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Haijia Yu

TitleResearch Associate
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction

    Collapse Research 
    Collapse research activities and funding
    R03AI135473     (YU, HAIJIA)May 3, 2018 - Apr 30, 2020
    Dissect Cytolytic Granule Secretion in Cytotoxic T Lymphocytes Using CRISPR Genetic Screens
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rathore SS, Liu Y, Yu H, Wan C, Lee M, Yin Q, Stowell MHB, Shen J. Intracellular Vesicle Fusion Requires a Membrane-Destabilizing Peptide Located at the Juxtamembrane Region of the v-SNARE. Cell Rep. 2019 Dec 24; 29(13):4583-4592.e3. PMID: 31875562.
      View in: PubMed
    2. Wang S, Crisman L, Miller J, Datta I, Gulbranson DR, Tian Y, Yin Q, Yu H, Shen J. Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. J Biol Chem. 2019 Dec 27; 294(52):19988-19996. PMID: 31740584.
      View in: PubMed
    3. Gulbranson DR, Crisman L, Lee M, Ouyang Y, Menasche BL, Demmitt BA, Wan C, Nomura T, Ye Y, Yu H, Shen J. AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis. Dev Cell. 2019 Aug 19; 50(4):436-446.e5. PMID: 31353312.
      View in: PubMed
    4. Yu H, Crisman L, Stowell MHB, Shen J. Functional Reconstitution of Intracellular Vesicle Fusion Using Purified SNAREs and Sec1/Munc18 (SM) Proteins. Methods Mol Biol. 2019; 1860:237-249. PMID: 30317509.
      View in: PubMed
    5. Shen C, Liu Y, Yu H, Gulbranson DR, Kogut I, Bilousova G, Zhang C, Stowell MHB, Shen J. The N-peptide-binding mode is critical to Munc18-1 function in synaptic exocytosis. J Biol Chem. 2018 11 23; 293(47):18309-18317. PMID: 30275014.
      View in: PubMed
    6. Menasche BL, Crisman L, Gulbranson DR, Davis EM, Yu H, Shen J. Fluorescence Activated Cell Sorting (FACS) in Genome-Wide Genetic Screening of Membrane Trafficking. Curr Protoc Cell Biol. 2019 03; 82(1):e68. PMID: 30265447.
      View in: PubMed
    7. Gulbranson DR, Davis EM, Demmitt BA, Ouyang Y, Ye Y, Yu H, Shen J. RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8224-E8233. PMID: 28894007.
      View in: PubMed
    8. Yu H, Liu Y, Gulbranson DR, Paine A, Rathore SS, Shen J. Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4362-7. PMID: 27044075.
      View in: PubMed
    9. Shen C, Rathore SS, Yu H, Gulbranson DR, Hua R, Zhang C, Schoppa NE, Shen J. The trans-SNARE-regulating function of Munc18-1 is essential to synaptic exocytosis. Nat Commun. 2015 Nov 17; 6:8852. PMID: 26572858.
      View in: PubMed
    10. Yu H, Rathore SS, Shen C, Liu Y, Ouyang Y, Stowell MH, Shen J. Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding. J Am Chem Soc. 2015 Oct 14; 137(40):12873-83. PMID: 26431309.
      View in: PubMed
    11. Yu H, Rathore SS, Gulbranson DR, Shen J. The N- and C-terminal domains of tomosyn play distinct roles in soluble N-ethylmaleimide-sensitive factor attachment protein receptor binding and fusion regulation. J Biol Chem. 2014 Sep 12; 289(37):25571-80. PMID: 25063806.
      View in: PubMed
    12. Yu H, Rathore SS, Lopez JA, Davis EM, James DE, Martin JL, Shen J. Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3271-80. PMID: 23918365.
      View in: PubMed
    13. Yu H, Rathore SS, Shen J. Synip arrests soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent membrane fusion as a selective target membrane SNARE-binding inhibitor. J Biol Chem. 2013 Jun 28; 288(26):18885-93. PMID: 23665562.
      View in: PubMed
    14. Yu H, Rathore SS, Davis EM, Ouyang Y, Shen J. Doc2b promotes GLUT4 exocytosis by activating the SNARE-mediated fusion reaction in a calcium- and membrane bending-dependent manner. Mol Biol Cell. 2013 Apr; 24(8):1176-84. PMID: 23427263.
      View in: PubMed
    15. Rathore SS, Bend EG, Yu H, Hammarlund M, Jorgensen EM, Shen J. Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22399-406. PMID: 21139055.
      View in: PubMed
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