deterding RR, White CW. Humidifier and environmental "chILD" risks. Am J Respir Crit Care Med. 2014 Jan 01; 189(1):10-2. PMID: 24381989.
      View in: PubMed
    21. Jain AK, Tewari-Singh N, Inturi S, Orlicky DJ, White CW, Agarwal R. Histopathological and immunohistochemical evaluation of nitrogen mustard-induced cutaneous effects in SKH-1 hairless and C57BL/6 mice. Exp Toxicol Pathol. 2014 Mar; 66(2-3):129-38. PMID: 24373750; PMCID: PMC3923453.
    22. Gabehart K, Correll KA, Yang J, Collins ML, Loader JE, Leach S, White CW, Dakhama A. Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. Toxicol Sci. 2014 Mar; 138(1):175-90. PMID: 24336422; PMCID: PMC3930365.
    23. Ghosh M, Ahmad S, Jian A, Li B, Smith RW, Helm KM, Seibold MA, Groshong SD, White CW, Reynolds SD. Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1127-34. PMID: 23927678; PMCID: PMC3931114.
    24. Inturi S, Tewari-Singh N, Jain AK, Roy S, White CW, Agarwal R. Absence of a p53 allele delays nitrogen mustard-induced early apoptosis and inflammation of murine skin. Toxicology. 2013 Sep 15; 311(3):184-90. PMID: 23845566; PMCID: PMC3808076.
    25. Ahmad A, Ahmad S, Malcolm KC, Miller SM, Hendry-Hofer T, Schaack JB, White CW. Differential regulation of pulmonary vascular cell growth by hypoxia-inducible transcription factor-1a and hypoxia-inducible transcription factor-2a. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):78-85. PMID: 23492195; PMCID: PMC3727885.
    26. Tewari-Singh N, Jain AK, Inturi S, White CW, Agarwal R. Clinically-relevant cutaneous lesions by nitrogen mustard: useful biomarkers of vesicants skin injury in SKH-1 hairless and C57BL/6 mice. PLoS One. 2013; 8(6):e67557. PMID: 23826320; PMCID: PMC3691145.
    27. Rancourt RC, Veress LA, Ahmad A, Hendry-Hofer TB, Rioux JS, Garlick RB, White CW. Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. Toxicol Appl Pharmacol. 2013 Oct 01; 272(1):86-95. PMID: 23727623; PMCID: PMC3775856.
    28. Ahmad A, Schaack JB, White CW, Ahmad S. Adenosine A2A receptor-dependent proliferation of pulmonary endothelial cells is mediated through calcium mobilization, PI3-kinase and ERK1/2 pathways. Biochem Biophys Res Commun. 2013 May 10; 434(3):566-71. PMID: 23583199; PMCID: PMC4046330.
    29. Veress LA, Hendry-Hofer TB, Loader JE, Rioux JS, Garlick RB, White CW. Tissue plasminogen activator prevents mortality from sulfur mustard analog-induced airway obstruction. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):439-47. PMID: 23258228; PMCID: PMC3653605.
    30. Ahmad S, Ahmad A, Rancourt RC, Neeves KB, Loader JE, Hendry-Hofer T, Di Paola J, Reynolds SD, White CW. Tissue factor signals airway epithelial basal cell survival via coagulation and protease-activated receptor isoforms 1 and 2. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):94-104. PMID: 23065128; PMCID: PMC3547080.
    31. Tewari-Singh N, Jain AK, Inturi S, Agarwal C, White CW, Agarwal R. Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation. PLoS One. 2012; 7(9):e46149. PMID: 23029417; PMCID: PMC3459894.
    32. del Rosario MA, Bender BG, White CW. Suicidal ideation and thought disorder associated with the formoterol component of combined asthma medication. Pediatr Pulmonol. 2013 Jan; 48(1):102-3. PMID: 22489078.
      View in: PubMed
    33. Ahmad S, Nichols DP, Strand M, Rancourt RC, Randell SH, White CW, Ahmad A. SERCA2 regulates non-CF and CF airway epithelial cell response to ozone. PLoS One. 2011; 6(11):e27451. PMID: 22096575; PMCID: PMC3214057.
    34. Ahmad S, Raemy DO, Loader JE, Kailey JM, Neeves KB, White CW, Ahmad A, Gehr P, Rothen-Rutishauser BM. Interaction and localization of synthetic nanoparticles in healthy and cystic fibrosis airway epithelial cells: effect of ozone exposure. J Aerosol Med Pulm Drug Deliv. 2012 Feb; 25(1):7-15. PMID: 22007674; PMCID: PMC3311910.
    35. Rancourt RC, Veress LA, Guo X, Jones TN, Hendry-Hofer TB, White CW. Airway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 01; 302(1):L82-92. PMID: 21964405; PMCID: PMC3349374.
    36. White CW, Short JL, Haynes JM, Matsui M, Ventura S. Contractions of the mouse prostate elicited by acetylcholine are mediated by M(3) muscarinic receptors. J Pharmacol Exp Ther. 2011 Dec; 339(3):870-7. PMID: 21885618.
      View in: PubMed
    37. Inturi S, Tewari-Singh N, Gu M, Shrotriya S, Gomez J, Agarwal C, White CW, Agarwal R. Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts. Free Radic Biol Med. 2011 Dec 15; 51(12):2272-80. PMID: 21920433; PMCID: PMC3662483.
    38. Jain AK, Tewari-Singh N, Gu M, Inturi S, White CW, Agarwal R. Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. Toxicol Lett. 2011 Sep 10; 205(3):293-301. PMID: 21722719; PMCID: PMC3207490.
    39. O'Neill HC, Orlicky DJ, Hendry-Hofer TB, Loader JE, Day BJ, White CW. Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):323-31. PMID: 21642592; PMCID: PMC3175559.
    40. Jain AK, Tewari-Singh N, Orlicky DJ, White CW, Agarwal R. 2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin. Toxicology. 2011 Apr 11; 282(3):129-38. PMID: 21295104; PMCID: PMC3085827.
    41. Schroeder SR, White CW, Jones TN, Hendry-Hofer TB, Day BJ, Eaton SS. Impact of SOD-Mimetic Manganoporphyrins on Spin Trapping of Superoxide and Related Artifacts. Appl Magn Reson. 2011 Feb; 40(1):125-134. PMID: 23853422.
      View in: PubMed
    42. McGovern T, Day BJ, White CW, Powell WS, Martin JG. AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury. Free Radic Biol Med. 2011 Mar 01; 50(5):602-8. PMID: 21156205; PMCID: PMC4026011.
    43. Vähätalo R, Asikainen TM, Karikoski R, Kinnula VL, White CW, Andersson S, Heikinheimo M, Myllärniemi M. Expression of Transcription Factor GATA-6 in Alveolar Epithelial Cells Is Linked to Neonatal Lung Disease. Neonatology. 2011; 99(3):231-40. PMID: 21071980; PMCID: PMC2992637.
    44. Tewari-Singh N, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. Efficacy of glutathione in ameliorating sulfur mustard analog-induced toxicity in cultured skin epidermal cells and in SKH-1 mouse skin in vivo. J Pharmacol Exp Ther. 2011 Feb; 336(2):450-9. PMID: 20974699; PMCID: PMC3033716.
    45. McGovern TK, Powell WS, Day BJ, White CW, Govindaraju K, Karmouty-Quintana H, Lavoie N, Tan JJ, Martin JG. Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma. Respir Res. 2010 Oct 06; 11:138. PMID: 20925946; PMCID: PMC2965137.
    46. White CW, Short JL, Haynes JM, Evans RJ, Ventura S. The residual nonadrenergic contractile response to nerve stimulation of the mouse prostate is mediated by acetylcholine but not ATP in a comparison with the mouse vas deferens. J Pharmacol Exp Ther. 2010 Nov; 335(2):489-96. PMID: 20724483; PMCID: PMC2967401.
    47. Veress LA, O'Neill HC, Hendry-Hofer TB, Loader JE, Rancourt RC, White CW. Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1352-61. PMID: 20639443; PMCID: PMC3029928.
    48. White CW, Martin JG. Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models. Proc Am Thorac Soc. 2010 Jul; 7(4):257-63. PMID: 20601629; PMCID: PMC3136961.
    49. Tewari-Singh N, Gu M, Agarwal C, White CW, Agarwal R. Biological and molecular mechanisms of sulfur mustard analogue-induced toxicity in JB6 and HaCaT cells: possible role of ataxia telangiectasia-mutated/ataxia telangiectasia-Rad3-related cell cycle checkpoint pathway. Chem Res Toxicol. 2010 Jun 21; 23(6):1034-44. PMID: 20469912; PMCID: PMC2891139.
    50. O'Neill HC, White CW, Veress LA, Hendry-Hofer TB, Loader JE, Min E, Huang J, Rancourt RC, Day BJ. Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide. Free Radic Biol Med. 2010 May 01; 48(9):1188-96. PMID: 20138141; PMCID: PMC2847650.
    51. Pal A, Tewari-Singh N, Gu M, Agarwal C, Huang J, Day BJ, White CW, Agarwal R. Sulfur mustard analog induces oxidative stress and activates signaling cascades in the skin of SKH-1 hairless mice. Free Radic Biol Med. 2009 Dec 01; 47(11):1640-51. PMID: 19761830; PMCID: PMC2801552.
    52. Stabler SP, Sekhar J, Allen RH, O'Neill HC, White CW. Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. Free Radic Biol Med. 2009 Oct 15; 47(8):1147-53. PMID: 19616616; PMCID: PMC2782850.
    53. Ahmad A, Ahmad S, Glover L, Miller SM, Shannon JM, Guo X, Franklin WA, Bridges JP, Schaack JB, Colgan SP, White CW. Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10684-9. PMID: 19541651; PMCID: PMC2705563.
    54. Ahmad S, Ahmad A, Dremina ES, Sharov VS, Guo X, Jones TN, Loader JE, Tatreau JR, Perraud AL, Schöneich C, Randell SH, White CW. Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death. Am J Respir Crit Care Med. 2009 May 01; 179(9):816-26. PMID: 19201925; PMCID: PMC2675566.
    55. Tewari-Singh N, Rana S, Gu M, Pal A, Orlicky DJ, White CW, Agarwal R. Inflammatory biomarkers of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced skin injury in SKH-1 hairless mice. Toxicol Sci. 2009 Mar; 108(1):194-206. PMID: 19075041; PMCID: PMC2644400.
    56. Gould NS, White CW, Day BJ. A role for mitochondrial oxidative stress in sulfur mustard analog 2-chloroethyl ethyl sulfide-induced lung cell injury and antioxidant protection. J Pharmacol Exp Ther. 2009 Mar; 328(3):732-9. PMID: 19064720; PMCID: PMC2682257.
    57. Panayiotidis MI, Stabler SP, Allen RH, Pappa A, White CW. Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutat Res. 2009 Mar 31; 674(1-2):23-30. PMID: 19010443.
      View in: PubMed
    58. O'Neill HC, Rancourt RC, White CW. Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH. Antioxid Redox Signal. 2008 Feb; 10(2):277-85. PMID: 18158760.
      View in: PubMed
    59. Asikainen TM, White CW. HIF stabilizing agents: shotgun or scalpel? Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L555-6. PMID: 17616644.
      View in: PubMed
    60. Rancourt RC, Lee RL, O'Neill H, Accurso FJ, White CW. Reduced thioredoxin increases proinflammatory cytokines and neutrophil influx in rat airways: modulation by airway mucus. Free Radic Biol Med. 2007 May 01; 42(9):1441-53. PMID: 17395017.
      View in: PubMed
    61. Grover TR, Asikainen TM, Kinsella JP, Abman SH, White CW. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1345-51. PMID: 17307811.
      View in: PubMed
    62. Panayiotidis MI, Rancourt RC, Pappa A, White CW. Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A549) cells. In Vivo. 2006 Nov-Dec; 20(6B):861-5. PMID: 17203780.
      View in: PubMed
    63. Asikainen TM, Chang LY, Coalson JJ, Schneider BK, Waleh NS, Ikegami M, Shannon JM, Winter VT, Grubb P, Clyman RI, Yoder BA, Crapo JD, White CW. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006 Aug; 20(10):1698-700. PMID: 16807366.
      View in: PubMed
    64. Asikainen TM, Waleh NS, Schneider BK, Clyman RI, White CW. Enhancement of angiogenic effectors through hypoxia-inducible factor in preterm primate lung in vivo. Am J Physiol Lung Cell Mol Physiol. 2006 Oct; 291(4):L588-95. PMID: 16679381.
      View in: PubMed
    65. Ahmad S, Ahmad A, White CW. Purinergic signaling and kinase activation for survival in pulmonary oxidative stress and disease. Free Radic Biol Med. 2006 Jul 01; 41(1):29-40. PMID: 16781450.
      View in: PubMed
    66. White CW. Commentary on "Hypoxia, hypoxic signaling, tissue damage, and detection of reactive oxygen species (ROS)". Free Radic Biol Med. 2006 Mar 15; 40(6):923-7. PMID: 16540387.
      View in: PubMed
    67. Ahmad S, Ahmad A, Schneider KB, White CW. Cholesterol interferes with the MTT assay in human epithelial-like (A549) and endothelial (HLMVE and HCAE) cells. Int J Toxicol. 2006 Jan-Feb; 25(1):17-23. PMID: 16510353.
      View in: PubMed
    68. Gerasimovskaya EV, Davie NJ, Ahmad S, Tucker DA, White CW, Stenmark KR. Extracellular adenosine triphosphate: a potential regulator of vasa vasorum neovascularization in hypoxia-induced pulmonary vascular remodeling. Chest. 2005 Dec; 128(6 Suppl):608S-610S. PMID: 16373860.
      View in: PubMed
    69. Asikainen TM, Ahmad A, Schneider BK, White CW. Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungs. Pediatr Pulmonol. 2005 Dec; 40(6):538-46. PMID: 16231377.
      View in: PubMed
    70. Panayiotidis MI, Stabler SP, Ahmad A, Pappa A, Legros LH, Hernandez-Saavedra D, Schneider BK, Allen RH, Vasiliou V, McCord JM, Kotb M, White CW. Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free Radic Biol Med. 2006 Jan 15; 40(2):348-58. PMID: 16413417.
      View in: PubMed
    71. Ahmad A, Ahmad S, Chang LY, Schaack J, White CW. Endothelial Akt activation by hyperoxia: role in cell survival. Free Radic Biol Med. 2006 Apr 01; 40(7):1108-18. PMID: 16545678.
      View in: PubMed
    72. Lee RL, Rancourt RC, del Val G, Pack K, Pardee C, Accurso FJ, White CW. Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum. Am J Physiol Lung Cell Mol Physiol. 2005 Nov; 289(5):L875-82. PMID: 16214824.
      View in: PubMed
    73. Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Günzler V, White CW. Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10212-7. PMID: 16009933; PMCID: PMC1177409.
    74. Asikainen TM, Ahmad A, Schneider BK, Ho WB, Arend M, Brenner M, Günzler V, White CW. Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells. Free Radic Biol Med. 2005 Apr 15; 38(8):1002-13. PMID: 15780758.
      View in: PubMed
    75. Ahmad S, Ahmad A, McConville G, Schneider BK, Allen CB, Manzer R, Mason RJ, White CW. Lung epithelial cells release ATP during ozone exposure: signaling for cell survival. Free Radic Biol Med. 2005 Jul 15; 39(2):213-26. PMID: 15964513.
      View in: PubMed
    76. Asikainen TM, White CW. Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD? Toxicol Appl Pharmacol. 2005 Mar 01; 203(2):177-88. PMID: 15710178.
      View in: PubMed
    77. Ahmad S, Ahmad A, Ghosh M, Leslie CC, White CW. Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. J Biol Chem. 2004 Apr 16; 279(16):16317-25. PMID: 14761947.
      View in: PubMed
    78. Asikainen TM, White CW. Pulmonary antioxidant defenses in the preterm newborn with respiratory distress and bronchopulmonary dysplasia in evolution: implications for antioxidant therapy. Antioxid Redox Signal. 2004 Feb; 6(1):155-67. PMID: 14713347.
      View in: PubMed
    79. Panayiotidis MI, Rancourt RC, Allen CB, Riddle SR, Schneider BK, Ahmad S, White CW. Hyperoxia-induced DNA damage causes decreased DNA methylation in human lung epithelial-like A549 cells. Antioxid Redox Signal. 2004 Feb; 6(1):129-36. PMID: 14713344.
      View in: PubMed
    80. Quintos-Alagheband ML, White CW, Schwarz MA. Potential role for antiangiogenic proteins in the evolution of bronchopulmonary dysplasia. Antioxid Redox Signal. 2004 Feb; 6(1):137-45. PMID: 14713345.
      View in: PubMed
    81. Panayiotidis MI, Stabler SP, Allen RH, Ahmad A, White CW. Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chem Biol Interact. 2004 Jan 15; 147(1):87-97. PMID: 14726155.
      View in: PubMed
    82. Rancourt RC, Tai S, King M, Heltshe SL, Penvari C, Accurso FJ, White CW. Thioredoxin liquefies and decreases the viscoelasticity of cystic fibrosis sputum. Am J Physiol Lung Cell Mol Physiol. 2004 May; 286(5):L931-8. PMID: 14695120.
      View in: PubMed
    83. Ahmad S, Ahmad A, Gerasimovskaya E, Stenmark KR, Allen CB, White CW. Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase. Am J Respir Cell Mol Biol. 2003 Feb; 28(2):179-87. PMID: 12540485.
      View in: PubMed
    84. Gerasimovskaya EV, Ahmad S, White CW, Jones PL, Carpenter TC, Stenmark KR. Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor. J Biol Chem. 2002 Nov 22; 277(47):44638-50. PMID: 12244041.
      View in: PubMed
    85. Ahmad A, Ahmad S, Schneider BK, Allen CB, Chang LY, White CW. Elevated expression of hexokinase II protects human lung epithelial-like A549 cells against oxidative injury. Am J Physiol Lung Cell Mol Physiol. 2002 Sep; 283(3):L573-84. PMID: 12169577.
      View in: PubMed
    86. Uhlson C, Harrison K, Allen CB, Ahmad S, White CW, Murphy RC. Oxidized phospholipids derived from ozone-treated lung surfactant extract reduce macrophage and epithelial cell viability. Chem Res Toxicol. 2002 Jul; 15(7):896-906. PMID: 12118999.
      View in: PubMed
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