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Harald Jobst Junge

TitleAsst Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
ORCID ORCID Icon0000-0003-2458-6010 Additional info

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    R01EY024261     (JUNGE, HARALD)Apr 1, 2014 - Mar 31, 2019
    Norrin/Frizzled4 Signaling in Retinal Angiogenesis: The Role of TSPAN12
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang Y, Cho C, Williams J, Smallwood PM, Zhang C, Junge HJ, Nathans J. Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proc Natl Acad Sci U S A. 2018 12 11; 115(50):E11827-E11836. PMID: 30478038.
      View in: PubMed
    2. Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ. Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature. Arterioscler Thromb Vasc Biol. 2018 Nov; 38(11):2691-2705. PMID: 30354230.
      View in: PubMed
    3. Junge HJ. Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In. Neuron. 2017 Aug 30; 95(5):983-985. PMID: 28858624.
      View in: PubMed
    4. Zhang C, Lai MB, Khandan L, Lee LA, Chen Z, Junge HJ. Norrin-induced Frizzled4 endocytosis and endo-lysosomal trafficking control retinal angiogenesis and barrier function. Nat Commun. 2017 07 04; 8:16050. PMID: 28675177.
      View in: PubMed
    5. Lai MB, Zhang C, Shi J, Johnson V, Khandan L, McVey J, Klymkowsky MW, Chen Z, Junge HJ. TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling. Cell Rep. 2017 06 27; 19(13):2809-2822. PMID: 28658627.
      View in: PubMed
    6. Junge HJ, Yung AR, Goodrich LV, Chen Z. Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord. Neural Dev. 2016 10 26; 11(1):19. PMID: 27784329.
      View in: PubMed
    7. Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z. NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. Elife. 2016 05 25; 5. PMID: 27223328; PMCID: PMC4930329.
    8. Saito Y, Miranda-Rottmann S, Ruggiu M, Park CY, Fak JJ, Zhong R, Duncan JS, Fabella BA, Junge HJ, Chen Z, Araya R, Fritzsch B, Hudspeth AJ, Darnell RB. NOVA2-mediated RNA regulation is required for axonal pathfinding during development. Elife. 2016 05 25; 5. PMID: 27223325; PMCID: PMC4930328.
    9. Johnson V, Xiang M, Chen Z, Junge HJ. Neurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant Mice. PLoS One. 2015; 10(7):e0132013. PMID: 26177550; PMCID: PMC4503745.
    10. Rodríguez-Castañeda F, Maestre-Martínez M, Coudevylle N, Dimova K, Junge H, Lipstein N, Lee D, Becker S, Brose N, Jahn O, Carlomagno T, Griesinger C. Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity. EMBO J. 2010 Feb 03; 29(3):680-91. PMID: 20010694; PMCID: PMC2830703.
    11. Junge HJ, Yang S, Burton JB, Paes K, Shu X, French DM, Costa M, Rice DS, Ye W. TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Cell. 2009 Oct 16; 139(2):299-311. PMID: 19837033.
      View in: PubMed
    12. Zikich D, Mezer A, Varoqueaux F, Sheinin A, Junge HJ, Nachliel E, Melamed R, Brose N, Gutman M, Ashery U. Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin. J Neurosci. 2008 Feb 20; 28(8):1949-60. PMID: 18287511.
      View in: PubMed
    13. Stevens DR, Wu ZX, Matti U, Junge HJ, Schirra C, Becherer U, Wojcik SM, Brose N, Rettig J. Identification of the minimal protein domain required for priming activity of Munc13-1. Curr Biol. 2005 Dec 20; 15(24):2243-8. PMID: 16271475.
      View in: PubMed
    14. Junge HJ, Rhee JS, Jahn O, Varoqueaux F, Spiess J, Waxham MN, Rosenmund C, Brose N. Calmodulin and Munc13 form a Ca2+ sensor/effector complex that controls short-term synaptic plasticity. Cell. 2004 Aug 06; 118(3):389-401. PMID: 15294163.
      View in: PubMed
    15. Betz A, Thakur P, Junge HJ, Ashery U, Rhee JS, Scheuss V, Rosenmund C, Rettig J, Brose N. Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron. 2001 Apr; 30(1):183-96. PMID: 11343654.
      View in: PubMed
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