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Joel L. Kaar

TitleAsst Professor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin
Phone303/492-6031

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Summers SR, Sprenger KG, Pfaendtner J, Marchant J, Summers MF, Kaar JL. Mechanism of Competitive Inhibition and Destabilization of Acidothermus cellulolyticus Endoglucanase 1 by Ionic Liquids. J Phys Chem B. 2017 Nov 21. PMID: 29120187.
      View in: PubMed
    2. Jung S, MacConaghy KI, Kaar JL, Stoykovich MP. Enhanced Optical Sensitivity in Thermoresponsive Photonic Crystal Hydrogels by Operating Near the Phase Transition. ACS Appl Mater Interfaces. 2017 Aug 23; 9(33):27927-27935. PMID: 28758737.
      View in: PubMed
    3. Kaar JL. Lipase Activation and Stabilization in Room-Temperature Ionic Liquids. Methods Mol Biol. 2017; 1504:25-35. PMID: 27770412.
      View in: PubMed
    4. Grover N, Plaks JG, Summers SR, Chado GR, Schurr MJ, Kaar JL. Acylase-containing polyurethane coatings with anti-biofilm activity. Biotechnol Bioeng. 2016 Dec; 113(12):2535-2543. PMID: 27240552.
      View in: PubMed
    5. Sprenger KG, Choudhury A, Kaar JL, Pfaendtner J. Lytic Polysaccharide Monooxygenases ScLPMO10B and ScLPMO10C Are Stable in Ionic Liquids As Determined by Molecular Simulations. J Phys Chem B. 2016 04 28; 120(16):3863-72. PMID: 27052057.
      View in: PubMed
    6. Faulón Marruecos D, Kastantin M, Schwartz DK, Kaar JL. Dense Poly(ethylene glycol) Brushes Reduce Adsorption and Stabilize the Unfolded Conformation of Fibronectin. Biomacromolecules. 2016 Mar 14; 17(3):1017-25. PMID: 26866385.
      View in: PubMed
    7. Weltz JS, Schwartz DK, Kaar JL. Surface-Mediated Protein Unfolding as a Search Process for Denaturing Sites. ACS Nano. 2016 Jan 26; 10(1):730-8. PMID: 26580418; PMCID: PMC4729621 [Available on 01/26/17].
    8. Nordwald EM, Plaks JG, Snell JR, Sousa MC, Kaar JL. Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem. 2015 Nov; 16(17):2456-9. PMID: 26388426; PMCID: PMC4827357 [Available on 11/01/16].
    9. MacConaghy KI, Chadly DM, Stoykovich MP, Kaar JL. Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels. Analyst. 2015 Sep 21; 140(18):6354-62. PMID: 26270146; PMCID: PMC4557741 [Available on 09/21/16].
    10. Plaks JG, Falatach R, Kastantin M, Berberich JA, Kaar JL. Multisite clickable modification of proteins using lipoic acid ligase. Bioconjug Chem. 2015 Jun 17; 26(6):1104-12. PMID: 25982177.
      View in: PubMed
    11. MacConaghy KI, Chadly DM, Stoykovich MP, Kaar JL. Optically diffracting hydrogels for screening kinase activity in vitro and in cell lysate: impact of material and solution properties. Anal Chem. 2015 Mar 17; 87(6):3467-75. PMID: 25714913.
      View in: PubMed
    12. Burney PR, Nordwald EM, Hickman K, Kaar JL, Pfaendtner J. Molecular dynamics investigation of the ionic liquid/enzyme interface: application to engineering enzyme surface charge. Proteins. 2015 Apr; 83(4):670-80. PMID: 25641162.
      View in: PubMed
    13. Swartzlander MD, Barnes CA, Blakney AK, Kaar JL, Kyriakides TR, Bryant SJ. Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics. Biomaterials. 2015 Feb; 41:26-36. PMID: 25522962; PMCID: PMC4629245.
    14. MacConaghy KI, Geary CI, Kaar JL, Stoykovich MP. Photonic crystal kinase biosensor. J Am Chem Soc. 2014 May 14; 136(19):6896-9. PMID: 24761969; PMCID: PMC4333580.
    15. Nordwald EM, Brunecky R, Himmel ME, Beckham GT, Kaar JL. Charge engineering of cellulases improves ionic liquid tolerance and reduces lignin inhibition. Biotechnol Bioeng. 2014 Aug; 111(8):1541-9. PMID: 24522957.
      View in: PubMed
    16. McLoughlin SY, Kastantin M, Schwartz DK, Kaar JL. Single-molecule resolution of protein structure and interfacial dynamics on biomaterial surfaces. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19396-401. PMID: 24235137; PMCID: PMC3845135.
    17. Nordwald EM, Kaar JL. Mediating electrostatic binding of 1-butyl-3-methylimidazolium chloride to enzyme surfaces improves conformational stability. J Phys Chem B. 2013 Aug 01; 117(30):8977-86. PMID: 23822219.
      View in: PubMed
    18. Nordwald EM, Kaar JL. Stabilization of enzymes in ionic liquids via modification of enzyme charge. Biotechnol Bioeng. 2013 Sep; 110(9):2352-60. PMID: 23532939.
      View in: PubMed
    19. Nordwald EM, Garst A, Gill RT, Kaar JL. Accelerated protein engineering for chemical biotechnology via homologous recombination. Curr Opin Biotechnol. 2013 Dec; 24(6):1017-22. PMID: 23540421.
      View in: PubMed
    20. Brandt T, Kaar JL, Fersht AR, Veprintsev DB. Stability of p53 homologs. PLoS One. 2012; 7(10):e47889. PMID: 23112865; PMCID: PMC3480436.
    21. Kaar JL. Lipase activation and stabilization in room-temperature ionic liquids. Methods Mol Biol. 2011; 679:25-35. PMID: 20865386.
      View in: PubMed
    22. Kaar JL, Basse N, Joerger AC, Stephens E, Rutherford TJ, Fersht AR. Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding. Protein Sci. 2010 Dec; 19(12):2267-78. PMID: 20878668; PMCID: PMC3009395.
    23. Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29; 17(1):46-56. PMID: 20142040.
      View in: PubMed
    24. Kaar JL, Li Y, Blair HC, Asche G, Koepsel RR, Huard J, Russell AJ. Matrix metalloproteinase-1 treatment of muscle fibrosis. Acta Biomater. 2008 Sep; 4(5):1411-20. PMID: 18440885.
      View in: PubMed
    25. Depp V, Kaar JL, Russell AJ, Lele BS. Enzyme sheathing enables nanoscale solubilization of biocatalyst and dramatically increases activity in organic solvent. Biomacromolecules. 2008 Apr; 9(4):1348-51. PMID: 18293899.
      View in: PubMed
    26. Bedair H, Liu TT, Kaar JL, Badlani S, Russell AJ, Li Y, Huard J. Matrix metalloproteinase-1 therapy improves muscle healing. J Appl Physiol (1985). 2007 Jun; 102(6):2338-45. PMID: 17551103.
      View in: PubMed
    27. Kaar JL, Oh HI, Russell AJ, Federspiel WJ. Towards improved artificial lungs through biocatalysis. Biomaterials. 2007 Jul; 28(20):3131-9. PMID: 17433433; PMCID: PMC3427004.
    28. Xu H, Kaar JL, Russell AJ, Wagner WR. Characterizing the modification of surface proteins with poly(ethylene glycol) to interrupt platelet adhesion. Biomaterials. 2006 Jun; 27(16):3125-35. PMID: 16457880; PMCID: PMC2857701.
    29. Sharma NK, Tickell MD, Anderson JL, Kaar J, Pino V, Wicker BF, Armstrong DW, Davis JH, Russell AJ. Do ion tethered functional groups affect IL solvent properties? The case of sulfoxides and sulfones. Chem Commun (Camb). 2006 Feb 14; (6):646-8. PMID: 16446838.
      View in: PubMed
    30. Berberich JA, Kaar JL, Russell AJ. Use of salt hydrate pairs to control water activity for enzyme catalysis in ionic liquids. Biotechnol Prog. 2003 May-Jun; 19(3):1029-32. PMID: 12790674.
      View in: PubMed
    31. Kaar JL, Jesionowski AM, Berberich JA, Moulton R, Russell AJ. Impact of ionic liquid physical properties on lipase activity and stability. J Am Chem Soc. 2003 Apr 09; 125(14):4125-31. PMID: 12670234.
      View in: PubMed
    32. Russell AJ, Erbeldinger M, DeFrank JJ, Kaar J, Drevon G. Catalytic buffers enable positive-response inhibition-based sensing of nerve agents. Biotechnol Bioeng. 2002 Feb 05; 77(3):352-7. PMID: 11753944.
      View in: PubMed
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