Paula L Hoffman
Title | Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-PHARM General Operations |
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Phone | 303/724-3628 |
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Research U01AA016654 (LASEK, AMY WOLVEN)Sep 30, 2006 - Aug 31, 2016 NIH RNA Interference Core Role: Co-Principal Investigator |
| U01AA016649 (HOFFMAN, PAULA)Sep 30, 2006 - Aug 31, 2014 NIH Regulation of alcohol consumption by chromatin modification Role: Principal Investigator |
| R01AA014021 (HOFFMAN, PAULA)Jan 15, 2005 - Dec 31, 2010 NIH Regulation of NMDA Receptor Localization by Ethanol Role: Principal Investigator |
| U01AA014101 (HOFFMAN, PAULA)Feb 1, 2003 - Jan 31, 2007 NIH Role of Glutamate Receptors in Excessive Ethanol Drinki* Role: Principal Investigator |
| R24AA013162 (TABAKOFF, BORIS)Aug 1, 2001 - Jul 31, 2022 NIH The Heritable Transcriptome and Alcoholism Role: Co-Principal Investigator |
| R13AG015097 (HOFFMAN, PAULA)Dec 1, 1997 - Nov 30, 1998 NIH ASN CONFERENCE--AGING AND NEURODEGENERATIVE DISEASE Role: Principal Investigator |
| R01AA009086 (HOFFMAN, PAULA)Feb 1, 1992 - Jan 31, 1996 NIH VASOPRESSIN AND ETHANOL TOLERANCE Role: Principal Investigator |
| R01AA009005 (HOFFMAN, PAULA)Aug 1, 1991 - Aug 31, 2002 NIH ETHANOL AND NMDA RECEPTOR FUNCTION Role: Principal Investigator |
| T32AA007464 (HOFFMAN, PAULA)Jan 1, 1986 - Jun 30, 2018 NIH Behavioral Pharmacogenetics of Drug and Alcohol Abuse Role: Principal Investigator |
Bibliographic
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Lusk R, Hoffman PL, Mahaffey S, Rosean S, Smith H, Silhavy J, Pravenec M, Tabakoff B, Saba LM. Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel. Front Genet. 2022; 13:821026. PMID: 35368676.
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Tanabe J, Neff S, Sutton B, Ellis S, Patten L, Brown MS, Hoffman PL, Tabakoff B, Burnham EL. Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder. Alcohol Clin Exp Res. 2021 05; 45(5):922-933. PMID: 33682145.
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Saba LM, Hoffman PL, Homanics GE, Mahaffey S, Daulatabad SV, Janga SC, Tabakoff B. A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats. Genes Brain Behav. 2021 02; 20(2):e12698. PMID: 32893479.
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Tabakoff B, Hoffman PL. Controlling the "Opioid Epidemic": A Novel Chemical Entity (NCE) to Reduce or Supplant Opiate Use for Chronic Pain. J Psychiatr Brain Sci. 2020; 5. PMID: 33117893.
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Tanabe J, Yamamoto DJ, Sutton B, Brown MS, Hoffman PL, Burnham EL, Glueck DH, Tabakoff B. Effects of Alcohol and Acetate on Cerebral Blood Flow: A Pilot Study. Alcohol Clin Exp Res. 2019 10; 43(10):2070-2078. PMID: 31386214.
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Tabakoff B, Smith H, Vanderlinden LA, Hoffman PL, Saba LM. Networking in Biology: The Hybrid Rat Diversity Panel. Methods Mol Biol. 2019; 2018:213-231. PMID: 31228159.
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Rudra P, Shi WJ, Russell P, Vestal B, Tabakoff B, Hoffman P, Kechris K, Saba L. Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse. BMC Genomics. 2018 Aug 29; 19(1):639. PMID: 30157779.
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Lusk R, Saba LM, Vanderlinden LA, Zidek V, Silhavy J, Pravenec M, Hoffman PL, Tabakoff B. Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. Alcohol Clin Exp Res. 2018 07; 42(7):1177-1191. PMID: 29689131.
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Hoffman PL, Saba LM, Vanderlinden LA, Tabakoff B. Voluntary exposure to a toxin: the genetic influence on ethanol consumption. Mamm Genome. 2018 02; 29(1-2):128-140. PMID: 29196862.
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Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B. Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes. Sci Rep. 2017 07 24; 7(1):6230. PMID: 28740086.
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Saba L, Hoffman P, Tabakoff B. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits. Methods Mol Biol. 2017; 1488:299-317. PMID: 27933531.
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Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84. PMID: 27401171.
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Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14. PMID: 27158117.
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Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. PMID: 26183165.
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Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff B. Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption. Mamm Genome. 2015 Feb; 26(1-2):43-56. PMID: 25559016.
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Ru Y, Kechris KJ, Tabakoff B, Hoffman P, Radcliffe RA, Bowler R, Mahaffey S, Rossi S, Calin GA, Bemis L, Theodorescu D. The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Res. 2014; 42(17):e133. PMID: 25063298.
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Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 2014 Jul; 38(7):2148-57. PMID: 24961585.
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Tabakoff B, Hoffman PL. The neurobiology of alcohol consumption and alcoholism: an integrative history. Pharmacol Biochem Behav. 2013 Nov 15; 113:20-37. PMID: 24141171.
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Vanderlinden LA, Saba LM, Kechris K, Miles MF, Hoffman PL, Tabakoff B. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS One. 2013; 8(7):e68878. PMID: 23894363.
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Procopio DO, Saba LM, Walter H, Lesch O, Skala K, Schlaff G, Vanderlinden L, Clapp P, Hoffman PL, Tabakoff B. Genetic markers of comorbid depression and alcoholism in women. Alcohol Clin Exp Res. 2013 Jun; 37(6):896-904. PMID: 23278386.
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Tabakoff B, Hoffman PL. Transducing emotionality: the role of adenylyl cyclases. Biol Psychiatry. 2012 Apr 01; 71(7):572-3. PMID: 22424112.
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Snell LD, Ramchandani VA, Saba L, Herion D, Heilig M, George DT, Pridzun L, Helander A, Schwandt ML, Phillips MJ, Hoffman PL, Tabakoff B. The biometric measurement of alcohol consumption. Alcohol Clin Exp Res. 2012 Feb; 36(2):332-41. PMID: 21895709.
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Desrivières S, Pronko SP, Lourdusamy A, Ducci F, Hoffman PL, Wodarz N, Ridinger M, Rietschel M, Zelenika D, Lathrop M, Schumann G, Tabakoff B. Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. Biol Psychiatry. 2011 Jun 01; 69(11):1100-8. PMID: 21481845.
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Bennett B, Saba LM, Hornbaker CK, Kechris KJ, Hoffman P, Tabakoff B. Genetical genomic analysis of complex phenotypes using the PhenoGen website. Behav Genet. 2011 Jul; 41(4):625-8. PMID: 21184165.
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Saba LM, Bennett B, Hoffman PL, Barcomb K, Ishii T, Kechris K, Tabakoff B. A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. Neuropharmacology. 2011 Jun; 60(7-8):1269-80. PMID: 21185315.
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Hoffman PL, Bennett B, Saba LM, Bhave SV, Carosone-Link PJ, Hornbaker CK, Kechris KJ, Williams RW, Tabakoff B. Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes. Addict Biol. 2011 Jul; 16(3):393-404. PMID: 21054686.
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Pronko SP, Saba LM, Hoffman PL, Tabakoff B. Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex. J Pharmacol Exp Ther. 2010 Jul; 334(1):44-52. PMID: 20363852.
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Clapp P, Gibson ES, Dell'acqua ML, Hoffman PL. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther. 2010 Mar; 332(3):720-9. PMID: 20008487.
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Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009 Oct 27; 7:70. PMID: 19874574.
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Tabakoff B, Saba L, Kechris K, Hu W, Bhave SV, Finn DA, Grahame NJ, Hoffman PL. The genomic determinants of alcohol preference in mice. Mamm Genome. 2008 May; 19(5):352-65. PMID: 18563486.
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Hu W, Saba L, Kechris K, Bhave SV, Hoffman PL, Tabakoff B. Genomic insights into acute alcohol tolerance. J Pharmacol Exp Ther. 2008 Sep; 326(3):792-800. PMID: 18550690.
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Saba L, Hoffman PL, Hornbaker C, Bhave SV, Tabakoff B. Expression quantitative trait loci and the PhenoGen database. Alcohol Res Health. 2008; 31(3):272-4. PMID: 23584876.
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Clapp P, Bhave SV, Hoffman PL. How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective. Alcohol Res Health. 2008; 31(4):310-39. PMID: 20729980.
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Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B. The PhenoGen informatics website: tools for analyses of complex traits. BMC Genet. 2007 Aug 30; 8:59. PMID: 17760997.
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Hines LM, Hoffman PL, Bhave S, Saba L, Kaiser A, Snell L, Goncharov I, LeGault L, Dongier M, Grant B, Pronko S, Martinez L, Yoshimura M, Tabakoff B. A sex-specific role of type VII adenylyl cyclase in depression. J Neurosci. 2006 Nov 29; 26(48):12609-19. PMID: 17135423.
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Bhave SV, Hoffman PL, Lassen N, Vasiliou V, Saba L, Deitrich RA, Tabakoff B. Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice. Alcohol Clin Exp Res. 2006 Oct; 30(10):1659-69. PMID: 17010133.
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Saba L, Bhave SV, Grahame N, Bice P, Lapadat R, Belknap J, Hoffman PL, Tabakoff B. Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm Genome. 2006 Jun; 17(6):669-88. PMID: 16783646.
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Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6368-73. PMID: 16618939.
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Sikela JM, Maclaren EJ, Kim Y, Karimpour-Fard A, Cai WW, Pollack J, Hitzemann R, Belknap J, McWeeney S, Kerns RT, Downing C, Johnson TE, Grant KJ, Tabakoff B, Hoffman P, Wu CC, Miles MF. DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res. 2006 Apr; 30(4):700-8. PMID: 16573589.
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Wurst FM, Tabakoff B, Alling C, Aradottir S, Wiesbeck GA, Müller-Spahn F, Pragst F, Johnson B, Javors M, Ait-Daoud N, Skipper GE, Spies C, Nachbar Y, Lesch O, Ramskogler K, Hartmann S, Wolfersdorf M, Dresen S, Weinmann W, Hines L, Kaiser A, Lu RB, Ko HC, Huang SY, Wang TJ, Wu YS, Whitfield J, Snell LD, Wu C, Hoffman PL. World Health Organization/International Society for Biomedical Research on Alcoholism study on state and trait markers of alcohol use and dependence: back to the future. Alcohol Clin Exp Res. 2005 Jul; 29(7):1268-75. PMID: 16088983.
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Hoffman P, Tabakoff B. Gene expression in animals with different acute responses to ethanol. Addict Biol. 2005 Mar; 10(1):63-9. PMID: 15849020.
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Donohue T, Hoffman PL, Tabakoff B. Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain. Alcohol Clin Exp Res. 2005 Mar; 29(3):310-6. PMID: 15770104.
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Bhave SV, Hoffman PL. Phosphatidylinositol 3'-OH kinase and protein kinase A pathways mediate the anti-apoptotic effect of pituitary adenylyl cyclase-activating polypeptide in cultured cerebellar granule neurons: modulation by ethanol. J Neurochem. 2004 Jan; 88(2):359-69. PMID: 14690524.
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Tabakoff B, Bhave SV, Hoffman PL. Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J Neurosci. 2003 Jun 01; 23(11):4491-8. PMID: 12805289.
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Hoffman PL, Miles M, Edenberg HJ, Sommer W, Tabakoff B, Wehner JM, Lewohl J. Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference. Alcohol Clin Exp Res. 2003 Feb; 27(2):155-68. PMID: 12605065.
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Hoffman PL. NMDA receptors in alcoholism. Int Rev Neurobiol. 2003; 56:35-82. PMID: 14696310.
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Hoffman PL, Glanz J, Tabakoff B. Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence. Alcohol Clin Exp Res. 2002 Jul; 26(7):1078-87. PMID: 12170118.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2002 | 1 | 2003 | 3 | 2004 | 1 | 2005 | 3 | 2006 | 5 | 2007 | 1 | 2008 | 4 | 2009 | 2 | 2010 | 4 | 2011 | 2 | 2012 | 2 | 2013 | 2 | 2014 | 2 | 2015 | 2 | 2016 | 2 | 2017 | 3 | 2018 | 2 | 2019 | 2 | 2020 | 2 | 2021 | 1 | 2022 | 1 |
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