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Michael J Morgan

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology
Phone303/724-5923

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A. The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis. Dev Cell. 2016 May 23; 37(4):337-49. PMID: 27219062.
      View in: PubMed
    2. Morgan MJ, Thorburn A. Measuring Autophagy in the Context of Cancer. Adv Exp Med Biol. 2016; 899:121-43. PMID: 27325265.
      View in: PubMed
    3. Hardy CM, Court LN, Morgan MJ. The complete mitochondrial DNA genome of Aedes vigilax (Diptera: Culicidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Jul; 27(4):2552-3. PMID: 26099979.
      View in: PubMed
    4. Morgan MJ, Kim YS. The serine threonine kinase RIP3: lost and found. BMB Rep. 2015 Jun; 48(6):303-12. PMID: 25858093.
      View in: PubMed
    5. Koo GB, Morgan MJ, Lee DG, Kim WJ, Yoon JH, Koo JS, Kim SI, Kim SJ, Son MK, Hong SS, Levy JM, Pollyea DA, Jordan CT, Yan P, Frankhouser D, Nicolet D, Maharry K, Marcucci G, Choi KS, Cho H, Thorburn A, Kim YS. Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics. Cell Res. 2015 Jun; 25(6):707-25. PMID: 25952668.
      View in: PubMed
    6. Yonekawa T, Gamez G, Kim J, Tan AC, Thorburn J, Gump J, Thorburn A, Morgan MJ. RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis. EMBO Rep. 2015 Jun; 16(6):700-8. PMID: 25908842.
      View in: PubMed
    7. Caswell AJ, Bond R, Duka T, Morgan MJ. Further evidence of the heterogeneous nature of impulsivity. Pers Individ Dif. 2015 Apr; 76:68-74. PMID: 25844002.
      View in: PubMed
    8. Thorburn A, Morgan MJ. Targeting Autophagy in BRAF-Mutant Tumors. Cancer Discov. 2015 Apr; 5(4):353-4. PMID: 25847956.
      View in: PubMed
    9. Kim SK, Kim WJ, Yoon JH, Ji JH, Morgan MJ, Cho H, Kim YC, Kim YS. Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis. J Invest Dermatol. 2015 Aug; 135(8):2021-30. PMID: 25748555.
      View in: PubMed
    10. Raphael S, Morgan MJ. The computation of relative numerosity, size and density. Vision Res. 2016 Jul; 124:15-23. PMID: 25595856.
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    11. Morgan MJ. Basal autophagy is negatively regulated by RIP1. Cell Cycle. 2015; 14(19):2997-8. PMID: 26260169.
      View in: PubMed
    12. Hardy CM, Court LN, Morgan MJ, Webb CE. The complete mitochondrial DNA genomes for two lineages of Aedes notoscriptus (Diptera: Culicidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016 May; 27(3):2024-5. PMID: 25350735.
      View in: PubMed
    13. Tomassini A, Solomon JA, Morgan MJ. Which way is down? Positional distortion in the tilt illusion. PLoS One. 2014; 9(10):e110729. PMID: 25343463.
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    14. Morgan MJ, Gamez G, Menke C, Hernandez A, Thorburn J, Gidan F, Staskiewicz L, Morgan S, Cummings C, Maycotte P, Thorburn A. Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy. 2014 Oct 01; 10(10):1814-26. PMID: 25136801.
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    15. Kim DG, Jung KH, Lee DG, Yoon JH, Choi KS, Kwon SW, Shen HM, Morgan MJ, Hong SS, Kim YS. 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin. Oncotarget. 2014 Jun 30; 5(12):4438-51. PMID: 24970805.
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    16. Levy JM, Thompson JC, Griesinger AM, Amani V, Donson AM, Birks DK, Morgan MJ, Mirsky DM, Handler MH, Foreman NK, Thorburn A. Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors. Cancer Discov. 2014 Jul; 4(7):773-80. PMID: 24823863.
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    17. Morgan MJ, Bass D, Bik H, Birky CW, Blaxter M, Crisp MD, Derycke S, Fitch D, Fontaneto D, Hardy CM, King AJ, Kiontke KC, Moens T, Pawlowski JW, Porazinska D, Tang CQ, Thomas WK, Yeates DK, Creer S. A critique of Rossberg et al.: Noise obscures the genetic signal of meiobiotal ecospecies in ecogenomic datasets. Proc Biol Sci. 2014 May 22; 281(1783):20133076. PMID: 24671969.
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    18. Maycotte P, Gearheart CM, Barnard R, Aryal S, Mulcahy Levy JM, Fosmire SP, Hansen RJ, Morgan MJ, Porter CC, Gustafson DL, Thorburn A. STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious. Cancer Res. 2014 May 01; 74(9):2579-90. PMID: 24590058.
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    19. Gump JM, Staskiewicz L, Morgan MJ, Bamberg A, Riches DW, Thorburn A. Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1. Nat Cell Biol. 2014 Jan; 16(1):47-54. PMID: 24316673.
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    20. Staskiewicz L, Thorburn J, Morgan MJ, Thorburn A. Inhibiting autophagy by shRNA knockdown: cautions and recommendations. Autophagy. 2013 Oct; 9(10):1449-50. PMID: 23800703.
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    21. Morgan MJ, Liu ZG. Programmed cell death with a necrotic-like phenotype. Biomol Concepts. 2013 Jun; 4(3):259-75. PMID: 25436579.
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    22. Lee JY, Jung KH, Morgan MJ, Kang YR, Lee HS, Koo GB, Hong SS, Kwon SW, Kim YS. Sensitization of TRAIL-induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells. Mol Cancer Ther. 2013 Mar; 12(3):274-85. PMID: 23053497.
      View in: PubMed
    23. Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ, Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy. 2012 Feb 01; 8(2):200-12. PMID: 22252008.
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    24. Zhang Y, Morgan MJ, Chen K, Choksi S, Liu ZG. Induction of autophagy is essential for monocyte-macrophage differentiation. Blood. 2012 Mar 22; 119(12):2895-905. PMID: 22223827.
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    25. Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, Morgan M, Li T, Jitkaew S, Cao X, Kim YS, Kim HS, Levitt P, Shih G, Birre M, Deng CX, Liu ZG. A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol Cell. 2011 Jun 10; 42(5):597-609. PMID: 21658601.
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    26. Pobezinskaya YL, Choksi S, Morgan MJ, Cao X, Liu ZG. The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling. J Immunol. 2011 May 01; 186(9):5212-6. PMID: 21421854.
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    27. Kim JY, Morgan M, Kim DG, Lee JY, Bai L, Lin Y, Liu ZG, Kim YS. TNFa induced noncanonical NF-?B activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci. 2011 Feb 15; 124(Pt 4):647-56. PMID: 21266470.
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    28. Morgan MJ, Liu ZG. Crosstalk of reactive oxygen species and NF-?B signaling. Cell Res. 2011 Jan; 21(1):103-15. PMID: 21187859.
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    29. Cao X, Pobezinskaya YL, Morgan MJ, Liu ZG. The role of TRADD in TRAIL-induced apoptosis and signaling. FASEB J. 2011 Apr; 25(4):1353-8. PMID: 21187341.
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    30. Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, Liu ZG. MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol. 2010 Sep; 11(9):799-805. PMID: 20711193.
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    31. Morgan MJ, Liu ZG. Reactive oxygen species in TNFalpha-induced signaling and cell death. Mol Cells. 2010 Jul; 30(1):1-12. PMID: 20652490.
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    32. Morgan MJ, Kim YS, Liu ZG. Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex. J Immunol. 2009 Sep 01; 183(5):3278-84. PMID: 19641134.
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    33. Kotiw M, Morgan M, Taylor SM, Shiels IA. Detection of anti-TNFalpha activity in canine hyperimmune serum using a TNFalpha inhibition assay. Vet Clin Pathol. 2010 Mar; 39(1):46-52. PMID: 19572976.
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    34. Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, Liu C, Liu Z. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol. 2008 Sep; 9(9):1047-54. PMID: 18641653.
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    35. Morgan MJ, Kim YS, Liu ZG. TNFalpha and reactive oxygen species in necrotic cell death. Cell Res. 2008 Mar; 18(3):343-9. PMID: 18301379.
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    36. Morgan MJ, Kim YS, Liu Z. Lipid rafts and oxidative stress-induced cell death. Antioxid Redox Signal. 2007 Sep; 9(9):1471-83. PMID: 17576159.
      View in: PubMed
    37. Kim YS, Morgan MJ, Choksi S, Liu ZG. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell. 2007 Jun 08; 26(5):675-87. PMID: 17560373.
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    38. Solomon JA, Morgan MJ. Stochastic re-calibration: contextual effects on perceived tilt. Proc Biol Sci. 2006 Oct 22; 273(1601):2681-6. PMID: 17002955.
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    39. Thomas LR, Bender LM, Morgan MJ, Thorburn A. Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5. Cell Death Differ. 2006 Jan; 13(1):160-2. PMID: 16003390.
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    40. Bender LM, Morgan MJ, Thomas LR, Liu ZG, Thorburn A. The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ. 2005 May; 12(5):473-81. PMID: 15761471.
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    41. Collins FS, Morgan M, Patrinos A. The Human Genome Project: lessons from large-scale biology. Science. 2003 Apr 11; 300(5617):286-90. PMID: 12690187.
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    42. Thorburn J, Bender LM, Morgan MJ, Thorburn A. Caspase- and serine protease-dependent apoptosis by the death domain of FADD in normal epithelial cells. Mol Biol Cell. 2003 Jan; 14(1):67-77. PMID: 12529427.
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    43. Morgan M, Thorburn J, Pandolfi PP, Thorburn A. Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms. J Cell Biol. 2002 Jun 10; 157(6):975-84. PMID: 12045187.
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    44. Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley RL, Chen YQ. Mediation of the DCC apoptotic signal by DIP13 alpha. J Biol Chem. 2002 Jul 19; 277(29):26281-5. PMID: 12011067.
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    45. Morgan MJ, Thorburn J, Thomas L, Maxwell T, Brothman AR, Thorburn A. An apoptosis signaling pathway induced by the death domain of FADD selectively kills normal but not cancerous prostate epithelial cells. Cell Death Differ. 2001 Jul; 8(7):696-705. PMID: 11464214.
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    46. Morgan MJ, Thorburn A. Measurement of caspase activity in individual cells reveals differences in the kinetics of caspase activation between cells. Cell Death Differ. 2001 Jan; 8(1):38-43. PMID: 11313701.
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    47. Walker JI, Morgan MJ, Faik P. Structure and organization of the human glucose phosphate isomerase gene (GPI). Genomics. 1995 Sep 01; 29(1):261-5. PMID: 8530082.
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    48. Pearce SR, Morgan MJ, Ball S, Peters J, Faik P. Sequence characterization of alleles Gpi1-Sa and Gpi1-Sb at the glucose phosphate isomerase structural locus. Mamm Genome. 1995 Aug; 6(8):537-9. PMID: 8589524.
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    49. Hassan-Walker AF, Morgan MJ, Faik P. Characterization of cDNAs coding for glucose phosphate isomerase and phosphoglycerate kinase in Chinese hamster ovary cell line CHO-K1 and identification of defects in R1.1.7, a glycolysis-deficient variant of CHO-K1. Somat Cell Mol Genet. 1995 Jan; 21(1):75-81. PMID: 7604358.
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    50. Vallari RC, Cook WJ, Audino DC, Morgan MJ, Jensen DE, Laudano AP, Denis CL. Glucose repression of the yeast ADH2 gene occurs through multiple mechanisms, including control of the protein synthesis of its transcriptional activator, ADR1. Mol Cell Biol. 1992 Apr; 12(4):1663-73. PMID: 1549119.
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