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Jose Ramon Castillo-Mancilla

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4934

    Collapse Research 
    Collapse research activities and funding
    K23AI104315     (CASTILLO-MANCILLA, JOSE RAMON)Jun 20, 2013 - May 31, 2018
    NIH/NIAID
    Quantifying Drug Adherence and Drug Exposure to Antiretroviral Therapy
    Role: Principal Investigator

    R21AI124859     (CASTILLO-MANCILLA, JOSE RAMON)Mar 15, 2016 - Feb 28, 2018
    NIH/NIAID
    Impact of ART Adherence on HIV Persistence and Inflammation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Siedner MJ, Bwana MB, Asiimwe S, Amanyire G, Musinguzi N, Castillo-Mancilla J, Tracy RP, Katz IT, Bangsberg DR, Hunt PW, Orrell C, Haberer JE. Timing of Antiretroviral Therapy and Systemic Inflammation in Sub-Saharan Africa: Results From the META Longitudinal Cohort Study. J Infect Dis. 2019 Jun 12. PMID: 31188451.
      View in: PubMed
    2. Brooks KM, Ibrahim ME, Castillo-Mancilla JR, MaWhinney S, Alexander K, Tilden S, Kerr BJ, Ellison L, McHugh C, Bushman LR, Kiser JJ, Hosek S, Huhn GD, Anderson PL. Pharmacokinetics of tenofovir monoester and association with intracellular tenofovir diphosphate following single-dose tenofovir disoproxil fumarate. J Antimicrob Chemother. 2019 May 15. PMID: 31093649.
      View in: PubMed
    3. Brooks KM, Castillo-Mancilla JR, Blum J, Huntley R, MaWhinney S, Alexander K, Kerr BJ, Ellison L, Bushman LR, MacBrayne CE, Anderson PL, Kiser JJ. Increased tenofovir monoester concentrations in patients receiving tenofovir disoproxil fumarate with ledipasvir/sofosbuvir. J Antimicrob Chemother. 2019 May 12. PMID: 31081036.
      View in: PubMed
    4. Frasca K, Castillo-Mancilla J, McNulty MC, Connors S, Sweitzer E, Zimmer S, Madinger N. A Mixed Methods Evaluation of an Inclusive Sexual History Taking and HIV Prevention Curriculum for Trainees. J Gen Intern Med. 2019 Apr 29. PMID: 31037543.
      View in: PubMed
    5. Castillo-Mancilla JR, Morrow M, Coyle RP, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Mawhinney S, Anderson PL. Tenofovir Diphosphate in Dried Blood Spots Is Strongly Associated With Viral Suppression in Individuals With Human Immunodeficiency Virus Infections. Clin Infect Dis. 2019 Apr 08; 68(8):1335-1342. PMID: 30137238.
      View in: PubMed
    6. Morrow M, Mawhinney S, Coyle RP, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Anderson PL, Castillo-Mancilla JR. Predictive value of tenofovir diphosphate in dried blood spots for future viremia in persons living with HIV. J Infect Dis. 2019 Apr 03. PMID: 30942881.
      View in: PubMed
    7. Coyle RP, Schneck CD, Morrow M, Coleman SS, Gardner EM, Zheng JH, Ellison L, Bushman LR, Kiser JJ, Mawhinney S, Anderson PL, Castillo-Mancilla JR. Engagement in Mental Health Care is Associated with Higher Cumulative Drug Exposure and Adherence to Antiretroviral Therapy. AIDS Behav. 2019 Feb 23. PMID: 30798457.
      View in: PubMed
    8. Velásquez GE, Huaman MA, Powell KR, Cohn SE, Swaminathan S, Outlaw M, Schulte G, McNeil Q, Currier JS, Del Rio C, Castillo-Mancilla J. Outcomes of a Career Development Program for Underrepresented Minority Investigators in the AIDS Clinical Trials Group. Open Forum Infect Dis. 2019 Mar; 6(3):ofz069. PMID: 30895207.
      View in: PubMed
    9. Frasca K, Morrow M, Coyle RP, Coleman SS, Ellison L, Bushman LR, Kiser JJ, Zheng JH, Mawhinney S, Anderson PL, Castillo-Mancilla J. Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short-term adherence to antiretroviral therapy. J Antimicrob Chemother. 2019 Jan 18. PMID: 30668713.
      View in: PubMed
    10. Koss CA, Liu AY, Castillo-Mancilla J, Bacchetti P, McHugh C, Kuncze K, Morrow M, Louie A, Seifert S, Okochi H, MaWhinney S, Gandhi M, Anderson PL. Similar tenofovir hair concentrations in men and women after directly observed dosing of tenofovir disoproxil fumarate/emtricitabine: implications for preexposure prophylaxis adherence monitoring. AIDS. 2018 Sep 24; 32(15):2189-2194. PMID: 30212404.
      View in: PubMed
    11. MacBrayne CE, Marks KM, Fierer DS, Naggie S, Chung RT, Hughes MD, Kim AY, Peters MG, Brainard DM, Seifert SM, Castillo-Mancilla JR, Bushman LR, Anderson PL, Kiser JJ. Effects of sofosbuvir-based hepatitis C treatment on the pharmacokinetics of tenofovir in HIV/HCV-coinfected individuals receiving tenofovir disoproxil fumarate. J Antimicrob Chemother. 2018 Aug 01; 73(8):2112-2119. PMID: 29746648.
      View in: PubMed
    12. Koss CA, Liu AY, Castillo-Mancilla J, Bacchetti P, Mchugh C, Kuncze K, Morrow M, Louie A, Seifert S, Okochi H, Mawhinney S, Gandhi M, Anderson PL. Similar tenofovir hair concentrations in men and women after directly-observed: dosing of TDF/FTC: implications for PrEP adherence monitoring. AIDS. 2018 Jul 12. PMID: 30005019.
      View in: PubMed
    13. Castillo-Mancilla JR, Morrow M, Boum Y, Byakwaga H, Haberer JE, Martin JN, Bangsberg D, Mawhinney S, Musinguzi N, Huang Y, Tracy RP, Burdo TH, Williams K, Muzzora C, Hunt PW, Siedner MJ. Brief Report: Higher ART Adherence Is Associated With Lower Systemic Inflammation in Treatment-Naive Ugandans Who Achieve Virologic Suppression. J Acquir Immune Defic Syndr. 2018 04 15; 77(5):507-513. PMID: 29346185.
      View in: PubMed
    14. Seifert SM, Castillo-Mancilla JR, Erlandson K, Morrow M, Gandhi M, Kuncze K, Horng H, Zheng JH, Bushman LR, Kiser JJ, MaWhinney S, Anderson PL. Brief Report: Adherence Biomarker Measurements in Older and Younger HIV-Infected Adults Receiving Tenofovir-Based Therapy. J Acquir Immune Defic Syndr. 2018 03 01; 77(3):295-298. PMID: 29189417.
      View in: PubMed
    15. Castillo-Mancilla JR, Haberer JE. Adherence Measurements in HIV: New Advancements in Pharmacologic Methods and Real-Time Monitoring. Curr HIV/AIDS Rep. 2018 02; 15(1):49-59. PMID: 29380227.
      View in: PubMed
    16. MacBrayne CE, Castillo-Mancilla J, Burton JR, MaWhinney S, Wagner CB, Micke K, Fey J, Huntley RT, Larson B, Bushman LR, Kiser JJ. Small increase in dolutegravir trough, but equivalent total dolutegravir exposure with simeprevir in HIV/HCV seronegative volunteers. J Antimicrob Chemother. 2018 Jan 01; 73(1):156-159. PMID: 29029135.
      View in: PubMed
    17. Castillo-Mancilla JR, Phillips AN, Neaton JD, Neuhaus J, Collins S, Mannheimer S, Pett S, Touzeau-Römer V, Polizzotto MN, Lundgren JD, Gardner EM. Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study. Open Forum Infect Dis. 2018 Jan; 5(1):ofx275. PMID: 29362724.
      View in: PubMed
    18. Anderson PL, Liu AY, Castillo-Mancilla JR, Gardner EM, Seifert SM, McHugh C, Wagner T, Campbell K, Morrow M, Ibrahim M, Buchbinder S, Bushman LR, Kiser JJ, MaWhinney S. Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots following Directly Observed Therapy. Antimicrob Agents Chemother. 2018 01; 62(1). PMID: 29038282.
      View in: PubMed
    19. Erlandson KM, Kitch D, Wester CW, Kalayjian RC, Overton ET, Castillo-Mancilla J, Koletar SL, Benson CA, Campbell TB, Robertson K, Lok JJ. The Impact of Statin and Angiotensin-Converting Enzyme Inhibitor/Angiotensin Receptor Blocker Therapy on Cognitive Function in Adults With Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 Nov 29; 65(12):2042-2049. PMID: 29020174.
      View in: PubMed
    20. Seifert SM, Castillo-Mancilla JR, Erlandson KM, Anderson PL. Inflammation and pharmacokinetics: potential implications for HIV-infection. Expert Opin Drug Metab Toxicol. 2017 Jun; 13(6):641-650. PMID: 28335648.
      View in: PubMed
    21. Chen X, Seifert SM, Castillo-Mancilla JR, Bushman LR, Zheng JH, Kiser JJ, MaWhinney S, Anderson PL. Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates. PLoS One. 2016; 11(11):e0165505. PMID: 27832147.
      View in: PubMed
    22. Castillo-Mancilla J, Seifert S, Campbell K, Coleman S, McAllister K, Zheng JH, Gardner EM, Liu A, Glidden DV, Grant R, Hosek S, Wilson CM, Bushman LR, MaWhinney S, Anderson PL. Emtricitabine-Triphosphate in Dried Blood Spots as a Marker of Recent Dosing. Antimicrob Agents Chemother. 2016 11; 60(11):6692-6697. PMID: 27572401.
      View in: PubMed
    23. Castillo-Mancilla JR, Brown TT, Erlandson KM, Palella FJ, Gardner EM, Macatangay BJ, Breen EC, Jacobson LP, Anderson PL, Wada NI. Suboptimal Adherence to Combination Antiretroviral Therapy Is Associated With Higher Levels of Inflammation Despite HIV Suppression. Clin Infect Dis. 2016 Dec 15; 63(12):1661-1667. PMID: 27660234.
      View in: PubMed
    24. Seifert SM, Chen X, Meditz AL, Castillo-Mancilla JR, Gardner EM, Predhomme JA, Clayton C, Austin G, Palmer BE, Zheng JH, Klein B, Kerr BJ, Guida LA, Rower C, Rower JE, Kiser JJ, Bushman LR, MaWhinney S, Anderson PL. Intracellular Tenofovir and Emtricitabine Anabolites in Genital, Rectal, and Blood Compartments from First Dose to Steady State. AIDS Res Hum Retroviruses. 2016 Oct/Nov; 32(10-11):981-991. PMID: 27526873.
      View in: PubMed
    25. Chen X, Castillo-Mancilla JR, Seifert SM, McAllister KB, Zheng JH, Bushman LR, MaWhinney S, Anderson PL. Analysis of the Endogenous Deoxynucleoside Triphosphate Pool in HIV-Positive and -Negative Individuals Receiving Tenofovir-Emtricitabine. Antimicrob Agents Chemother. 2016 09; 60(9):5387-92. PMID: 27353267.
      View in: PubMed
    26. Anderson PL, Reirden D, Castillo-Mancilla J. Pharmacologic Considerations for Preexposure Prophylaxis in Transgender Women. J Acquir Immune Defic Syndr. 2016 08 15; 72 Suppl 3:S230-4. PMID: 27429188.
      View in: PubMed
    27. Castillo-Mancilla JR, Aquilante CL, Wempe MF, Smeaton LM, Firnhaber C, LaRosa AM, Kumarasamy N, Andrade A, Baheti G, Fletcher CV, Campbell TB, Haas DW, MaWhinney S, Anderson PL. Pharmacogenetics of unboosted atazanavir in HIV-infected individuals in resource-limited settings: a sub-study of the AIDS Clinical Trials Group (ACTG) PEARLS study (NWCS 342). J Antimicrob Chemother. 2016 06; 71(6):1609-18. PMID: 26892777.
      View in: PubMed
    28. Zheng JH, Rower C, McAllister K, Castillo-Mancilla J, Klein B, Meditz A, Guida LA, Kiser JJ, Bushman LR, Anderson PL. Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. J Pharm Biomed Anal. 2016 Apr 15; 122:16-20. PMID: 26829517.
      View in: PubMed
    29. Chai PR, Castillo-Mancilla J, Buffkin E, Darling C, Rosen RK, Horvath KJ, Boudreaux ED, Robbins GK, Hibberd PL, Boyer EW. Utilizing an Ingestible Biosensor to Assess Real-Time Medication Adherence. J Med Toxicol. 2015 Dec; 11(4):439-44. PMID: 26245878.
      View in: PubMed
    30. Castillo-Mancilla JR, Meditz A, Wilson C, Zheng JH, Palmer BE, Lee EJ, Gardner EM, Seifert S, Kerr B, Bushman LR, MaWhinney S, Anderson PL. Reduced immune activation during tenofovir-emtricitabine therapy in HIV-negative individuals. J Acquir Immune Defic Syndr. 2015 Apr 15; 68(5):495-501. PMID: 25763783.
      View in: PubMed
    31. Heumann C, Cohn SE, Krishnan S, Castillo-Mancilla JR, Cespedes M, Floris-Moore M, Smith KY. Regional variation in HIV clinical trials participation in the United States. South Med J. 2015 Feb; 108(2):107-16. PMID: 25688896.
      View in: PubMed
    32. Castillo-Mancilla JR, Searls K, Caraway P, Zheng JH, Gardner EM, Predhomme J, Bushman LR, Anderson PL, Meditz AL. Short communication: Tenofovir diphosphate in dried blood spots as an objective measure of adherence in HIV-infected women. AIDS Res Hum Retroviruses. 2015 Apr; 31(4):428-32. PMID: 25328112.
      View in: PubMed
    33. Seifert SM, Glidden DV, Meditz AL, Castillo-Mancilla JR, Gardner EM, Predhomme JA, Rower C, Klein B, Kerr BJ, Guida LA, Zheng JH, Bushman LR, Anderson PL. Dose response for starting and stopping HIV preexposure prophylaxis for men who have sex with men. Clin Infect Dis. 2015 Mar 01; 60(5):804-10. PMID: 25409469.
      View in: PubMed
    34. Castillo-Mancilla JR, Cohn SE, Krishnan S, Cespedes M, Floris-Moore M, Schulte G, Pavlov G, Mildvan D, Smith KY. Minorities remain underrepresented in HIV/AIDS research despite access to clinical trials. HIV Clin Trials. 2014 Jan-Feb; 15(1):14-26. PMID: 24518211.
      View in: PubMed
    35. Zheng JH, Guida LA, Rower C, Castillo-Mancilla J, Meditz A, Klein B, Kerr BJ, Langness J, Bushman L, Kiser J, Anderson PL. Quantitation of tenofovir and emtricitabine in dried blood spots (DBS) with LC-MS/MS. J Pharm Biomed Anal. 2014 Jan; 88:144-51. PMID: 24055850.
      View in: PubMed
    36. Carten ML, Castillo-Mancilla JR, Allshouse AA, Johnson SC. Characteristics of foreign-born HIV infected individuals and differences by region of origin and gender. J Immigr Minor Health. 2013 Aug; 15(4):667-72. PMID: 22562621.
      View in: PubMed
    37. Henao-Martínez AF, Castillo-Mancilla JR, Barron MA, Nichol AC. Combination Antifungal Therapy in the Treatment of Scedosporium apiospermum Central Nervous System Infections. Case Rep Infect Dis. 2013; 2013:589490. PMID: 23738164.
      View in: PubMed
    38. Henao-Martínez AF, Castillo-Mancilla JR. The Hispanic HIV Epidemic. Curr Infect Dis Rep. 2013 Feb; 15(1):46-51. PMID: 23184612.
      View in: PubMed
    39. Henao-Martínez AF, González-Fontal GR, Castillo-Mancilla JR, Yang IV. Enterobacteriaceae bacteremias among cancer patients: an observational cohort study. Int J Infect Dis. 2013 Jun; 17(6):e374-8. PMID: 23313157.
      View in: PubMed
    40. Castillo-Mancilla JR, Zheng JH, Rower JE, Meditz A, Gardner EM, Predhomme J, Fernandez C, Langness J, Kiser JJ, Bushman LR, Anderson PL. Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure. AIDS Res Hum Retroviruses. 2013 Feb; 29(2):384-90. PMID: 22935078.
      View in: PubMed
    41. Kile DA, MaWhinney S, Aquilante CL, Rower JE, Castillo-Mancilla JR, Anderson PL. A population pharmacokinetic-pharmacogenetic analysis of atazanavir. AIDS Res Hum Retroviruses. 2012 Oct; 28(10):1227-34. PMID: 22394315.
      View in: PubMed
    42. Castillo-Mancilla JR, Campbell TB. Comparative effectiveness of efavirenz-based antiretroviral regimens in resource-limited settings. J Comp Eff Res. 2012 Mar; 1(2):157-170. PMID: 22707879.
      View in: PubMed
    43. Castillo-Mancilla J, Allshouse A, Collins C, Hastings-Tolsma M, Campbell TB, Mawhinney S. Differences in sexual risk behavior and HIV/AIDS risk factors among foreign-born and US-born Hispanic women. J Immigr Minor Health. 2012 Feb; 14(1):89-99. PMID: 21932002.
      View in: PubMed
    44. Castillo-Mancilla JR, Carten M. The need for a US registry of HIV in foreign-born people. Lancet Infect Dis. 2010 Jun; 10(6):370-1. PMID: 20510276.
      View in: PubMed
    45. Christensen JB, Vitko NP, Voskuil MI, Castillo-Mancilla JR. Implantable cardiac defibrillator pocket infection due to a previously undescribed Cupriavidus species. J Clin Microbiol. 2010 Jul; 48(7):2623-5. PMID: 20427695.
      View in: PubMed
    46. Castillo-Mancilla JR. The changing HIV epidemic in Mexico. JAMA. 2008 Dec 03; 300(21):2484. PMID: 19050189.
      View in: PubMed
    47. Panchal R, Avery R, Mehta AC, Castillo JR, Farver C, Aboussouan LS. A young man with a cough, an abnormal chest radiograph, and multiple skin lesions. Cleve Clin J Med. 2006 Mar; 73(3):273-80. PMID: 16548450.
      View in: PubMed
    48. Castillo JR, Kirchner E, Farver C, Calabrese LH. Cryoglobulinemic vasculitis and lymphocytic interstitial pneumonitis in a person with HIV infection. AIDS Read. 2005 May; 15(5):252-5. PMID: 15900636.
      View in: PubMed
    49. Castillo JR, Gordon SM, Arroliga AC. Cross-transmission in the intensive care unit: one piece of the puzzle. Crit Care Med. 2005 May; 33(5):1147-8. PMID: 15891354.
      View in: PubMed
    50. Castillo JR, Zagler A, Carrillo-Jimenez R, Hennekens CH. Brain natriuretic peptide: a potential marker for mortality in septic shock. Int J Infect Dis. 2004 Sep; 8(5):271-4. PMID: 15325595.
      View in: PubMed
    51. Volkow P, Jacquemin B, Vilar-Compte D, Castillo RJ. Contact with hospital syringes containing body fluids. Implications for medical waste management regulation. Salud Publica Mex. 2003 Mar-Apr; 45(2):120-2. PMID: 12736991.
      View in: PubMed
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