Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Rafeul Alam

TitlePrincipal Investigator
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Verma M, Liu S, Michalec L, Sripada A, Gorska MM, Alam R. Title: Experimental Asthma Persists in IL33 Receptor Knockout Mice Due to the Emergence of a TSLP-driven IL9+ and IL13+ ILC2 subpopulations. J Allergy Clin Immunol. 2017 Nov 10. PMID: 29132961.
      View in: PubMed
    2. Lenberg J, Qian Q, Sun Z, Alam R, Gorska MM. Pre-pregnancy exposure to diesel exhaust predisposes offspring to asthma through IL-1ß and IL-17A. J Allergy Clin Immunol. 2017 Sep 21. PMID: 28943469.
      View in: PubMed
    3. Gaurav R, Varasteh JT, Weaver MR, Jacobson SR, Hernandez-Lagunas L, Liu Q, Nozik-Grayck E, Chu HW, Alam R, Nordestgaard BG, Kobylecki CJ, Afzal S, Chupp GL, Bowler RP. The R213G polymorphism in SOD3 protects against allergic airway inflammation. JCI Insight. 2017 Sep 07; 2(17). PMID: 28878123.
      View in: PubMed
    4. Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann RH, Fu Z, Locci M, Rosales S, Vijayanand P, Sette A, Alam R, Crotty S, Peters B. Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol. 2017 May 12. PMID: 28506846.
      View in: PubMed
    5. Liu S, Verma M, Michalec L, Liu W, Sripada A, Rollins D, Good J, Ito Y, Chu H, Gorska MM, Martin RJ, Alam R. Steroid resistance of airway type 2 innate lymphoid cells from patients with severe asthma: The role of thymic stromal lymphopoietin. J Allergy Clin Immunol. 2017 Apr 20. PMID: 28433687.
      View in: PubMed
    6. Alam R, Good J, Rollins D, Verma M, Chu H, Pham TH, Martin RJ. Airway and serum biochemical correlates of refractory neutrophilic asthma. J Allergy Clin Immunol. 2017 Oct; 140(4):1004-1014.e13. PMID: 28163052.
      View in: PubMed
    7. Liu W, Liu S, Verma M, Zafar I, Good JT, Rollins D, Groshong S, Gorska MM, Martin RJ, Alam R. Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma. J Allergy Clin Immunol. 2017 May; 139(5):1548-1558.e4. PMID: 27702673.
      View in: PubMed
    8. Katial RK, Martucci M, Burnett T, Faino A, Finkas L, Liu S, Alam R. Nonsteroidal anti-inflammatory-induced inhibition of signal transducer and activator of transcription 6 (STAT-6) phosphorylation in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016 Aug; 138(2):579-85. PMID: 26915678.
      View in: PubMed
    9. Germinaro M, Reynolds P, Knight V, Alam R. Association of B-cell activating factor receptor deficiency with the P21R polymorphism and common variable immunodeficiency. Ann Allergy Asthma Immunol. 2015 Jul; 115(1):82-3. PMID: 26012370; PMCID: PMC4760690.
    10. Gelfand EW, Alam R. The other side of asthma: Steroid-refractory disease in the absence of TH2-mediated inflammation. J Allergy Clin Immunol. 2015 May; 135(5):1196-8. PMID: 25772592.
      View in: PubMed
    11. Christianson CA, Goplen NP, Zafar I, Irvin C, Good JT, Rollins DR, Gorentla B, Liu W, Gorska MM, Chu H, Martin RJ, Alam R. Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33. J Allergy Clin Immunol. 2015 Jul; 136(1):59-68.e14. PMID: 25617223; PMCID: PMC4494983.
    12. Alam R. Reply: To PMID 25042748. J Allergy Clin Immunol. 2015 Jan; 135(1):291. PMID: 25445823.
      View in: PubMed
    13. Alam R. Obesity and asthma--is there a causal association? Immunol Allergy Clin North Am. 2014 Nov; 34(4):xi-xii. PMID: 25282296.
      View in: PubMed
    14. Irvin C, Zafar I, Good J, Rollins D, Christianson C, Gorska MM, Martin RJ, Alam R. Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma. J Allergy Clin Immunol. 2014 Nov; 134(5):1175-1186.e7. PMID: 25042748; PMCID: PMC4254017.
    15. Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol. 2014 Nov; 134(5):1076-83. PMID: 25042980; PMCID: PMC4253970.
    16. Alam R. The complexity of drug hypersensitivity. Foreword. Immunol Allergy Clin North Am. 2014 Aug; 34(3):xiii-xiv. PMID: 25017688.
      View in: PubMed
    17. Alam R. The amazing mast cell. Immunol Allergy Clin North Am. 2014 May; 34(2):xv-xvi. PMID: 24745686.
      View in: PubMed
    18. Manners S, Alam R, Schwartz DA, Gorska MM. A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust. J Allergy Clin Immunol. 2014 Jul; 134(1):63-72. PMID: 24365139; PMCID: PMC4065237.
    19. Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-? autoantibody. Clin Infect Dis. 2014 Mar; 58(6):e115-8. PMID: 24336756; PMCID: PMC3935498.
    20. Alam R. Urticaria: an evolving story. Immunol Allergy Clin North Am. 2014 Feb; 34(1):xiii-xiv. PMID: 24262699.
      View in: PubMed
    21. Alam R. Angioedema: what we know and what we need to know. Immunol Allergy Clin North Am. 2013 Nov; 33(4):ix-x. PMID: 24176219.
      View in: PubMed
    22. Chen Z, Wang S, Erekosima N, Li Y, Hong J, Qi X, Merkel P, Nagabhushanam V, Choo E, Katial R, Alam R, Trikha A, Chu HW, Zhuang Y, Jin M, Bai C, Huang H. IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling. J Allergy Clin Immunol. 2013 Oct; 132(4):912-21.e1-5. PMID: 23958647; PMCID: PMC3788709.
    23. Alam R. Exercise, our breathing, and our health. Immunol Allergy Clin North Am. 2013 Aug; 33(3):xiii-xiv. PMID: 23830135.
      View in: PubMed
    24. Burnett T, Katial R, Alam R. Mechanisms of aspirin desensitization. Immunol Allergy Clin North Am. 2013 May; 33(2):223-36. PMID: 23639710.
      View in: PubMed
    25. Christianson CA, Alam R. Mechanisms of sustained signalling in asthma. Curr Opin Allergy Clin Immunol. 2013 Feb; 13(1):100-5. PMID: 23222156.
      View in: PubMed
    26. Guo L, Chen C, Liang Q, Karim MZ, Gorska MM, Alam R. Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor. J Immunol. 2013 Jan 01; 190(1):159-67. PMID: 23225884; PMCID: PMC3530839.
    27. Alam R. Conditions mimicking asthma. Foreword. Immunol Allergy Clin North Am. 2013 Feb; 33(1):ix-x. PMID: 23337068.
      View in: PubMed
    28. Schulten V, Oseroff C, Alam R, Broide D, Vijayanand P, Peters B, Sette A. The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol. 2013 Jan; 110(1):7-10. PMID: 23244651; PMCID: PMC3547526.
    29. Gorska MM, Alam R. Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia. Curr Allergy Asthma Rep. 2012 Oct; 12(5):396-401. PMID: 22729960.
      View in: PubMed
    30. Alam R. Interstitial lung diseases. Foreword. Immunol Allergy Clin North Am. 2012 Nov; 32(4):xiii-xiv. PMID: 23102072.
      View in: PubMed
    31. Lichtenstein KA, Armon C, Nagabhushanam V, Efaw BJ, Frazer-Abel A, Hiserote ME, Alam R. A pilot study to assess inflammatory biomarker changes when raltegravir is added to a virologically suppressive HAART regimen in HIV-1-infected patients with limited immunological responses. Antivir Ther. 2012; 17(7):1301-9. PMID: 22948290.
      View in: PubMed
    32. Alam R. Biomarkers in asthma and allergy. Immunol Allergy Clin North Am. 2012 Aug; 32(3):xi-xii. PMID: 22877622.
      View in: PubMed
    33. Tundwal K, Alam R. JAK and Src tyrosine kinase signaling in asthma. Front Biosci (Landmark Ed). 2012 Jun 01; 17:2107-21. PMID: 22652767.
      View in: PubMed
    34. Hanifi A, Goplen N, Matin M, Salters RE, Alam R. A linear parametric approach for analysis of mouse respiratory impedance. IEEE Trans Biomed Circuits Syst. 2012 Jun; 6(3):287-94. PMID: 23853150.
      View in: PubMed
    35. Alam R. Cutaneous immunity and autoimmunity. Immunol Allergy Clin North Am. 2012 May; 32(2):xi-xii. PMID: 22560147.
      View in: PubMed
    36. Goplen N, Karim Z, Guo L, Zhuang Y, Huang H, Gorska MM, Gelfand E, Pagés G, Pouysségur J, Alam R. ERK1 is important for Th2 differentiation and development of experimental asthma. FASEB J. 2012 May; 26(5):1934-45. PMID: 22262639; PMCID: PMC3336776.
    37. Alam R. Is food allergy giving me a headache? Immunol Allergy Clin North Am. 2012 Feb; 32(1):xiii-xiv. PMID: 22244240.
      View in: PubMed
    38. Gorska MM, Alam R. A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia. Blood. 2012 Feb 09; 119(6):1399-406. PMID: 22184408; PMCID: PMC3286207.
    39. Ostroukhova M, Goplen N, Karim MZ, Michalec L, Guo L, Liang Q, Alam R. The role of low-level lactate production in airway inflammation in asthma. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 01; 302(3):L300-7. PMID: 22080752; PMCID: PMC3289274.
    40. Alam R. When the workplace air makes me wheeze--occupational asthma. Immunol Allergy Clin North Am. 2011 Nov; 31(4):ix-x. PMID: 21978858.
      View in: PubMed
    41. Alam R. The burden of allergic rhinitis beyond allergies. Immunol Allergy Clin North Am. 2011 Aug; 31(3):ix-x. PMID: 21737033.
      View in: PubMed
    42. Alam R. Foreword: allergen immunotherapy. Immunol Allergy Clin North Am. 2011 May; 31(2):xv-xvi. PMID: 21530809.
      View in: PubMed
    43. Alam R. Foreword: the stress of writing about stress. Immunol Allergy Clin North Am. 2011 Feb; 31(1):xi-xii. PMID: 21094918.
      View in: PubMed
    44. Alam R. Foreword. Infection and asthma. Immunol Allergy Clin North Am. 2010 Nov; 30(4):xi-xii. PMID: 21029930.
      View in: PubMed
    45. Liang Q, Guo L, Gogate S, Karim Z, Hanifi A, Leung DY, Gorska MM, Alam R. IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma. J Immunol. 2010 Nov 15; 185(10):5704-13. PMID: 20926789; PMCID: PMC3367768.
    46. Katial RK, Strand M, Prasertsuntarasai T, Leung R, Zheng W, Alam R. The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases. J Allergy Clin Immunol. 2010 Oct; 126(4):738-44. PMID: 20728206.
      View in: PubMed
    47. Alam R. Foreword. Atopic dermatitis. Immunol Allergy Clin North Am. 2010 Aug; 30(3):xiii-xiv. PMID: 20670810.
      View in: PubMed
    48. Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol. 2010 Jul 15; 185(2):943-55. PMID: 20554959; PMCID: PMC3310373.
    49. Alam R. Foreword: Hematopoietic stem cell transplantation for primary immunodeficiency disorders, part II. Immunol Allergy Clin North Am. 2010 May; 30(2):ix-x. PMID: 20493391.
      View in: PubMed
    50. Gorska MM, Goplen N, Liang Q, Alam R. Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. J Immunol. 2010 Apr 15; 184(8):4488-96. PMID: 20220094.
      View in: PubMed
    51. Liu W, Tundwal K, Liang Q, Goplen N, Rozario S, Quayum N, Gorska M, Wenzel S, Balzar S, Alam R. Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function. Mol Cell Biol. 2010 Apr; 30(7):1783-99. PMID: 20123980; PMCID: PMC2838067.
    52. Alam R. Foreword. Immunol Allergy Clin North Am. 2010 Feb; 30(1):xi-xii. PMID: 20113881.
      View in: PubMed
    53. Alam R. Chronic sinusitis. Foreword. Immunol Allergy Clin North Am. 2009 Nov; 29(4):xiii. PMID: 19879436.
      View in: PubMed
    54. Karim Z, Vepachedu R, Gorska M, Alam R. UNC119 inhibits dynamin and dynamin-dependent endocytic processes. Cell Signal. 2010 Jan; 22(1):128-37. PMID: 19781630.
      View in: PubMed
    55. Alam R. Foreword. Drug allergy and primum non-nocere. Immunol Allergy Clin North Am. 2009 Aug; 29(3):xiii-xiv. PMID: 19563986.
      View in: PubMed
    56. Gorska MM, Liang Q, Karim Z, Alam R. Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. J Immunol. 2009 Aug 01; 183(3):1675-84. PMID: 19592652.
      View in: PubMed
    57. Alam R. Foreword: psychoneuroimmunology--the essence of a three's company. Immunol Allergy Clin North Am. 2009 May; 29(2):xiii-xiv. PMID: 19389576.
      View in: PubMed
    58. Vepachedu R, Karim Z, Patel O, Goplen N, Alam R. Unc119 protects from Shigella infection by inhibiting the Abl family kinases. PLoS One. 2009; 4(4):e5211. PMID: 19381274; PMCID: PMC2667249.
    59. Goplen N, Karim MZ, Liang Q, Gorska MM, Rozario S, Guo L, Alam R. Combined sensitization of mice to extracts of dust mite, ragweed, and Aspergillus species breaks through tolerance and establishes chronic features of asthma. J Allergy Clin Immunol. 2009 Apr; 123(4):925-32.e11. PMID: 19348928; PMCID: PMC2683988.
    60. Alam R. Foreword: what do eosinophils do in the gastrointestinal mucosa? Immunol Allergy Clin North Am. 2009 Feb; 29(1):xvii-xviii. PMID: 19141335.
      View in: PubMed
    61. Alam R. The question of when and how. Foreword. Immunol Allergy Clin North Am. 2008 Nov; 28(4):xiii-xiv. PMID: 18940568.
      View in: PubMed
    62. Alam R. Foreword: environmental factors in asthma. Immunol Allergy Clin North Am. 2008 Aug; 28(3):xiii-xiv. PMID: 18572101; PMCID: PMC2535930.
    63. Cyr MM, Baatjes AJ, Dorman SC, Crawford L, Sehmi R, Foley R, Alam R, Byrne PO, Denburg JA. In vitro effects of budesonide on eosinophil-basophil lineage commitment. Open Respir Med J. 2008; 2:60-6. PMID: 19343093; PMCID: PMC2606647.
    64. Alam R. Foreword immunodeficiency--improving the deficiency of knowledge. Immunol Allergy Clin North Am. 2008 May; 28(2):xiii-xiv. PMID: 18424329.
      View in: PubMed
    65. Liu W, Liang Q, Balzar S, Wenzel S, Gorska M, Alam R. Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways. J Allergy Clin Immunol. 2008 Apr; 121(4):893-902.e2. PMID: 18395552.
      View in: PubMed
    66. Goplen N, Gorska MM, Stafford SJ, Rozario S, Guo L, Liang Q, Alam R. A phosphosite screen identifies autocrine TGF-beta-driven activation of protein kinase R as a survival-limiting factor for eosinophils. J Immunol. 2008 Mar 15; 180(6):4256-64. PMID: 18322238.
      View in: PubMed
    67. Alam R. When my eyes tear. Foreword. Immunol Allergy Clin North Am. 2008 Feb; 28(1):ix-x. PMID: 18282540.
      View in: PubMed
    68. Vepachedu R, Gorska MM, Singhania N, Cosgrove GP, Brown KK, Alam R. Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. J Immunol. 2007 Jul 01; 179(1):682-90. PMID: 17579091.
      View in: PubMed
    69. Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L, Sur S, Gaestel M, Alam R. MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med. 2007 Jul 09; 204(7):1637-52. PMID: 17576778; PMCID: PMC2118652.
    70. Dharajiya N, Choudhury BK, Bacsi A, Boldogh I, Alam R, Sur S. Inhibiting pollen reduced nicotinamide adenine dinucleotide phosphate oxidase-induced signal by intrapulmonary administration of antioxidants blocks allergic airway inflammation. J Allergy Clin Immunol. 2007 Mar; 119(3):646-53. PMID: 17336614; PMCID: PMC3042252.
    71. Alam R. Foreword. Immunol Allergy Clin North Am. 2007 Feb; 27(1):xiii-xiv. PMID: 17276874.
      View in: PubMed
    72. Yasnowsky KM, Dreskin SC, Efaw B, Schoen D, Vedanthan PK, Alam R, Harbeck RJ. Chronic urticaria sera increase basophil CD203c expression. J Allergy Clin Immunol. 2006 Jun; 117(6):1430-4. PMID: 16751009.
      View in: PubMed
    73. Gorska MM, Cen O, Liang Q, Stafford SJ, Alam R. Differential regulation of interleukin 5-stimulated signaling pathways by dynamin. J Biol Chem. 2006 May 19; 281(20):14429-39. PMID: 16556602.
      View in: PubMed
    74. Boldogh I, Bacsi A, Choudhury BK, Dharajiya N, Alam R, Hazra TK, Mitra S, Goldblum RM, Sur S. ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation. J Clin Invest. 2005 Aug; 115(8):2169-79. PMID: 16075057; PMCID: PMC1180538.
    75. Gorska MM, Alam R. The signaling mechanism of eosinophil activation. Expert Rev Clin Immunol. 2005 Jul; 1(2):247-56. PMID: 20476938.
      View in: PubMed
    76. Gorska MM, Stafford SJ, Cen O, Sur S, Alam R. Unc119, a novel activator of Lck/Fyn, is essential for T cell activation. J Exp Med. 2004 Feb 02; 199(3):369-79. PMID: 14757743; PMCID: PMC2211793.
    77. Alam R, Busse WW. The eosinophil--quo vadis? J Allergy Clin Immunol. 2004 Jan; 113(1):38-42. PMID: 14713905.
      View in: PubMed
    78. Gorska MM, Alam R. Signaling molecules as therapeutic targets in allergic diseases. J Allergy Clin Immunol. 2003 Aug; 112(2):241-50; quiz 251. PMID: 12897726.
      View in: PubMed
    79. Alam R, Gorska M. 3. Lymphocytes. J Allergy Clin Immunol. 2003 Feb; 111(2 Suppl):S476-85. PMID: 12592294.
      View in: PubMed
    80. Adachi T, Stafford S, Kayaba H, Chihara J, Alam R. Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner. J Allergy Clin Immunol. 2003 Jan; 111(1):113-6. PMID: 12532105.
      View in: PubMed
    81. Cen O, Gorska MM, Stafford SJ, Sur S, Alam R. Identification of UNC119 as a novel activator of SRC-type tyrosine kinases. J Biol Chem. 2003 Mar 07; 278(10):8837-45. PMID: 12496276.
      View in: PubMed
    82. Choudhury BK, Wild JS, Alam R, Klinman DM, Boldogh I, Dharajiya N, Mileski WJ, Sur S. In vivo role of p38 mitogen-activated protein kinase in mediating the anti-inflammatory effects of CpG oligodeoxynucleotide in murine asthma. J Immunol. 2002 Nov 15; 169(10):5955-61. PMID: 12421981.
      View in: PubMed
    83. Stafford S, Lowell C, Sur S, Alam R. Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation. J Immunol. 2002 Feb 15; 168(4):1978-83. PMID: 11823534.
      View in: PubMed
    84. Michalec L, Choudhury BK, Postlethwait E, Wild JS, Alam R, Lett-Brown M, Sur S. CCL7 and CXCL10 orchestrate oxidative stress-induced neutrophilic lung inflammation. J Immunol. 2002 Jan 15; 168(2):846-52. PMID: 11777981.
      View in: PubMed
    85. Alam R, DeJarnatt A, Stafford S, Forsythe PA, Kumar D, Grant JA. Misoprostol Inhibits the Cutaneous Late-Phase Allergic Response to Antigens. Results of a Double-Blind Placebo-Controlled Randomized Study and an Investigation into the Mechanism of Action. Am J Ther. 1995 Oct; 2(10):749-754. PMID: 11854781.
      View in: PubMed
    Alam's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)