Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Joel L. Kaar

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin
Phone303/492-6031

    Collapse Research 
    Collapse research activities and funding
    R01AI177678     (BRYANT, STEPHANIE J)Feb 5, 2024 - Dec 31, 2028
    NIH
    Tunable Surface Coatings to Control Protein Dynamics and Attenuate the FBR
    Role: Co-Principal Investigator
    R21AG062979     (KAAR, JOEL)Apr 1, 2019 - Jan 31, 2021
    NIH
    Inhibition of Amyloid Formation by Heterogeneous Nanoparticles with Chaperone-like Activity
    Role: Principal Investigator
    R21AR071550     (KAAR, JOEL)Mar 21, 2018 - Feb 28, 2021
    NIH
    Single-molecule resolution of DAMPs and their impact on the FBR
    Role: Principal Investigator
    R21AI135581     (KAAR, JOEL)Dec 14, 2017 - Nov 30, 2020
    NIH
    CCA-containing Hydrogels as a Novel Platform for Label-free Zika Detection
    Role: Principal Investigator
    R03EB018422     (KAAR, JOEL)Sep 30, 2014 - Jul 31, 2016
    NIH
    Enzyme-containing Anti-biofilm Coatings for Urological Catheters
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Coleman H, Saylor Perez J, Schwartz DK, Kaar J, Garcea RL, Randolph TW. Effect of mechanical stresses on viral capsid disruption during droplet formation and drying. Colloids Surf B Biointerfaces. 2024 Jan; 233:113661. PMID: 38006709.
      View in: PubMed
    2. Bisirri EA, Wright TA, Schwartz DK, Kaar JL. Tuning Polymer Composition Leads to Activity-Stability Tradeoff in Enzyme-Polymer Conjugates. Biomacromolecules. 2023 09 11; 24(9):4033-4041. PMID: 37610792.
      View in: PubMed
    3. Reichelderfer VT, Chaparro Sosa AF, Kaar JL, Schwartz DK. Tuning the surface charge of phospholipid bilayers inhibits insulin fibrilization. Colloids Surf B Biointerfaces. 2022 Dec; 220:112904. PMID: 36265317.
      View in: PubMed
    4. Abadia AV, Herbert KM, White TJ, Schwartz DK, Kaar JL. Biocatalytic 3D Actuation in Liquid Crystal Elastomers via Enzyme Patterning. ACS Appl Mater Interfaces. 2022 Jun 02. PMID: 35652291.
      View in: PubMed
    5. Jung S, MacConaghy KI, Guarnieri MT, Kaar JL, Stoykovich MP. Quantification of Metabolic Products from Microbial Hosts in Complex Media Using Optically Diffracting Hydrogels. ACS Appl Bio Mater. 2022 03 21; 5(3):1252-1258. PMID: 35166523.
      View in: PubMed
    6. Velasco Abadia A, Herbert KM, Matavulj VM, White TJ, Schwartz DK, Kaar JL. Chemically Triggered Changes in Mechanical Properties of Responsive Liquid Crystal Polymer Networks with Immobilized Urease. J Am Chem Soc. 2021 Oct 13; 143(40):16740-16749. PMID: 34590861.
      View in: PubMed
    7. S?nchez-Mor?n H, Weltz JS, Schwartz DK, Kaar JL. Understanding Design Rules for Optimizing the Interface between Immobilized Enzymes and Random Copolymer Brushes. ACS Appl Mater Interfaces. 2021 Jun 16; 13(23):26694-26703. PMID: 34081428.
      View in: PubMed
    8. Chaparro Sosa AF, Bednar RM, Mehl RA, Schwartz DK, Kaar JL. Faster Surface Ligation Reactions Improve Immobilized Enzyme Structure and Activity. J Am Chem Soc. 2021 05 12; 143(18):7154-7163. PMID: 33914511.
      View in: PubMed
    9. Summers SR, Alamdari S, Kraft CJ, Brunecky R, Pfaendtner J, Kaar JL. Substitution of distal and active site residues reduces product inhibition of E1 from Acidothermus Cellulolyticus. Protein Eng Des Sel. 2021 02 15; 34. PMID: 34935952.
      View in: PubMed
    10. Plaks JG, Brewer JA, Jacobsen NK, McKenna M, Uzarski JR, Lawton TJ, Filocamo SF, Kaar JL. Rosetta-Enabled Structural Prediction of Permissive Loop Insertion Sites in Proteins. Biochemistry. 2020 10 20; 59(41):3993-4002. PMID: 32970423.
      View in: PubMed
    11. Chaparro Sosa AF, de Oliveira da Silva SM, Morgan GP, Schwartz DK, Kaar JL. Mixed Phospholipid Vesicles Catalytically Inhibit and Reverse Amyloid Fibril Formation. J Phys Chem Lett. 2020 Sep 03; 11(17):7417-7422. PMID: 32803986.
      View in: PubMed
    12. Kienle DF, Chaparro Sosa AF, Kaar JL, Schwartz DK. Polyelectrolyte Multilayers Enhance the Dry Storage and pH Stability of Physically Entrapped Enzymes. ACS Appl Mater Interfaces. 2020 May 20; 12(20):22640-22649. PMID: 32352745.
      View in: PubMed
    13. Choudhury A, Fankhauser RG, Freed EF, Oh EJ, Morgenthaler AB, Bassalo MC, Copley SD, Kaar JL, Gill RT. Determinants for Efficient Editing with Cas9-Mediated Recombineering in Escherichia coli. ACS Synth Biol. 2020 May 15; 9(5):1083-1099. PMID: 32298586.
      View in: PubMed
    14. Choudhury A, Fenster JA, Fankhauser RG, Kaar JL, Tenaillon O, Gill RT. CRISPR/Cas9 recombineering-mediated deep mutational scanning of essential genes in Escherichia coli. Mol Syst Biol. 2020 Mar; 16(3):e9265. PMID: 32175691.
      View in: PubMed
    15. Weltz JS, Kienle DF, Schwartz DK, Kaar JL. Reduced Enzyme Dynamics upon Multipoint Covalent Immobilization Leads to Stability-Activity Trade-off. J Am Chem Soc. 2020 02 19; 142(7):3463-3471. PMID: 31986020.
      View in: PubMed
    16. Hedayati M, Marruecos DF, Krapf D, Kaar JL, Kipper MJ. Protein adsorption measurements on low fouling and ultralow fouling surfaces: A critical comparison of surface characterization techniques. Acta Biomater. 2020 01 15; 102:169-180. PMID: 31731023.
      View in: PubMed
    17. Faul?n Marruecos D, Saleh LS, Kim HH, Bryant SJ, Schwartz DK, Kaar JL. Stabilization of Fibronectin by Random Copolymer Brushes Inhibits Macrophage Activation. ACS Appl Bio Mater. 2019 Nov 18; 2(11):4698-4702. PMID: 35021468.
      View in: PubMed
    18. Bull DS, Kienle DF, Chaparro Sosa AF, Nelson N, Roy S, Cha JN, Schwartz DK, Kaar JL, Goodwin AP. Surface-Templated Nanobubbles Protect Proteins from Surface-Mediated Denaturation. J Phys Chem Lett. 2019 Jun 06; 10(11):2641-2647. PMID: 31067058.
      View in: PubMed
    19. Plaks JG, Kaar JL. Lipoic Acid Ligase-Promoted Bioorthogonal Protein Modification and Immobilization. Methods Mol Biol. 2019; 2012:279-297. PMID: 31161513.
      View in: PubMed
    20. Kienle DF, Falatach RM, Kaar JL, Schwartz DK. Correlating Structural and Functional Heterogeneity of Immobilized Enzymes. ACS Nano. 2018 08 28; 12(8):8091-8103. PMID: 30067333.
      View in: PubMed
    21. Chaparro Sosa AF, Kienle DF, Falatach RM, Flanagan J, Kaar JL, Schwartz DK. Stabilization of Immobilized Enzymes via the Chaperone-Like Activity of Mixed Lipid Bilayers. ACS Appl Mater Interfaces. 2018 Jun 13; 10(23):19504-19513. PMID: 29767959.
      View in: PubMed
    22. Faul?n Marruecos D, Kienle DF, Kaar JL, Schwartz DK. Grafting Density Impacts Local Nanoscale Hydrophobicity in Poly(ethylene glycol) Brushes. ACS Macro Lett. 2018 Apr 17; 7(4):498-503. PMID: 35619349.
      View in: PubMed
    23. Chado GR, Holland EN, Tice AK, Stoykovich MP, Kaar JL. Modification of Lipase with Poly(4-acryloylmorpholine) Enhances Solubility and Transesterification Activity in Anhydrous Ionic Liquids. Biomacromolecules. 2018 04 09; 19(4):1324-1332. PMID: 29522328.
      View in: PubMed
    24. Summers SR, Sprenger KG, Pfaendtner J, Marchant J, Summers MF, Kaar JL. Mechanism of Competitive Inhibition and Destabilization of Acidothermus cellulolyticus Endoglucanase 1 by Ionic Liquids. J Phys Chem B. 2017 12 07; 121(48):10793-10803. PMID: 29120187.
      View in: PubMed
    25. Jung S, MacConaghy KI, Kaar JL, Stoykovich MP. Enhanced Optical Sensitivity in Thermoresponsive Photonic Crystal Hydrogels by Operating Near the Phase Transition. ACS Appl Mater Interfaces. 2017 Aug 23; 9(33):27927-27935. PMID: 28758737.
      View in: PubMed
    26. Kastantin M, Faul?n Marruecos D, Grover N, Yu McLoughlin S, Schwartz DK, Kaar JL. Connecting Protein Conformation and Dynamics with Ligand-Receptor Binding Using Three-Color F?rster Resonance Energy Transfer Tracking. J Am Chem Soc. 2017 07 26; 139(29):9937-9948. PMID: 28658579.
      View in: PubMed
    27. Kaar JL. Lipase Activation and Stabilization in Room-Temperature Ionic Liquids. Methods Mol Biol. 2017; 1504:25-35. PMID: 27770412.
      View in: PubMed
    28. Grover N, Plaks JG, Summers SR, Chado GR, Schurr MJ, Kaar JL. Acylase-containing polyurethane coatings with anti-biofilm activity. Biotechnol Bioeng. 2016 12; 113(12):2535-2543. PMID: 27240552.
      View in: PubMed
    29. Sprenger KG, Choudhury A, Kaar JL, Pfaendtner J. Lytic Polysaccharide Monooxygenases ScLPMO10B and ScLPMO10C Are Stable in Ionic Liquids As Determined by Molecular Simulations. J Phys Chem B. 2016 04 28; 120(16):3863-72. PMID: 27052057.
      View in: PubMed
    30. Faul?n Marruecos D, Kastantin M, Schwartz DK, Kaar JL. Dense Poly(ethylene glycol) Brushes Reduce Adsorption and Stabilize the Unfolded Conformation of Fibronectin. Biomacromolecules. 2016 Mar 14; 17(3):1017-25. PMID: 26866385.
      View in: PubMed
    31. Weltz JS, Schwartz DK, Kaar JL. Surface-Mediated Protein Unfolding as a Search Process for Denaturing Sites. ACS Nano. 2016 Jan 26; 10(1):730-8. PMID: 26580418.
      View in: PubMed
    32. Nordwald EM, Plaks JG, Snell JR, Sousa MC, Kaar JL. Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Enzyme Structure. Chembiochem. 2015 Nov; 16(17):2456-9. PMID: 26388426.
      View in: PubMed
    33. MacConaghy KI, Chadly DM, Stoykovich MP, Kaar JL. Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels. Analyst. 2015 Sep 21; 140(18):6354-62. PMID: 26270146.
      View in: PubMed
    34. Plaks JG, Falatach R, Kastantin M, Berberich JA, Kaar JL. Multisite clickable modification of proteins using lipoic acid ligase. Bioconjug Chem. 2015 Jun 17; 26(6):1104-12. PMID: 25982177.
      View in: PubMed
    35. MacConaghy KI, Chadly DM, Stoykovich MP, Kaar JL. Optically diffracting hydrogels for screening kinase activity in vitro and in cell lysate: impact of material and solution properties. Anal Chem. 2015 Mar 17; 87(6):3467-75. PMID: 25714913.
      View in: PubMed
    36. Burney PR, Nordwald EM, Hickman K, Kaar JL, Pfaendtner J. Molecular dynamics investigation of the ionic liquid/enzyme interface: application to engineering enzyme surface charge. Proteins. 2015 Apr; 83(4):670-80. PMID: 25641162.
      View in: PubMed
    37. Swartzlander MD, Barnes CA, Blakney AK, Kaar JL, Kyriakides TR, Bryant SJ. Linking the foreign body response and protein adsorption to PEG-based hydrogels using proteomics. Biomaterials. 2015 Feb; 41:26-36. PMID: 25522962.
      View in: PubMed
    38. MacConaghy KI, Geary CI, Kaar JL, Stoykovich MP. Photonic crystal kinase biosensor. J Am Chem Soc. 2014 May 14; 136(19):6896-9. PMID: 24761969.
      View in: PubMed
    39. Nordwald EM, Brunecky R, Himmel ME, Beckham GT, Kaar JL. Charge engineering of cellulases improves ionic liquid tolerance and reduces lignin inhibition. Biotechnol Bioeng. 2014 Aug; 111(8):1541-9. PMID: 24522957.
      View in: PubMed
    40. McLoughlin SY, Kastantin M, Schwartz DK, Kaar JL. Single-molecule resolution of protein structure and interfacial dynamics on biomaterial surfaces. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19396-401. PMID: 24235137.
      View in: PubMed
    41. Nordwald EM, Kaar JL. Mediating electrostatic binding of 1-butyl-3-methylimidazolium chloride to enzyme surfaces improves conformational stability. J Phys Chem B. 2013 Aug 01; 117(30):8977-86. PMID: 23822219.
      View in: PubMed
    42. Nordwald EM, Kaar JL. Stabilization of enzymes in ionic liquids via modification of enzyme charge. Biotechnol Bioeng. 2013 Sep; 110(9):2352-60. PMID: 23532939.
      View in: PubMed
    43. Nordwald EM, Garst A, Gill RT, Kaar JL. Accelerated protein engineering for chemical biotechnology via homologous recombination. Curr Opin Biotechnol. 2013 Dec; 24(6):1017-22. PMID: 23540421.
      View in: PubMed
    44. Brandt T, Kaar JL, Fersht AR, Veprintsev DB. Stability of p53 homologs. PLoS One. 2012; 7(10):e47889. PMID: 23112865.
      View in: PubMed
    45. Kaar JL. Lipase activation and stabilization in room-temperature ionic liquids. Methods Mol Biol. 2011; 679:25-35. PMID: 20865386.
      View in: PubMed
    46. Kaar JL, Basse N, Joerger AC, Stephens E, Rutherford TJ, Fersht AR. Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding. Protein Sci. 2010 Dec; 19(12):2267-78. PMID: 20878668.
      View in: PubMed
    47. Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29; 17(1):46-56. PMID: 20142040.
      View in: PubMed
    48. Kaar JL, Li Y, Blair HC, Asche G, Koepsel RR, Huard J, Russell AJ. Matrix metalloproteinase-1 treatment of muscle fibrosis. Acta Biomater. 2008 Sep; 4(5):1411-20. PMID: 18440885.
      View in: PubMed
    49. Depp V, Kaar JL, Russell AJ, Lele BS. Enzyme sheathing enables nanoscale solubilization of biocatalyst and dramatically increases activity in organic solvent. Biomacromolecules. 2008 Apr; 9(4):1348-51. PMID: 18293899.
      View in: PubMed
    50. Bedair H, Liu TT, Kaar JL, Badlani S, Russell AJ, Li Y, Huard J. Matrix metalloproteinase-1 therapy improves muscle healing. J Appl Physiol (1985). 2007 Jun; 102(6):2338-45. PMID: 17551103.
      View in: PubMed
    51. Kaar JL, Oh HI, Russell AJ, Federspiel WJ. Towards improved artificial lungs through biocatalysis. Biomaterials. 2007 Jul; 28(20):3131-9. PMID: 17433433.
      View in: PubMed
    52. Xu H, Kaar JL, Russell AJ, Wagner WR. Characterizing the modification of surface proteins with poly(ethylene glycol) to interrupt platelet adhesion. Biomaterials. 2006 Jun; 27(16):3125-35. PMID: 16457880.
      View in: PubMed
    53. Sharma NK, Tickell MD, Anderson JL, Kaar J, Pino V, Wicker BF, Armstrong DW, Davis JH, Russell AJ. Do ion tethered functional groups affect IL solvent properties? The case of sulfoxides and sulfones. Chem Commun (Camb). 2006 Feb 14; (6):646-8. PMID: 16446838.
      View in: PubMed
    54. Berberich JA, Kaar JL, Russell AJ. Use of salt hydrate pairs to control water activity for enzyme catalysis in ionic liquids. Biotechnol Prog. 2003 May-Jun; 19(3):1029-32. PMID: 12790674.
      View in: PubMed
    55. Kaar JL, Jesionowski AM, Berberich JA, Moulton R, Russell AJ. Impact of ionic liquid physical properties on lipase activity and stability. J Am Chem Soc. 2003 Apr 09; 125(14):4125-31. PMID: 12670234.
      View in: PubMed
    56. Russell AJ, Erbeldinger M, DeFrank JJ, Kaar J, Drevon G. Catalytic buffers enable positive-response inhibition-based sensing of nerve agents. Biotechnol Bioeng. 2002 Feb 05; 77(3):352-7. PMID: 11753944.
      View in: PubMed
    Kaar's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (252) concept(s)
    _
    Co-Authors Expand Description
    See all (11) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)