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Jonathan Paul Hannan

TitleResearch Associate
InstitutionUniversity of Colorado Boulder

    Collapse Biography 
    Collapse awards and honors
    2011Fellow, Higher Education Academy,

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Swisher GH, Hannan JP, Cordaro NJ, Erbse AH, Falke JJ. Ras-guanine nucleotide complexes: A UV spectral deconvolution method to analyze protein concentration, nucleotide stoichiometry, and purity. Anal Biochem. 2021 04 01; 618:114066. PMID: 33485819.
      View in: PubMed
    2. Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 01 01; 200(1):316-326. PMID: 29187587.
      View in: PubMed
    3. Kane SJ, Swanson E, Gordon EO, Rocha S, Bender HR, Donius LR, Aguzzi A, Hannan JP, Zabel MD. Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice. mSphere. 2017 Nov-Dec; 2(6). PMID: 29202042.
      View in: PubMed
    4. Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLoS One. 2016; 11(11):e0166200. PMID: 27814381.
      View in: PubMed
    5. Hannan, JP. Curr Protein Pept Sci. The structure-function relationships of complement receptor type 2 (CR2/CD21). 2016; 17(5):463-487.
    6. Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int. 2016 07; 90(1):109-22. PMID: 27165610.
      View in: PubMed
    7. Renner, Brandon Tong, Hua-Hua Laskowski, Jennifer Jonscher, Karen Goetz, Lindsey Woolaver, Rachel Hannan, Jonathan Li, Yong Xing Hourcade, Dennis E. Pickering, Matthew C. Holers, V. Michael Thurman, Joshua M. Annexin A2 enhances complement activation by inhibiting factor H. Journal of Immunology. 2016; 196:1355-1365.
    8. Hannan JP. The Structure-Function Relationships of Complement Receptor Type 2 (CR2; CD21). Curr Protein Pept Sci. 2016; 17(5):463-87. PMID: 26916158.
      View in: PubMed
    9. Blaum, BS Hannan, JP Herbert, AP Kavanagh, D Uhrin, D Stehle, T. Structural basis for sialic acid-mediated self-recognition by complement factor H. Nat Chem Biol. 2015; 11:77-82.
    10. Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013 May; 123(5):2218-30. PMID: 23619360.
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    11. Herbert, AP Kavanagh, D Johansson, C Morgan, HP Blaum, BS Hannan, JP Barlow, PN Uhrin, D. Structural and Functional Characterization of the Product of Disease-Related Factor H Gene Conversion. Biochemistry. 2012; 51(9):1874-1884.
    12. Morgan, HP Mertens, HDT Guariento, M Schmidt, CQ Soares, D.C. Svergun, DI Herbert, AP Barlow, PN Hannan, JP. Structural Analysis of the C-Terminal Region (Modules 18-20) of Complement Regulator Factor H (FH). PLoS One. 2012; 7(2):e32187.
    13. Thiel J, Kimmig L, Salzer U, Grudzien M, Lebrecht D, Hagena T, Draeger R, Voelxen N, Völxen N, Bergbreiter A, Jennings S, Gutenberger S, Aichem A, Illges H, Hannan JP, Kienzler AK, Rizzi M, Eibel H, Peter HH, Warnatz K, Grimbacher B, Rump JA, Schlesier M. Genetic CD21 deficiency is associated with hypogammaglobulinemia. J Allergy Clin Immunol. 2012 Mar; 129(3):801-810.e6. PMID: 22035880.
      View in: PubMed
    14. Morgan, HP Jiang, J Herbert, AP Kavanagh, D Uhrin, D Barlow, PN Hannan, JP. Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H. Acta Crystallogr Sect D Biol Crystallogr. 2011; 67:593-600.
    15. Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HD, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP. Structural basis for engagement by complement factor H of C3b on a self surface. Nat Struct Mol Biol. 2011 Apr; 18(4):463-70. PMID: 21317894.
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    16. Shaw CD, Storek MJ, Young KA, Kovacs JM, Thurman JM, Holers VM, Hannan JP. Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking. J Mol Biol. 2010 Dec 10; 404(4):697-710. PMID: 20951140.
      View in: PubMed
    17. Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair. J Biol Chem. 2010 Aug 27; 285(35):27251-27258. PMID: 20558730.
      View in: PubMed
    18. Kovacs JM, Hannan JP, Eisenmesser EZ, Holers VM. Mapping of the C3d ligand binding site on complement receptor 2 (CR2/CD21) using nuclear magnetic resonance and chemical shift analysis. J Biol Chem. 2009 Apr 03; 284(14):9513-20. PMID: 19164292.
      View in: PubMed
    19. Young KA, Herbert AP, Barlow PN, Holers VM, Hannan JP. Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350. J Virol. 2008 Nov; 82(22):11217-27. PMID: 18786993.
      View in: PubMed
    20. Li K, Okemefuna AI, Gor J, Hannan JP, Asokan R, Holers VM, Perkins SJ. Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2. J Mol Biol. 2008 Dec 05; 384(1):137-50. PMID: 18804116.
      View in: PubMed
    21. Young KA, Chen XS, Holers VM, Hannan JP. Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21). J Biol Chem. 2007 Dec 14; 282(50):36614-25. PMID: 17925391.
      View in: PubMed
    22. Szakonyi G, Klein MG, Hannan JP, Young KA, Ma RZ, Asokan R, Holers VM, Chen XS. Structure of the Epstein-Barr virus major envelope glycoprotein. Nat Struct Mol Biol. 2006 Nov; 13(11):996-1001. PMID: 17072314.
      View in: PubMed
    23. Asokan R, Hua J, Young KA, Gould HJ, Hannan JP, Kraus DM, Szakonyi G, Grundy GJ, Chen XS, Crow MK, Holers VM. Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus. J Immunol. 2006 Jul 01; 177(1):383-94. PMID: 16785534.
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    24. Hibbert, RG Teriete, P Grundy, GJ Beavil, RL Reljic, R. Holers, VM Hannan, JP Sutton, BJ Gould, HJ McDonnell, JM. The structure of human CD23 and its interactions with IgE and CD21. J Exp Med. 2005; 202(6):751-760.
    25. Gilbert, HE Eaton, JT Hannan, JP Holers, VM Perkins, SJ. Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: An X-ray scattering and sedimentation modelling study. J Mol Biol. 2005; 346(3):859-873.
    26. Hannan JP, Young KA, Guthridge JM, Asokan R, Szakonyi G, Chen XS, Holers VM. Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d. J Mol Biol. 2005 Feb 25; 346(3):845-58. PMID: 15713467.
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    27. Hannan JP, Szakonyi G, Asokan R., Chen X, Holers, VM. Complement Receptor CR2/CD21 and CR2-C3d complexes. Structural Biology of the Complement System. 2005; 143-160.
    28. Hannan, J Young, K Szakonyi, G Overduin, MJ Perkins, SJ Chen, X Holers, VM. Structure of complement receptor (CR) 2 and CR2-C3d complexes. Biochem Soc Trans. 2002; 30:983-989.
    29. Hannan JP, Busch JL, Breton J, James R, Thomson AJ, Moore GR, Davy SL. Characterisation of oxidised 7Fe dicluster ferredoxins with NMR spectroscopy. J Biol Inorg Chem. 2000 Aug; 5(4):432-47. PMID: 10968614.
      View in: PubMed
    30. Hannan JP, Whittaker SB-M, Hemmings AM, James R, Kleanthous C, Moore GR. NMR studies of metal ion binding to the ZN-finger-like HNH motif of colicin E9. J Inorg Biochem. 2000; 79(1-4):365-370.
    31. Hannan JP, Busch JLH, Breton J, James R, Thomson AJ, Moore GR, Davy SL. Characterisation of oxidised 7Fe dicluster ferredoxins with NMR spectroscopy. J Biol Inorg Chem. 2000; 5(4):432-447.
    32. Hannan, JP Whittaker, SB-M Davy, SL Kühlmann, UC Pommer, AJ Hemmings, AM James, R Kleanthous, C Moore, GR . NMR study of Ni2+ binding to the H-N-H endonuclease domain of colicin E9. Protein Science. 1999; 8:1711-1713.
    33. Hannan JP, Davy SL, Moore GR, Eady RR, Andrew CR. Effect of nickel(II) substitution on the resonance Raman and NMR spectra of Alcaligenes xylosoxidans azurin II: implications for axial-ligand bonding interactions in cupredoxin active sites. J Biol Inorg Chem. 1998; 3(3):282-291.
    34. Welsh DT, Lindsay YE, Caumette P, Herbert RA, Hannan J. Identification of trehalose and glycine betaine as compatible solutes in the moderately halophilic sulfate reducing bacterium, Desulfovibrio halophilus. FEMS Microbiol Lett. 1996; 140(2-3):203-207.
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