Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

David Ross

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-7265
    Other Positions
    TitleChair
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOP-Administration


    Collapse Research 
    Collapse research activities and funding
    R01ES004112     (ROSS, DAVID)Jul 1, 1986 - Jun 30, 1997
    NIH/NIEHS
    METABOLIC BASIS OF BENZENE-INDUCED MYELOTOXICITY
    Role: Principal Investigator
    R01CA051210     (ROSS, DAVID)Jul 1, 1990 - Nov 30, 2017
    NIH/NCI
    Biochemical and molecular studies on NQO1. Design of less toxic Hsp90 inhibitors
    Role: Principal Investigator
    R01ES009554     (ROSS, DAVID)Jul 15, 1998 - Nov 30, 2009
    NIH/NIEHS
    NQO1 in Protection Against Benzene Toxicicity
    Role: Principal Investigator
    R01NS044613     (ROSS, DAVID)Jul 1, 2002 - Jun 30, 2009
    NIH/NINDS
    NQ01, Oxidative Stress and Proteasomal Inhibition
    Role: Principal Investigator
    R01CA114441     (ROSS, DAVID)Sep 30, 2005 - Jul 31, 2010
    NIH/NCI
    NQO1 Inhibitors and Pancreatic Cancer Therapy
    Role: Principal Investigator
    R21HL095995     (ROSS, DAVID)Jul 30, 2009 - Jun 30, 2012
    NIH/NHLBI
    Targeting of NQ02 in CML
    Role: Principal Investigator
    R01ES018943     (ROSS, DAVID)Jun 4, 2010 - Mar 31, 2015
    NIH/NIEHS
    Novel Mechanisms of Quinone Toxicity
    Role: Principal Investigator
    R01DK109964     (ROSS, DAVID)Apr 1, 2017 - Mar 31, 2022
    NIH/NIDDK
    Regulation of insulin signaling and sensitivity by the xenobiotic metabolizing enzyme NQO1
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ferguson L, Grant AD, Lewis J, Kielmann K, Watson-Jones D, Vusha S, Ong'ech JO, Ross DA. Linking women who test HIV-positive in pregnancy-related services to HIV care and treatment services in Kenya: a mixed methods prospective cohort study. PLoS One. 2014; 9(3):e89764. PMID: 24646492; PMCID: PMC3960101.
      View in: PubMed, PubMed Central
    2. Greim H, Kaden DA, Larson RA, Palermo CM, Rice JM, Ross D, Snyder R. The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment. Ann N Y Acad Sci. 2014 Mar; 1310:7-31. PMID: 24495159; PMCID: PMC4002179.
      View in: PubMed, PubMed Central
    3. Pasceri R, Siegel D, Ross D, Moody CJ. Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A. J Med Chem. 2013 Apr 25; 56(8):3310-7. PMID: 23521768.
      View in: PubMed
    4. Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem. 2013 Apr; 5(4):307-14. PMID: 23511419.
      View in: PubMed
    5. Quentin W, Terris-Prestholt F, Changalucha J, Soteli S, Edmunds WJ, Hutubessy R, Ross DA, Kapiga S, Hayes R, Watson-Jones D. Costs of delivering human papillomavirus vaccination to schoolgirls in Mwanza Region, Tanzania. BMC Med. 2012 Nov 13; 10:137. PMID: 23148516.
      View in: PubMed
    6. Siegel D, Kepa JK, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells. PLoS One. 2012; 7(9):e44861. PMID: 22984577; PMCID: PMC3439439.
      View in: PubMed, PubMed Central
    7. Siew EL, Chan KM, Williams GT, Ross D, Inayat-Hussain SH. Protection of hydroquinone-induced apoptosis by downregulation of Fau is mediated by NQO1. Free Radic Biol Med. 2012 Oct 15; 53(8):1616-24. PMID: 22687461.
      View in: PubMed
    8. Siegel D, Yan C, Ross D. NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Biochem Pharmacol. 2012 Apr 15; 83(8):1033-40. PMID: 22209713; PMCID: PMC3482497.
      View in: PubMed, PubMed Central
    9. Yan C, Siegel D, Newsome J, Chilloux A, Moody CJ, Ross D. Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling. Mol Pharmacol. 2012 Mar; 81(3):401-10. PMID: 22147753; PMCID: PMC3286294.
      View in: PubMed, PubMed Central
    10. Luke MM, Berger K, Rowland CM, Catanese JJ, Tong CH, Ross DA, Garcia V, Kuhlenbaeumer G, Ringelstein EB, Pullinger CR, Malloy MJ, Deedwania P, Ellis SG, Kane JP, Devlin JJ, Lalouschek W, Mannhalter C. Polymorphisms and noncardioembolic stroke in three case-control studies. Cerebrovasc Dis. 2012; 33(1):80-5. PMID: 22134093.
      View in: PubMed
    11. Yan C, Dufour M, Siegel D, Reigan P, Gomez J, Shieh B, Moody CJ, Ross D. Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems. Biochemistry. 2011 Aug 09; 50(31):6678-88. PMID: 21718050; PMCID: PMC3291479.
      View in: PubMed, PubMed Central
    12. Dufour M, Yan C, Siegel D, Colucci MA, Jenner M, Oldham NJ, Gomez J, Reigan P, Li Y, De Matteis CI, Ross D, Moody CJ. Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition. Chembiochem. 2011 May 16; 12(8):1203-8. PMID: 21506232; PMCID: PMC3880221.
      View in: PubMed, PubMed Central
    13. Reigan P, Siegel D, Guo W, Ross D. A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins. Mol Pharmacol. 2011 May; 79(5):823-32. PMID: 21285336; PMCID: PMC3082934.
      View in: PubMed, PubMed Central
    14. Siegel D, Shieh B, Yan C, Kepa JK, Ross D. Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells. J Pharmacol Exp Ther. 2011 Mar; 336(3):874-80. PMID: 21156818; PMCID: PMC3061536.
      View in: PubMed, PubMed Central
    15. Ross D, Zhou H, Siegel D. Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function. Chem Biol Interact. 2011 Jun 30; 192(1-2):145-9. PMID: 20970411; PMCID: PMC3155573.
      View in: PubMed, PubMed Central
    16. Zhou H, Dehn D, Kepa JK, Siegel D, Scott DE, Tan W, Ross D. NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion. J Pharmacol Exp Ther. 2010 Jul; 334(1):260-8. PMID: 20378716; PMCID: PMC2912043.
      View in: PubMed, PubMed Central
    17. Inayat-Hussain SH, Ibrahim HA, Siew EL, Rajab NF, Chan KM, Ross D. Modulation of the benzene metabolite hydroquinone induced toxicity: evidence for an important role of fau. Chem Biol Interact. 2010 Mar 19; 184(1-2):310-2. PMID: 20025857.
      View in: PubMed
    18. Nolan KA, Doncaster JR, Dunstan MS, Scott KA, Frenkel AD, Siegel D, Ross D, Barnes J, Levy C, Leys D, Whitehead RC, Stratford IJ, Bryce RA. Synthesis and biological evaluation of coumarin-based inhibitors of NAD(P)H: quinone oxidoreductase-1 (NQO1). J Med Chem. 2009 Nov 26; 52(22):7142-56. PMID: 19877692.
      View in: PubMed
    19. Ross D, Zhou H. Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity. Chem Biol Interact. 2010 Mar 19; 184(1-2):222-8. PMID: 19941840; PMCID: PMC2846242.
      View in: PubMed, PubMed Central
    20. Zhou H, Kepa JK, Siegel D, Miura S, Hiraki Y, Ross D. Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells. Mol Pharmacol. 2009 Sep; 76(3):579-87. PMID: 19525446; PMCID: PMC2730389.
      View in: PubMed, PubMed Central
    21. Yan C, Shieh B, Reigan P, Zhang Z, Colucci MA, Chilloux A, Newsome JJ, Siegel D, Chan D, Moody CJ, Ross D. Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target. Mol Pharmacol. 2009 Jul; 76(1):163-72. PMID: 19364812; PMCID: PMC2701460.
      View in: PubMed, PubMed Central
    22. Guo W, Siegel D, Ross D. Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation. J Pharm Sci. 2008 Dec; 97(12):5147-57. PMID: 18393300; PMCID: PMC2580801.
      View in: PubMed, PubMed Central
    23. Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Mol Pharmacol. 2008 Dec; 74(6):1657-65. PMID: 18794327; PMCID: PMC2612562.
      View in: PubMed, PubMed Central
    24. Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. PLoS One. 2008 Aug 06; 3(8):e2895. PMID: 18682748; PMCID: PMC2483345.
      View in: PubMed, PubMed Central
    25. Guo W, Reigan P, Siegel D, Ross D. Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action. Drug Metab Dispos. 2008 Oct; 36(10):2050-7. PMID: 18635747; PMCID: PMC2574845.
      View in: PubMed, PubMed Central
    26. Awadallah NS, Dehn D, Shah RJ, Russell Nash S, Chen YK, Ross D, Bentz JS, Shroyer KR. NQO1 expression in pancreatic cancer and its potential use as a biomarker. Appl Immunohistochem Mol Morphol. 2008 Jan; 16(1):24-31. PMID: 18091324.
      View in: PubMed
    27. Nolan KA, Zhao H, Faulder PF, Frenkel AD, Timson DJ, Siegel D, Ross D, Burke TR, Stratford IJ, Bryce RA. Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity. J Med Chem. 2007 Dec 13; 50(25):6316-25. PMID: 17999461.
      View in: PubMed
    28. Everett DB, Weiss HA, Changalucha J, Anemona A, Chirwa T, Ross DA, Watson-Jones D, Parry JV, Hayes R, Mabey DC. Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents. Trop Med Int Health. 2007 Nov; 12(11):1323-6. PMID: 17949396.
      View in: PubMed
    29. Colucci MA, Reigan P, Siegel D, Chilloux A, Ross D, Moody CJ. Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity. J Med Chem. 2007 Nov 15; 50(23):5780-9. PMID: 17944451; PMCID: PMC2536657.
      View in: PubMed, PubMed Central
    30. Reigan P, Colucci MA, Siegel D, Chilloux A, Moody CJ, Ross D. Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells. Biochemistry. 2007 May 22; 46(20):5941-50. PMID: 17455910.
      View in: PubMed
    31. Atwal GS, Bond GL, Metsuyanim S, Papa M, Friedman E, Distelman-Menachem T, Ben Asher E, Lancet D, Ross DA, Sninsky J, White TJ, Levine AJ, Yarden R. Haplotype structure and selection of the MDM2 oncogene in humans. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4524-9. PMID: 17360557; PMCID: PMC1838634.
      View in: PubMed, PubMed Central
    32. Lennard ML, Hikima J, Ross DA, Kruiswijk CP, Wilson MR, Miller NW, Warr GW. Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription? BMC Mol Biol. 2007 Jan 31; 8:8. PMID: 17266766; PMCID: PMC1800861.
      View in: PubMed, PubMed Central
    33. Zhu H, Jia Z, Mahaney JE, Ross D, Misra HP, Trush MA, Li Y. The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger. Cardiovasc Toxicol. 2007; 7(3):202-11. PMID: 17901563.
      View in: PubMed
    34. Siegel D, Kepa JK, Ross D. Biochemical and genetic analysis of NAD(P)H:quinone oxidoreductase 1 (NQO1). Curr Protoc Toxicol. 2007; Chapter 4:Unit4.22. PMID: 23045144.
      View in: PubMed
    35. Begleiter A, Hewitt D, Maksymiuk AW, Ross DA, Bird RP. A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2422-6. PMID: 17164365.
      View in: PubMed
    36. Fang L, Battisti RF, Cheng H, Reigan P, Xin Y, Shen J, Ross D, Chan KK, Martin EW, Wang PG, Sun D. Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates. J Med Chem. 2006 Oct 19; 49(21):6290-7. PMID: 17034135; PMCID: PMC2596603.
      View in: PubMed, PubMed Central
    37. Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins. Mol Pharmacol. 2006 Oct; 70(4):1194-203. PMID: 16825487.
      View in: PubMed
    38. Dehn DL, Siegel D, Zafar KS, Reigan P, Swann E, Moody CJ, Ross D. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol Cancer Ther. 2006 Jul; 5(7):1702-9. PMID: 16891456.
      View in: PubMed
    39. Zafar KS, Siegel D, Ross D. A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition. Mol Pharmacol. 2006 Sep; 70(3):1079-86. PMID: 16790533.
      View in: PubMed
    40. Vasiliou V, Ross D, Nebert DW. Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. Hum Genomics. 2006 Mar; 2(5):329-35. PMID: 16595077; PMCID: PMC3500182.
      View in: PubMed, PubMed Central
    41. Guo W, Reigan P, Siegel D, Zirrolli J, Gustafson D, Ross D. Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition. Cancer Res. 2005 Nov 01; 65(21):10006-15. PMID: 16267026.
      View in: PubMed
    42. Begleiter A, Norman A, Leitao D, Cabral T, Hewitt D, Pan S, Grandis JR, Siegfried JM, El-Sayed S, Sutherland D, Ross DA, Kerr PD. Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck. Oral Oncol. 2005 Oct; 41(9):927-33. PMID: 16054862.
      View in: PubMed
    43. Ross D. Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity. Chem Biol Interact. 2005 May 30; 153-154:137-46. PMID: 15935810.
      View in: PubMed
    44. Inayat-Hussain SH, Ross D. Intrinsic pathway of hydroquinone induced apoptosis occurs via both caspase-dependent and caspase-independent mechanisms. Chem Res Toxicol. 2005 Mar; 18(3):420-7. PMID: 15777082.
      View in: PubMed
    45. Dehn DL, Inayat-Hussain SH, Ross D. RH1 induces cellular damage in an NAD(P)H:quinone oxidoreductase 1-dependent manner: relationship between DNA cross-linking, cell cycle perturbations, and apoptosis. J Pharmacol Exp Ther. 2005 May; 313(2):771-9. PMID: 15665137.
      View in: PubMed
    46. Bironaite D, Siegel D, Moran JL, Weksler BB, Ross D. Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chem Biol Interact. 2004 Oct 15; 149(2-3):177-88. PMID: 15586939.
      View in: PubMed
    47. Ross D. Quinone reductases multitasking in the metabolic world. Drug Metab Rev. 2004 Oct; 36(3-4):639-54. PMID: 15554240.
      View in: PubMed
    48. van Muiswinkel FL, de Vos RA, Bol JG, Andringa G, Jansen Steur EN, Ross D, Siegel D, Drukarch B. Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra. Neurobiol Aging. 2004 Oct; 25(9):1253-62. PMID: 15312971.
      View in: PubMed
    49. Bironaite D, Siegel D, Moran JL, Weksler BB, Ross D. Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Chem Biol Interact. 2004 Aug 10; 149(1):37-49. PMID: 15356918.
      View in: PubMed
    50. Dehn DL, Winski SL, Ross D. Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1. Clin Cancer Res. 2004 May 01; 10(9):3147-55. PMID: 15131056.
      View in: PubMed
    51. Siegel D, Gustafson DL, Dehn DL, Han JY, Boonchoong P, Berliner LJ, Ross D. NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger. Mol Pharmacol. 2004 May; 65(5):1238-47. PMID: 15102952.
      View in: PubMed
    52. Ross D, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics. Methods Enzymol. 2004; 382:115-44. PMID: 15047100.
      View in: PubMed
    53. Hu X, Schrodi SJ, Ross DA, Cargill M. Selecting tagging SNPs for association studies using power calculations from genotype data. Hum Hered. 2004; 57(3):156-70. PMID: 15297809.
      View in: PubMed
    54. Kepa JK, Ross D. Differential expression of the antioxidant response element within the hNQO1 promoter in NSCLC versus SCLC. Biochem Biophys Res Commun. 2003 Nov 14; 311(2):446-53. PMID: 14592434.
      View in: PubMed
    55. Sarbia M, Bitzer M, Siegel D, Ross D, Schulz WA, Zotz RB, Kiel S, Geddert H, Kandemir Y, Walter A, Willers R, Gabbert HE. Association between NAD(P)H: quinone oxidoreductase 1 (NQ01) inactivating C609T polymorphism and adenocarcinoma of the upper gastrointestinal tract. Int J Cancer. 2003 Nov 10; 107(3):381-6. PMID: 14506737.
      View in: PubMed
    56. Dehn DL, Siegel D, Swann E, Moody CJ, Ross D. Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems. Mol Pharmacol. 2003 Sep; 64(3):714-20. PMID: 12920209.
      View in: PubMed
    57. Zhang J, Schulz WA, Li Y, Wang R, Zotz R, Wen D, Siegel D, Ross D, Gabbert HE, Sarbia M. Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population. Carcinogenesis. 2003 May; 24(5):905-9. PMID: 12771035.
      View in: PubMed
    58. Gustafson DL, Siegel D, Rastatter JC, Merz AL, Parpal JC, Kepa JK, Ross D, Long ME. Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo. J Pharmacol Exp Ther. 2003 Jun; 305(3):1079-86. PMID: 12649308.
      View in: PubMed
    59. Anwar A, Dehn D, Siegel D, Kepa JK, Tang LJ, Pietenpol JA, Ross D. Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. J Biol Chem. 2003 Mar 21; 278(12):10368-73. PMID: 12529318.
      View in: PubMed
    60. Winski SL, Koutalos Y, Bentley DL, Ross D. Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells. Cancer Res. 2002 Mar 01; 62(5):1420-4. PMID: 11888914.
      View in: PubMed
    61. Anwar A, Siegel D, Kepa JK, Ross D. Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1. J Biol Chem. 2002 Apr 19; 277(16):14060-7. PMID: 11821413.
      View in: PubMed
    62. Winski SL, Faig M, Bianchet MA, Siegel D, Swann E, Fung K, Duncan MW, Moody CJ, Amzel LM, Ross D. Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches. Biochemistry. 2001 Dec 18; 40(50):15135-42. PMID: 11735396.
      View in: PubMed
    63. Siegel D, Ryder J, Ross D. NAD(P)H: quinone oxidoreductase 1 expression in human bone marrow endothelial cells. Toxicol Lett. 2001 Dec 15; 125(1-3):93-8. PMID: 11701227.
      View in: PubMed
    64. Inayat-Hussain SH, Winski SL, Ross D. Differential involvement of caspases in hydroquinone-induced apoptosis in human leukemic hl-60 and jurkat cells. Toxicol Appl Pharmacol. 2001 Sep 01; 175(2):95-103. PMID: 11543641.
      View in: PubMed
    65. Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Biochem Pharmacol. 2001 Jun 15; 61(12):1509-16. PMID: 11377380.
      View in: PubMed
    66. Wilson MW, Schelonka LP, Siegel D, Meininger A, Ross D. Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis. Curr Eye Res. 2001 May; 22(5):348-52. PMID: 11600935.
      View in: PubMed
    67. Siegel D, Anwar A, Winski SL, Kepa JK, Zolman KL, Ross D. Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1. Mol Pharmacol. 2001 Feb; 59(2):263-8. PMID: 11160862.
      View in: PubMed
    68. Ross D, Kepa JK, Winski SL, Beall HD, Anwar A, Siegel D. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact. 2000 Dec 01; 129(1-2):77-97. PMID: 11154736.
      View in: PubMed
    69. Ross D. The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues. J Toxicol Environ Health A. 2000 Nov; 61(5-6):357-72. PMID: 11086940.
      View in: PubMed
    70. Siegel D, Ross D. Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med. 2000 Aug; 29(3-4):246-53. PMID: 11035253.
      View in: PubMed
    71. Schelonka LP, Siegel D, Wilson MW, Meininger A, Ross D. Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1617-22. PMID: 10845577.
      View in: PubMed
    72. Faig M, Bianchet MA, Talalay P, Chen S, Winski S, Ross D, Amzel LM. Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3177-82. PMID: 10706635; PMCID: PMC16212.
      View in: PubMed, PubMed Central
    73. McGuinness SM, Johansson R, Lundstrom J, Ross D. Induction of apoptosis by remoxipride metabolites in HL60 and CD34+/CD19- human bone marrow progenitor cells: potential relevance to remoxipride-induced aplastic anemia. Chem Biol Interact. 1999 Aug 01; 121(3):253-65. PMID: 10462057.
      View in: PubMed
    74. Moran JL, Siegel D, Ross D. A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):8150-5. PMID: 10393963; PMCID: PMC22203.
      View in: PubMed, PubMed Central
    75. Kepa JK, Ross D. DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation. Br J Cancer. 1999 Apr; 79(11-12):1679-84. PMID: 10206277; PMCID: PMC2362807.
      View in: PubMed, PubMed Central
    76. Siegel D, McGuinness SM, Winski SL, Ross D. Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1. Pharmacogenetics. 1999 Feb; 9(1):113-21. PMID: 10208650.
      View in: PubMed
    77. Winski SL, Hargreaves RH, Butler J, Ross D. A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Clin Cancer Res. 1998 Dec; 4(12):3083-8. PMID: 9865924.
      View in: PubMed
    78. Beall HD, Winski S, Swann E, Hudnott AR, Cotterill AS, O'Sullivan N, Green SJ, Bien R, Siegel D, Ross D, Moody CJ. Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity. J Med Chem. 1998 Nov 19; 41(24):4755-66. PMID: 9822546.
      View in: PubMed
    79. Siegel D, Franklin WA, Ross D. Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. Clin Cancer Res. 1998 Sep; 4(9):2065-70. PMID: 9748120.
      View in: PubMed
    80. Nieusma JL, Claffey DJ, Ruth JA, Ross D. Stereochemical aspects of the conjugation of epoxide metabolites of butadiene with glutathione in rat liver cytosol and freshly isolated rat hepatocytes. Toxicol Sci. 1998 Jun; 43(2):102-9. PMID: 9710951.
      View in: PubMed
    81. Nieusma JL, Claffey DJ, Koop DR, Chen W, Peter RM, Nelson SD, Ruth JA, Ross D. Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human. Toxicol Lett. 1998 Mar 31; 95(2):123-9. PMID: 9635416.
      View in: PubMed
    82. Beall HD, Hudnott AR, Winski S, Siegel D, Swann E, Ross D, Moody CJ. Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1. Bioorg Med Chem Lett. 1998 Mar 03; 8(5):545-8. PMID: 9871615.
      View in: PubMed
    83. Siegel D, Bolton EM, Burr JA, Liebler DC, Ross D. The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant. Mol Pharmacol. 1997 Aug; 52(2):300-5. PMID: 9271353.
      View in: PubMed
    84. Rothman N, Smith MT, Hayes RB, Traver RD, Hoener B, Campleman S, Li GL, Dosemeci M, Linet M, Zhang L, Xi L, Wacholder S, Lu W, Meyer KB, Titenko-Holland N, Stewart JT, Yin S, Ross D. Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res. 1997 Jul 15; 57(14):2839-42. PMID: 9230185.
      View in: PubMed
    85. Nieusma JL, Claffey DJ, Maniglier-Poulet C, Imiolczyk T, Ross D, Ruth JA. Stereochemical aspects of 1,3-butadiene metabolism and toxicity in rat and mouse liver microsomes and freshly isolated rat hepatocytes. Chem Res Toxicol. 1997 Apr; 10(4):450-6. PMID: 9114983.
      View in: PubMed
    86. Kelsey KT, Ross D, Traver RD, Christiani DC, Zuo ZF, Spitz MR, Wang M, Xu X, Lee BK, Schwartz BS, Wiencke JK. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Br J Cancer. 1997; 76(7):852-4. PMID: 9328142; PMCID: PMC2228056.
      View in: PubMed, PubMed Central
    87. Traver RD, Siegel D, Beall HD, Phillips RM, Gibson NW, Franklin WA, Ross D. Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). Br J Cancer. 1997; 75(1):69-75. PMID: 9000600; PMCID: PMC2222704.
      View in: PubMed, PubMed Central
    88. Ross D, Siegel D, Schattenberg DG, Sun XM, Moran JL. Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ Health Perspect. 1996 Dec; 104 Suppl 6:1177-82. PMID: 9118890; PMCID: PMC1469724.
      View in: PubMed, PubMed Central
    89. Gustafson DL, Beall HD, Bolton EM, Ross D, Waldren CA. Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Mol Pharmacol. 1996 Oct; 50(4):728-35. PMID: 8863816; PMCID: PMC3883621.
      View in: PubMed, PubMed Central
    90. Moran JL, Siegel D, Sun XM, Ross D. Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells. Mol Pharmacol. 1996 Sep; 50(3):610-5. PMID: 8794901.
      View in: PubMed
    91. Ross D. Metabolic basis of benzene toxicity. Eur J Haematol Suppl. 1996; 60:111-8. PMID: 8987252.
      View in: PubMed
    92. Maniglier-Poulet C, Cheng X, Ruth JA, Ross D. Metabolism of 1,3-butadiene to butadiene monoxide in mouse and human bone marrow cells. Chem Biol Interact. 1995 Jul 14; 97(2):119-29. PMID: 7606811.
      View in: PubMed
    93. Miller AC, Schattenberg DG, Malkinson AM, Ross D. Decreased content of the IL1 alpha processing enzyme calpain in murine bone marrow-derived macrophages after treatment with the benzene metabolite hydroquinone. Toxicol Lett. 1994 Nov; 74(2):177-84. PMID: 7940599.
      View in: PubMed
    94. Schattenberg DG, Stillman WS, Gruntmeir JJ, Helm KM, Irons RD, Ross D. Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity. Mol Pharmacol. 1994 Aug; 46(2):346-51. PMID: 8078496.
      View in: PubMed
    95. Cheng X, Maniglier-Poulet C, Ross D, Ruth JA. Solvolytic formation of 1,2-dichloro-3,4-epoxybutane from butadiene monoxide under physiological conditions. Drug Metab Dispos. 1994 Mar-Apr; 22(2):206-10. PMID: 8013275.
      View in: PubMed
    96. Lévay G, Ross D, Bodell WJ. Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow. Carcinogenesis. 1993 Nov; 14(11):2329-34. PMID: 8242863.
      View in: PubMed
    97. Goon D, Matsuura J, Ross D. Metabolism and cytotoxicity of trans,trans-muconaldehyde and its derivatives: potential markers of benzene ring cleavage reactions. Chem Biol Interact. 1993 Jul; 88(1):37-53. PMID: 8330323.
      View in: PubMed
    98. Goon D, Saxena M, Awasthi YC, Ross D. Activity of mouse liver glutathione S-transferases toward trans,trans-muconaldehyde and trans-4-hydroxy-2-nonenal. Toxicol Appl Pharmacol. 1993 Apr; 119(2):175-80. PMID: 8480327.
      View in: PubMed
    99. Gibson NW, Ross D. Mitomycin C. Cancer Chemother Biol Response Modif. 1993; 14:45-54. PMID: 8312113.
      View in: PubMed
    100. Ganousis LG, Goon D, Zyglewska T, Wu KK, Ross D. Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites. Mol Pharmacol. 1992 Dec; 42(6):1118-25. PMID: 1480134.
      View in: PubMed
    101. Goon D, Cheng X, Ruth JA, Petersen DR, Ross D. Metabolism of trans,trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite. Toxicol Appl Pharmacol. 1992 May; 114(1):147-55. PMID: 1585367.
      View in: PubMed
    102. Traver RD, Horikoshi T, Danenberg KD, Stadlbauer TH, Danenberg PV, Ross D, Gibson NW. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res. 1992 Feb 15; 52(4):797-802. PMID: 1737339.
      View in: PubMed
    103. Monks TJ, Hanzlik RP, Cohen GM, Ross D, Graham DG. Quinone chemistry and toxicity. Toxicol Appl Pharmacol. 1992 Jan; 112(1):2-16. PMID: 1733045.
      View in: PubMed
    104. Subrahmanyam VV, Ross D, Eastmond DA, Smith MT. Potential role of free radicals in benzene-induced myelotoxicity and leukemia. Free Radic Biol Med. 1991; 11(5):495-515. PMID: 1769608.
      View in: PubMed
    105. Subrahmanyam VV, Doane-Setzer P, Steinmetz KL, Ross D, Smith MT. Phenol-induced stimulation of hydroquinone bioactivation in mouse bone marrow in vivo: possible implications in benzene myelotoxicity. Toxicology. 1990 May 14; 62(1):107-16. PMID: 2343455.
      View in: PubMed
    106. Thomas DJ, Sadler A, Subrahmanyam VV, Siegel D, Reasor MJ, Wierda D, Ross D. Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells. Mol Pharmacol. 1990 Feb; 37(2):255-62. PMID: 2154673.
      View in: PubMed
    107. Ross D, Siegel D, Gibson NW, Pacheco D, Thomas DJ, Reasor M, Wierda D. Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma. Free Radic Res Commun. 1990; 8(4-6):373-81. PMID: 2113030.
      View in: PubMed
    108. Sadler A, Subrahmanyam VV, Ross D. Oxidation of catechol by horseradish peroxidase and human leukocyte peroxidase: reactions of o-benzoquinone and o-benzosemiquinone. Toxicol Appl Pharmacol. 1988 Mar 30; 93(1):62-71. PMID: 2832975.
      View in: PubMed
    109. Sandy MS, Moldeus P, Ross D, Smith MT. Cytotoxicity of the redox cycling compound diquat in isolated hepatocytes: involvement of hydrogen peroxide and transition metals. Arch Biochem Biophys. 1987 Nov 15; 259(1):29-37. PMID: 2825600.
      View in: PubMed
    110. Ross D, Moldeus P, Sies H, Smith MT. Mechanism and relevance of glutathione mutagenicity. Mutat Res. 1986 Nov; 175(3):127-31. PMID: 2877394.
      View in: PubMed
    111. Sandy MS, Moldeus P, Ross D, Smith MT. Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity. Studies with a compromised isolated hepatocyte model system. Biochem Pharmacol. 1986 Sep 15; 35(18):3095-101. PMID: 3019355.
      View in: PubMed
    112. Ross D, Thor H, Threadgill MD, Sandy MS, Smith MT, Moldéus P, Orrenius S. The role of oxidative processes in the cytotoxicity of substituted 1,4-naphthoquinones in isolated hepatocytes. Arch Biochem Biophys. 1986 Aug 01; 248(2):460-6. PMID: 3017211.
      View in: PubMed
    113. Porubek D, Rundgren M, Larsson R, Albano E, Ross D, Nelson SD, Moldéus P. Quinone imines as biological reactive intermediates. Adv Exp Med Biol. 1986; 197:631-44. PMID: 3766286.
      View in: PubMed
    114. Ross D, Moldeus P. Thiyl radicals--their generation and further reactions. Adv Exp Med Biol. 1986; 197:329-35. PMID: 3020933.
      View in: PubMed
    115. Ross D, Mehlhorn RJ, Moldeus P, Smith MT. Metabolism of diethylstilbestrol by horseradish peroxidase and prostaglandin synthase--evidence for a free radical intermediate. Adv Exp Med Biol. 1986; 197:323-8. PMID: 3020932.
      View in: PubMed
    116. Ross D, Mehlhorn RJ, Moldeus P, Smith MT. Metabolism of diethylstilbestrol by horseradish peroxidase and prostaglandin-H synthase. Generation of a free radical intermediate and its interaction with glutathione. J Biol Chem. 1985 Dec 25; 260(30):16210-4. PMID: 2999150.
      View in: PubMed
    117. Ross D, Norbeck K, Moldéus P. The generation and subsequent fate of glutathionyl radicals in biological systems. J Biol Chem. 1985 Dec 05; 260(28):15028-32. PMID: 2999101.
      View in: PubMed
    118. Ross D, Moldeus P. Generation of reactive species and fate of thiols during peroxidase-catalyzed metabolic activation of aromatic amines and phenols. Environ Health Perspect. 1985 Dec; 64:253-7. PMID: 3007092; PMCID: PMC1568597.
      View in: PubMed, PubMed Central
    119. Larsson R, Ross D, Berlin T, Olsson LI, Moldéus P. Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney. J Pharmacol Exp Ther. 1985 Nov; 235(2):475-80. PMID: 3932643.
      View in: PubMed
    120. Moldéus P, Ross D, Larsson R. Co-oxidation of xenobiotics. Biochem Soc Trans. 1985 Oct; 13(5):847-50. PMID: 3934012.
      View in: PubMed
    121. Ross D, Thor H, Orrenius S, Moldeus P. Interaction of menadione (2-methyl-1,4-naphthoquinone) with glutathione. Chem Biol Interact. 1985 Oct; 55(1-2):177-84. PMID: 2998631.
      View in: PubMed
    122. Ross D, Cotgreave I, Moldéus P. The interaction of reduced glutathione with active oxygen species generated by xanthine-oxidase-catalyzed metabolism of xanthine. Biochim Biophys Acta. 1985 Sep 06; 841(3):278-82. PMID: 2992602.
      View in: PubMed
    123. Ohno Y, Ormstad K, Ross D, Orrenius S. Mechanism of allyl alcohol toxicity and protective effects of low-molecular-weight thiols studied with isolated rat hepatocytes. Toxicol Appl Pharmacol. 1985 Apr; 78(2):169-79. PMID: 2930914.
      View in: PubMed
    124. Ross D, Larsson R, Norbeck K, Ryhage R, Moldéus P. Characterization and mechanism of formation of reactive products formed during peroxidase-catalyzed oxidation of p-phenetidine. Trapping of reactive species by reduced glutathione and butylated hydroxyanisole. Mol Pharmacol. 1985 Feb; 27(2):277-86. PMID: 3969071.
      View in: PubMed
    125. Ross D, Larsson R, Andersson B, Nilsson U, Lindquist T, Lindeke B, Moldéus P. The oxidation of p-phenetidine by horseradish peroxidase and prostaglandin synthase and the fate of glutathione during such oxidations. Biochem Pharmacol. 1985 Feb 01; 34(3):343-51. PMID: 2982385.
      View in: PubMed
    126. Di Monte D, Ross D, Bellomo G, Eklöw L, Orrenius S. Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes. Arch Biochem Biophys. 1984 Dec; 235(2):334-42. PMID: 6097182.
      View in: PubMed
    127. Ross D, Albano E, Nilsson U, Moldéus P. Thiyl radicals--formation during peroxidase-catalyzed metabolism of acetaminophen in the presence of thiols. Biochem Biophys Res Commun. 1984 Nov 30; 125(1):109-15. PMID: 6095833.
      View in: PubMed
    128. Larsson R, Ross D, Nordenskjöld M, Lindeke B, Olsson LI, Moldéus P. Reactive products formed by peroxidase catalyzed oxidation of p-phenetidine. Chem Biol Interact. 1984 Nov; 52(1):1-14. PMID: 6499076.
      View in: PubMed
    129. Moldéus P, Larsson R, Ross D, Andersson B. Peroxidase-catalysed metabolism of drugs and carcinogens. Biochem Soc Trans. 1984 Feb; 12(1):20-3. PMID: 6423419.
      View in: PubMed
    Ross's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (504) concept(s)
    _
    Co-Authors Expand Description
    See all (7) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)