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Carol Aherne

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology
Phone303/724-5819

    Collapse Biography 
    Collapse awards and honors
    2013 - 2018NIH K01 Mentored Scientist Award, NIDDK
    2013 - 2016Crohn's and Colitis Foundation of America Career Development Award
    2013 - 2015American Gastroenterological Association President's Research Scholar
    2010 - 2013Crohn's and Colitis Foundation of America Research Fellow

    Collapse Research 
    Collapse research activities and funding
    K01DK099485     (AHERNE, CAROL)Sep 1, 2013 - Aug 31, 2018
    NIH/NIDDK
    Epithelial-released netrin-1 controls CD4 effector T cell trafficking during chro
    Role: Principal Investigator

    R01DK111856     (AHERNE, CAROL)Jan 13, 2018 - Dec 31, 2022
    NIH/NIDDK
    microRNA-dependent regulation of intestinal T-cells²
    Role: Principal Investigator

    R03DK114545     (AHERNE, CAROL)Apr 1, 2018 - Mar 31, 2020
    NIH/NIDDK
    Epithelial A2B-mediated Muc5ac expression protects the intestinal barrier during inflammation.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Aherne CM, Collins CB, Rapp CR, Olli KE, Perrenoud L, Jedlicka P, Bowser JL, Mills TW, Karmouty-Quintana H, Blackburn MR, Eltzschig HK. Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation. JCI Insight. 2018 10 18; 3(20). PMID: 30333323.
      View in: PubMed
    2. Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019 01; 12(1):200-211. PMID: 30327532.
      View in: PubMed
    3. Leinwand KL, Jones AA, Huang RH, Jedlicka P, Kao DJ, de Zoeten EF, Ghosh S, Moaddel R, Wehkamp J, Ostaff MJ, Bader J, Aherne CM, Collins CB. Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease. J Crohns Colitis. 2017 Oct 27; 11(11):1369-1380. PMID: 28981653.
      View in: PubMed
    4. Belkind-Gerson J, Graham HK, Reynolds J, Hotta R, Nagy N, Cheng L, Kamionek M, Shi HN, Aherne CM, Goldstein AM. Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells. Sci Rep. 2017 05 31; 7(1):2525. PMID: 28566702.
      View in: PubMed
    5. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May; 8(3):699. PMID: 25943416.
      View in: PubMed
    6. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38. PMID: 25850656.
      View in: PubMed
    7. Collins CB, Strassheim D, Aherne CM, Yeckes AR, Jedlicka P, de Zoeten EF. Targeted inhibition of heat shock protein 90 suppresses tumor necrosis factor-a and ameliorates murine intestinal inflammation. Inflamm Bowel Dis. 2014 Apr; 20(4):685-94. PMID: 24552830.
      View in: PubMed
    8. Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73. PMID: 23835442.
      View in: PubMed
    9. Aherne CM, Collins CB, Eltzschig HK. Netrin-1 guides inflammatory cell migration to control mucosal immune responses during intestinal inflammation. Tissue Barriers. 2013 Apr 01; 1(2):e24957. PMID: 24665394.
      View in: PubMed
    10. Collins CB, Aherne CM, Yeckes A, Pound K, Eltzschig HK, Jedlicka P, de Zoeten EF. Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function. Mucosal Immunol. 2013 Sep; 6(5):960-71. PMID: 23321985.
      View in: PubMed
    11. Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul; 6(4):762-75. PMID: 23187315.
      View in: PubMed
    12. Mohan HM, Aherne CM, Rogers AC, Baird AW, Winter DC, Murphy EP. Molecular pathways: the role of NR4A orphan nuclear receptors in cancer. Clin Cancer Res. 2012 Jun 15; 18(12):3223-8. PMID: 22566377.
      View in: PubMed
    13. Collins CB, Aherne CM, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. Flt3 ligand expands CD103? dendritic cells and FoxP3? T regulatory cells, and attenuates Crohn's-like murine ileitis. Gut. 2012 Aug; 61(8):1154-62. PMID: 22068168.
      View in: PubMed
    14. Collins CB, Aherne CM, Kominsky D, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells. Gastroenterology. 2011 Nov; 141(5):1821-31. PMID: 22027263.
      View in: PubMed
    15. Aherne CM, Collins CB, Masterson JC, Tizzano M, Boyle TA, Westrich JA, Parnes JA, Furuta GT, Rivera-Nieves J, Eltzschig HK. Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis. Gut. 2012 May; 61(5):695-705. PMID: 21813473.
      View in: PubMed
    16. Grenz A, Dalton JH, Bauerle JD, Badulak A, Ridyard D, Gandjeva A, Aherne CM, Brodsky KS, Kim JH, Tuder RM, Eltzschig HK. Partial netrin-1 deficiency aggravates acute kidney injury. PLoS One. 2011; 6(5):e14812. PMID: 21625583.
      View in: PubMed
    17. Glover LE, Irizarry K, Scully M, Campbell EL, Bowers BE, Aherne CM, Kominsky DJ, MacManus CF, Colgan SP. IFN-? attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1ß. J Immunol. 2011 Feb 01; 186(3):1790-8. PMID: 21199896.
      View in: PubMed
    18. Aherne CM, Kewley EM, Eltzschig HK. The resurgence of A2B adenosine receptor signaling. Biochim Biophys Acta. 2011 May; 1808(5):1329-39. PMID: 20546702.
      View in: PubMed
    19. Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS, Murphy EP. Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct; 46(16):3345-57. PMID: 19732956.
      View in: PubMed
    20. Breathnach RM, Baker KP, Quinn PJ, McGeady TA, Aherne CM, Jones BR. Clinical, immunological and histopathological findings in a subpopulation of dogs with pododermatitis. Vet Dermatol. 2005 Dec; 16(6):364-72. PMID: 16359303.
      View in: PubMed
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