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Yosef Refaeli

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Dermatology
Phone303/724-0966

    Collapse Research 
    Collapse research activities and funding
    R01CA117802     (REFAELI, YOSEF)Jun 19, 2006 - Apr 30, 2011
    NIH/NCI
    MYC-induced breach of B-cell anergy in AIDS-related NHLs
    Role: Principal Investigator

    R43AI078563     (TURNER, BRIAN CURTIS)Aug 15, 2008 - Jul 31, 2010
    NIH/NIAID
    Rapid Generation of Human Therapuetic Antibodies Against Influenza
    Role: Co-Principal Investigator

    R43HL091740     (TURNER, BRIAN CURTIS)Sep 19, 2008 - Sep 18, 2010
    NIH/NHLBI
    Generating HIV resistant cells from conditionally transformed HSC cell lines
    Role: Co-Principal Investigator

    R44HL091740     (TURNER, BRIAN CURTIS)Sep 19, 2008 - Jan 31, 2013
    NIH/NHLBI
    Generation of HIV resistant cells from protein transduced hematopoetic stem cell
    Role: Co-Principal Investigator

    R43AI089307     (REFAELI, YOSEF)Mar 1, 2010 - Aug 31, 2011
    NIH/NIAID
    Molecular based strategies to generate protective immune responses to HIV-1
    Role: Principal Investigator

    R43HL104760     (REFAELI, YOSEF)Sep 1, 2010 - Feb 28, 2012
    NIH/NHLBI
    Large-scale generation of human red blood cells for transfusion therapy
    Role: Principal Investigator

    R01AR060388     (ROOP, DENNIS)Sep 1, 2011 - Jun 30, 2016
    NIH/NIAMS
    The consequences of loricrin deficiency on epidermal barrier function
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Morton JJ, Bird G, Refaeli Y, Jimeno A. Humanized Mouse Xenograft Models: Narrowing the Tumor-Microenvironment Gap. Cancer Res. 2016 Nov 01; 76(21):6153-6158. PMID: 27587540.
      View in: PubMed
    2. Morton JJ, Bird G, Keysar SB, Astling DP, Lyons TR, Anderson RT, Glogowska MJ, Estes P, Eagles JR, Le PN, Gan G, McGettigan B, Fernandez P, Padilla-Just N, Varella-Garcia M, Song JI, Bowles DW, Schedin P, Tan AC, Roop DR, Wang XJ, Refaeli Y, Jimeno A. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene. 2016 Jan 21; 35(3):290-300. PMID: 25893296; PMCID: PMC4613815.
    3. Bird GA, Polsky A, Estes P, Hanlon T, Hamilton H, Morton JJ, Gutman J, Jimeno A, Turner BC, Refaeli Y. Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins. PLoS One. 2014; 9(8):e105525. PMID: 25170611; PMCID: PMC4149411.
    4. Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind JS, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8. PMID: 23475202; PMCID: PMC3780964.
    5. Bjordahl RL, Gapin L, Marrack P, Refaeli Y. iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. PLoS One. 2012; 7(8):e42635. PMID: 22880059; PMCID: PMC3413636.
    6. Young RM, Polsky A, Refaeli Y. TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas. Blood. 2009 Dec 03; 114(24):5016-23. PMID: 19755676; PMCID: PMC2788975.
    7. Refaeli Y, Bhoumik A, Roop DR, Ronai ZA. Melanoma-initiating cells: a compass needed. EMBO Rep. 2009 Sep; 10(9):965-72. PMID: 19680286; PMCID: PMC2750051.
    8. Clarke RL, Thiemann S, Refaeli Y, Werlen G, Potter TA. A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction. Eur J Immunol. 2009 Jun; 39(6):1619-31. PMID: 19449311; PMCID: PMC3049189.
    9. Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Retraction. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity. 2009 Apr 17; 30(4):611. PMID: 19382300.
      View in: PubMed
    10. Van Parijs L, Refaeli Y, Abbas AK, Baltimore D. Retraction. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes. Immunity. 2009 Apr 17; 30(4):612. PMID: 19378495.
      View in: PubMed
    11. Zemans RL, Briones N, Young SK, Malcolm KC, Refaeli Y, Downey GP, Worthen GS. A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction. J Immunol Methods. 2009 Jan 30; 340(2):102-15. PMID: 19010330; PMCID: PMC2633587.
    12. Young RM, Hardy IR, Clarke RL, Lundy N, Pine P, Turner BC, Potter TA, Refaeli Y. Mouse models of non-Hodgkin lymphoma reveal Syk as an important therapeutic target. Blood. 2009 Mar 12; 113(11):2508-16. PMID: 18981293; PMCID: PMC2947310.
    13. Young RM, Turner BC, Refaeli Y. B-cell receptor signaling in the genesis and maintenance of B-cell lymphoma. Future Oncol. 2008 Oct; 4(5):591-4. PMID: 18922114; PMCID: PMC2575750.
    14. Refaeli Y, Young RM, Turner BC, Duda J, Field KA, Bishop JM. The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas. PLoS Biol. 2008 Jun 24; 6(6):e152. PMID: 18578569; PMCID: PMC2435152.
    15. Field KA, Charoenthongtrakul S, Bishop JM, Refaeli Y. Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas. Mol Cancer. 2008 May 19; 7:39. PMID: 18489761; PMCID: PMC2409375.
    16. Turner BC, Eves T, Refaeli Y. Small-molecule inhibitors of Bcl-2 family proteins are able to induce tumor regression in a mouse model of pre-B-cell acute lymphocytic lymphoma. DNA Cell Biol. 2008 Mar; 27(3):133-42. PMID: 18163880.
      View in: PubMed
    17. Jin L, Stolpa JC, Young RM, Pugh-Bernard AE, Refaeli Y, Cambier JC. MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death. Immunol Lett. 2008 Mar 15; 116(2):184-94. PMID: 18194817; PMCID: PMC2424217.
    18. Jorgensen TN, McKee A, Wang M, Kushnir E, White J, Refaeli Y, Kappler JW, Marrack P. Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol. 2007 Sep 15; 179(6):3417-24. PMID: 17785775.
      View in: PubMed
    19. Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, Moss T, Refaeli Y, Bowler R, Wenzel SE, Chen Z, Zdunek J, Breed R, Young R, Allaire E, Martin RJ. Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation. J Immunol. 2007 Sep 15; 179(6):3995-4002. PMID: 17785838.
      View in: PubMed
    20. Refaeli Y, Field KA, Turner BC, Trumpp A, Bishop JM. The protooncogene MYC can break B cell tolerance. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):4097-102. PMID: 15753301; PMCID: PMC552974.
    21. Refaeli Y, Van Parijs L, Alexander SI, Abbas AK. Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med. 2002 Oct 07; 196(7):999-1005. PMID: 12370261; PMCID: PMC2194022.
    22. Kelly E, Won A, Refaeli Y, Van Parijs L. IL-2 and related cytokines can promote T cell survival by activating AKT. J Immunol. 2002 Jan 15; 168(2):597-603. PMID: 11777951.
      View in: PubMed
    23. Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Murphy M, Martin GR, Bishop JM. c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature. 2001 Dec 13; 414(6865):768-73. PMID: 11742404.
      View in: PubMed
    24. Lois C, Refaeli Y, Qin XF, Van Parijs L. Retroviruses as tools to study the immune system. Curr Opin Immunol. 2001 Aug; 13(4):496-504. PMID: 11498308.
      View in: PubMed
    25. Buchholz F, Refaeli Y, Trumpp A, Bishop JM. Inducible chromosomal translocation of AML1 and ETO genes through Cre/loxP-mediated recombination in the mouse. EMBO Rep. 2000 Aug; 1(2):133-9. PMID: 11265752; PMCID: PMC1084259.
    26. Dickey C, Ziegner U, Agadjanyan MG, Srikantan V, Refaeli Y, Prabhu A, Sato A, Williams WV, Weiner DB, Ugen KE. Murine monoclonal antibodies biologically active against the amino region of HIV-1 gp120: isolation and characterization. DNA Cell Biol. 2000 Apr; 19(4):243-52. PMID: 10798448.
      View in: PubMed
    27. Van Parijs L, Refaeli Y, Abbas AK, Baltimore D. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes. Immunity. 1999 Dec; 11(6):763-70. PMID: 10626898.
      View in: PubMed
    28. Van Parijs L, Refaeli Y, Lord JD, Nelson BH, Abbas AK, Baltimore D. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity. 1999 Sep; 11(3):281-8. PMID: 10514006.
      View in: PubMed
    29. Refaeli Y, Van Parijs L, Abbas AK. Genetic models of abnormal apoptosis in lymphocytes. Immunol Rev. 1999 Jun; 169:273-82. PMID: 10450524.
      View in: PubMed
    30. Refaeli Y, Abbas AK. Role of cytokines in autoimmunity. Eur Cytokine Netw. 1998 Sep; 9(3 Suppl):81-2. PMID: 9831192.
      View in: PubMed
    31. Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity. 1998 May; 8(5):615-23. PMID: 9620682.
      View in: PubMed
    32. Boyer JD, Ugen KE, Wang B, Agadjanyan M, Gilbert L, Bagarazzi ML, Chattergoon M, Frost P, Javadian A, Williams WV, Refaeli Y, Ciccarelli RB, McCallus D, Coney L, Weiner DB. Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat Med. 1997 May; 3(5):526-32. PMID: 9142121.
      View in: PubMed
    33. Wang B, Ugen KE, Srikantan V, Agadjanyan MG, Dang K, Refaeli Y, Sato AI, Boyer J, Williams WV, Weiner DB. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1993 May 01; 90(9):4156-60. PMID: 8483929; PMCID: PMC46465.
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