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Audrey M. Bergouignan

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse awards and honors
    2006Young Researcher Award, French Space Agency (CNES)
    2008Sable Award, University of Colorado
    20092008 Best PhD Thesis Award, University of Strasbourg, France
    2011 - 2014Young Investigator Award, National Obesity Research Center (NORC)
    2011 - 2014Mentored Pilot Study Award, Colorado CTSI
    2014Endeavor Postgraduate Research Award, Australian Government
    2014 - 2019K99/R00 Transition to the Independence Award, NIH/NIDDK

    Collapse Overview 
    Collapse overview
    Dr Bergouignan is an integrative physiologist whose research focuses on the study of energetic and lipid metabolism regulation, core components of body weight control, and their regulation by environmental factors, i.e. physical activity and diet. She received her PhD in Human Physiology at the University of Strasbourg, France in 2008 and completed a postdoctoral fellowship in Human Metabolism and Obesity within the Center for Human Nutrition at the University of Colorado, USA, 2009-2013. She was the recipient of a 2014 Australian Endeavour Postgraduate Research Fellowship Award. She completed this fellowship at the Baker IDI in Melbourne where she has investigated some of the biological mechanisms underlying the relationships observed at the population level between sedentary behaviors and metabolic health. She also is the recipient of a US NIH Pathway to Independence K99/R00 Award to conduct an integrative study on the role of sedentary behaviors in the development of obesity and associated metabolic diseases, 2014-2019. Dr Bergouignan is now working at the University of Colorado with international collaborators to develop her research program in the burgeoning field of the physiology of sedentary behaviors.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Damiot A, Demangel R, Noone J, Chery I, Zahariev A, Normand S, Brioche T, Crampes F, de Glisezinski I, Lefai E, Bareille MP, Chopard A, Drai J, Collin-Chavagnac D, Heer M, Gauquelin-Koch G, Prost M, Simon P, Py G, Blanc S, Simon C, Bergouignan A, O'Gorman DJ. A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study. J Appl Physiol (1985). 2018 Oct 04. PMID: 30284519.
      View in: PubMed
    2. Rudwill F, O'Gorman D, Lefai E, Chery I, Zahariev A, Normand S, Pagano AF, Chopard A, Damiot A, Laurens C, Hodson L, Canet-Soulas E, Heer M, Meuthen PF, Buehlmeier J, Baecker N, Meiller L, Gauquelin-Koch G, Blanc S, Simon C, Bergouignan A. Metabolic Inflexibility Is an Early Marker of Bed-Rest-Induced Glucose Intolerance Even When Fat Mass Is Stable. J Clin Endocrinol Metab. 2018 May 01; 103(5):1910-1920. PMID: 29546280.
      View in: PubMed
    3. Creasy SA, Rynders CA, Bergouignan A, Kealey EH, Bessesen DH. Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring). 2018 Apr; 26(4):696-702. PMID: 29570248.
      View in: PubMed
    4. Foright RM, Presby DM, Sherk VD, Kahn D, Checkley LA, Giles ED, Bergouignan A, Higgins JA, Jackman MR, Hill JO, MacLean PS. Is regular exercise an effective strategy for weight loss maintenance? Physiol Behav. 2018 May 01; 188:86-93. PMID: 29382563.
      View in: PubMed
    5. Rynders CA, Schmidt SL, Bergouignan A, Horton TJ, Bessesen DH. Effects of short-term sex steroid suppression on dietary fat storage patterns in healthy males. Physiol Rep. 2018 Jan; 6(2). PMID: 29380951.
      View in: PubMed
    6. Rynders CA, Blanc S, DeJong N, Bessesen DH, Bergouignan A. Sedentary behaviour is a key determinant of metabolic inflexibility. J Physiol. 2018 Apr 15; 596(8):1319-1330. PMID: 28543022.
      View in: PubMed
    7. Lefai E, Blanc S, Momken I, Antoun E, Chery I, Zahariev A, Gabert L, Bergouignan A, Simon C. Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype. Int J Obes (Lond). 2017 Dec; 41(12):1728-1736. PMID: 28669989.
      View in: PubMed
    8. Rynders CA, Bergouignan A, Kealey E, Bessesen DH. Ability to adjust nocturnal fat oxidation in response to overfeeding predicts 5-year weight gain in adults. Obesity (Silver Spring). 2017 05; 25(5):873-880. PMID: 28440048.
      View in: PubMed
    9. Bergouignan A, Legget KT, De Jong N, Kealey E, Nikolovski J, Groppel JL, Jordan C, O'Day R, Hill JO, Bessesen DH. Effect of frequent interruptions of prolonged sitting on self-perceived levels of energy, mood, food cravings and cognitive function. Int J Behav Nutr Phys Act. 2016 11 03; 13(1):113. PMID: 27809874.
      View in: PubMed
    10. Gastebois C, Villars C, Drai J, Canet-Soulas E, Blanc S, Bergouignan A, Lefai E, Simon C. Effects of training and detraining on adiponectin plasma concentration and muscle sensitivity in lean and overweight men. Eur J Appl Physiol. 2016 Dec; 116(11-12):2135-2144. PMID: 27632382.
      View in: PubMed
    11. Bergouignan A, Latouche C, Heywood S, Grace MS, Reddy-Luthmoodoo M, Natoli AK, Owen N, Dunstan DW, Kingwell BA. Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. Sci Rep. 2016 08 24; 6:32044. PMID: 27554943.
      View in: PubMed
    12. Bergouignan A, Stein TP, Habold C, Coxam V, O' Gorman D, Blanc S. Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities. NPJ Microgravity. 2016; 2:16029. PMID: 28725737.
      View in: PubMed
    13. Bergouignan A, Stein TP, Habold C, Coxam V, O’Gorman D, Blanc S. Towards human exploration of space: The THESEUS review series on nutrition and metabolism research priorities. npj Microgravity. 2016; 2:16029.
    14. Rudwill F, Bergouignan A, Gastebois C, Gauquelin-Koch G, Lefai E, Blanc S, Simon C. Effect of enforced physical inactivity induced by 60-day of bed rest on hepatic markers of NAFLD in healthy normal-weight women. Liver Int. 2015 Jun; 35(6):1700-6. PMID: 25413107.
      View in: PubMed
    15. Bergouignan A, Kealey EH, Schmidt SL, Jackman MR, Bessesen DH. Twenty-four hour total and dietary fat oxidation in lean, obese and reduced-obese adults with and without a bout of exercise. PLoS One. 2014; 9(4):e94181. PMID: 24714529; PMCID: PMC3979741.
    16. Simon C, Kellou N, Dugas J, Platat C, Copin N, Schweitzer B, Hausser F, Bergouignan A, Lefai E, Blanc S. A socio-ecological approach promoting physical activity and limiting sedentary behavior in adolescence showed weight benefits maintained 2.5 years after intervention cessation. Int J Obes (Lond). 2014 Jul; 38(7):936-43. PMID: 24509504; PMCID: PMC4088336.
    17. Bergouignan A, Momken I, Lefai E, Antoun E, Schoeller DA, Platat C, Chery I, Zahariev A, Vidal H, Gabert L, Normand S, Freyssenet D, Laville M, Simon C, Blanc S. Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations. Am J Clin Nutr. 2013 Sep; 98(3):648-58. PMID: 23902784.
      View in: PubMed
    18. Rudwill F, Blanc S, Gauquelin-Koch G, Choukèr A, Heer M, Simon C, Bergouignan A. Effects of different levels of physical inactivity on plasma visfatin in healthy normal-weight men. Appl Physiol Nutr Metab. 2013 Jun; 38(6):689-93. PMID: 23724888.
      View in: PubMed
    19. Bergouignan A, Antoun E, Momken I, Schoeller DA, Gauquelin-Koch G, Simon C, Blanc S. Effect of contrasted levels of habitual physical activity on metabolic flexibility. J Appl Physiol (1985). 2013 Feb; 114(3):371-9. PMID: 23239872.
      View in: PubMed
    20. Villars C, Bergouignan A, Dugas J, Antoun E, Schoeller DA, Roth H, Maingon AC, Lefai E, Blanc S, Simon C. Validity of combining heart rate and uniaxial acceleration to measure free-living physical activity energy expenditure in young men. J Appl Physiol (1985). 2012 Dec 01; 113(11):1763-71. PMID: 23019315.
      View in: PubMed
    21. Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS One. 2012; 7(1):e30164. PMID: 22253914; PMCID: PMC3257254.
    22. Bergouignan A, Rudwill F, Simon C, Blanc S. Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies. J Appl Physiol (1985). 2011 Oct; 111(4):1201-10. PMID: 21836047.
      View in: PubMed
    23. Momken I, Stevens L, Bergouignan A, Desplanches D, Rudwill F, Chery I, Zahariev A, Zahn S, Stein TP, Sebedio JL, Pujos-Guillot E, Falempin M, Simon C, Coxam V, Andrianjafiniony T, Gauquelin-Koch G, Picquet F, Blanc S. Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat. FASEB J. 2011 Oct; 25(10):3646-60. PMID: 21715682.
      View in: PubMed
    24. Maclean PS, Bergouignan A, Cornier MA, Jackman MR. Biology's response to dieting: the impetus for weight regain. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R581-600. PMID: 21677272; PMCID: PMC3174765.
    25. Bergouignan A, Habold C, Rudwill F, Gauquelin-Koch G, Normand S, Simon C, Blanc S. Urinary C-peptide is not an accurate bioindicator of energy balance in humans. Obesity (Silver Spring). 2012 Mar; 20(3):683-8. PMID: 21566564.
      View in: PubMed
    26. Antoun E, Momken I, Bergouignan A, Villars C, Platat C, Schoeller DA, Blanc S, Simon C. The [1-13 C] acetate recovery factor to correct tracer-derived dietary fat oxidation is lower in overweight insulin-resistant subjects. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism. 2010; 5(4):e173-e179.
    27. Melanson EL, Ingebrigtsen JP, Bergouignan A, Ohkawara K, Kohrt WM, Lighton JR. A new approach for flow-through respirometry measurements in humans. Am J Physiol Regul Integr Comp Physiol. 2010 Jun; 298(6):R1571-9. PMID: 20200135; PMCID: PMC2886696.
    28. Bergouignan A, Momken I, Schoeller DA, Normand S, Zahariev A, Lescure B, Simon C, Blanc S. Regulation of energy balance during long-term physical inactivity induced by bed rest with and without exercise training. J Clin Endocrinol Metab. 2010 Mar; 95(3):1045-53. PMID: 20061436.
      View in: PubMed
    29. Bergouignan A, Momken I, Schoeller DA, Simon C, Blanc S. Metabolic fate of saturated and monounsaturated dietary fats: the Mediterranean diet revisited from epidemiological evidence to cellular mechanisms. Prog Lipid Res. 2009 May-Jul; 48(3-4):128-47. PMID: 19275915.
      View in: PubMed
    30. Bergouignan A, Trudel G, Simon C, Chopard A, Schoeller DA, Momken I, Votruba SB, Desage M, Burdge GC, Gauquelin-Koch G, Normand S, Blanc S. Physical inactivity differentially alters dietary oleate and palmitate trafficking. Diabetes. 2009 Feb; 58(2):367-76. PMID: 19017764; PMCID: PMC2628610.
    31. Bergouignan A, Schoeller DA, Votruba S, Simon C, Blanc S. The acetate recovery factor to correct tracer-derived dietary fat oxidation in humans. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E645-53. PMID: 18212023.
      View in: PubMed
    32. Bergouignan A, Schoeller DA, Normand S, Gauquelin-Koch G, Laville M, Shriver T, Desage M, Le Maho Y, Ohshima H, Gharib C, Blanc S. Effect of physical inactivity on the oxidation of saturated and monounsaturated dietary Fatty acids: results of a randomized trial. PLoS Clin Trials. 2006 Sep 29; 1(5):e27. PMID: 17016547; PMCID: PMC1584255.
    33. Bergouignan A, Blanc S. [The energetics of obesity]. J Soc Biol. 2006; 200(1):29-35. PMID: 17144159.
      View in: PubMed
    34. Zahariev A, Bergouignan A, Caloin M, Normand S, Gauquelin-Koch G, Gharib C, Blanc S. Skinfold thickness versus isotope dilution for body fat assessment during simulated microgravity: results from three bed-rest campaigns in men and women with and without countermeasures. Eur J Appl Physiol. 2005 Oct; 95(4):344-50. PMID: 16151838.
      View in: PubMed
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