Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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James M Sikela

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics
Phone303/724-3385

     Bibliographic 
     selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Quick VB, Davis JM, Olincy A, Sikela JM. DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases. Transl Psychiatry. 2016 Feb 09; 6:e735.
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    2. Searles Quick VB, Davis JM, Olincy A, Sikela JM. DUF1220 copy number is associated with schizophrenia risk and severity: implications for understanding autism and schizophrenia as related diseases. Transl Psychiatry. 2015 Dec 15; 5:e697.
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    3. Davis JM, Searles Quick VB, Sikela JM. Replicated linear association between DUF1220 copy number and severity of social impairment in autism. Hum Genet. 2015 Jun; 134(6):569-75.
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    4. Sikela JM. Human evolutionary genomics and the search for the genes that made us human. Pac Symp Biocomput. 2015; 479-81.
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    5. Keeney JG, O'Bleness MS, Anderson N, Davis JM, Arevalo N, Busquet N, Chick W, Rozman J, Hölter SM, Garrett L, Horsch M. Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity. Mamm Genome. 2015 Feb; 26(1-2):33-42.
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    6. Davis JM, Searles VB, Anderson N, Keeney J, Raznahan A, Horwood LJ, Fergusson DM, Kennedy MA, Giedd J, Sikela JM. DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores. Hum Genet. 2015 Jan; 134(1):67-75.
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    7. Carbone L, Harris RA, Gnerre S, Veeramah KR, Lorente-Galdos B, Huddleston J, Meyer TJ, Herrero J, Roos C, Aken B, Anaclerio F, Archidiacono N, Baker C, Barrell D, Batzer MA, Beal K, Blancher A, Bohrson CL, Brameier M, Campbell MS, Capozzi O, Casola C, Chiatante G, Cree A, Damert A, de Jong PJ, Dumas L, Fernandez-Callejo M, Flicek P, Fuchs NV, Gut I, Gut M, Hahn MW, Hernandez-Rodriguez J, Hillier LW, Hubley R, Ianc B, Izsvák Z, Jablonski NG, Johnstone LM, Karimpour-Fard A, Konkel MK, Kostka D, Lazar NH, Lee SL, Lewis LR, Liu Y, Locke DP, Mallick S, Mendez FL, Muffato M, Nazareth LV, Nevonen KA, O'Bleness M, Ochis C, Odom DT, Pollard KS, Quilez J, Reich D, Rocchi M, Schumann GG, Searle S, Sikela JM, Skollar G, Smit A, Sonmez K, ten Hallers B, Terhune E, Thomas GW, Ullmer B, Ventura M, Walker JA, Wall JD, Walter L, Ward MC, Wheelan SJ, Whelan CW, White S, Wilhelm LJ, Woerner AE, Yandell M, Zhu B, Hammer MF, Marques-Bonet T, Eichler EE, Fulton L, Fronick C, Muzny DM, Warren WC, Worley KC, Rogers J, Wilson RK, Gibbs RA. Gibbon genome and the fast karyotype evolution of small apes. Nature. 2014 Sep 11; 513(7517):195-201.
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    8. Sikela JM. Finding and mapping new genes faster than ever: revisited. Genetics. 2014 Aug; 197(4):1063-7.
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    9. Keeney JG, Davis JM, Siegenthaler J, Post MD, Nielsen BS, Hopkins WD, Sikela JM. DUF1220 protein domains drive proliferation in human neural stem cells and are associated with increased cortical volume in anthropoid primates. Brain Struct Funct. 2015 Sep; 220(5):3053-60.
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    10. Keeney JG, Dumas L, Sikela JM. The case for DUF1220 domain dosage as a primary contributor to anthropoid brain expansion. Front Hum Neurosci. 2014; 8:427.
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    11. O'Bleness M, Searles VB, Dickens CM, Astling D, Albracht D, Mak AC, Lai YY, Lin C, Chu C, Graves T, Kwok PY, Wilson RK, Sikela JM. Finished sequence and assembly of the DUF1220-rich 1q21 region using a haploid human genome. BMC Genomics. 2014 May 20; 15:387.
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    12. Davis JM, Searles VB, Anderson N, Keeney J, Dumas L, Sikela JM. DUF1220 dosage is linearly associated with increasing severity of the three primary symptoms of autism. PLoS Genet. 2014 Mar; 10(3):e1004241.
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    13. Dumas L, Dickens CM, Anderson N, Davis J, Bennett B, Radcliffe RA, Sikela JM. Exome sequencing and arrayCGH detection of gene sequence and copy number variation between ILS and ISS mouse strains. Mamm Genome. 2014 Jun; 25(5-6):235-43.
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    14. Davis JM, Keeney JG, Sikela JM, Hepburn S. Mode of genetic inheritance modifies the association of head circumference and autism-related symptoms: a cross-sectional study. PLoS One. 2013; 8(9):e74940.
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    15. O'Bleness M, Searles VB, Varki A, Gagneux P, Sikela JM. Evolution of genetic and genomic features unique to the human lineage. Nat Rev Genet. 2012 Dec; 13(12):853-66.
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    16. O'Bleness MS, Dickens CM, Dumas LJ, Kehrer-Sawatzki H, Wyckoff GJ, Sikela JM. Evolutionary history and genome organization of DUF1220 protein domains. G3 (Bethesda). 2012 Sep; 2(9):977-86.
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    17. Dumas LJ, O'Bleness MS, Davis JM, Dickens CM, Anderson N, Keeney JG, Jackson J, Sikela M, Raznahan A, Giedd J, Rapoport J, Nagamani SS, Erez A, Brunetti-Pierri N, Sugalski R, Lupski JR, Fingerlin T, Cheung SW, Sikela JM. DUF1220-domain copy number implicated in human brain-size pathology and evolution. Am J Hum Genet. 2012 Sep 07; 91(3):444-54.
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    18. Coors ME, Glover JJ, Juengst ET, Sikela JM. The ethics of using transgenic non-human primates to study what makes us human. Nat Rev Genet. 2010 09; 11(9):658-62.
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    19. Karimpour-Fard A, Dumas L, Phang T, Sikela JM, Hunter LE. A survey of analysis software for array-comparative genomic hybridisation studies to detect copy number variation. Hum Genomics. 2010 Aug; 4(6):421-7.
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    20. Dumas L, Sikela JM. DUF1220 domains, cognitive disease, and human brain evolution. Cold Spring Harb Symp Quant Biol. 2009; 74:375-82.
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    21. Babcock M, Yatsenko S, Hopkins J, Brenton M, Cao Q, de Jong P, Stankiewicz P, Lupski JR, Sikela JM, Morrow BE. Hominoid lineage specific amplification of low-copy repeats on 22q11.2 (LCR22s) associated with velo-cardio-facial/digeorge syndrome. Hum Mol Genet. 2007 Nov 01; 16(21):2560-71.
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    22. Dumas L, Kim YH, Karimpour-Fard A, Cox M, Hopkins J, Pollack JR, Sikela JM. Gene copy number variation spanning 60 million years of human and primate evolution. Genome Res. 2007 Sep; 17(9):1266-77.
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    23. Evolutionary and biomedical insights from the rhesus macaque genome. Science. 2007 Apr 13; 316(5822):222-34.
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    24. Popesco MC, Maclaren EJ, Hopkins J, Dumas L, Cox M, Meltesen L, McGavran L, Wyckoff GJ, Sikela JM. Human lineage-specific amplification, selection, and neuronal expression of DUF1220 domains. Science. 2006 Sep 01; 313(5791):1304-7.
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    25. Sikela JM. The jewels of our genome: the search for the genomic changes underlying the evolutionarily unique capacities of the human brain. PLoS Genet. 2006 May; 2(5):e80.
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    26. Sikela JM, Maclaren EJ, Kim Y, Karimpour-Fard A, Cai WW, Pollack J, Hitzemann R, Belknap J, McWeeney S, Kerns RT, Downing C, Johnson TE, Grant KJ, Tabakoff B, Hoffman P, Wu CC, Miles MF. DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res. 2006 Apr; 30(4):700-8.
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    27. Moniaux N, Nemos C, Schmied BM, Chauhan SC, Deb S, Morikane K, Choudhury A, Vanlith M, Sutherlin M, Sikela JM, Hollingsworth MA, Batra SK. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. Oncogene. 2006 Jun 01; 25(23):3247-57.
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    28. MacLaren EJ, Bennett B, Johnson TE, Sikela JM. Expression profiling identifies novel candidate genes for ethanol sensitivity QTLs. Mamm Genome. 2006 Feb; 17(2):147-56.
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    29. Haughey HM, Kaiser AL, Johnson TE, Bennett B, Sikela JM, Zahniser NR. Norepinephrine transporter: a candidate gene for initial ethanol sensitivity in inbred long-sleep and short-sleep mice. Alcohol Clin Exp Res. 2005 Oct; 29(10):1759-68.
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    30. MacLaren EJ, Sikela JM. Cerebellar gene expression profiling and eQTL analysis in inbred mouse strains selected for ethanol sensitivity. Alcohol Clin Exp Res. 2005 Sep; 29(9):1568-79.
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    31. Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Sikela JM, Williams RW, Miles MF. Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J Neurosci. 2005 Mar 02; 25(9):2255-66.
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    32. Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol. 2004 Jul; 2(7):E207.
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    33. Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Gensler B, Burgers S, Williams RW, Manly K, Flint J, Talbot C. A strategy for the integration of QTL, gene expression, and sequence analyses. Mamm Genome. 2003 Nov; 14(11):733-47.
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    34. Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, Churchill GA, Cook M, Crabbe JC, Crusio WE, Darvasi A, de Haan G, Dermant P, Doerge RW, Elliot RW, Farber CR, Flaherty L, Flint J, Gershenfeld H, Gibson JP, Gu J, Gu W, Himmelbauer H, Hitzemann R, Hsu HC, Hunter K, Iraqi FF, Jansen RC, Johnson TE, Jones BC, Kempermann G, Lammert F, Lu L, Manly KF, Matthews DB, Medrano JF, Mehrabian M, Mittlemann G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Mountz JD, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Paigen B, Palmer AA, Peirce JL, Pomp D, Rosemann M, Rosen GD, Schalkwyk LC, Seltzer Z, Settle S, Shimomura K, Shou S, Sikela JM, Siracusa LD, Spearow JL, Teuscher C, Threadgill DW, Toth LA, Toye AA, Vadasz C, Van Zant G, Wakeland E, Williams RW, Zhang HG, Zou F. The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet. 2003 Nov; 4(11):911-6.
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    35. Hink RL, Hokanson JE, Shah I, Long JC, Goldman D, Sikela JM. Investigation of DUSP8 and CALCA in alcohol dependence. Addict Biol. 2003 Sep; 8(3):305-12.
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    36. Saito M, Ehringer MA, Toth R, Oros M, Szakall I, Sikela JM, Vadasz C. Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice. Alcohol. 2003 Jan; 29(1):39-49.
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    37. Marshall KE, Godden EL, Yang F, Burgers S, Buck KJ, Sikela JM. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol. 2002; 3(12):RESEARCH0078.
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    38. Ehringer MA, Thompson J, Conroy O, Yang F, Hink R, Bennett B, Johnson TE, Sikela JM. Fine mapping of polymorphic alcohol-related quantitative trait loci candidate genes using interval-specific congenic recombinant mice. Alcohol Clin Exp Res. 2002 Nov; 26(11):1603-8.
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    39. Ehringer MA, Thompson J, Conroy O, Goldman D, Smith TL, Schuckit MA, Sikela JM. Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. Addict Biol. 2002 Oct; 7(4):365-71.
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    40. Kirstein SL, Davidson KL, Ehringer MA, Sikela JM, Erwin VG, Tabakoff B. Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. J Pharmacol Exp Ther. 2002 Sep; 302(3):1238-45.
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    41. Ehringer MA, Sikela JM. Genomic approaches to the genetics of alcoholism. Alcohol Res Health. 2002; 26(3):181-92.
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    42. Xu Y, Demarest K, Hitzemann R, Sikela JM. Gene coding variant in Cas1 between the C57BL/6J and DBA/2J inbred mouse strains: linkage to a QTL for ethanol-induced locomotor activation. Alcohol Clin Exp Res. 2002 Jan; 26(1):1-7.
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    43. Ehringer MA, Thompson J, Conroy O, Xu Y, Yang F, Canniff J, Beeson M, Gordon L, Bennett B, Johnson TE, Sikela JM. High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Mamm Genome. 2001 Aug; 12(8):657-63.
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    44. Xu Y, Ehringer M, Yang F, Sikela JM. Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. Alcohol Clin Exp Res. 2001 Jun; 25(6):810-8.
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    45. Bateman JB, Geyer DD, Flodman P, Johannes M, Sikela J, Walter N, Moreira AT, Clancy K, Spence MA. A new betaA1-crystallin splice junction mutation in autosomal dominant cataract. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3278-85.
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    46. McConkey EH, Fouts R, Goodman M, Nelson D, Penny D, Ruvolo M, Sikela J, Stewart CB, Varki A, Wise S. Proposal for a human genome evolution project. Mol Phylogenet Evol. 2000 Apr; 15(1):1-4.
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    47. Deloukas P, Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tomé P, Hui L, Matise TC, McKusick KB, Beckmann JS, Bentolila S, Bihoreau M, Birren BB, Browne J, Butler A, Castle AB, Chiannilkulchai N, Clee C, Day PJ, Dehejia A, Dibling T, Drouot N, Duprat S, Fizames C, Fox S, Gelling S, Green L, Harrison P, Hocking R, Holloway E, Hunt S, Keil S, Lijnzaad P, Louis-Dit-Sully C, Ma J, Mendis A, Miller J, Morissette J, Muselet D, Nusbaum HC, Peck A, Rozen S, Simon D, Slonim DK, Staples R, Stein LD, Stewart EA, Suchard MA, Thangarajah T, Vega-Czarny N, Webber C, Wu X, Hudson J, Auffray C, Nomura N, Sikela JM, Polymeropoulos MH, James MR, Lander ES, Hudson TJ, Myers RM, Cox DR, Weissenbach J, Boguski MS, Bentley DR. A physical map of 30,000 human genes. Science. 1998 Oct 23; 282(5389):744-6.
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    48. Johannes M, Geyer DD, Berry R, Walter NA, Sikela JM, Bateman JB. Comparison of fluorescent genotyping methods. Anal Biochem. 1998 Sep 10; 262(2):193-5.
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    49. Radcliffe RA, Walter NA, Sikela JM, Erwin VG. Discovery of a new Pomc1 allele in the LS x SS recombinant inbred strains: relationship to locomotor behavior. Behav Genet. 1998 Jan; 28(1):49-55.
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    50. Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov; 7(11):1085-93.
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    51. Sjøholt G, Molven A, Løvlie R, Wilcox A, Sikela JM, Steen VM. Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). Genomics. 1997 Oct 01; 45(1):113-22.
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    52. Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tomé P, Aggarwal A, Bajorek E, Bentolila S, Birren BB, Butler A, Castle AB, Chiannilkulchai N, Chu A, Clee C, Cowles S, Day PJ, Dibling T, Drouot N, Dunham I, Duprat S, East C, Edwards C, Fan JB, Fang N, Fizames C, Garrett C, Green L, Hadley D, Harris M, Harrison P, Brady S, Hicks A, Holloway E, Hui L, Hussain S, Louis-Dit-Sully C, Ma J, MacGilvery A, Mader C, Maratukulam A, Matise TC, McKusick KB, Morissette J, Mungall A, Muselet D, Nusbaum HC, Page DC, Peck A, Perkins S, Piercy M, Qin F, Quackenbush J, Ranby S, Reif T, Rozen S, Sanders C, She X, Silva J, Slonim DK, Soderlund C, Sun WL, Tabar P, Thangarajah T, Vega-Czarny N, Vollrath D, Voyticky S, Wilmer T, Wu X, Adams MD, Auffray C, Walter NA, Brandon R, Dehejia A, Goodfellow PN, Houlgatte R, Hudson JR, Ide SE, Iorio KR, Lee WY, Seki N, Nagase T, Ishikawa K, Nomura N, Phillips C, Polymeropoulos MH, Sandusky M, Schmitt K, Berry R, Swanson K, Torres R, Venter JC, Sikela JM, Beckmann JS, Weissenbach J, Myers RM, Cox DR, James MR, Bentley D, Deloukas P, Lander ES, Hudson TJ. A gene map of the human genome. Science. 1996 Oct 25; 274(5287):540-6.
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    53. Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit. Mol Pharmacol. 1996 Sep; 50(3):670-8.
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    54. Gordon DF, Wagner J, Atkinson BL, Chiono M, Berry R, Sikela J, Gutierrez-Hartmann A. Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA. DNA Cell Biol. 1996 Jul; 15(7):531-41.
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    55. Orlicky DJ, Berry R, Sikela JM. Human chromosome 1 localization of the gene for a prostaglandin F2alpha receptor negative regulatory protein. Hum Genet. 1996 May; 97(5):655-8.
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    56. Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. FEBS Lett. 1995 Nov 13; 375(1-2):75-8.
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    57. Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM. Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map. Nat Genet. 1995 Aug; 10(4):415-23.
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    58. Berry R, Walter NA, Stevens TJ, Rubano T, Wilcox AS, Hopkins JA, Sikela JM. A strategy for the identification of candidate genes for alcohol-related phenotypes and other human disorders using rapid polymerase chain reaction mapping of gene-based sequence-tagged sites. Alcohol Clin Exp Res. 1995 Aug; 19(4):821-3.
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    59. Greger V, Knoll JH, Woolf E, Glatt K, Tyndale RF, DeLorey TM, Olsen RW, Tobin AJ, Sikela JM, Nakatsu Y, et al. The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation. Genomics. 1995 Mar 20; 26(2):258-64.
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    60. Hellevuo K, Berry R, Sikela JM, Tabakoff B. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. Hum Genet. 1995 Feb; 95(2):197-200.
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    61. Tokumitsu H, Brickey DA, Glod J, Hidaka H, Sikela J, Soderling TR. Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase. J Biol Chem. 1994 Nov 18; 269(46):28640-7.
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    62. Le Bourdellès B, Wafford KA, Kemp JA, Marshall G, Bain C, Wilcox AS, Sikela JM, Whiting PJ. Cloning, functional coexpression, and pharmacological characterisation of human cDNAs encoding NMDA receptor NR1 and NR2A subunits. J Neurochem. 1994 Jun; 62(6):2091-8.
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    63. Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, Wilson AW, Wilcox AS, Sikela JM, Ragan CI, et al. Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors. Mol Pharmacol. 1993 Dec; 44(6):1211-8.
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    64. Gulya K, Orpana AK, Sikela JM, Hoffman PL. Prodynorphin and vasopressin mRNA levels are differentially affected by chronic ethanol ingestion in the mouse. Brain Res Mol Brain Res. 1993 Oct; 20(1-2):1-8.
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    65. Polymeropoulos MH, Xiao H, Sikela JM, Adams M, Venter JC, Merril CR. Chromosomal distribution of 320 genes from a brain cDNA library. Nat Genet. 1993 Aug; 4(4):381-6.
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    66. Byerley W, Khan AS, Holik J, Hoff M, Sikela JM. Dinucleotide repeat polymorphism in the 3' untranslated region of an anonymous brain cDNA mapping to chromosome 2 (D2S230). Hum Mol Genet. 1993 Aug; 2(8):1329.
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    67. Nakatsu Y, Tyndale RF, DeLorey TM, Durham-Pierre D, Gardner JM, McDanel HJ, Nguyen Q, Wagstaff J, Lalande M, Sikela JM, et al. A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locus. Nature. 1993 Jul 29; 364(6436):448-50.
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    68. Sikela JM, Auffray C. Finding new genes faster than ever. Nat Genet. 1993 Mar; 3(3):189-91.
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    69. Knoll JH, Sinnett D, Wagstaff J, Glatt K, Wilcox AS, Whiting PM, Wingrove P, Sikela JM, Lalande M. FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regions. Hum Mol Genet. 1993 Feb; 2(2):183-9.
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    70. Bowers BJ, Parham CL, Sikela JM, Wehner JM. Isolation and sequence of a mouse brain cDNA coding for protein kinase C-gamma isozyme. Gene. 1993 Jan 30; 123(2):263-5.
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    71. Khan AS, Wilcox AS, Polymeropoulos MH, Hopkins JA, Stevens TJ, Robinson M, Orpana AK, Sikela JM. Single pass sequencing and physical and genetic mapping of human brain cDNAs. Nat Genet. 1992 Nov; 2(3):180-5.
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    72. Warrington JA, Bailey SK, Armstrong E, Aprelikova O, Alitalo K, Dolganov GM, Wilcox AS, Sikela JM, Wolfe SF, Lovett M, et al. A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5. Genomics. 1992 Jul; 13(3):803-8.
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    73. Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM. Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5857-61.
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    74. Zahniser NR, Buck KJ, Curella P, McQuilkin SJ, Wilson-Shaw D, Miller CL, Klein RL, Heidenreich KA, Keir WJ, Sikela JM, et al. GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brain. Brain Res Mol Brain Res. 1992 Jul; 14(3):196-206.
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    75. Buck KJ, Harris RA, Sikela JM. A general method for quantitative PCR analysis of mRNA levels for members of gene families: application to GABAA receptor subunits. Biotechniques. 1991 Nov; 11(5):636-41.
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    76. Buck KJ, Hahner L, Sikela J, Harris RA. Chronic ethanol treatment alters brain levels of gamma-aminobutyric acidA receptor subunit mRNAs: relationship to genetic differences in ethanol withdrawal seizure severity. J Neurochem. 1991 Oct; 57(4):1452-5.
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    77. Jones DA, Glod J, Wilson-Shaw D, Hahn WE, Sikela JM. cDNA sequence and differential expression of the mouse Ca2+/calmodulin-dependent protein kinase IV gene. FEBS Lett. 1991 Sep 02; 289(1):105-9.
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    78. Sikela JM, Leidenheimer NJ, Gambarana C, Buck KJ, Lin LH, Khan AS, Wilson-Shaw D, Siegel RE. Localization and functional expression of alternatively spliced forms of the GABA(A) receptor gamma(2) subunit. Mol Cell Neurosci. 1991 Aug; 2(4):338-43.
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    79. Wafford KA, Burnett DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM. Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron. 1991 Jul; 7(1):27-33.
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    80. Wilson-Shaw D, Robinson M, Gambarana C, Siegel RE, Sikela JM. A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. FEBS Lett. 1991 Jun 24; 284(2):211-5.
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    81. Wilcox AS, Khan AS, Hopkins JA, Sikela JM. Use of 3' untranslated sequences of human cDNAs for rapid chromosome assignment and conversion to STSs: implications for an expression map of the genome. Nucleic Acids Res. 1991 Apr 25; 19(8):1837-43.
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    82. Khan AS, Wilcox AS, Hopkins JA, Sikela JM. Efficient double stranded sequencing of cDNA clones containing long poly(A) tails using anchored poly(dT) primers. Nucleic Acids Res. 1991 Apr 11; 19(7):1715.
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    83. Keir WJ, Kozak CA, Chakraborti A, Deitrich RA, Sikela JM. The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene. Genomics. 1991 Feb; 9(2):390-5.
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    84. Keir WJ, Deitrich RA, Sikela JM. Sequence comparison of the GABAA receptor alpha 1 subunit cDNA in long and short sleep mice by direct sequencing of polymerase chain reaction amplified cDNA. Ann N Y Acad Sci. 1991; 625:551-4.
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    85. Sikela JM, Adamson MC, Wilson-Shaw D, Kozak CA. Genetic mapping of the gene for Ca2+/calmodulin-dependent protein kinase IV (Camk-4) to mouse chromosome 18. Genomics. 1990 Nov; 8(3):579-82.
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    86. Owens GP, Sinha AK, Sikela JM, Hahn WE. Sequence and expression of the murine diazepam binding inhibitor. Brain Res Mol Brain Res. 1989 Nov; 6(2-3):101-8.
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    87. Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB. Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. DNA. 1989 Nov; 8(9):675-82.
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    88. Sikela JM, Law ML, Kao FT, Hartz JA, Wei Q, Hahn WE. Chromosomal localization of the human gene for brain Ca2+/calmodulin-dependent protein kinase type IV. Genomics. 1989 Jan; 4(1):21-7.
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    89. Sikela JM, Hahn WE. Screening an expression library with a ligand probe: isolation and sequence of a cDNA corresponding to a brain calmodulin-binding protein. Proc Natl Acad Sci U S A. 1987 May; 84(9):3038-42.
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    90. Dush MK, Tischfield JA, Khan SA, Feliciano E, Sikela JM, Kozak CA, Stambrook PJ. An unusual adenine phosphoribosyltransferase pseudogene is syntenic with its functional gene and is flanked by highly polymorphic DNAs. Mol Cell Biol. 1986 Dec; 6(12):4161-7.
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    91. Dush MK, Sikela JM, Khan SA, Tischfield JA, Stambrook PJ. Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement. Proc Natl Acad Sci U S A. 1985 May; 82(9):2731-5.
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    92. Sikela JM, Khan SA, Feliciano E, Trill J, Tischfield JA, Stambrook PJ. Cloning and expression of a mouse adenine phosphoribosyltransferase gene. Gene. 1983 May-Jun; 22(2-3):219-28.
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