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Curt R Freed

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-6002
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionClinical Pharmacology


    Collapse Research 
    Collapse research activities and funding
    T32HD041697     (RESTREPO, DIEGO)Jul 3, 2001 - Jun 30, 2016
    NIH
    Neuroscience Training Grant
    Role: Co-Principal Investigator
    R01NS032368     (FREED, CURT R)Jan 1, 1994 - Dec 31, 1997
    NIH
    EMBRYONIC DOPAMINE CELL IMPLANTS FOR PARKINSONISM
    Role: Principal Investigator
    R01NS023918     (FREED, CURT R)Feb 1, 1988 - Mar 31, 1995
    NIH
    BRAIN TRANSPLANT TREATMENT FOR PARKINSONIANS
    Role: Principal Investigator
    R01HL030722     (FREED, CURT R)Jul 1, 1983 - Jul 31, 1992
    NIH
    CATECHOLAMINES AND SEROTONIN IN BLOOD PRESSURE CONTROL
    Role: Principal Investigator
    R01NS018639     (FREED, CURT R)Apr 1, 1983 - Aug 31, 1999
    NIH
    IMPROVING DOPAMINE CELL SURVIVAL AFTER NEURAL TRANSPLANT
    Role: Principal Investigator
    T32GM007063     (FREED, CURT R)Jul 1, 1975 - Jun 30, 1995
    NIH
    CLINICAL PHARMACOLOGY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Greene PE, Fahn S, Eidelberg D, Bjugstad KB, Breeze RE, Freed CR. Persistent dyskinesias in patients with fetal tissue transplantation for Parkinson disease. NPJ Parkinsons Dis. 2021 Apr 23; 7(1):38. PMID: 33893319.
      View in: PubMed
    2. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27512998.
      View in: PubMed
    3. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29272304.
      View in: PubMed
    4. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11814405.
      View in: PubMed
    5. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19697349.
      View in: PubMed
    6. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10718512.
      View in: PubMed
    7. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3734789.
      View in: PubMed
    8. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8854893.
      View in: PubMed
    9. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11768583.
      View in: PubMed
    10. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15958283.
      View in: PubMed
    11. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7499533.
      View in: PubMed
    12. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2414630.
      View in: PubMed
    13. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2461245.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 7627575.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9585230.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10338282.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 20802212.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18772316.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16036799.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2724147.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2707338.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 6977639.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3807639.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21997523.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11164822.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 357873.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9211823.
      View in: PubMed
    28. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15174028.
      View in: PubMed
    29. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 14579124.
      View in: PubMed
    30. Bahmed K, Messier EM, Zhou W, Tuder RM, Freed CR, Chu HW, Kelsen SG, Bowler RP, Mason RJ, Kosmider B. DJ-1 Modulates Nuclear Erythroid 2-Related Factor-2-Mediated Protection in Human Primary Alveolar Type II Cells in Smokers. Am J Respir Cell Mol Biol. 2016 09; 55(3):439-49. PMID: 27093578.
      View in: PubMed
    31. Xiong R, Zhou W, Siegel D, Kitson RR, Freed CR, Moody CJ, Ross D. A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T a-Synuclein Toxicity. Mol Pharmacol. 2015 Dec; 88(6):1045-54. PMID: 26405178.
      View in: PubMed
    32. Jenkins PM, Laughter MR, Lee DJ, Lee YM, Freed CR, Park D. A nerve guidance conduit with topographical and biochemical cues: potential application using human neural stem cells. Nanoscale Res Lett. 2015 Dec; 10(1):972. PMID: 26071111.
      View in: PubMed
    33. Yun D, Lee YM, Laughter MR, Freed CR, Park D. Substantial Differentiation of Human Neural Stem Cells Into Motor Neurons on a Biomimetic Polyurea. Macromol Biosci. 2015 Sep; 15(9):1206-11. PMID: 26033933.
      View in: PubMed
    34. Yun D, Famili A, Lee YM, Jenkins PM, Freed CR, Park D. Biomimetic poly(serinol hexamethylene urea) for promotion of neurite outgrowth and guidance. J Biomater Sci Polym Ed. 2014; 25(4):354-69. PMID: 24279744.
      View in: PubMed
    35. Lee KS, Zhou W, Scott-McKean JJ, Emmerling KL, Cai GY, Krah DL, Costa AC, Freed CR, Levin MJ. Human sensory neurons derived from induced pluripotent stem cells support varicella-zoster virus infection. PLoS One. 2012; 7(12):e53010. PMID: 23285249.
      View in: PubMed
    36. Zhou W, Bercury K, Cummiskey J, Luong N, Lebin J, Freed CR. Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. J Biol Chem. 2011 Apr 29; 286(17):14941-51. PMID: 21372141.
      View in: PubMed
    37. Ma Y, Tang C, Chaly T, Greene P, Breeze R, Fahn S, Freed C, Dhawan V, Eidelberg D. Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes. J Nucl Med. 2010 Jan; 51(1):7-15. PMID: 20008998.
      View in: PubMed
    38. Zhou W, Lee YM, Guy VC, Freed CR. Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice. Stem Cells. 2009 Dec; 27(12):2952-61. PMID: 19750538.
      View in: PubMed
    39. Goetz CG, Wuu J, McDermott MP, Adler CH, Fahn S, Freed CR, Hauser RA, Olanow WC, Shoulson I, Tandon PK, Leurgans S. Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventions. Mov Disord. 2008 Apr 15; 23(5):690-9. PMID: 18228568.
      View in: PubMed
    40. Zhou W, Milder JB, Freed CR. Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease. J Biol Chem. 2008 Apr 11; 283(15):9863-70. PMID: 18238775.
      View in: PubMed
    41. Freed CR, Michael Zawada W, Leehey M, Zhou W, Breeze RE. Transplantation. Handb Clin Neurol. 2007; 84:279-90. PMID: 18808953.
      View in: PubMed
    42. Bjugstad KB, Crnic LS, Goodman SI, Freed CR. Infant mice with glutaric acidaemia type I have increased vulnerability to 3-nitropropionic acid toxicity. J Inherit Metab Dis. 2006 Oct; 29(5):612-9. PMID: 16944278.
      View in: PubMed
    43. Zhou W, Freed CR. DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J Biol Chem. 2005 Dec 30; 280(52):43150-8. PMID: 16227205.
      View in: PubMed
    44. Schilling B, Bharath M M S, Row RH, Murray J, Cusack MP, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW. Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line. Mol Cell Proteomics. 2005 Jan; 4(1):84-96. PMID: 15591592.
      View in: PubMed
    45. Gordon PH, Yu Q, Qualls C, Winfield H, Dillon S, Greene PE, Fahn S, Breeze RE, Freed CR, Pullman SL. Reaction time and movement time after embryonic cell implantation in Parkinson disease. Arch Neurol. 2004 Jun; 61(6):858-61. PMID: 15210522.
      View in: PubMed
    46. McRae C, Cherin E, Yamazaki TG, Diem G, Vo AH, Russell D, Ellgring JH, Fahn S, Greene P, Dillon S, Winfield H, Bjugstad KB, Freed CR. Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trial. Arch Gen Psychiatry. 2004 Apr; 61(4):412-20. PMID: 15066900.
      View in: PubMed
    47. Buytaert-Hoefen KA, Alvarez E, Freed CR. Generation of tyrosine hydroxylase positive neurons from human embryonic stem cells after coculture with cellular substrates and exposure to GDNF. Stem Cells. 2004; 22(5):669-74. PMID: 15342931.
      View in: PubMed
    48. Zhou W, Freed CR. Tyrosine-to-cysteine modification of human alpha-synuclein enhances protein aggregation and cellular toxicity. J Biol Chem. 2004 Mar 12; 279(11):10128-35. PMID: 14699135.
      View in: PubMed
    49. Ahmadi FA, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM. The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem. 2003 Nov; 87(4):914-21. PMID: 14622122.
      View in: PubMed
    50. Björklund A, Dunnett SB, Brundin P, Stoessl AJ, Freed CR, Breeze RE, Levivier M, Peschanski M, Studer L, Barker R. Neural transplantation for the treatment of Parkinson's disease. Lancet Neurol. 2003 Jul; 2(7):437-45. PMID: 12849125.
      View in: PubMed
    51. Trott CT, Fahn S, Greene P, Dillon S, Winfield H, Winfield L, Kao R, Eidelberg D, Freed CR, Breeze RE, Stern Y. Cognition following bilateral implants of embryonic dopamine neurons in PD: a double blind study. Neurology. 2003 Jun 24; 60(12):1938-43. PMID: 12821736.
      View in: PubMed
    52. McRae C, Cherin E, Diem G, Vo AH, Ellgring JH, Russell D, Fahn S, Freed C. Does personality change as a result of fetal tissue transplantation in the brain? J Neurol. 2003 Mar; 250(3):282-6. PMID: 12638017.
      View in: PubMed
    53. Nahreini P, Andreatta C, Kumar B, Hanson A, Edwards-Prasad J, Freed CR, Prasad KN. Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells. Cell Mol Neurobiol. 2003 Feb; 23(1):27-42. PMID: 12701882.
      View in: PubMed
    54. Ma Y, Feigin A, Dhawan V, Fukuda M, Shi Q, Greene P, Breeze R, Fahn S, Freed C, Eidelberg D. Dyskinesia after fetal cell transplantation for parkinsonism: a PET study. Ann Neurol. 2002 Nov; 52(5):628-34. PMID: 12402261.
      View in: PubMed
    55. Freed CR. Will embryonic stem cells be a useful source of dopamine neurons for transplant into patients with Parkinson's disease? Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1755-7. PMID: 11854478.
      View in: PubMed
    56. Veng LM, Bjugstad KB, Freed CR, Marrack P, Clarkson ED, Bell KP, Hutt C, Zawada WM. Xenografts of MHC-deficient mouse embryonic mesencephalon improve behavioral recovery in hemiparkinsonian rats. Cell Transplant. 2002; 11(1):5-16. PMID: 12095220.
      View in: PubMed
    57. Nakamura T, Dhawan V, Chaly T, Fukuda M, Ma Y, Breeze R, Greene P, Fahn S, Freed C, Eidelberg D. Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease. Ann Neurol. 2001 Aug; 50(2):181-7. PMID: 11506400.
      View in: PubMed
    58. Ourednik V, Ourednik J, Flax JD, Zawada WM, Hutt C, Yang C, Park KI, Kim SU, Sidman RL, Freed CR, Snyder EY. Segregation of human neural stem cells in the developing primate forebrain. Science. 2001 Sep 07; 293(5536):1820-4. PMID: 11474066.
      View in: PubMed
    59. Kumar B, Hovland AR, Prasad JE, Clarkson E, Cole WC, Nahreini P, Freed CR, Prasad KN. Establishment of human embryonic brain cell lines. In Vitro Cell Dev Biol Anim. 2001 May; 37(5):259-62. PMID: 11513078.
      View in: PubMed
    60. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med. 2001 Mar 08; 344(10):710-9. PMID: 11236774.
      View in: PubMed
    61. Clarkson ED, Zawada WM, Bell KP, Esplen JE, Choi PK, Heidenreich KA, Freed CR. IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands. Exp Neurol. 2001 Mar; 168(1):183-91. PMID: 11170733.
      View in: PubMed
    62. Bjugstad KB, Goodman SI, Freed CR. Age at symptom onset predicts severity of motor impairment and clinical outcome of glutaric acidemia type 1. J Pediatr. 2000 Nov; 137(5):681-6. PMID: 11060535.
      View in: PubMed
    63. Zhou W, Hurlbert MS, Schaack J, Prasad KN, Freed CR. Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells. Brain Res. 2000 Jun 02; 866(1-2):33-43. PMID: 10825478.
      View in: PubMed
    64. Freed CR, Breeze RE, Fahn S. Placebo surgery in trials of therapy for Parkinson's disease. N Engl J Med. 2000 Feb 03; 342(5):353-4; author reply 354-5. PMID: 10660397.
      View in: PubMed
    65. Clarkson ED, Edwards-Prasad J, Freed CR, Prasad KN. Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotection. Proc Soc Exp Biol Med. 1999 Nov; 222(2):157-63. PMID: 10564540.
      View in: PubMed
    66. Clarkson ED, Freed CR. Development of fetal neural transplantation as a treatment for Parkinson's disease. Life Sci. 1999 Oct 29; 65(23):2427-37. PMID: 10622227.
      View in: PubMed
    67. Hurlbert MS, Zhou W, Wasmeier C, Kaddis FG, Hutton JC, Freed CR. Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes. Diabetes. 1999 Mar; 48(3):649-51. PMID: 10078572.
      View in: PubMed
    68. Clarkson ED, Zawada WM, Adams FS, Bell KP, Freed CR. Strands of embryonic mesencephalic tissue show greater dopamine neuron survival and better behavioral improvement than cell suspensions after transplantation in parkinsonian rats. Brain Res. 1998 Sep 21; 806(1):60-8. PMID: 9739108.
      View in: PubMed
    69. Prasad KN, Clarkson ED, La Rosa FG, Edwards-Prasad J, Freed CR. Efficacy of grafted immortalized dopamine neurons in an animal model of parkinsonism: a review. Mol Genet Metab. 1998 Sep; 65(1):1-9. PMID: 9787089.
      View in: PubMed
    70. Zawada WM, Zastrow DJ, Clarkson ED, Adams FS, Bell KP, Freed CR. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res. 1998 Mar 09; 786(1-2):96-103. PMID: 9554968.
      View in: PubMed
    71. Bakay RA, Boyer KL, Freed CR, Ansari AA. Immunological responses to injury and grafting in the central nervous system of nonhuman primates. Cell Transplant. 1998 Mar-Apr; 7(2):109-20. PMID: 9588593.
      View in: PubMed
    72. Clarkson ED, Rosa FG, Edwards-Prasad J, Weiland DA, Witta SE, Freed CR, Prasad KN. Improvement of neurological deficits in 6-hydroxydopamine-lesioned rats after transplantation with allogeneic simian virus 40 large tumor antigen gene-induced immortalized dopamine cells. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1265-70. PMID: 9448320.
      View in: PubMed
    73. Clarkson ED, La Rosa FG, Edwards-Prasad J, Kumar S, Kumar A, Cole W, Freed CR, Prasad KN. Brain contains inhibiting factors specific to the large T-antigen gene. Cancer Lett. 1998 Jan 09; 122(1-2):31-6. PMID: 9464488.
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    74. Kuhar MJ, Vaughan R, Uhl G, Cerruti C, Revay R, Freed C, Nirenburg M, Pickel V. Localization of dopamine transporter protein by microscopic histochemistry. Adv Pharmacol. 1998; 42:168-70. PMID: 9327870.
      View in: PubMed
    75. Baker KK, Ramig LO, Johnson AB, Freed CR. Preliminary voice and speech analysis following fetal dopamine transplants in 5 individuals with Parkinson disease. J Speech Lang Hear Res. 1997 Jun; 40(3):615-26. PMID: 9210118.
      View in: PubMed
    76. Yasui RK, Culclasure TF, Kaufman D, Freed CR. Flecainide overdose: is cardiopulmonary support the treatment? Ann Emerg Med. 1997 May; 29(5):680-2. PMID: 9140253.
      View in: PubMed
    77. Kaddis FG, Clarkson ED, Weber MJ, Vandenbergh DJ, Donovan DM, Mallet J, Horellou P, Uhl GR, Freed CR. Intrastriatal grafting of Cos cells stably expressing human aromatic L-amino acid decarboxylase: neurochemical effects. J Neurochem. 1997 Apr; 68(4):1520-6. PMID: 9084422.
      View in: PubMed
    78. La Rosa FG, Adams FS, Krause GE, Meyers AD, Edwards-Prasad J, Kumar R, Freed CR, Prasad KN. Inhibition of proliferation and expression of T-antigen in SV40 large T-antigen gene-induced immortalized cells following transplantations. Cancer Lett. 1997 Feb 26; 113(1-2):55-60. PMID: 9065801.
      View in: PubMed
    79. Kummer JL, Zawada WM, Freed CR, Chernausek SD, Heidenreich KA. Insulin-like growth factor binding proteins in fetal rat mesencephalic cultures: regulation by fibroblast growth factor and insulin-like growth factor I. Endocrinology. 1996 Aug; 137(8):3551-6. PMID: 8754786.
      View in: PubMed
    80. Zawada WM, Kirschman DL, Cohen JJ, Heidenreich KA, Freed CR. Growth factors rescue embryonic dopamine neurons from programmed cell death. Exp Neurol. 1996 Jul; 140(1):60-7. PMID: 8682180.
      View in: PubMed
    81. Adams FS, La Rosa FG, Kumar S, Edwards-Prasad J, Kentroti S, Vernadakis A, Freed CR, Prasad KN. Characterization and transplantation of two neuronal cell lines with dopaminergic properties. Neurochem Res. 1996 May; 21(5):619-27. PMID: 8726972.
      View in: PubMed
    82. Clarkson ED, Zawada WM, Freed CR. GDNF reduces apoptosis in dopaminergic neurons in vitro. Neuroreport. 1995 Dec 29; 7(1):145-9. PMID: 8742438.
      View in: PubMed
    83. Freed CR, Breeze RE, Schneck SA. Transplantation of fetal mesencephalic tissue in Parkinson's disease. N Engl J Med. 1995 Sep 14; 333(11):730-1. PMID: 7637761.
      View in: PubMed
    84. Breeze RE, Wells TH, Freed CR. Implantation of fetal tissue for the management of Parkinson's disease: a technical note. Neurosurgery. 1995 May; 36(5):1044-7; discussion 1047-8. PMID: 7791972.
      View in: PubMed
    85. Ansari AA, Mayne A, Freed CR, Breeze RE, Schneck SA, O'Brien CF, Kriek EH, Zhang YB, Mazziotta JC, Hutchinson M, et al. Lack of a detectable systemic humoral/cellular allogeneic response in human and nonhuman primate recipients of embryonic mesencephalic allografts for the therapy of Parkinson's disease. Transplant Proc. 1995 Feb; 27(1):1401-5. PMID: 7878926.
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    86. Patino P, Garcia-Munoz M, Freed CR. Electrophysiology of ventromedial striatal neurons during movement. Brain Res Bull. 1995; 37(5):481-6. PMID: 7633896.
      View in: PubMed
    87. Prasad KN, Carvalho E, Kentroti S, Edwards-Prasad J, Freed C, Vernadakis A. Establishment and characterization of immortalized clonal cell lines from fetal rat mesencephalic tissue. In Vitro Cell Dev Biol Anim. 1994 Sep; 30A(9):596-603. PMID: 7820310.
      View in: PubMed
    88. Prasad KN, Carvalho E, Kentroti S, Edwards-Prasad J, La Rosa FG, Kumar S, Freed CR, Vernadakis A. Production of terminally differentiated neuroblastoma cells in culture. Restor Neurol Neurosci. 1994 Jan 01; 7(1):13-9. PMID: 21551767.
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    89. Richards JB, Sabol KE, Kriek EH, Freed CR. Trained and amphetamine-induced circling behavior in lesioned, transplanted rats. J Neural Transplant Plast. 1993 Apr-Jun; 4(2):157-66. PMID: 8110866.
      View in: PubMed
    90. Freed CR, Breeze RE, Rosenberg NL, Schneck SA. Embryonic dopamine cell implants as a treatment for the second phase of Parkinson's disease. Replacing failed nerve terminals. Adv Neurol. 1993; 60:721-8. PMID: 8420217.
      View in: PubMed
    91. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Kriek E, Qi JX, Lone T, Zhang YB, Snyder JA, Wells TH, et al. Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N Engl J Med. 1992 Nov 26; 327(22):1549-55. PMID: 1435881.
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    92. Dev BR, Mason PA, Freed CR. Drug-induced changes in blood pressure lead to changes in extracellular concentrations of epinephrine, dihydroxyphenylacetic acid, and 5-hydroxyindoleacetic acid in the rostral ventrolateral medulla of the rat. J Neurochem. 1992 Apr; 58(4):1386-94. PMID: 1372344.
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    93. Freed CR, Rosenberg NL, Schneck SA, Breeze RE. Improved drug responsiveness following fetal tissue implant for Parkinson's disease. Neurochem Int. 1992 Mar; 20 Suppl:321S-327S. PMID: 1365449.
      View in: PubMed
    94. Richards JB, Sabol KE, Freed CR. Conditioned rotation: a behavioral analysis. Physiol Behav. 1990 Jun; 47(6):1083-7. PMID: 2395913.
      View in: PubMed
    95. Richards JB, Sabol KE, Freed CR. Unilateral dopamine depletion causes bilateral deficits in conditioned rotation in rats. Pharmacol Biochem Behav. 1990 Jun; 36(2):217-23. PMID: 2113295.
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    96. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, Grafton ST, Huang SC, Eidelberg D, Rottenberg DA. Transplantation of human fetal dopamine cells for Parkinson's disease. Results at 1 year. Arch Neurol. 1990 May; 47(5):505-12. PMID: 2334298.
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    97. Sabol KE, Richards JB, Freed CR. In vivo dialysis measurements of dopamine and DOPAC in rats trained to turn on a circular treadmill. Pharmacol Biochem Behav. 1990 May; 36(1):21-8. PMID: 2349264.
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    98. Wilcox CL, Smith RL, Freed CR, Johnson EM. Nerve growth factor-dependence of herpes simplex virus latency in peripheral sympathetic and sensory neurons in vitro. J Neurosci. 1990 Apr; 10(4):1268-75. PMID: 2158529.
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    99. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Wells TH, Barrett JN, Grafton ST, Mazziotta JC, Eidelberg D, Rottenberg DA. Therapeutic effects of human fetal dopamine cells transplanted in a patient with Parkinson's disease. Prog Brain Res. 1990; 82:715-21. PMID: 2290975.
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    100. Mason PA, Durr JA, Bhaskaran D, Freed CR. Plasma osmolality predicts extracellular fluid catechol concentrations in the lateral hypothalamus. J Neurochem. 1988 Aug; 51(2):552-60. PMID: 3392546.
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    101. Sabol KE, Freed CR. Brain acetaminophen measurement by in vivo dialysis, in vivo electrochemistry and tissue assay: a study of the dialysis technique in the rat. J Neurosci Methods. 1988 Jun; 24(2):163-8. PMID: 3405012.
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    102. Bhaskaran D, Freed CR. Changes in arterial blood pressure lead to baroreceptor-mediated changes in norepinephrine and 5-hydroxyindoleacetic acid in rat nucleus tractus solitarius. J Pharmacol Exp Ther. 1988 Apr; 245(1):356-63. PMID: 2452247.
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    103. Diana M, Garcia-Munoz M, Freed CR. Wire electrodes for chronic single unit recording of dopamine cells in substantia nigra pars compacta of awake rats. J Neurosci Methods. 1987 Sep; 21(1):71-9. PMID: 3657271.
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    104. Bhaskaran D, Freed CR. Nucleus tractus solitarius: an evaluation by in vivo voltammetry. Life Sci. 1987 Jul 20; 41(3):323-31. PMID: 2885706.
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    105. Echizen H, Freed CR. Factors affecting in vivo electrochemistry: electrode-tissue interaction and the ascorbate amplification effect. Life Sci. 1986 Jul 07; 39(1):77-89. PMID: 2425210.
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    106. Freed CR. The trained circling rat and in vivo electrochemistry: a behavioral model and a measurement method to study the dynamic role of dopamine in movement. Ann N Y Acad Sci. 1986; 473:188-99. PMID: 3467624.
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    107. Freed CR, Yamamoto BK. Regional brain dopamine metabolism: a marker for the speed, direction, and posture of moving animals. Science. 1985 Jul 05; 229(4708):62-5. PMID: 4012312.
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    108. Cheney-Thamm J, Reite M, Alianiello EA, Yamamoto BK, Capitanio JP, Freed CR. Caudate electrochemical response following amphetamine administration in pigtail monkeys. Life Sci. 1984 Oct 01; 35(14):1453-60. PMID: 6482665.
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    109. Morgan ME, Yamamoto BK, Freed CR. Unilateral activation of caudate tyrosine hydroxylase during voluntary circling behavior. J Neurochem. 1984 Sep; 43(3):737-41. PMID: 6146659.
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    110. Freed CR, Wang CH, U'Prichard DC. Changes in brain alpha-adrenergic receptors after alpha-methyldopa administration to spontaneously hypertensive rats. Hypertension. 1984 Sep-Oct; 6(5 Pt 2):II34-9. PMID: 6094347.
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    111. Echizen H, Freed CR. Measurement of serotonin turnover rate in rat dorsal raphe nucleus by in vivo electrochemistry. J Neurochem. 1984 May; 42(5):1483-6. PMID: 6200572.
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    112. Echizen H, Freed CR. Altered serotonin and norepinephrine metabolism in rat dorsal raphe nucleus after drug-induced hypertension. Life Sci. 1984 Apr 16; 34(16):1581-9. PMID: 6717246.
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    113. Yamamoto BK, Freed CR. Asymmetric dopamine and serotonin metabolism in nigrostriatal and limbic structures of the trained circling rat. Brain Res. 1984 Apr 09; 297(1):115-9. PMID: 6202362.
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    114. Yamamoto BK, Freed CR. Reversal of amphetamine-induced circling preference in trained circling rats. Life Sci. 1984 Feb 13; 34(7):675-82. PMID: 6538253.
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    115. Echizen H, Freed CR. In vivo electrochemical detection of extraneuronal 5-hydroxyindole acetic acid and norepinephrine in the dorsal raphe nucleus of urethane-anesthetized rats. Brain Res. 1983 Oct 24; 277(1):55-62. PMID: 6196081.
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    116. Yamamoto BK, Freed CR. The trained circling rat: a model for inducing unilateral caudate dopamine metabolism. Nature. 1982 Jul 29; 298(5873):467-8. PMID: 7088191.
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    117. Yamamoto BK, Lane RF, Freed CR. Normal rats trained to circle show asymmetric caudate dopamine release. Life Sci. 1982 Jun 21; 30(25):2155-62. PMID: 7109843.
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    118. Morgan ME, Freed CR. Acetaminophen as an internal standard for calibrating in vivo electrochemical electrodes. J Pharmacol Exp Ther. 1981 Oct; 219(1):49-53. PMID: 7288615.
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    119. Freed CR, Asmus PA. Brain tissue and plasma assay of L-DOPA and alpha-methyldopa metabolites by high performance liquid chromatography with electrochemical detection. J Neurochem. 1979 Jan; 32(1):163-8. PMID: 759567.
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    120. Freed CR, Murphy RC. Mass spectrometric measurement of catecholamine turnover in rat hypothalamus after long-term L-dopa infusion. J Pharmacol Exp Ther. 1978 Jun; 205(3):702-9. PMID: 660538.
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    121. Freed CR, Weinkam RJ, Melmon KL, Castagnoli N. Chemical lonization mass spectrometric measurement of alpha-methyldopa and s-dopa metabolites in rat brain regions. Anal Biochem. 1977 Apr; 78(2):319-32. PMID: 851208.
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