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Paula L Hoffman

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology
Phone303/724-3628

    Collapse Research 
    Collapse research activities and funding
    T32AA007464     (HOFFMAN, PAULA)Jan 1, 1986 - Jun 30, 2017
    NIH/NIAAA
    Behavioral Pharmacogenetics of Drug and Alcohol Abuse
    Role: Principal Investigator
    R01AA009005     (HOFFMAN, PAULA)Aug 1, 1991 - Aug 31, 2002
    NIH/NIAAA
    ETHANOL AND NMDA RECEPTOR FUNCTION
    Role: Principal Investigator
    R01AA009086     (HOFFMAN, PAULA)Feb 1, 1992 - Jan 31, 1996
    NIH/NIAAA
    VASOPRESSIN AND ETHANOL TOLERANCE
    Role: Principal Investigator
    R13AG015097     (HOFFMAN, PAULA)Dec 1, 1997 - Nov 30, 1998
    NIH/NIA
    ASN CONFERENCE--AGING AND NEURODEGENERATIVE DISEASE
    Role: Principal Investigator
    R24AA013162     (TABAKOFF, BORIS)Aug 1, 2001 - Jul 31, 2022
    NIH/NIAAA
    The Heritable Transcriptome and Alcoholism
    Role: Co-Principal Investigator
    U01AA014101     (HOFFMAN, PAULA)Feb 1, 2003 - Jan 31, 2007
    NIH/NIAAA
    Role of Glutamate Receptors in Excessive Ethanol Drinki*
    Role: Principal Investigator
    R01AA014021     (HOFFMAN, PAULA)Jan 15, 2005 - Dec 31, 2010
    NIH/NIAAA
    Regulation of NMDA Receptor Localization by Ethanol
    Role: Principal Investigator
    U01AA016649     (HOFFMAN, PAULA)Sep 30, 2006 - Aug 31, 2014
    NIH/NIAAA
    Regulation of alcohol consumption by chromatin modification
    Role: Principal Investigator
    U01AA016654     (LASEK, AMY WOLVEN)Sep 30, 2006 - Aug 31, 2016
    NIH/NIAAA
    RNA Interference Core
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Rudra P, Shi WJ, Russell P, Vestal B, Tabakoff B, Hoffman P, Kechris K, Saba L. Predictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse. BMC Genomics. 2018 Aug 29; 19(1):639. PMID: 30157779.
      View in: PubMed
    2. Lusk R, Saba LM, Vanderlinden LA, Zidek V, Silhavy J, Pravenec M, Hoffman PL, Tabakoff B. Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism. Alcohol Clin Exp Res. 2018 Jul; 42(7):1177-1191. PMID: 29689131.
      View in: PubMed
    3. Hoffman PL, Saba LM, Vanderlinden LA, Tabakoff B. Voluntary exposure to a toxin: the genetic influence on ethanol consumption. Mamm Genome. 2018 02; 29(1-2):128-140. PMID: 29196862.
      View in: PubMed
    4. Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B. Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes. Sci Rep. 2017 Jul 24; 7(1):6230. PMID: 28740086.
      View in: PubMed
    5. Saba L, Hoffman P, Tabakoff B. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits. Methods Mol Biol. 2017; 1488:299-317. PMID: 27933531.
      View in: PubMed
    6. Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84. PMID: 27401171; PMCID: PMC5002042.
      View in: PubMed, PubMed Central
    7. Tabakoff B, Ren W, Vanderlinden L, Snell LD, Matheson CJ, Wang ZJ, Levinson R, Smothers CT, Woodward JJ, Honse Y, Lovinger D, Rush AM, Sather WA, Gustafson DL, Hoffman PL. A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2016 Aug 05; 784:1-14. PMID: 27158117; PMCID: PMC5024723 [Available on 08/05/17].
      View in: PubMed, PubMed Central
    8. Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome--its use in identifying networks predisposing alcohol consumption. FEBS J. 2015 Sep; 282(18):3556-78. PMID: 26183165.
      View in: PubMed
    9. Vanderlinden LA, Saba LM, Bennett B, Hoffman PL, Tabakoff B. Influence of sex on genetic regulation of "drinking in the dark" alcohol consumption. Mamm Genome. 2015 Feb; 26(1-2):43-56. PMID: 25559016; PMCID: PMC4306387.
      View in: PubMed, PubMed Central
    10. Ru Y, Kechris KJ, Tabakoff B, Hoffman P, Radcliffe RA, Bowler R, Mahaffey S, Rossi S, Calin GA, Bemis L, Theodorescu D. The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Res. 2014; 42(17):e133. PMID: 25063298; PMCID: PMC4176155.
      View in: PubMed, PubMed Central
    11. Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcohol Clin Exp Res. 2014 Jul; 38(7):2148-57. PMID: 24961585; PMCID: PMC4142977.
      View in: PubMed, PubMed Central
    12. Tabakoff B, Hoffman PL. The neurobiology of alcohol consumption and alcoholism: an integrative history. Pharmacol Biochem Behav. 2013 Nov 15; 113:20-37. PMID: 24141171; PMCID: PMC3867277.
      View in: PubMed, PubMed Central
    13. Vanderlinden LA, Saba LM, Kechris K, Miles MF, Hoffman PL, Tabakoff B. Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. PLoS One. 2013; 8(7):e68878. PMID: 23894363; PMCID: PMC3720886.
      View in: PubMed, PubMed Central
    14. Procopio DO, Saba LM, Walter H, Lesch O, Skala K, Schlaff G, Vanderlinden L, Clapp P, Hoffman PL, Tabakoff B. Genetic markers of comorbid depression and alcoholism in women. Alcohol Clin Exp Res. 2013 Jun; 37(6):896-904. PMID: 23278386; PMCID: PMC3620932.
      View in: PubMed, PubMed Central
    15. Tabakoff B, Hoffman PL. Transducing emotionality: the role of adenylyl cyclases. Biol Psychiatry. 2012 Apr 01; 71(7):572-3. PMID: 22424112.
      View in: PubMed
    16. Snell LD, Ramchandani VA, Saba L, Herion D, Heilig M, George DT, Pridzun L, Helander A, Schwandt ML, Phillips MJ, Hoffman PL, Tabakoff B. The biometric measurement of alcohol consumption. Alcohol Clin Exp Res. 2012 Feb; 36(2):332-41. PMID: 21895709.
      View in: PubMed
    17. Desrivières S, Pronko SP, Lourdusamy A, Ducci F, Hoffman PL, Wodarz N, Ridinger M, Rietschel M, Zelenika D, Lathrop M, Schumann G, Tabakoff B. Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. Biol Psychiatry. 2011 Jun 01; 69(11):1100-8. PMID: 21481845; PMCID: PMC3094753.
      View in: PubMed, PubMed Central
    18. Bennett B, Saba LM, Hornbaker CK, Kechris KJ, Hoffman P, Tabakoff B. Genetical genomic analysis of complex phenotypes using the PhenoGen website. Behav Genet. 2011 Jul; 41(4):625-8. PMID: 21184165; PMCID: PMC3121939.
      View in: PubMed, PubMed Central
    19. Saba LM, Bennett B, Hoffman PL, Barcomb K, Ishii T, Kechris K, Tabakoff B. A systems genetic analysis of alcohol drinking by mice, rats and men: influence of brain GABAergic transmission. Neuropharmacology. 2011 Jun; 60(7-8):1269-80. PMID: 21185315; PMCID: PMC3079014.
      View in: PubMed, PubMed Central
    20. Hoffman PL, Bennett B, Saba LM, Bhave SV, Carosone-Link PJ, Hornbaker CK, Kechris KJ, Williams RW, Tabakoff B. Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes. Addict Biol. 2011 Jul; 16(3):393-404. PMID: 21054686; PMCID: PMC3115429.
      View in: PubMed, PubMed Central
    21. Pronko SP, Saba LM, Hoffman PL, Tabakoff B. Type 7 adenylyl cyclase-mediated hypothalamic-pituitary-adrenal axis responsiveness: influence of ethanol and sex. J Pharmacol Exp Ther. 2010 Jul; 334(1):44-52. PMID: 20363852; PMCID: PMC2912051.
      View in: PubMed, PubMed Central
    22. Clapp P, Gibson ES, Dell'acqua ML, Hoffman PL. Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. J Pharmacol Exp Ther. 2010 Mar; 332(3):720-9. PMID: 20008487; PMCID: PMC2835432.
      View in: PubMed, PubMed Central
    23. Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biol. 2009 Oct 27; 7:70. PMID: 19874574; PMCID: PMC2777866.
      View in: PubMed, PubMed Central
    24. Tabakoff B, Saba L, Kechris K, Hu W, Bhave SV, Finn DA, Grahame NJ, Hoffman PL. The genomic determinants of alcohol preference in mice. Mamm Genome. 2008 May; 19(5):352-65. PMID: 18563486; PMCID: PMC2583933.
      View in: PubMed, PubMed Central
    25. Hu W, Saba L, Kechris K, Bhave SV, Hoffman PL, Tabakoff B. Genomic insights into acute alcohol tolerance. J Pharmacol Exp Ther. 2008 Sep; 326(3):792-800. PMID: 18550690; PMCID: PMC2574863.
      View in: PubMed, PubMed Central
    26. Saba L, Hoffman PL, Hornbaker C, Bhave SV, Tabakoff B. Expression quantitative trait loci and the PhenoGen database. Alcohol Res Health. 2008; 31(3):272-4. PMID: 23584876; PMCID: PMC3860474.
      View in: PubMed, PubMed Central
    27. Clapp P, Bhave SV, Hoffman PL. How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective. Alcohol Res Health. 2008; 31(4):310-39. PMID: 20729980.
      View in: PubMed
    28. Bhave SV, Hornbaker C, Phang TL, Saba L, Lapadat R, Kechris K, Gaydos J, McGoldrick D, Dolbey A, Leach S, Soriano B, Ellington A, Ellington E, Jones K, Mangion J, Belknap JK, Williams RW, Hunter LE, Hoffman PL, Tabakoff B. The PhenoGen informatics website: tools for analyses of complex traits. BMC Genet. 2007 Aug 30; 8:59. PMID: 17760997; PMCID: PMC2034588.
      View in: PubMed, PubMed Central
    29. Hines LM, Hoffman PL, Bhave S, Saba L, Kaiser A, Snell L, Goncharov I, LeGault L, Dongier M, Grant B, Pronko S, Martinez L, Yoshimura M, Tabakoff B. A sex-specific role of type VII adenylyl cyclase in depression. J Neurosci. 2006 Nov 29; 26(48):12609-19. PMID: 17135423.
      View in: PubMed
    30. Bhave SV, Hoffman PL, Lassen N, Vasiliou V, Saba L, Deitrich RA, Tabakoff B. Gene array profiles of alcohol and aldehyde metabolizing enzymes in brains of C57BL/6 and DBA/2 mice. Alcohol Clin Exp Res. 2006 Oct; 30(10):1659-69. PMID: 17010133.
      View in: PubMed
    31. Saba L, Bhave SV, Grahame N, Bice P, Lapadat R, Belknap J, Hoffman PL, Tabakoff B. Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm Genome. 2006 Jun; 17(6):669-88. PMID: 16783646.
      View in: PubMed
    32. Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6368-73. PMID: 16618939; PMCID: PMC1458884.
      View in: PubMed, PubMed Central
    33. Sikela JM, Maclaren EJ, Kim Y, Karimpour-Fard A, Cai WW, Pollack J, Hitzemann R, Belknap J, McWeeney S, Kerns RT, Downing C, Johnson TE, Grant KJ, Tabakoff B, Hoffman P, Wu CC, Miles MF. DNA microarray and proteomic strategies for understanding alcohol action. Alcohol Clin Exp Res. 2006 Apr; 30(4):700-8. PMID: 16573589; PMCID: PMC2709534.
      View in: PubMed, PubMed Central
    34. Wurst FM, Tabakoff B, Alling C, Aradottir S, Wiesbeck GA, Müller-Spahn F, Pragst F, Johnson B, Javors M, Ait-Daoud N, Skipper GE, Spies C, Nachbar Y, Lesch O, Ramskogler K, Hartmann S, Wolfersdorf M, Dresen S, Weinmann W, Hines L, Kaiser A, Lu RB, Ko HC, Huang SY, Wang TJ, Wu YS, Whitfield J, Snell LD, Wu C, Hoffman PL. World Health Organization/International Society for Biomedical Research on Alcoholism study on state and trait markers of alcohol use and dependence: back to the future. Alcohol Clin Exp Res. 2005 Jul; 29(7):1268-75. PMID: 16088983.
      View in: PubMed
    35. Hoffman P, Tabakoff B. Gene expression in animals with different acute responses to ethanol. Addict Biol. 2005 Mar; 10(1):63-9. PMID: 15849020.
      View in: PubMed
    36. Donohue T, Hoffman PL, Tabakoff B. Effect of ethanol on DARPP-32 phosphorylation in transgenic mice that express human type VII adenylyl cyclase in brain. Alcohol Clin Exp Res. 2005 Mar; 29(3):310-6. PMID: 15770104.
      View in: PubMed
    37. Bhave SV, Hoffman PL. Phosphatidylinositol 3'-OH kinase and protein kinase A pathways mediate the anti-apoptotic effect of pituitary adenylyl cyclase-activating polypeptide in cultured cerebellar granule neurons: modulation by ethanol. J Neurochem. 2004 Jan; 88(2):359-69. PMID: 14690524.
      View in: PubMed
    38. Tabakoff B, Bhave SV, Hoffman PL. Selective breeding, quantitative trait locus analysis, and gene arrays identify candidate genes for complex drug-related behaviors. J Neurosci. 2003 Jun 01; 23(11):4491-8. PMID: 12805289.
      View in: PubMed
    39. Hoffman PL, Miles M, Edenberg HJ, Sommer W, Tabakoff B, Wehner JM, Lewohl J. Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference. Alcohol Clin Exp Res. 2003 Feb; 27(2):155-68. PMID: 12605065.
      View in: PubMed
    40. Hoffman PL. NMDA receptors in alcoholism. Int Rev Neurobiol. 2003; 56:35-82. PMID: 14696310.
      View in: PubMed
    41. Hoffman PL, Glanz J, Tabakoff B. Platelet adenylyl cyclase activity as a state or trait marker in alcohol dependence: results of the WHO/ISBRA Study on State and Trait Markers of Alcohol Use and Dependence. Alcohol Clin Exp Res. 2002 Jul; 26(7):1078-87. PMID: 12170118.
      View in: PubMed
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