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Eoin Neil McNamee

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse awards and honors
    2011 - 2013Research Fellowship, Crohn's & Colitis Foundation of America
    2013 - 2016Career Development Award, Crohn's & Colitis Foundation of America
    2016 - 2019Senior Research Award, Crohn's & Colitis Foundation of America

    Collapse Research 
    Collapse research activities and funding
    R01DK111856     (MCNAMEE, EOIN NEIL)Jan 13, 2018 - Dec 31, 2022
    microRNA-dependent regulation of intestinal T-cells²
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P, Brodsky KS, Gerich ME, Mack M, Robertson AAB, Cooper MA, Furuta GT, Dinarello CA, O'Neill LA, Eltzschig HK, Masters SL, McNamee EN. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med. 2017 Jun 05; 214(6):1737-1752. PMID: 28487310.
      View in: PubMed
    2. McNamee EN, Rivera-Nieves J. Defective Lymphatics in Crohn's Disease: Tertiary Lymphoid Follicles Plug the Gap. Gastroenterology. 2017 03; 152(4):908-910. PMID: 28153586.
      View in: PubMed
    3. McNamee EN, Biette KA, Hammer J, Harris R, Miyazawa H, Lee JJ, Furuta GT, Masterson JC. Targeting granulocyte-macrophage colony-stimulating factor in epithelial and vascular remodeling in experimental eosinophilic esophagitis. Allergy. 2017 Aug; 72(8):1232-1242. PMID: 27926989.
      View in: PubMed
    4. Hoegl S, Ehrentraut H, Brodsky KS, Victorino F, Golden-Mason L, Eltzschig HK, McNamee EN. NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury. J Leukoc Biol. 2017 02; 101(2):471-480. PMID: 27601626.
      View in: PubMed
    5. McNamee EN, Rivera-Nieves J. Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur? Front Immunol. 2016; 7:308. PMID: 27579025; PMCID: PMC4985530.
    6. Frasch SC, McNamee EN, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, Mack M, Furuta GT, Lee JJ, Henson PM, Colgan SP, Bratton DL. G2A Signaling Dampens Colitic Inflammation via Production of IFN-?. J Immunol. 2016 08 15; 197(4):1425-34. PMID: 27402702; PMCID: PMC4975950 [Available on 08/15/17].
    7. McNamee EN, Vohwinkel C, Eltzschig HK. Hydroxylation-independent HIF-1a stabilization through PKA: A new paradigm for hypoxia signaling. Sci Signal. 2016 May 31; 9(430):fs11. PMID: 27245611.
      View in: PubMed
    8. Ferrari D, McNamee EN, Idzko M, Gambari R, Eltzschig HK. Purinergic Signaling During Immune Cell Trafficking. Trends Immunol. 2016 06; 37(6):399-411. PMID: 27142306.
      View in: PubMed
    9. Ryan KM, Griffin ÉW, Ryan KJ, Tanveer R, Vanattou-Saifoudine N, McNamee EN, Fallon E, Heffernan S, Harkin A, Connor TJ. Clenbuterol activates the central IL-1 system via the ß2-adrenoceptor without provoking inflammatory response related behaviours in rats. Brain Behav Immun. 2016 Aug; 56:114-29. PMID: 26928198.
      View in: PubMed
    10. Henry CJ, Casás-Selves M, Kim J, Zaberezhnyy V, Aghili L, Daniel AE, Jimenez L, Azam T, McNamee EN, Clambey ET, Klawitter J, Serkova NJ, Tan AC, Dinarello CA, DeGregori J. Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest. 2015 Dec; 125(12):4666-80. PMID: 26551682; PMCID: PMC4665776.
    11. Victorino F, Sojka DK, Brodsky KS, McNamee EN, Masterson JC, Homann D, Yokoyama WM, Eltzschig HK, Clambey ET. Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti-Asialo-GM1 Antibody. J Immunol. 2015 Nov 15; 195(10):4973-85. PMID: 26453755; PMCID: PMC4640895 [Available on 11/15/16].
    12. Masterson JC, Capocelli KE, Hosford L, Biette K, McNamee EN, de Zoeten EF, Harris R, Fernando SD, Jedlicka P, Protheroe C, Lee JJ, Furuta GT. Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis. Inflamm Bowel Dis. 2015 Oct; 21(10):2429-40. PMID: 26218140; PMCID: PMC4567482 [Available on 10/01/16].
    13. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Erratum: Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 May; 8(3):699. PMID: 25943416.
      View in: PubMed
    14. Aherne CM, Saeedi B, Collins CB, Masterson JC, McNamee EN, Perrenoud L, Rapp CR, Curtis VF, Bayless A, Fletcher A, Glover LE, Evans CM, Jedlicka P, Furuta GT, de Zoeten EF, Colgan SP, Eltzschig HK. Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis. Mucosal Immunol. 2015 Nov; 8(6):1324-38. PMID: 25850656; PMCID: PMC4598274.
    15. McNamee EN, Masterson JC, Veny M, Collins CB, Jedlicka P, Byrne FR, Ng GY, Rivera-Nieves J. Chemokine receptor CCR7 regulates the intestinal TH1/TH17/Treg balance during Crohn's-like murine ileitis. J Leukoc Biol. 2015 Jun; 97(6):1011-22. PMID: 25637591; PMCID: PMC4438744.
    16. Masterson JC, McNamee EN, Fillon SA, Hosford L, Harris R, Fernando SD, Jedlicka P, Iwamoto R, Jacobsen E, Protheroe C, Eltzschig HK, Colgan SP, Arita M, Lee JJ, Furuta GT. Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis. Gut. 2015 Aug; 64(8):1236-47. PMID: 25209655; PMCID: PMC4515997.
    17. Campbell EL, Bruyninckx WJ, Kelly CJ, Glover LE, McNamee EN, Bowers BE, Bayless AJ, Scully M, Saeedi BJ, Golden-Mason L, Ehrentraut SF, Curtis VF, Burgess A, Garvey JF, Sorensen A, Nemenoff R, Jedlicka P, Taylor CT, Kominsky DJ, Colgan SP. Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation. Immunity. 2014 Jan 16; 40(1):66-77. PMID: 24412613; PMCID: PMC3951457.
    18. Khailova L, Baird CH, Rush AA, McNamee EN, Wischmeyer PE. Lactobacillus rhamnosus GG improves outcome in experimental pseudomonas aeruginosa pneumonia: potential role of regulatory T cells. Shock. 2013 Dec; 40(6):496-503. PMID: 24240593.
      View in: PubMed
    19. Collins CB, Aherne CM, Ehrentraut SF, Gerich ME, McNamee EN, McManus MC, Lebsack MD, Jedlicka P, Azam T, de Zoeten EF, Dinarello CA, Rivera-Nieves J. Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis. Inflamm Bowel Dis. 2013 Aug; 19(9):1964-73. PMID: 23835442; PMCID: PMC4654462.
    20. Ryan KJ, Griffin É, Yssel JD, Ryan KM, McNamee EN, Harkin A, Connor TJ. Stimulation of central ß2-adrenoceptors suppresses NF?B activity in rat brain: a role for I?B. Neurochem Int. 2013 Nov; 63(5):368-78. PMID: 23896303.
      View in: PubMed
    21. Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, McNamee EN, Eltzschig HK, Kominsky DJ, Colgan SP. Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. Mucosal Immunol. 2014 Jan; 7(1):114-23. PMID: 23695513; PMCID: PMC3772994.
    22. McNamee EN, Korns Johnson D, Homann D, Clambey ET. Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function. Immunol Res. 2013 Mar; 55(1-3):58-70. PMID: 22961658; PMCID: PMC3919451.
    23. Ehrentraut H, Clambey ET, McNamee EN, Brodsky KS, Ehrentraut SF, Poth JM, Riegel AK, Westrich JA, Colgan SP, Eltzschig HK. CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury. FASEB J. 2013 Jun; 27(6):2207-19. PMID: 23413361; PMCID: PMC3659359.
    24. Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA, Eltzschig HK. Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 2013 Jul; 6(4):762-75. PMID: 23187315; PMCID: PMC3890100.
    25. Masterson JC, McNamee EN, Hosford L, Capocelli KE, Ruybal J, Fillon SA, Doyle AD, Eltzschig HK, Rustgi AK, Protheroe CA, Lee NA, Lee JJ, Furuta GT. Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis. Gut. 2014 Jan; 63(1):43-53. PMID: 23161496; PMCID: PMC3884674.
    26. Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP, Eltzschig HK. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2784-93. PMID: 22988108; PMCID: PMC3478644.
    27. McNamee EN, Masterson JC, Jedlicka P, Collins CB, Williams IR, Rivera-Nieves J. Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis. Gut. 2013 Jan; 62(1):53-62. PMID: 22267601; PMCID: PMC3726216.
    28. Collins CB, Aherne CM, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. Flt3 ligand expands CD103? dendritic cells and FoxP3? T regulatory cells, and attenuates Crohn's-like murine ileitis. Gut. 2012 Aug; 61(8):1154-62. PMID: 22068168; PMCID: PMC3684390.
    29. Collins CB, Aherne CM, Kominsky D, McNamee EN, Lebsack MD, Eltzschig H, Jedlicka P, Rivera-Nieves J. Retinoic acid attenuates ileitis by restoring the balance between T-helper 17 and T regulatory cells. Gastroenterology. 2011 Nov; 141(5):1821-31. PMID: 22027263; PMCID: PMC3684415.
    30. Masterson JC, McNamee EN, Jedlicka P, Fillon S, Ruybal J, Hosford L, Rivera-Nieves J, Lee JJ, Furuta GT. CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling. Am J Pathol. 2011 Nov; 179(5):2302-14. PMID: 21945903; PMCID: PMC3204091.
    31. McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB, Nold MF, Nold-Petry C, Bufler P, Dinarello CA, Rivera-Nieves J. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16711-6. PMID: 21873195; PMCID: PMC3189085.
    32. Wermers JD, McNamee EN, Wurbel MA, Jedlicka P, Rivera-Nieves J. The chemokine receptor CCR9 is required for the T-cell-mediated regulation of chronic ileitis in mice. Gastroenterology. 2011 May; 140(5):1526-35.e3. PMID: 21300065; PMCID: PMC3086928.
    33. McNamee EN, Wermers JD, Masterson JC, Collins CB, Lebsack MD, Fillon S, Robinson ZD, Grenawalt J, Lee JJ, Jedlicka P, Furuta GT, Rivera-Nieves J. Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse. Inflamm Bowel Dis. 2010 May; 16(5):743-52. PMID: 19856411; PMCID: PMC3786705.
    34. McNamee EN, Griffin EW, Ryan KM, Ryan KJ, Heffernan S, Harkin A, Connor TJ. Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex. Neuropharmacology. 2010 Jul-Aug; 59(1-2):37-48. PMID: 20361987.
      View in: PubMed
    35. McNamee EN, Ryan KM, Griffin EW, González-Reyes RE, Ryan KJ, Harkin A, Connor TJ. Noradrenaline acting at central beta-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: implications for neurodegeneration. Brain Behav Immun. 2010 May; 24(4):660-71. PMID: 20193756.
      View in: PubMed
    36. McNamee EN, Collins CB, Lebsack MD, Rivera-Nieves J. Cell-specific inhibition of p38alpha as a therapeutic strategy for inflammatory bowel disease. Gastroenterology. 2010 Apr; 138(4):1237-9. PMID: 20184972; PMCID: PMC4414012.
    37. Collins CB, McNamee EN, Wermers JD, Lebsack MD, Rivera-Nieves J. Chemokine decoy receptor D6 in inflammatory bowel disease (IBD) and IBD-associated colon cancer. Gut. 2010 Feb; 59(2):151-2. PMID: 20176637; PMCID: PMC4418614.
    38. McNamee EN, Ryan KM, Kilroy D, Connor TJ. Noradrenaline induces IL-1ra and IL-1 type II receptor expression in primary glial cells and protects against IL-1beta-induced neurotoxicity. Eur J Pharmacol. 2010 Jan 25; 626(2-3):219-28. PMID: 19818755.
      View in: PubMed
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