Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Richard J Johnson

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4865

    Collapse Research 
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    T32DK007135     (JOHNSON, RICHARD JOSEPH)Jul 1, 1983 - Jun 30, 2019
    NIH/NIDDK
    Renal and Electrolyte Disease and Hypertension
    Role: Principal Investigator

    T32DK007518     (SEGAL, MARK S.)Jul 1, 1985 - Jun 30, 2013
    NIH/NIDDK
    Pre &Post-Doctoral Training in Nephrology &Hypertension
    Role: Co-Principal Investigator

    R29DK039068     (JOHNSON, RICHARD JOSEPH)Aug 1, 1987 - Jul 31, 1992
    NIH/NIDDK
    MYELOPEROXIDASE-H202-HALIDE SYSTEM IN GLOMERULAR INJURY
    Role: Principal Investigator

    R55DK043422     (JOHNSON, RICHARD JOSEPH)Aug 1, 1991 - Jul 31, 1997
    NIH/NIDDK
    MESANGIAL RESPONSE TO INJURY
    Role: Principal Investigator

    R01DK043422     (JOHNSON, RICHARD JOSEPH)Aug 1, 1991 - Jul 31, 2000
    NIH/NIDDK
    MESANGIAL RESPONSE TO INJURY
    Role: Principal Investigator

    K04DK002142     (JOHNSON, RICHARD JOSEPH)Aug 1, 1992 - Jul 30, 1997
    NIH/NIDDK
    PLATELETS IN IMMUNE GLOMERULAR INJURY
    Role: Principal Investigator

    R01DK052121     (JOHNSON, RICHARD JOSEPH)Sep 30, 1996 - Sep 10, 2010
    NIH/NIDDK
    Endothelial Cell in Progressive Renal Disease
    Role: Principal Investigator

    R01HL068607     (JOHNSON, RICHARD JOSEPH)Jan 1, 2002 - Mar 31, 2013
    NIH/NHLBI
    Role of Uric Acid in Cardiovascular and Renal Disease
    Role: Principal Investigator

    R01HL079352     (SEGAL, MARK S.)Aug 1, 2005 - Apr 30, 2010
    NIH/NHLBI
    Uric Acid and Hypertension in African-Americans
    Role: Co-Principal Investigator

    RC4DK090859     (JOHNSON, RICHARD JOSEPH)Sep 30, 2010 - Aug 31, 2013
    NIH/NIDDK
    Development of inhibitors of AMP Deaminase Isoform 2 as a Mechanism for Treating
    Role: Principal Investigator

    R01DK080764     (JOHNSON, RICHARD JOSEPH)Sep 20, 2011 - Aug 31, 2014
    NIH/NIDDK
    CD80 Expression on Podocytes and the Pathogenesis of Minimal Change Disease
    Role: Principal Investigator

    R21HL113809     (WRIGHT, RICHARD M)Feb 1, 2013 - Jan 31, 2016
    NIH/NHLBI
    PROINFLAMMATORY ROLE OF URIC ACID IN LUNG DISEASE: NOVEL MODELS AND CLINICAL VALI
    Role: Co-Principal Investigator

    I01BX002586     (JOHNSON, RICHARD JOSEPH)Oct 1, 2014 - Sep 30, 2018
    VA
    Fructokinase and Nondiabetic and Aging-Associated Chronic Kidney Disease
    Role: Principal Investigator

    R41DK104432     (JOHNSON, RICHARD JOSEPH)Sep 15, 2015 - Aug 31, 2016
    NIH/NIDDK
    Scientific Merit and Feasibility of Fructokinase Inhibiton for Obesity
    Role: Principal Investigator

    R42DK104432     (JOHNSON, RICHARD JOSEPH)Sep 15, 2015 - Aug 31, 2019
    NIH/NIDDK
    Scientific Merit and Feasibility of Fructokinase Inhibition for Obesity
    Role: Principal Investigator

    R01DK108408     (JOHNSON, RICHARD JOSEPH)Apr 1, 2016 - Mar 31, 2020
    NIH/NIDDK
    Dietary Salt has an Unrecognized Role in Modulating Energy Intake and Metabolic Syndrome
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hurtado-Arestegui A, Plata-Cornejo R, Cornejo A, Mas G, Carbajal L, Sharma S, Swenson ER, Johnson RJ, Pando J. Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol. 2017 Nov 08. PMID: 29119539.
      View in: PubMed
    2. Kuwabara M, Kuwabara R, Hisatome I, Niwa K, Roncal-Jimenez CA, Bjornstad P, Andres-Hernando A, Sato Y, Jensen T, Garcia G, Ohno M, Hill JO, Lanaspa MA, Johnson RJ. "Metabolically Healthy" Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5-year Japanese Cohort Study. Obesity (Silver Spring). 2017 Sep 18. PMID: 28922565.
      View in: PubMed
    3. Johnson RJ, Shimada M. Contemporary Management of Hepatitis C in Patients with CKD. Clin J Am Soc Nephrol. 2017 10 06; 12(10):1563-1565. PMID: 28882856.
      View in: PubMed
    4. Todd AS, Walker RJ, MacGinley RJ, Kelly J, Merriman TR, Major TJ, Johnson RJ. Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans. Am J Hypertens. 2017 Sep 07. PMID: 28985270.
      View in: PubMed
    5. Bjornstad P, Pyle L, Cherney DZI, Johnson RJ, Sippl R, Wong R, Rewers M, Snell-Bergeon JK. Plasma biomarkers improve prediction of diabetic kidney disease in adults with type 1 diabetes over a 12-year follow-up: CACTI study. Nephrol Dial Transplant. 2017 Aug 21. PMID: 28992280.
      View in: PubMed
    6. García-Arroyo FE, Tapia E, Blas-Marron MG, Gonzaga G, Silverio O, Cristóbal M, Osorio H, Arellano-Buendía AS, Zazueta C, Aparicio-Trejo OE, Reyes-García JG, Pedraza-Chaverri J, Soto V, Roncal-Jiménez C, Johnson RJ, Sánchez-Lozada LG. Vasopressin Mediates the Renal Damage Induced by Limited Fructose Rehydration in Recurrently Dehydrated Rats. Int J Biol Sci. 2017; 13(8):961-975. PMID: 28924378.
      View in: PubMed
    7. Sharma S, Gralla J, Ordonez JG, Hurtado ME, Swenson ER, Schoene RB, Kelly JP, Callacondo D, Rivard C, Roncal-Jimenez C, Sirota J, Fuquay R, Jackson BP, Swenson KE, Johnson RJ, Hurtado A, Escudero E. Acetazolamide and N-acetylcysteine in the treatment of chronic mountain sickness (Monge's disease). Respir Physiol Neurobiol. 2017 Dec; 246:1-8. PMID: 28720395.
      View in: PubMed
    8. Rodriguez-Iturbe B, Pons H, Johnson RJ. Role of the Immune System in Hypertension. Physiol Rev. 2017 Jul 01; 97(3):1127-1164. PMID: 28566539.
      View in: PubMed
    9. Johnson RJ, Sánchez-Lozada LG, Andrews P, Lanaspa MA. Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Adv Nutr. 2017 May; 8(3):412-422. PMID: 28507007.
      View in: PubMed
    10. Yamada K, Shah JA, Tanabe T, Lanaspa MA, Johnson RJ. Xenotransplantation: Where Are We with Potential Kidney Recipients? Recent Progress and Potential Future Clinical Trials. Curr Transplant Rep. 2017 Jun; 4(2):101-109. PMID: 28989853.
      View in: PubMed
    11. Kuwabara M, Niwa K, Hisatome I, Nakagawa T, Roncal-Jimenez CA, Andres-Hernando A, Bjornstad P, Jensen T, Sato Y, Milagres T, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Asymptomatic Hyperuricemia Without Comorbidities Predicts Cardiometabolic Diseases: Five-Year Japanese Cohort Study. Hypertension. 2017 Jun; 69(6):1036-1044. PMID: 28396536.
      View in: PubMed
    12. Kuwabara M, Bjornstad P, Hisatome I, Niwa K, Roncal-Jimenez CA, Andres-Hernando A, Jensen T, Milagres T, Sato Y, Garcia G, Ohno M, Lanaspa MA, Johnson RJ. Elevated Serum Uric Acid Level Predicts Rapid Decline in Kidney Function. Am J Nephrol. 2017; 45(4):330-337. PMID: 28285309.
      View in: PubMed
    13. Kuwabara M, Sato Y, Kanbay M, Johnson RJ. Uric Acid and Left Ventricular Hypertrophy: A Potentially New Modifiable Target? Am J Hypertens. 2017 Mar 01; 30(3):229-231. PMID: 28096149.
      View in: PubMed
    14. Andres-Hernando A, Li N, Cicerchi C, Inaba S, Chen W, Roncal-Jimenez C, Le MT, Wempe MF, Milagres T, Ishimoto T, Fini M, Nakagawa T, Johnson RJ, Lanaspa MA. Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice. Nat Commun. 2017 Feb 13; 8:14181. PMID: 28194018.
      View in: PubMed
    15. Roncal-Jimenez CA, Milagres T, Andres-Hernando A, Kuwabara M, Jensen T, Song Z, Bjornstad P, Garcia GE, Sato Y, Sanchez-Lozada LG, Lanaspa MA, Johnson RJ. Effects of exogenous desmopressin on a model of heat stress nephropathy in mice. Am J Physiol Renal Physiol. 2017 Mar 01; 312(3):F418-F426. PMID: 28003190.
      View in: PubMed
    16. Wesseling C, Aragón A, González M, Weiss I, Glaser J, Rivard CJ, Roncal-Jiménez C, Correa-Rotter R, Johnson RJ. Heat stress, hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of Mesoamerican nephropathy in Nicaragua. BMJ Open. 2016 Dec 08; 6(12):e011034. PMID: 27932336.
      View in: PubMed
    17. Bjornstad P, Johnson RJ, Snell-Bergeon JK, Pyle L, Davis A, Foster N, Cherney DZ, Maahs DM. Albuminuria is associated with greater copeptin concentrations in men with type 1 diabetes: A brief report from the T1D exchange Biobank. J Diabetes Complications. 2017 Feb; 31(2):387-389. PMID: 27979439.
      View in: PubMed
    18. Shah P, Bjornstad P, Johnson RJ. Hyperuricemia as a potential risk factor for type 2 diabetes and diabetic nephropathy. J Bras Nefrol. 2016 Dec; 38(4):386-387. PMID: 28001176.
      View in: PubMed
    19. Song ??? Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ. Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice. J Neurophysiol. 2017 Feb 01; 117(2):646-654. PMID: 27852737.
      View in: PubMed
    20. Hahn K, Ejaz AA, Kanbay M, Lanaspa MA, Johnson RJ. Acute kidney injury from SGLT2 inhibitors: potential mechanisms. Nat Rev Nephrol. 2016 Nov 16; 12(12):711-712. PMID: 27847389.
      View in: PubMed
    21. Anutrakulchai S, Titipungul T, Pattay T, Mesung P, Puapairoj A, Sirivongs D, Pongsakul C, Futrakul P, Thinkhamrop B, Johnson RJ. Relation of peritubular capillary features to class of lupus nephritis. BMC Nephrol. 2016 Nov 09; 17(1):169. PMID: 27829387.
      View in: PubMed
    22. Hahn K, Kanbay M, Lanaspa MA, Johnson RJ, Ejaz AA. Serum uric acid and acute kidney injury: A mini review. J Adv Res. 2017 Sep; 8(5):529-536. PMID: 28748118.
      View in: PubMed
    23. Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 Mar; 28(3):943-952. PMID: 27620990.
      View in: PubMed
    24. Bjornstad P, Škrtic M, Lytvyn Y, Maahs DM, Johnson RJ, Cherney DZ. The Gomez' equations and renal hemodynamic function in kidney disease research. Am J Physiol Renal Physiol. 2016 Sep 07; ajprenal.00415.2016. PMID: 27605583.
      View in: PubMed
    25. Lee SK, Lanaspa MA, Sánchez-Lozada LG, Johnson RJ. Hyponatremia with Persistent Elevated Urinary Fractional Uric Acid Excretion: Evidence for Proximal Tubular Injury? Kidney Blood Press Res. 2016; 41(5):535-544. PMID: 27561821.
      View in: PubMed
    26. Koratala A, Singhania G, Alquadan KF, Shimada M, Johnson RJ, Ejaz AA. Serum Uric Acid Exhibits Inverse Relationship with Estimated Glomerular Filtration Rate. Nephron. 2016; 134(4):231-237. PMID: 27548821.
      View in: PubMed
    27. Gutiérrez-Salmeán G, Meaney E, Lanaspa MA, Cicerchi C, Johnson RJ, Dugar S, Taub P, Ramírez-Sánchez I, Villarreal F, Schreiner G, Ceballos G. A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects. Int J Cardiol. 2016 Nov 15; 223:500-506. PMID: 27552564.
      View in: PubMed
    28. Roncal-Jimenez CA, Ishimoto T, Lanaspa MA, Milagres T, Hernando AA, Jensen T, Miyazaki M, Doke T, Hayasaki T, Nakagawa T, Marumaya S, Long DA, Garcia GE, Kuwabara M, Sánchez-Lozada LG, Kang DH, Johnson RJ. Aging-associated renal disease in mice is fructokinase dependent. Am J Physiol Renal Physiol. 2016 Oct 01; 311(4):F722-F730. PMID: 27465991.
      View in: PubMed
    29. Kanbay M, Solak Y, Afsar B, Nistor I, Aslan G, Çaglayan OH, Aykanat A, Donciu MD, Lanaspa MA, Ejaz AA, Johnson RJ, Covic A. Serum Uric Acid and Risk for Acute Kidney Injury Following Contrast. Angiology. 2017 Feb; 68(2):132-144. PMID: 27106252.
      View in: PubMed
    30. Cara-Fuentes G, Clapp WL, Johnson RJ, Garin EH. Pathogenesis of proteinuria in idiopathic minimal change disease: molecular mechanisms. Pediatr Nephrol. 2016 Dec; 31(12):2179-2189. PMID: 27384691.
      View in: PubMed
    31. Le MT, Lanaspa MA, Cicerchi CM, Rana J, Scholten JD, Hunter BL, Rivard CJ, Randolph RK, Johnson RJ. Bioactivity-Guided Identification of Botanical Inhibitors of Ketohexokinase. PLoS One. 2016; 11(6):e0157458. PMID: 27322374; PMCID: PMC4913896.
    32. Bjornstad P, Pyle L, Kinney GL, Rewers M, Johnson RJ, Maahs DM, Snell-Bergeon JK. Adiponectin is associated with early diabetic kidney disease in adults with type 1 diabetes: A Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. J Diabetes Complications. 2017 Feb; 31(2):369-374. PMID: 27368123.
      View in: PubMed
    33. Johnson RJ, Stenvinkel P, Jensen T, Lanaspa MA, Roncal C, Song Z, Bankir L, Sánchez-Lozada LG. Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors. J Am Soc Nephrol. 2016 Aug; 27(8):2247-56. PMID: 27283495; PMCID: PMC4978060 [Available on 08/01/17].
    34. Glaser J, Lemery J, Rajagopalan B, Diaz HF, García-Trabanino R, Taduri G, Madero M, Amarasinghe M, Abraham G, Anutrakulchai S, Jha V, Stenvinkel P, Roncal-Jimenez C, Lanaspa MA, Correa-Rotter R, Sheikh-Hamad D, Burdmann EA, Andres-Hernando A, Milagres T, Weiss I, Kanbay M, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy. Clin J Am Soc Nephrol. 2016 Aug 08; 11(8):1472-83. PMID: 27151892; PMCID: PMC4974898 [Available on 08/08/17].
    35. Bjornstad P, Maahs DM, Jensen T, Lanaspa MA, Johnson RJ, Rewers M, Snell-Bergeon JK. Elevated copeptin is associated with atherosclerosis and diabetic kidney disease in adults with type 1 diabetes. J Diabetes Complications. 2016 Aug; 30(6):1093-6. PMID: 27141815; PMCID: PMC4949105 [Available on 08/01/17].
    36. Kanbay M, Afsar B, Siriopol D, Unal HU, Karaman M, Saglam M, Eyileten T, Gezer M, Verim S, Oguz Y, Vural A, Ortiz A, Johnson RJ, Covic A, Yilmaz MI. Relevance of uric acid and asymmetric dimethylarginine for modeling cardiovascular risk prediction in chronic kidney disease patients. Int Urol Nephrol. 2016 Jul; 48(7):1129-36. PMID: 27007614.
      View in: PubMed
    37. Mendi MA, Afsar B, Oksuz F, Turak O, Yayla C, Ozcan F, Johnson RJ, Kanbay M. Uric Acid is a Useful Tool to Predict Contrast-Induced Nephropathy. Angiology. 2017 Aug; 68(7):627-632. PMID: 27006404.
      View in: PubMed
    38. Bjornstad P, Maahs DM, Duca LM, Pyle L, Rewers M, Johnson RJ, Snell-Bergeon JK. Estimated insulin sensitivity predicts incident micro- and macrovascular complications in adults with type 1 diabetes over 6 years: the coronary artery calcification in type 1 diabetes study. J Diabetes Complications. 2016 May-Jun; 30(4):586-90. PMID: 26936306; PMCID: PMC4834265 [Available on 05/01/17].
    39. Wesseling C, Aragón A, González M, Weiss I, Glaser J, Bobadilla NA, Roncal-Jiménez C, Correa-Rotter R, Johnson RJ, Barregard L. Kidney function in sugarcane cutters in Nicaragua--A longitudinal study of workers at risk of Mesoamerican nephropathy. Environ Res. 2016 May; 147:125-32. PMID: 26866450.
      View in: PubMed
    40. Roncal-Jimenez CA, García-Trabanino R, Wesseling C, Johnson RJ. Mesoamerican Nephropathy or Global Warming Nephropathy? Blood Purif. 2016; 41(1-3):135-8. PMID: 26766409.
      View in: PubMed
    41. Ejaz AA, Alquadan KF, Dass B, Shimada M, Kanbay M, Johnson RJ. Effects of Serum Uric Acid on Estimated GFR in Cardiac Surgery Patients: A Pilot Study. Am J Nephrol. 2015; 42(6):402-9. PMID: 26731594.
      View in: PubMed
    42. Bjornstad P, Roncal C, Milagres T, Pyle L, Lanaspa MA, Bishop FK, Snell-Bergeon JK, Johnson RJ, Wadwa RP, Maahs DM. Hyperfiltration and uricosuria in adolescents with type 1 diabetes. Pediatr Nephrol. 2016 May; 31(5):787-93. PMID: 26701836; PMCID: PMC4808359 [Available on 05/01/17].
    43. Kanbay M, Jensen T, Solak Y, Le M, Roncal-Jimenez C, Rivard C, Lanaspa MA, Nakagawa T, Johnson RJ. Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med. 2016 Apr; 29:3-8. PMID: 26703429; PMCID: PMC4826346.
    44. Takir M, Kostek O, Ozkok A, Elcioglu OC, Bakan A, Erek A, Mutlu HH, Telci O, Semerci A, Odabas AR, Afsar B, Smits G, ALanaspa M, Sharma S, Johnson RJ, Kanbay M. Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia. J Investig Med. 2015 Dec; 63(8):924-9. PMID: 26571421.
      View in: PubMed
    45. Johnson RJ, Shankland SJ, Lucia MS. A Systematic Method for Categorizing GN. J Am Soc Nephrol. 2016 May; 27(5):1265-6. PMID: 26604212; PMCID: PMC4849841 [Available on 05/01/17].
    46. Roncal-Jimenez C, García-Trabanino R, Barregard L, Lanaspa MA, Wesseling C, Harra T, Aragón A, Grases F, Jarquin ER, González MA, Weiss I, Glaser J, Sánchez-Lozada LG, Johnson RJ. Heat Stress Nephropathy From Exercise-Induced Uric Acid Crystalluria: A Perspective on Mesoamerican Nephropathy. Am J Kidney Dis. 2016 Jan; 67(1):20-30. PMID: 26455995.
      View in: PubMed
    47. Couser WG, Johnson RJ. Expanding the Domain of Postinfectious Glomerulonephritis. Am J Kidney Dis. 2015 Oct; 66(4):725. PMID: 26408237.
      View in: PubMed
    48. De Cosmo S, Viazzi F, Pacilli A, Giorda C, Ceriello A, Gentile S, Russo G, Rossi MC, Nicolucci A, Guida P, Feig D, Johnson RJ, Pontremoli R. Serum Uric Acid and Risk of CKD in Type 2 Diabetes. Clin J Am Soc Nephrol. 2015 Nov 06; 10(11):1921-9. PMID: 26342044; PMCID: PMC4633786 [Available on 11/06/16].
    49. Sulikowska B, Johnson RJ, Wiechecka-Korenkiewicz J, Korenkiewicz J, Marszalek A, Odrowaz-Sypniewska G, Manitius J. Dopamine-Induced Changes in Serum Erythropoietin and Creatinine Clearance Reflect Risk Factors for Progression of IgA Nephropathy. J Investig Med. 2015 Aug; 63(6):811-5. PMID: 26107422.
      View in: PubMed
    50. Johnson RJ, Merriman T, Lanaspa MA. Causal or Noncausal Relationship of Uric Acid With Diabetes. Diabetes. 2015 Aug; 64(8):2720-2. PMID: 26207039.
      View in: PubMed
    51. Madero M, Rodríguez Castellanos FE, Jalal D, Villalobos-Martín M, Salazar J, Vazquez-Rangel A, Johnson RJ, Sanchez-Lozada LG. A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial. J Am Soc Hypertens. 2015 Nov; 9(11):837-44. PMID: 26329473.
      View in: PubMed
    52. Wegman D, Glaser J, Johnson RJ, Hogstedt C, Wesseling C. Comment: Mesoamerican nephropathy--new evidence and the need to act now. Int J Occup Environ Health. 2015; 21(4):333-6. PMID: 26201706; PMCID: PMC4727593 [Available on 10/01/16].
    53. García-Trabanino R, Jarquín E, Wesseling C, Johnson RJ, González-Quiroz M, Weiss I, Glaser J, José Vindell J, Stockfelt L, Roncal C, Harra T, Barregard L. Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador--A cross-shift study of workers at risk of Mesoamerican nephropathy. Environ Res. 2015 Oct; 142:746-55. PMID: 26209462.
      View in: PubMed
    54. Bjornstad P, Lanaspa MA, Ishimoto T, Kosugi T, Kume S, Jalal D, Maahs DM, Snell-Bergeon JK, Johnson RJ, Nakagawa T. Fructose and uric acid in diabetic nephropathy. Diabetologia. 2015 Sep; 58(9):1993-2002. PMID: 26049401; PMCID: PMC4826347.
    55. Bjornstad P, Cherney DZ, Snell-Bergeon JK, Pyle L, Rewers M, Johnson RJ, Maahs DM. Rapid GFR decline is associated with renal hyperfiltration and impaired GFR in adults with Type 1 diabetes. Nephrol Dial Transplant. 2015 Oct; 30(10):1706-11. PMID: 26050268; PMCID: PMC4838003 [Available on 10/01/16].
    56. Johnson RJ, Nangaku M. Endothelial Dysfunction: The Secret Agent Driving Kidney Disease. J Am Soc Nephrol. 2016 Jan; 27(1):3-5. PMID: 26038532; PMCID: PMC4696590 [Available on 01/01/17].
    57. Yracheta JM, Lanaspa MA, Le MT, Abdelmalak MF, Alfonso J, Sánchez-Lozada LG, Johnson RJ. Diabetes and Kidney Disease in American Indians: Potential Role of Sugar-Sweetened Beverages. Mayo Clin Proc. 2015 Jun; 90(6):813-23. PMID: 26046414.
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    58. Segal MS, Srinivas TR, Mohandas R, Shuster JJ, Wen X, Whidden E, Tantravahi J, Johnson RJ. The effect of the addition of allopurinol on blood pressure control in African Americans treated with a thiazide-like diuretic. J Am Soc Hypertens. 2015 Aug; 9(8):610-619.e1. PMID: 26140739; PMCID: PMC4554982.
    59. Donderski R, Miskowiec-Wisniewska I, Kretowicz M, Grajewska M, Manitius J, Kaminska A, Junik R, Siódmiak J, Stefanska A, Odrowaz-Sypniewska G, Pluta A, Lanaspa M, Johnson RJ. The fructose tolerance test in patients with chronic kidney disease and metabolic syndrome in comparison to healthy controls. BMC Nephrol. 2015 May 03; 16:68. PMID: 25935771; PMCID: PMC4450852.
    60. Lanaspa MA, Epperson LE, Li N, Cicerchi C, Garcia GE, Roncal-Jimenez CA, Trostel J, Jain S, Mant CT, Rivard CJ, Ishimoto T, Shimada M, Sanchez-Lozada LG, Nakagawa T, Jani A, Stenvinkel P, Martin SL, Johnson RJ. Opposing activity changes in AMP deaminase and AMP-activated protein kinase in the hibernating ground squirrel. PLoS One. 2015; 10(4):e0123509. PMID: 25856396; PMCID: PMC4391924.
    61. Aykas F, Solak Y, Erden A, Bulut K, Dogan S, Sarli B, Acmaz G, Afsar B, Siriopol D, Covic A, Sharma S, Johnson RJ, Kanbay M. Persistence of cardiovascular risk factors in women with previous preeclampsia: a long-term follow-up study. J Investig Med. 2015 Apr; 63(4):641-5. PMID: 25738648.
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    62. Cristóbal-García M, García-Arroyo FE, Tapia E, Osorio H, Arellano-Buendía AS, Madero M, Rodríguez-Iturbe B, Pedraza-Chaverrí J, Correa F, Zazueta C, Johnson RJ, Lozada LG. Renal oxidative stress induced by long-term hyperuricemia alters mitochondrial function and maintains systemic hypertension. Oxid Med Cell Longev. 2015; 2015:535686. PMID: 25918583; PMCID: PMC4396880.
    63. Ejaz AA, Pourafshar N, Mohandas R, Smallwood BA, Johnson RJ, Hsu JW. Uric acid and the prediction models of tumor lysis syndrome in AML. PLoS One. 2015; 10(3):e0119497. PMID: 25775138; PMCID: PMC4361475.
    64. Yracheta JM, Alfonso J, Lanaspa MA, Roncal-Jimenez C, Johnson SB, Sánchez-Lozada LG, Johnson RJ. Hispanic Americans living in the United States and their risk for obesity, diabetes and kidney disease: Genetic and environmental considerations. Postgrad Med. 2015 Jun; 127(5):503-10. PMID: 25746679.
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    65. Johnson RJ. Why focus on uric acid? Curr Med Res Opin. 2015; 31 Suppl 2:3-7. PMID: 26414730.
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    66. Johnson RJ, Lanaspa MA, Gabriela Sánchez-Lozada L, Rodriguez-Iturbe B. The discovery of hypertension: evolving views on the role of the kidneys, and current hot topics. Am J Physiol Renal Physiol. 2015 Feb 01; 308(3):F167-78. PMID: 25377913.
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    67. Shiraishi T, Tamura Y, Taniguchi K, Higaki M, Ueda S, Shima T, Nagura M, Nakagawa T, Johnson RJ, Uchida S. Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1313-22. PMID: 25320353.
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    68. Garin EH, Reiser J, Cara-Fuentes G, Wei C, Matar D, Wang H, Alachkar N, Johnson RJ. Case series: CTLA4-IgG1 therapy in minimal change disease and focal segmental glomerulosclerosis. Pediatr Nephrol. 2015 Mar; 30(3):469-77. PMID: 25239302; PMCID: PMC4869736.
    69. Correa-Rotter R, Wesseling C, Johnson RJ. In reply to 'Pesticides and the epidemic of CKD in Central America'. Am J Kidney Dis. 2014 Sep; 64(3):477-8. PMID: 25150855.
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    70. Rodríguez-Iturbe B, Pons H, Quiroz Y, Johnson RJ. The immunological basis of hypertension. Am J Hypertens. 2014 Nov; 27(11):1327-37. PMID: 25150828; PMCID: PMC4263946.
    71. Choi YJ, Shin HS, Choi HS, Park JW, Jo I, Oh ES, Lee KY, Lee BH, Johnson RJ, Kang DH. Uric acid induces fat accumulation via generation of endoplasmic reticulum stress and SREBP-1c activation in hepatocytes. Lab Invest. 2014 Oct; 94(10):1114-25. PMID: 25111690.
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    72. Saab KR, Kendrick J, Yracheta JM, Lanaspa MA, Pollard M, Johnson RJ. New insights on the risk for cardiovascular disease in African Americans: the role of added sugars. J Am Soc Nephrol. 2015 Feb; 26(2):247-57. PMID: 25090991; PMCID: PMC4310665.
    73. Cara-Fuentes G, Wasserfall CH, Wang H, Johnson RJ, Garin EH. Minimal change disease: a dysregulation of the podocyte CD80-CTLA-4 axis? Pediatr Nephrol. 2014 Dec; 29(12):2333-40. PMID: 25017621; PMCID: PMC4213236.
    74. Bjornstad P, Maahs DM, Rewers M, Johnson RJ, Snell-Bergeon JK. ABC goal achievement predicts microvascular but not macrovascular complications over 6-years in adults with type 1 diabetes: the Coronary Artery Calcification in Type 1 Diabetes Study. J Diabetes Complications. 2014 Nov-Dec; 28(6):762-6. PMID: 25270733; PMCID: PMC4252593.
    75. Bjornstad P, Maahs DM, Rivard CJ, Pyle L, Rewers M, Johnson RJ, Snell-Bergeon JK. Serum uric acid predicts vascular complications in adults with type 1 diabetes: the coronary artery calcification in type 1 diabetes study. Acta Diabetol. 2014 Oct; 51(5):783-91. PMID: 24929955; PMCID: PMC4399796.
    76. Turak O, Afsar B, Ozcan F, Canpolat U, Grbovic E, Mendi MA, Oksuz F, Siriopol D, Covic A, Caliskan M, McFann K, Johnson RJ, Kanbay M. Relationship between elevated morning blood pressure surge, uric acid, and cardiovascular outcomes in hypertensive patients. J Clin Hypertens (Greenwich). 2014 Jul; 16(7):530-5. PMID: 24919769.
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    77. Mohandas R, Sautina L, Beem E, Schuler A, Chan WY, Domsic J, McKenna R, Johnson RJ, Segal MS. Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret. Exp Cell Res. 2014 Aug 01; 326(1):136-42. PMID: 24925478; PMCID: PMC4107633.
    78. Fini MA, Wright RM, Stenmark KR, Daniels SR, Johnson RJ. Is uric acid an underdiagnosed mediator of adverse outcome in metabolically healthy overweight/obese individuals? Am J Med. 2014 Jun; 127(6):e21. PMID: 24856327.
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    79. Lanaspa MA, Ishimoto T, Cicerchi C, Tamura Y, Roncal-Jimenez CA, Chen W, Tanabe K, Andres-Hernando A, Orlicky DJ, Finol E, Inaba S, Li N, Rivard CJ, Kosugi T, Sanchez-Lozada LG, Petrash JM, Sautin YY, Ejaz AA, Kitagawa W, Garcia GE, Bonthron DT, Asipu A, Diggle CP, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014 Nov; 25(11):2526-38. PMID: 24876114; PMCID: PMC4214522.
    80. Cara-Fuentes G, Johnson RJ, Reiser J, Garin EH. CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance: response. Pediatr Nephrol. 2014 Aug; 29(8):1467-8. PMID: 24817342; PMCID: PMC4136515.
    81. Johnson RJ, Rodriguez-Iturbe B, Roncal-Jimenez C, Lanaspa MA, Ishimoto T, Nakagawa T, Correa-Rotter R, Wesseling C, Bankir L, Sanchez-Lozada LG. Hyperosmolarity drives hypertension and CKD--water and salt revisited. Nat Rev Nephrol. 2014 07; 10(7):415-20. PMID: 24802066.
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    82. Kanbay A, Inonu H, Solak Y, Erden A, Uslu E, Yuksel SA, Ozturk MA, McFann K, Johnson RJ, Kanbay M. Uric acid as a potential mediator of cardiovascular morbidity in obstructive sleep apnea syndrome. Eur J Intern Med. 2014 Jun; 25(5):471-6. PMID: 24793835.
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    83. Cicerchi C, Li N, Kratzer J, Garcia G, Roncal-Jimenez CA, Tanabe K, Hunter B, Rivard CJ, Sautin YY, Gaucher EA, Johnson RJ, Lanaspa MA. Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids. FASEB J. 2014 Aug; 28(8):3339-50. PMID: 24755741; PMCID: PMC4101654.
    84. Kanbay M, Siriopol D, Nistor I, Elcioglu OC, Telci O, Takir M, Johnson RJ, Covic A. Effects of allopurinol on endothelial dysfunction: a meta-analysis. Am J Nephrol. 2014; 39(4):348-56. PMID: 24751886.
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    85. Johnson RJ, Glaser J, Sánchez-Lozada LG. Chronic kidney disease of unknown etiology: a disease related to global warming? MEDICC Rev. 2014 Apr; 16(2):79-80. PMID: 24878656.
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    86. Bjornstad P, Paul Wadwa R, Sirota JC, Snell-Bergeon JK, McFann K, Rewers M, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric acid and hypertension in adults: a paradoxical relationship in type 1 diabetes. J Clin Hypertens (Greenwich). 2014 Apr; 16(4):283-8. PMID: 24667019; PMCID: PMC3989383.
    87. Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, Ortlund EA, Johnson RJ, Gaucher EA. Evolutionary history and metabolic insights of ancient mammalian uricases. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3763-8. PMID: 24550457; PMCID: PMC3956161.
    88. Jefferson JA, Escudero E, Johnson RJ, Swenson ER, Hurtado A. Increased oxidative stress at altitude. Chest. 2014 Feb; 145(2):423. PMID: 24493532.
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    89. Correa-Rotter R, Wesseling C, Johnson RJ. CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy. Am J Kidney Dis. 2014 Mar; 63(3):506-20. PMID: 24412050.
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    90. Bjornstad P, Snell-Bergeon JK, McFann K, Wadwa RP, Rewers M, Rivard CJ, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Serum uric acid and insulin sensitivity in adolescents and adults with and without type 1 diabetes. J Diabetes Complications. 2014 May-Jun; 28(3):298-304. PMID: 24461546; PMCID: PMC4004676.
    91. Roncal Jimenez CA, Ishimoto T, Lanaspa MA, Rivard CJ, Nakagawa T, Ejaz AA, Cicerchi C, Inaba S, Le M, Miyazaki M, Glaser J, Correa-Rotter R, González MA, Aragón A, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Fructokinase activity mediates dehydration-induced renal injury. Kidney Int. 2014 Aug; 86(2):294-302. PMID: 24336030; PMCID: PMC4120672.
    92. Nakagawa T, Sato W, Kosugi T, Johnson RJ. Uncoupling of VEGF with endothelial NO as a potential mechanism for abnormal angiogenesis in the diabetic nephropathy. J Diabetes Res. 2013; 2013:184539. PMID: 24386643; PMCID: PMC3872226.
    93. Huskey J, Rivard C, Myint H, Lucia S, Smith M, Shimada M, Ishimoto T, Araya C, Garin EH, Johnson RJ. Minimal change disease in graft versus host disease: a podocyte response to the graft? Clin Nephrol. 2013 Dec; 80(6):469-73. PMID: 23006339; PMCID: PMC4504137.
    94. Cara-Fuentes G, Wei C, Segarra A, Ishimoto T, Rivard C, Johnson RJ, Reiser J, Garin EH. CD80 and suPAR in patients with minimal change disease and focal segmental glomerulosclerosis: diagnostic and pathogenic significance. Pediatr Nephrol. 2014 Aug; 29(8):1363-71. PMID: 24263531; PMCID: PMC4136522.
    95. Rodríguez-Iturbe B, Pons H, Quiroz Y, Lanaspa MA, Johnson RJ. Autoimmunity in the pathogenesis of hypertension. Nat Rev Nephrol. 2014 Jan; 10(1):56-62. PMID: 24247285.
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    96. Stenvinkel P, Johnson RJ. Kidney biomimicry--a rediscovered scientific field that could provide hope to patients with kidney disease. Arch Med Res. 2013 Nov; 44(8):584-90. PMID: 24220764.
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    97. Johnson RJ, Nakagawa T, Sánchez-Lozada LG, Lanaspa MA, Tamura Y, Tanabe K, Ishimoto T, Thomas J, Inaba S, Kitagawa W, Rivard CJ. Umami: the taste that drives purine intake. J Rheumatol. 2013 Nov; 40(11):1794-6. PMID: 24187156.
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    98. Tharabenjasin P, Douard V, Patel C, Krishnamra N, Johnson RJ, Zuo J, Ferraris RP. Acute interactions between intestinal sugar and calcium transport in vitro. Am J Physiol Gastrointest Liver Physiol. 2014 Jan 01; 306(1):G1-12. PMID: 24177030.
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    99. Chen W, Roncal-Jimenez C, Lanaspa M, Gerard S, Chonchol M, Johnson RJ, Jalal D. Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo. Metabolism. 2014 Jan; 63(1):150-60. PMID: 24269076; PMCID: PMC3859721.
    100. Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov; 58(5):1632-43. PMID: 23813872; PMCID: PMC3894259.
    101. Solak Y, Akilli H, Kayrak M, Aribas A, Gaipov A, Turk S, Perez-Pozo SE, Covic A, McFann K, Johnson RJ, Kanbay M. Uric acid level and erectile dysfunction in patients with coronary artery disease. J Sex Med. 2014 Jan; 11(1):165-72. PMID: 24433559; PMCID: PMC3962193.
    102. Bjornstad P, Snell-Bergeon JK, Rewers M, Jalal D, Chonchol MB, Johnson RJ, Maahs DM. Early diabetic nephropathy: a complication of reduced insulin sensitivity in type 1 diabetes. Diabetes Care. 2013 Nov; 36(11):3678-83. PMID: 24026551; PMCID: PMC3816872.
    103. Stenvinkel P, Fröbert O, Anderstam B, Palm F, Eriksson M, Bragfors-Helin AC, Qureshi AR, Larsson T, Friebe A, Zedrosser A, Josefsson J, Svensson M, Sahdo B, Bankir L, Johnson RJ. Metabolic changes in summer active and anuric hibernating free-ranging brown bears (Ursus arctos). PLoS One. 2013; 8(9):e72934. PMID: 24039826; PMCID: PMC3767665.
    104. Johnson RJ, Sánchez-Lozada LG. Chronic kidney disease: Mesoamerican nephropathy--new clues to the cause. Nat Rev Nephrol. 2013 Oct; 9(10):560-1. PMID: 23999393.
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    105. Fini MA, Johnson RJ, Stenmark KR, Wright RM. Hypertension, nitrate-nitrite, and xanthine oxidoreductase catalyzed nitric oxide generation: pros and cons. Hypertension. 2013 Sep; 62(3):e9. PMID: 23897071.
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    106. Maahs DM, Jalal D, Chonchol M, Johnson RJ, Rewers M, Snell-Bergeon JK. Impaired renal function further increases odds of 6-year coronary artery calcification progression in adults with type 1 diabetes: the CACTI study. Diabetes Care. 2013 Sep; 36(9):2607-14. PMID: 23835686; PMCID: PMC3747879.
    107. Cara-Fuentes G, Kairalla JA, Ishimoto T, Rivard C, Johnson RJ, Garin EH. Rituximab in idiopathic nephrotic syndrome: does it make sense? Pediatr Nephrol. 2014 Aug; 29(8):1313-9. PMID: 23793923; PMCID: PMC3856183.
    108. Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Köttgen A, Levey AS, Levin A. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet. 2013 Jul 13; 382(9887):158-69. PMID: 23727165.
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    109. Ishimoto T, Cara-Fuentes G, Wang H, Shimada M, Wasserfall CH, Winter WE, Rivard CJ, Araya CE, Saleem MA, Mathieson PW, Johnson RJ, Garin EH. Serum from minimal change patients in relapse increases CD80 expression in cultured podocytes. Pediatr Nephrol. 2013 Sep; 28(9):1803-12. PMID: 23689904; PMCID: PMC3723775.
    110. Johnson RJ, Stenvinkel P, Martin SL, Jani A, Sánchez-Lozada LG, Hill JO, Lanaspa MA. Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring). 2013 Apr; 21(4):659-64. PMID: 23401356; PMCID: PMC3660463.
    111. Johnson RJ, Nakagawa T, Jalal D, Sánchez-Lozada LG, Kang DH, Ritz E. Uric acid and chronic kidney disease: which is chasing which? Nephrol Dial Transplant. 2013 Sep; 28(9):2221-8. PMID: 23543594; PMCID: PMC4318947.
    112. Johnson RJ, Sánchez-Lozada LG, Mazzali M, Feig DI, Kanbay M, Sautin YY. What are the key arguments against uric acid as a true risk factor for hypertension? Hypertension. 2013 May; 61(5):948-51. PMID: 23460277.
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    113. Inaba S, Sautin Y, Garcia GE, Johnson RJ. What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us? Rheumatology (Oxford). 2013 Jun; 52(6):963-5. PMID: 23413026.
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    114. Kanbay M, Turak O, Johnson RJ. REPLY TO: Serum uric acid still carries controversies about its role in endothelial dysfunction. J Clin Hypertens (Greenwich). 2013 Apr; 15(4):297. PMID: 23551732.
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    115. Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. Uric acid and the origins of hypertension. J Pediatr. 2013 May; 162(5):896-902. PMID: 23403249.
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    116. Shroff RC, Price KL, Kolatsi-Joannou M, Todd AF, Wells D, Deanfield J, Johnson RJ, Rees L, Woolf AS, Long DA. Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis. PLoS One. 2013; 8(2):e56273. PMID: 23409162; PMCID: PMC3568077.
    117. Johnson RJ, Rivard C, Lanaspa MA, Otabachian-Smith S, Ishimoto T, Cicerchi C, Cheeke PR, Macintosh B, Hess T. Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome: An Equine Connection? J Equine Vet Sci. 2013 Feb; 33(2):120-126. PMID: 23439477.
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    118. Franco M, Tapia E, Bautista R, Pacheco U, Santamaria J, Quiroz Y, Johnson RJ, Rodriguez-Iturbe B. Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstitial immune cell infiltration in the kidney. Am J Physiol Renal Physiol. 2013 Apr 01; 304(7):F982-90. PMID: 23364804; PMCID: PMC3625854.
    119. Kanbay M, Segal M, Afsar B, Kang DH, Rodriguez-Iturbe B, Johnson RJ. The role of uric acid in the pathogenesis of human cardiovascular disease. Heart. 2013 Jun; 99(11):759-66. PMID: 23343689.
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    120. Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC. ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1. Chem Biol Interact. 2013 Feb 25; 202(1-3):22-31. PMID: 23348497; PMCID: PMC3746320.
    121. Le MT, Lobmeyer MT, Campbell M, Cheng J, Wang Z, Turner ST, Chapman AB, Boerwinkle E, Gums JG, Gong Y, Johnson RJ, Johnson JA. Impact of genetic polymorphisms of SLC2A2, SLC2A5, and KHK on metabolic phenotypes in hypertensive individuals. PLoS One. 2013; 8(1):e52062. PMID: 23341889; PMCID: PMC3544854.
    122. Tapia E, Cristóbal M, García-Arroyo FE, Soto V, Monroy-Sánchez F, Pacheco U, Lanaspa MA, Roncal-Jiménez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sánchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol. 2013 Mar 15; 304(6):F727-36. PMID: 23303409; PMCID: PMC3602695.
    123. Ryu ES, Kim MJ, Shin HS, Jang YH, Choi HS, Jo I, Johnson RJ, Kang DH. Uric acid-induced phenotypic transition of renal tubular cells as a novel mechanism of chronic kidney disease. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F471-80. PMID: 23283992.
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    124. Rodriguez-Iturbe B, Franco M, Johnson RJ. Impaired pressure natriuresis is associated with interstitial inflammation in salt-sensitive hypertension. Curr Opin Nephrol Hypertens. 2013 Jan; 22(1):37-44. PMID: 23165109.
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    125. Lanaspa MA, Ishimoto T, Li N, Cicerchi C, Orlicky DJ, Ruzycki P, Ruzicky P, Rivard C, Inaba S, Roncal-Jimenez CA, Bales ES, Diggle CP, Asipu A, Petrash JM, Kosugi T, Maruyama S, Sanchez-Lozada LG, McManaman JL, Bonthron DT, Sautin YY, Johnson RJ. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013; 4:2434. PMID: 24022321; PMCID: PMC3833672.
    126. Cara-Fuentes G, Araya C, Wei C, Rivard C, Ishimoto T, Reiser J, Johnson RJ, Garin EH. CD80, suPAR and nephrotic syndrome in a case of NPHS2 mutation. Nefrologia. 2013; 33(5):727-31. PMID: 24089165.
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    127. Ishimoto T, Shimada M, Gabriela G, Kosugi T, Sato W, Lee PY, Lanaspa MA, Rivard C, Maruyama S, Garin EH, Johnson RJ. Toll-like receptor 3 ligand, polyIC, induces proteinuria and glomerular CD80, and increases urinary CD80 in mice. Nephrol Dial Transplant. 2013 Jun; 28(6):1439-46. PMID: 23262434; PMCID: PMC4318967.
    128. Stenvinkel P, Jani AH, Johnson RJ. Hibernating bears (Ursidae): metabolic magicians of definite interest for the nephrologist. Kidney Int. 2013 Feb; 83(2):207-12. PMID: 23254895.
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    129. Sánchez-Lozada LG, Lanaspa MA, Cristóbal-García M, García-Arroyo F, Soto V, Cruz-Robles D, Nakagawa T, Yu MA, Kang DH, Johnson RJ. Uric acid-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP concentrations. Nephron Exp Nephrol. 2012; 121(3-4):e71-8. PMID: 23235493; PMCID: PMC3656428.
    130. Hurtado A, Escudero E, Pando J, Sharma S, Johnson RJ. Cardiovascular and renal effects of chronic exposure to high altitude. Nephrol Dial Transplant. 2012 Dec; 27 Suppl 4:iv11-6. PMID: 23258804.
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    131. Rivard C, Thomas J, Lanaspa MA, Johnson RJ. Sack and sugar, and the aetiology of gout in England between 1650 and 1900. Rheumatology (Oxford). 2013 Mar; 52(3):421-6. PMID: 23175570.
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    132. Lanaspa MA, Cicerchi C, Garcia G, Li N, Roncal-Jimenez CA, Rivard CJ, Hunter B, Andrés-Hernando A, Ishimoto T, Sánchez-Lozada LG, Thomas J, Hodges RS, Mant CT, Johnson RJ. Counteracting roles of AMP deaminase and AMP kinase in the development of fatty liver. PLoS One. 2012; 7(11):e48801. PMID: 23152807; PMCID: PMC3494720.
    133. Turak O, Ozcan F, Tok D, Isleyen A, Sökmen E, Tasoglu I, Aydogdu S, Sen N, McFann K, Johnson RJ, Kanbay M. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich). 2013 Jan; 15(1):7-13. PMID: 23282120.
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    134. Pons H, Ferrebuz A, Quiroz Y, Romero-Vasquez F, Parra G, Johnson RJ, Rodriguez-Iturbe B. Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2013 Feb 01; 304(3):F289-99. PMID: 23097471; PMCID: PMC3566521.
    135. Lanaspa MA, Sanchez-Lozada LG, Cicerchi C, Li N, Roncal-Jimenez CA, Ishimoto T, Le M, Garcia GE, Thomas JB, Rivard CJ, Andres-Hernando A, Hunter B, Schreiner G, Rodriguez-Iturbe B, Sautin YY, Johnson RJ. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLoS One. 2012; 7(10):e47948. PMID: 23112875; PMCID: PMC3480441.
    136. Liu Q, Li Z, Wang H, Chen X, Dong X, Mao H, Tan J, Luo N, Johnson RJ, Chen W, Yu X, Chen W. High prevalence and associated risk factors for impaired renal function and urinary abnormalities in a rural adult population from southern China. PLoS One. 2012; 7(10):e47100. PMID: 23056593; PMCID: PMC3467213.
    137. Lanaspa MA, Sanchez-Lozada LG, Choi YJ, Cicerchi C, Kanbay M, Roncal-Jimenez CA, Ishimoto T, Li N, Marek G, Duranay M, Schreiner G, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Sautin YY, Johnson RJ. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. J Biol Chem. 2012 Nov 23; 287(48):40732-44. PMID: 23035112; PMCID: PMC3504786.
    138. Quiroz Y, Johnson RJ, Rodríguez-Iturbe B. The role of T cells in the pathogenesis of primary hypertension. Nephrol Dial Transplant. 2012 Dec; 27 Suppl 4:iv2-5. PMID: 23036901; PMCID: PMC3526981.
    139. Sirota JC, McFann K, Targher G, Johnson RJ, Chonchol M, Jalal DI. Elevated serum uric acid levels are associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in the United States: Liver ultrasound data from the National Health and Nutrition Examination Survey. Metabolism. 2013 Mar; 62(3):392-9. PMID: 23036645; PMCID: PMC3565047.
    140. Kanbay M, Yilmaz MI, Sonmez A, Solak Y, Saglam M, Cakir E, Unal HU, Arslan E, Verim S, Madero M, Caglar K, Oguz Y, McFann K, Johnson RJ. Serum uric acid independently predicts cardiovascular events in advanced nephropathy. Am J Nephrol. 2012; 36(4):324-31. PMID: 23007099.
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    141. Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Schreiner GF, Villarreal FJ, Johnson RJ, Nakagawa T. Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy. Am J Physiol Renal Physiol. 2012 Nov 01; 303(9):F1264-74. PMID: 22933302.
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    142. Li Z, Liu Q, Mao H, Li Z, Dong X, Liu Y, Lin J, Chen W, Wang H, Johnson RJ, Yu X, Chen W. Gender difference in the association of hyperuricemia with chronic kidney disease in southern China. Kidney Blood Press Res. 2012; 36(1):98-106. PMID: 22948067.
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    143. Fini MA, Elias A, Johnson RJ, Wright RM. Contribution of uric acid to cancer risk, recurrence, and mortality. Clin Transl Med. 2012 Aug 15; 1(1):16. PMID: 23369448; PMCID: PMC3560981.
    144. Abdelmalek MF, Lazo M, Horska A, Bonekamp S, Lipkin EW, Balasubramanyam A, Bantle JP, Johnson RJ, Diehl AM, Clark JM. Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes. Hepatology. 2012 Sep; 56(3):952-60. PMID: 22467259; PMCID: PMC3406258.
    145. Wei X, Xu R, Yang Z, Li Z, Liao Y, Johnson RJ, Yu X, Chen W. Novel uromodulin mutation in familial juvenile hyperuricemic nephropathy. Am J Nephrol. 2012; 36(2):114-20. PMID: 22776760.
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    146. Ejaz AA, Kambhampati G, Ejaz NI, Dass B, Lapsia V, Arif AA, Asmar A, Shimada M, Alsabbagh MM, Aiyer R, Johnson RJ. Post-operative serum uric acid and acute kidney injury. J Nephrol. 2012 Jul-Aug; 25(4):497-505. PMID: 22684655.
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    147. Johnson RJ, Lanaspa MA, Roncal-Jimenez C, Sanchez-Lozada LG. Effects of excessive fructose intake on health. Ann Intern Med. 2012 Jun 19; 156(12):905; author reply 905-6. PMID: 22711095.
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    148. Shafiu M, Johnson RJ, Turner ST, Langaee T, Gong Y, Chapman AB, Gums JG, Johnson JA. Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension. Kidney Blood Press Res. 2012; 35(6):477-82. PMID: 22688828; PMCID: PMC3480975.
    149. Ejaz AA, Dass B, Lingegowda V, Shimada M, Beaver TM, Ejaz NI, Abouhamze AS, Johnson RJ. Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Int Urol Nephrol. 2013 Apr; 45(2):449-58. PMID: 22648289.
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    150. Tamura Y, Tanabe K, Kitagawa W, Uchida S, Schreiner GF, Johnson RJ, Nakagawa T. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F339-49. PMID: 22622455.
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    151. Madero M, Lozada LG, Johnson RJ. Fructose likely does have a role in hypertension. Hypertension. 2012 Jun; 59(6):e54; author reply e55-6. PMID: 22547437.
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    152. Ejaz AA, Dass B, Kambhampati G, Ejaz NI, Maroz N, Dhatt GS, Arif AA, Faldu C, Lanaspa MA, Shah G, Johnson RJ. Lowering serum uric acid to prevent acute kidney injury. Med Hypotheses. 2012 Jun; 78(6):796-9. PMID: 22503466.
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    153. Lapsia V, Johnson RJ, Dass B, Shimada M, Kambhampati G, Ejaz NI, Arif AA, Ejaz AA. Elevated uric acid increases the risk for acute kidney injury. Am J Med. 2012 Mar; 125(3):302.e9-17. PMID: 22340933.
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    154. Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4320-5. PMID: 22371574; PMCID: PMC3306692.
    155. Tanabe K, Lanaspa MA, Kitagawa W, Rivard CJ, Miyazaki M, Klawitter J, Schreiner GF, Saleem MA, Mathieson PW, Makino H, Johnson RJ, Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse. Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1151-60. PMID: 22338086; PMCID: PMC3362173.
    156. Le MT, Frye RF, Rivard CJ, Cheng J, McFann KK, Segal MS, Johnson RJ, Johnson JA. Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects. Metabolism. 2012 May; 61(5):641-51. PMID: 22152650; PMCID: PMC3306467.
    157. Mazali FC, Johnson RJ, Mazzali M. Use of uric acid-lowering agents limits experimental cyclosporine nephropathy. Nephron Exp Nephrol. 2012; 120(1):e12-9. PMID: 22126908; PMCID: PMC3254032.
    158. Sulikowska B, Johnson RJ, Odrowaz-Sypniewska G, Manitius J. Uric acid, renal vasoconstriction and erythropoietin relationship in IgA nephropathy revealed by dopamine-induced glomerular filtration response. Kidney Blood Press Res. 2012; 35(3):161-6. PMID: 22116260.
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    159. Shi Y, Chen W, Jalal D, Li Z, Chen W, Mao H, Yang Q, Johnson RJ, Yu X. Clinical outcome of hyperuricemia in IgA nephropathy: a retrospective cohort study and randomized controlled trial. Kidney Blood Press Res. 2012; 35(3):153-60. PMID: 22116196; PMCID: PMC3242707.
    160. Johnson RJ, Kanbay M, Sánchez-Lozada LG. The rediscovery of uric acid in cardiorenal disease: introduction. Semin Nephrol. 2011 Sep; 31(5):391-3. PMID: 22000644.
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    161. Johnson RJ, Gold MS, Johnson DR, Ishimoto T, Lanaspa MA, Zahniser NR, Avena NM. Attention-deficit/hyperactivity disorder: is it time to reappraise the role of sugar consumption? Postgrad Med. 2011 Sep; 123(5):39-49. PMID: 21904085; PMCID: PMC3598008.
    162. Johnson RJ, Lanaspa MA, Gaucher EA. Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations. Semin Nephrol. 2011 Sep; 31(5):394-9. PMID: 22000645; PMCID: PMC3203212.
    163. Johnson RJ, Kanbay M, Kang DH, Sánchez-Lozada LG, Feig D. Uric acid: a clinically useful marker to distinguish preeclampsia from gestational hypertension. Hypertension. 2011 Oct; 58(4):548-9. PMID: 21876074; PMCID: PMC3203211.
    164. Basar N, Sen N, Ozcan F, Erden G, Kanat S, Sokmen E, Isleyen A, Yuzgecer H, Ozlu MF, Yildirimkaya M, Maden O, Covic A, Johnson RJ, Kanbay M. Elevated serum uric acid predicts angiographic impaired reperfusion and 1-year mortality in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention. J Investig Med. 2011 Aug; 59(6):931-7. PMID: 21415772.
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    165. Kanbay M, Huddam B, Azak A, Solak Y, Kadioglu GK, Kirbas I, Duranay M, Covic A, Johnson RJ. A randomized study of allopurinol on endothelial function and estimated glomular filtration rate in asymptomatic hyperuricemic subjects with normal renal function. Clin J Am Soc Nephrol. 2011 Aug; 6(8):1887-94. PMID: 21784838; PMCID: PMC3359530.
    166. Kretowicz M, Johnson RJ, Ishimoto T, Nakagawa T, Manitius J. The impact of fructose on renal function and blood pressure. Int J Nephrol. 2011; 2011:315879. PMID: 21792388; PMCID: PMC3139867.
    167. Ishimoto T, Shimada M, Araya CE, Huskey J, Garin EH, Johnson RJ. Minimal change disease: a CD80 podocytopathy? Semin Nephrol. 2011 Jul; 31(4):320-5. PMID: 21839364.
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    168. Afsar B, Elsurer R, Covic A, Johnson RJ, Kanbay M. Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease. Am J Nephrol. 2011; 34(1):49-54. PMID: 21659739; PMCID: PMC3121541.
    169. Nakagawa T, Johnson RJ. Endothelial nitric oxide synthase. Contrib Nephrol. 2011; 170:93-101. PMID: 21659762.
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    170. Madero M, Arriaga JC, Jalal D, Rivard C, McFann K, Pérez-Méndez O, Vázquez A, Ruiz A, Lanaspa MA, Jimenez CR, Johnson RJ, Lozada LG. The effect of two energy-restricted diets, a low-fructose diet versus a moderate natural fructose diet, on weight loss and metabolic syndrome parameters: a randomized controlled trial. Metabolism. 2011 Nov; 60(11):1551-9. PMID: 21621801.
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    171. Shimada M, Ishimoto T, Lee PY, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Wymer DT, Yamabe H, Mathieson PW, Saleem MA, Garin EH, Johnson RJ. Toll-like receptor 3 ligands induce CD80 expression in human podocytes via an NF-?B-dependent pathway. Nephrol Dial Transplant. 2012 Jan; 27(1):81-9. PMID: 21617192.
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    172. Brymora A, Flisinski M, Johnson RJ, Goszka G, Stefanska A, Manitius J. Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease. Nephrol Dial Transplant. 2012 Feb; 27(2):608-12. PMID: 21613382; PMCID: PMC3350341.
    173. Arestegui AH, Fuquay R, Sirota J, Swenson ER, Schoene RB, Jefferson JA, Chen W, Yu XQ, Kelly JP, Johnson RJ, Escudero E. High altitude renal syndrome (HARS). J Am Soc Nephrol. 2011 Nov; 22(11):1963-8. PMID: 21566053.
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    174. Garcia GE, Truong LD, Chen JF, Johnson RJ, Feng L. Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney Int. 2011 Aug; 80(4):378-88. PMID: 21508927.
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    175. Roncal-Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Jalal D, Andres-Hernando A, Tanabe K, Madero M, Li N, Cicerchi C, Mc Fann K, Sautin YY, Johnson RJ. Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism. 2011 Sep; 60(9):1259-70. PMID: 21489572; PMCID: PMC3137694.
    176. Kanbay M, Ikizek M, Solak Y, Selcoki Y, Uysal S, Armutcu F, Eryonucu B, Covic A, Johnson RJ. Uric acid and pentraxin-3 levels are independently associated with coronary artery disease risk in patients with stage 2 and 3 kidney disease. Am J Nephrol. 2011; 33(4):325-31. PMID: 21389698; PMCID: PMC3064941.
    177. Kanbay M, Yilmaz MI, Sonmez A, Turgut F, Saglam M, Cakir E, Yenicesu M, Covic A, Jalal D, Johnson RJ. Serum uric acid level and endothelial dysfunction in patients with nondiabetic chronic kidney disease. Am J Nephrol. 2011; 33(4):298-304. PMID: 21389694; PMCID: PMC3064939.
    178. Baldwin W, McRae S, Marek G, Wymer D, Pannu V, Baylis C, Johnson RJ, Sautin YY. Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011 Apr; 60(4):1258-69. PMID: 21346177; PMCID: PMC3064099.
    179. Madero M, Perez-Pozo SE, Jalal D, Johnson RJ, Sánchez-Lozada LG. Dietary fructose and hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):29-35. PMID: 20957458.
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    180. Hovind P, Rossing P, Johnson RJ, Parving HH. Serum uric acid as a new player in the development of diabetic nephropathy. J Ren Nutr. 2011 Jan; 21(1):124-7. PMID: 21195935.
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    181. Johnson RJ, Sanchez-Lozada LG, Nakagawa T. The effect of fructose on renal biology and disease. J Am Soc Nephrol. 2010 Dec; 21(12):2036-9. PMID: 21115612.
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    182. Nakagawa T, Tanabe K, Croker BP, Johnson RJ, Grant MB, Kosugi T, Li Q. Endothelial dysfunction as a potential contributor in diabetic nephropathy. Nat Rev Nephrol. 2011 Jan; 7(1):36-44. PMID: 21045790; PMCID: PMC3653134.
    183. Shimada M, Araya C, Rivard C, Ishimoto T, Johnson RJ, Garin EH. Minimal change disease: a "two-hit" podocyte immune disorder? Pediatr Nephrol. 2011 Apr; 26(4):645-9. PMID: 21052729.
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    184. Chen W, Liu Q, Wang H, Chen W, Johnson RJ, Dong X, Li H, Ba S, Tan J, Luo N, Liu T, He H, Yu X. Prevalence and risk factors of chronic kidney disease: a population study in the Tibetan population. Nephrol Dial Transplant. 2011 May; 26(5):1592-9. PMID: 20940370.
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    185. Kanbay M, Sánchez-Lozada LG, Franco M, Madero M, Solak Y, Rodriguez-Iturbe B, Covic A, Johnson RJ. Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin. Nephrol Dial Transplant. 2011 Feb; 26(2):430-7. PMID: 20935013.
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    186. Nakagawa T, Johnson RJ. Hypertension: Is there a dark side to thiazide therapy for hypertension? Nat Rev Nephrol. 2010 Oct; 6(10):564-6. PMID: 20871636.
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    187. Goldberg RJ, Nakagawa T, Johnson RJ, Thurman JM. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis. 2010 Dec; 56(6):1168-74. PMID: 20843591; PMCID: PMC3148799.
    188. Rodrigues TC, Maahs DM, Johnson RJ, Jalal DI, Kinney GL, Rivard C, Rewers M, Snell-Bergeon JK. Serum uric acid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease. Diabetes Care. 2010 Nov; 33(11):2471-3. PMID: 20798338; PMCID: PMC2963516.
    189. Rodriguez-Iturbe B, Johnson RJ. The role of renal microvascular disease and interstitial inflammation in salt-sensitive hypertension. Hypertens Res. 2010 Oct; 33(10):975-80. PMID: 20686485.
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    190. Johnson RJ, Murray R. Fructose, exercise, and health. Curr Sports Med Rep. 2010 Jul-Aug; 9(4):253-8. PMID: 20622544.
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    191. Jalal DI, Smits G, Johnson RJ, Chonchol M. Increased fructose associates with elevated blood pressure. J Am Soc Nephrol. 2010 Sep; 21(9):1543-9. PMID: 20595676; PMCID: PMC3013529.
    192. Abdelmalek MF, Suzuki A, Guy C, Unalp-Arida A, Colvin R, Johnson RJ, Diehl AM. Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease. Hepatology. 2010 Jun; 51(6):1961-71. PMID: 20301112; PMCID: PMC2922495.
    193. Yu MA, Sánchez-Lozada LG, Johnson RJ, Kang DH. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens. 2010 Jun; 28(6):1234-42. PMID: 20486275.
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    194. Garin EH, Mu W, Arthur JM, Rivard CJ, Araya CE, Shimada M, Johnson RJ. Urinary CD80 is elevated in minimal change disease but not in focal segmental glomerulosclerosis. Kidney Int. 2010 Aug; 78(3):296-302. PMID: 20485332.
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    195. Li Q, Verma A, Han PY, Nakagawa T, Johnson RJ, Grant MB, Campbell-Thompson M, Jarajapu YP, Lei B, Hauswirth WW. Diabetic eNOS-knockout mice develop accelerated retinopathy. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5240-6. PMID: 20435587; PMCID: PMC3066622.
    196. Mazzali M, Kanbay M, Segal MS, Shafiu M, Jalal D, Feig DI, Johnson RJ. Uric acid and hypertension: cause or effect? Curr Rheumatol Rep. 2010 Apr; 12(2):108-17. PMID: 20425019.
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    197. Todd AS, Macginley RJ, Schollum JB, Johnson RJ, Williams SM, Sutherland WH, Mann JI, Walker RJ. Dietary salt loading impairs arterial vascular reactivity. Am J Clin Nutr. 2010 Mar; 91(3):557-64. PMID: 20107199.
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    198. Nakayama T, Kosugi T, Gersch M, Connor T, Sanchez-Lozada LG, Lanaspa MA, Roncal C, Perez-Pozo SE, Johnson RJ, Nakagawa T. Dietary fructose causes tubulointerstitial injury in the normal rat kidney. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F712-20. PMID: 20071464; PMCID: PMC2838595.
    199. Zharikov SI, Swenson ER, Lanaspa M, Block ER, Patel JM, Johnson RJ. Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension? Med Hypotheses. 2010 Jun; 74(6):1069-74. PMID: 20064695; PMCID: PMC2854831.
    200. Jalal DI, Rivard CJ, Johnson RJ, Maahs DM, McFann K, Rewers M, Snell-Bergeon JK. Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study. Nephrol Dial Transplant. 2010 Jun; 25(6):1865-9. PMID: 20064950; PMCID: PMC2902891.
    201. Johnson RJ, Andrews P, Benner SA, Oliver W. Theodore E. Woodward award. The evolution of obesity: insights from the mid-Miocene. Trans Am Clin Climatol Assoc. 2010; 121:295-305; discussion 305-8. PMID: 20697570; PMCID: PMC2917125.
    202. Johnson RJ, Sánchez-Lozada LG, Rodríguez-Iturbe B. Hypertension: New treatment target for systolic blood pressure? Nat Rev Nephrol. 2009 Dec; 5(12):675-6. PMID: 19935814.
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    203. Osterberg KL, Pallardy SE, Johnson RJ, Horswill CA. Carbohydrate exerts a mild influence on fluid retention following exercise-induced dehydration. J Appl Physiol (1985). 2010 Feb; 108(2):245-50. PMID: 19940093.
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    204. Ejaz AA, Beaver TM, Shimada M, Sood P, Lingegowda V, Schold JD, Kim T, Johnson RJ. Uric acid: a novel risk factor for acute kidney injury in high-risk cardiac surgery patients? Am J Nephrol. 2009; 30(5):425-9. PMID: 19752530.
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    205. Johnson RJ, Rivard C, Nakagawa T, Sautin YY, Sanchez-Lozada LG. Uric acid: more to learn, more experiments to do. Am J Hypertens. 2009 Sep; 22(9):952-3. PMID: 19701166.
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    206. Roncal CA, Reungjui S, Sánchez-Lozada LG, Mu W, Sautin YY, Nakagawa T, Johnson RJ. Combination of captopril and allopurinol retards fructose-induced metabolic syndrome. Am J Nephrol. 2009; 30(5):399-404. PMID: 19696478; PMCID: PMC2783362.
    207. Sánchez-Lozada LG, Mu W, Roncal C, Sautin YY, Abdelmalek M, Reungjui S, Le M, Nakagawa T, Lan HY, Yu X, Johnson RJ. Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver. Eur J Nutr. 2010 Feb; 49(1):1-9. PMID: 19626358; PMCID: PMC2805058.
    208. Shimada M, Johnson RJ, May WS, Lingegowda V, Sood P, Nakagawa T, Van QC, Dass B, Ejaz AA. A novel role for uric acid in acute kidney injury associated with tumour lysis syndrome. Nephrol Dial Transplant. 2009 Oct; 24(10):2960-4. PMID: 19581334.
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    209. Ejaz AA, Martin TD, Johnson RJ, Winterstein AG, Klodell CT, Hess PJ, Ali AK, Whidden EM, Staples NL, Alexander JA, House-Fancher MA, Beaver TM. Prophylactic nesiritide does not prevent dialysis or all-cause mortality in patients undergoing high-risk cardiac surgery. J Thorac Cardiovasc Surg. 2009 Oct; 138(4):959-64. PMID: 19660420.
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    210. Abdel-Hafez M, Shimada M, Lee PY, Johnson RJ, Garin EH. Idiopathic nephrotic syndrome and atopy: is there a common link? Am J Kidney Dis. 2009 Nov; 54(5):945-53. PMID: 19556042; PMCID: PMC2895907.
    211. Kim KM, Henderson GN, Ouyang X, Frye RF, Sautin YY, Feig DI, Johnson RJ. A sensitive and specific liquid chromatography-tandem mass spectrometry method for the determination of intracellular and extracellular uric acid. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jul 15; 877(22):2032-8. PMID: 19520625; PMCID: PMC2752364.
    212. Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, Roncal C, Johnson RJ, Nakagawa T. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol. 2009 Aug; 297(2):F481-8. PMID: 19458127; PMCID: PMC2724243.
    213. Hovind P, Rossing P, Tarnow L, Johnson RJ, Parving HH. Serum uric acid as a predictor for development of diabetic nephropathy in type 1 diabetes: an inception cohort study. Diabetes. 2009 Jul; 58(7):1668-71. PMID: 19411615; PMCID: PMC2699868.
    214. Cirillo P, Sautin YY, Kanellis J, Kang DH, Gesualdo L, Nakagawa T, Johnson RJ. Systemic inflammation, metabolic syndrome and progressive renal disease. Nephrol Dial Transplant. 2009 May; 24(5):1384-7. PMID: 19208772; PMCID: PMC2721462.
    215. Gersch C, Palii SP, Imaram W, Kim KM, Karumanchi SA, Angerhofer A, Johnson RJ, Henderson GN. Reactions of peroxynitrite with uric acid: formation of reactive intermediates, alkylated products and triuret, and in vivo production of triuret under conditions of oxidative stress. Nucleosides Nucleotides Nucleic Acids. 2009 Feb; 28(2):118-49. PMID: 19219741; PMCID: PMC2742358.
    216. Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderson GN, Johnson RJ, Sautin YY. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol. 2009 Mar; 20(3):545-53. PMID: 19158351; PMCID: PMC2653686.
    217. Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, Shafiu M, Segal M, Glassock RJ, Shimada M, Roncal C, Nakagawa T. Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev. 2009 Feb; 30(1):96-116. PMID: 19151107; PMCID: PMC2647706.
    218. Garin EH, Diaz LN, Mu W, Wasserfall C, Araya C, Segal M, Johnson RJ. Urinary CD80 excretion increases in idiopathic minimal-change disease. J Am Soc Nephrol. 2009 Feb; 20(2):260-6. PMID: 19056875; PMCID: PMC2637046.
    219. Parra G, Quiroz Y, Salazar J, Bravo Y, Pons H, Chavez M, Johnson RJ, Rodriguez-Iturbe B. Experimental induction of salt-sensitive hypertension is associated with lymphocyte proliferative response to HSP70. Kidney Int Suppl. 2008 Dec; (111):S55-9. PMID: 19034328.
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    220. Nakayama T, Sato W, Kosugi T, Zhang L, Campbell-Thompson M, Yoshimura A, Croker BP, Johnson RJ, Nakagawa T. Endothelial injury due to eNOS deficiency accelerates the progression of chronic renal disease in the mouse. Am J Physiol Renal Physiol. 2009 Feb; 296(2):F317-27. PMID: 19036847; PMCID: PMC4063508.
    221. Kim KM, Henderson GN, Frye RF, Galloway CD, Brown NJ, Segal MS, Imaram W, Angerhofer A, Johnson RJ. Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 01; 877(1-2):65-70. PMID: 19081307; PMCID: PMC2684329.
    222. Sánchez-Lozada LG, Le M, Segal M, Johnson RJ. How safe is fructose for persons with or without diabetes? Am J Clin Nutr. 2008 Nov; 88(5):1189-90. PMID: 18996851.
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    223. Mohandas R, Johnson RJ. Uric acid levels increase risk for new-onset kidney disease. J Am Soc Nephrol. 2008 Dec; 19(12):2251-3. PMID: 18971373.
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    224. Mu W, Long DA, Ouyang X, Agarwal A, Cruz PE, Roncal CA, Nakagawa T, Yu X, Hauswirth WW, Johnson RJ. Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism. Am J Physiol Renal Physiol. 2009 Jan; 296(1):F145-52. PMID: 18971211; PMCID: PMC2636910.
    225. Chen W, Chen W, Wang H, Dong X, Liu Q, Mao H, Tan J, Lin J, Zhou F, Luo N, He H, Johnson RJ, Zhou SF, Yu X. Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant. 2009 Apr; 24(4):1205-12. PMID: 18952699; PMCID: PMC3203397.
    226. Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008 Oct 23; 359(17):1811-21. PMID: 18946066; PMCID: PMC2684330.
    227. Luks AM, Johnson RJ, Swenson ER. Chronic kidney disease at high altitude. J Am Soc Nephrol. 2008 Dec; 19(12):2262-71. PMID: 18842990.
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    228. Rodriguez-Iturbe B, Vaziri ND, Johnson RJ. Inflammation, angiotensin II, and hypertension. Hypertension. 2008 Nov; 52(5):e135; author reply e136. PMID: 18838621; PMCID: PMC2717623.
    229. Zharikov S, Krotova K, Hu H, Baylis C, Johnson RJ, Block ER, Patel J. Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1183-90. PMID: 18784379; PMCID: PMC2584985.
    230. Reungjui S, Pratipanawatr T, Johnson RJ, Nakagawa T. Do thiazides worsen metabolic syndrome and renal disease? The pivotal roles for hyperuricemia and hypokalemia. Curr Opin Nephrol Hypertens. 2008 Sep; 17(5):470-6. PMID: 18695387; PMCID: PMC2903051.
    231. Feig DI, Soletsky B, Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008 Aug 27; 300(8):924-32. PMID: 18728266; PMCID: PMC2684336.
    232. Hu H, Lu L, Mu W, Johnson RJ, Block ER, Patel JM. Priming donor lungs with thioredoxin-1 attenuates acute allograft injury in a rat model of lung transplantation. J Heart Lung Transplant. 2008 Oct; 27(10):1142-9. PMID: 18926407; PMCID: PMC2590662.
    233. Tapia E, Sánchez-González DJ, Medina-Campos ON, Soto V, Avila-Casado C, Martínez-Martínez CM, Johnson RJ, Rodríguez-Iturbe B, Pedraza-Chaverrí J, Franco M, Sánchez-Lozada LG. Treatment with pyrrolidine dithiocarbamate improves proteinuria, oxidative stress, and glomerular hypertension in overload proteinuria. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1431-9. PMID: 18753301; PMCID: PMC2584905.
    234. Shapiro A, Mu W, Roncal C, Cheng KY, Johnson RJ, Scarpace PJ. Fructose-induced leptin resistance exacerbates weight gain in response to subsequent high-fat feeding. Am J Physiol Regul Integr Comp Physiol. 2008 Nov; 295(5):R1370-5. PMID: 18703413; PMCID: PMC2584858.
    235. Sánchez-Lozada LG, Soto V, Tapia E, Avila-Casado C, Sautin YY, Nakagawa T, Franco M, Rodríguez-Iturbe B, Johnson RJ. Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1134-41. PMID: 18701632; PMCID: PMC2576157.
    236. Lee SM, Lee AL, Winters TJ, Tam E, Jaleel M, Stenvinkel P, Johnson RJ. Low serum uric acid level is a risk factor for death in incident hemodialysis patients. Am J Nephrol. 2009; 29(2):79-85. PMID: 18689987; PMCID: PMC2786018.
    237. Gersch C, Palii SP, Kim KM, Angerhofer A, Johnson RJ, Henderson GN. Inactivation of nitric oxide by uric acid. Nucleosides Nucleotides Nucleic Acids. 2008 Aug; 27(8):967-78. PMID: 18696365; PMCID: PMC2701227.
    238. Johnson RJ, Sautin YY, Oliver WJ, Roncal C, Mu W, Gabriela Sanchez-Lozada L, Rodriguez-Iturbe B, Nakagawa T, Benner SA. Lessons from comparative physiology: could uric acid represent a physiologic alarm signal gone awry in western society? J Comp Physiol B. 2009 Jan; 179(1):67-76. PMID: 18649082; PMCID: PMC2684327.
    239. Le MT, Shafiu M, Mu W, Johnson RJ. SLC2A9--a fructose transporter identified as a novel uric acid transporter. Nephrol Dial Transplant. 2008 Sep; 23(9):2746-9. PMID: 18606621; PMCID: PMC2734172.
    240. Sautin YY, Johnson RJ. Uric acid: the oxidant-antioxidant paradox. Nucleosides Nucleotides Nucleic Acids. 2008 Jun; 27(6):608-19. PMID: 18600514; PMCID: PMC2895915.
    241. Glushakova O, Kosugi T, Roncal C, Mu W, Heinig M, Cirillo P, Sánchez-Lozada LG, Johnson RJ, Nakagawa T. Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep; 19(9):1712-20. PMID: 18508964; PMCID: PMC2518440.
    242. Dharnidharka VR, Johnson RJ. Uric acid--a bad acid for the kidney? Pediatr Transplant. 2008 Dec; 12(8):821-2. PMID: 18503480.
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    243. Sánchez-Lozada LG, Tapia E, Soto V, Avila-Casado C, Franco M, Wessale JL, Zhao L, Johnson RJ. Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia. Nephron Physiol. 2008; 108(4):p69-78. PMID: 18434753.
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    244. Ouyang X, Cirillo P, Sautin Y, McCall S, Bruchette JL, Diehl AM, Johnson RJ, Abdelmalek MF. Fructose consumption as a risk factor for non-alcoholic fatty liver disease. J Hepatol. 2008 Jun; 48(6):993-9. PMID: 18395287; PMCID: PMC2423467.
    245. Johnson RJ, Gaucher EA, Sautin YY, Henderson GN, Angerhofer AJ, Benner SA. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Med Hypotheses. 2008; 71(1):22-31. PMID: 18331782; PMCID: PMC2495042.
    246. Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C, Mu W, Sánchez-Lozada LG, Johnson RJ. The conundrum of hyperuricemia, metabolic syndrome, and renal disease. Intern Emerg Med. 2008 Dec; 3(4):313-8. PMID: 18320146; PMCID: PMC2895906.
    247. Johnson RJ, Feig DI, Nakagawa T, Sanchez-Lozada LG, Rodriguez-Iturbe B. Pathogenesis of essential hypertension: historical paradigms and modern insights. J Hypertens. 2008 Mar; 26(3):381-91. PMID: 18300843; PMCID: PMC2742362.
    248. Sánchez-Lozada LG, Tapia E, Bautista-García P, Soto V, Avila-Casado C, Vega-Campos IP, Nakagawa T, Zhao L, Franco M, Johnson RJ. Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F710-8. PMID: 18216151.
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    249. Franco M, Sanchez-Lozada LG, Bautista R, Johnson RJ, Rodriguez-Iturbe B. Pathophysiology of salt-sensitive hypertension: a new scope of an old problem. Blood Purif. 2008; 26(1):45-8. PMID: 18182795.
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    250. Reungjui S, Roncal CA, Sato W, Glushakova OY, Croker BP, Suga S, Ouyang X, Tungsanga K, Nakagawa T, Johnson RJ, Mu W. Hypokalemic nephropathy is associated with impaired angiogenesis. J Am Soc Nephrol. 2008 Jan; 19(1):125-34. PMID: 18178802; PMCID: PMC2391040.
    251. Sánchez-Lozada LG, Tapia E, Soto V, Avila-Casado C, Franco M, Zhao L, Johnson RJ. Treatment with the xanthine oxidase inhibitor febuxostat lowers uric acid and alleviates systemic and glomerular hypertension in experimental hyperuricaemia. Nephrol Dial Transplant. 2008 Apr; 23(4):1179-85. PMID: 18048425.
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    252. Hohenstein B, Braun A, Amann KU, Johnson RJ, Hugo CP. A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy. Nephrol Dial Transplant. 2008 Apr; 23(4):1144-56. PMID: 18045820.
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    253. Rodriguez-Iturbe B, Romero F, Johnson RJ. Pathophysiological mechanisms of salt-dependent hypertension. Am J Kidney Dis. 2007 Oct; 50(4):655-72. PMID: 17900467.
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    254. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG. Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr. 2007 Oct; 86(4):899-906. PMID: 17921363.
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    255. Reungjui S, Roncal CA, Mu W, Srinivas TR, Sirivongs D, Johnson RJ, Nakagawa T. Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol. 2007 Oct; 18(10):2724-31. PMID: 17855639.
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    256. Segal MS, Gollub E, Johnson RJ. Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index? Eur J Nutr. 2007 Oct; 46(7):406-17. PMID: 17763967.
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    257. Roncal C, Mu W, Reungjui S, Kim KM, Henderson GN, Ouyang X, Nakagawa T, Johnson RJ. Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1391-6. PMID: 17715263.
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    258. Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1256-61. PMID: 17670904.
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    259. Nakagawa T, Segal M, Croker B, Johnson RJ. A breakthrough in diabetic nephropathy: the role of endothelial dysfunction. Nephrol Dial Transplant. 2007 Oct; 22(10):2775-7. PMID: 17595179.
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    260. Franco M, Martínez F, Quiroz Y, Galicia O, Bautista R, Johnson RJ, Rodríguez-Iturbe B. Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol. 2007 Jul; 293(1):R251-6. PMID: 17475676.
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    261. Garcia GE, Truong LD, Li P, Zhang P, Johnson RJ, Wilson CB, Feng L. Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis. Am J Pathol. 2007 May; 170(5):1485-96. PMID: 17456756; PMCID: PMC1854945.
    262. Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C584-96. PMID: 17428837.
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    263. Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, Campbell-Thompson M, Yuzawa Y, Atkinson MA, Johnson RJ, Croker B. Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol. 2007 Feb; 18(2):539-50. PMID: 17202420.
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    264. Roncal CA, Mu W, Croker B, Reungjui S, Ouyang X, Tabah-Fisch I, Johnson RJ, Ejaz AA. Effect of elevated serum uric acid on cisplatin-induced acute renal failure. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F116-22. PMID: 17210794.
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    265. Ejaz AA, Johnson RJ. Heart failure, natriuretic peptides, and the nephrologist. Rev Cardiovasc Med. 2007; 8 Suppl 5:S30-1. PMID: 18192952.
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    266. Feig DI, Johnson RJ. The role of uric acid in pediatric hypertension. J Ren Nutr. 2007 Jan; 17(1):79-83. PMID: 17198939; PMCID: PMC1847593.
    267. Sánchez-Lozada LG, Tapia E, López-Molina R, Nepomuceno T, Soto V, Avila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J, Franco M. Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. Am J Physiol Renal Physiol. 2007 Apr; 292(4):F1238-44. PMID: 17190912.
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    268. Ejaz AA, Mu W, Kang DH, Roncal C, Sautin YY, Henderson G, Tabah-Fisch I, Keller B, Beaver TM, Nakagawa T, Johnson RJ. Could uric acid have a role in acute renal failure? Clin J Am Soc Nephrol. 2007 Jan; 2(1):16-21. PMID: 17699382.
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    269. Cirillo P, Sato W, Reungjui S, Heinig M, Gersch M, Sautin Y, Nakagawa T, Johnson RJ. Uric acid, the metabolic syndrome, and renal disease. J Am Soc Nephrol. 2006 Dec; 17(12 Suppl 3):S165-8. PMID: 17130256.
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    270. Heinig M, Johnson RJ. Role of uric acid in hypertension, renal disease, and metabolic syndrome. Cleve Clin J Med. 2006 Dec; 73(12):1059-64. PMID: 17190309.
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    271. Germain AM, Romanik MC, Guerra I, Solari S, Reyes MS, Johnson RJ, Price K, Karumanchi SA, Valdés G. Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension. 2007 Jan; 49(1):90-5. PMID: 17116761.
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    272. Suliman ME, Johnson RJ, García-López E, Qureshi AR, Molinaei H, Carrero JJ, Heimbürger O, Bárány P, Axelsson J, Lindholm B, Stenvinkel P. J-shaped mortality relationship for uric acid in CKD. Am J Kidney Dis. 2006 Nov; 48(5):761-71. PMID: 17059995.
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    273. Gersch MS, Johnson RJ. Uric acid and the immune response. Nephrol Dial Transplant. 2006 Nov; 21(11):3046-7. PMID: 16963481.
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    274. Sánchez-Lozada LG, Tapia E, Jiménez A, Bautista P, Cristóbal M, Nepomuceno T, Soto V, Avila-Casado C, Nakagawa T, Johnson RJ, Herrera-Acosta J, Franco M. Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F423-9. PMID: 16940562.
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    275. Franco M, Martínez F, Rodríguez-Iturbe B, Johnson RJ, Santamaría J, Montoya A, Nepomuceno T, Bautista R, Tapia E, Herrera-Acosta J. Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1281-7. PMID: 16868307.
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    276. Gersch MS, Sautin YY, Gersch CM, Henderson G, Bankir L, Johnson RJ. Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis? Nephrol Dial Transplant. 2006 Oct; 21(10):2938-42. PMID: 16861244.
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    277. Keller K, Daniel C, Schöcklmann H, Endlich KH, Kerjaschki D, Johnson RJ, Hugo C. Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy. Nephrol Dial Transplant. 2006 Oct; 21(10):2724-35. PMID: 16861242.
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    278. Long DA, Mu W, Price KL, Roncal C, Schreiner GF, Woolf AS, Johnson RJ. Vascular endothelial growth factor administration does not improve microvascular disease in the salt-dependent phase of post-angiotensin II hypertension. Am J Physiol Renal Physiol. 2006 Dec; 291(6):F1248-54. PMID: 16804104.
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    279. Price KL, Sautin YY, Long DA, Zhang L, Miyazaki H, Mu W, Endou H, Johnson RJ. Human vascular smooth muscle cells express a urate transporter. J Am Soc Nephrol. 2006 Jul; 17(7):1791-5. PMID: 16775029.
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    280. Feig DI, Rodriguez-Iturbe B, Nakagawa T, Johnson RJ. Nephron number, uric acid, and renal microvascular disease in the pathogenesis of essential hypertension. Hypertension. 2006 Jul; 48(1):25-6. PMID: 16682608.
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    281. Feig DI, Kang DH, Nakagawa T, Mazzali M, Johnson RJ. Uric acid and hypertension. Curr Hypertens Rep. 2006 May; 8(2):111-5. PMID: 16672142.
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    282. Feig DI, Mazzali M, Kang DH, Nakagawa T, Price K, Kannelis J, Johnson RJ. Serum uric acid: a risk factor and a target for treatment? J Am Soc Nephrol. 2006 Apr; 17(4 Suppl 2):S69-73. PMID: 16565251.
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    283. Araya CE, Wasserfall CH, Brusko TM, Mu W, Segal MS, Johnson RJ, Garin EH. A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol. 2006 May; 21(5):603-10. PMID: 16525836.
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    284. Segal MS, Baylis C, Johnson RJ. Endothelial health and diversity in the kidney. J Am Soc Nephrol. 2006 Feb; 17(2):323-4. PMID: 16434502; PMCID: PMC2756809.
    285. Nakagawa T, Sato W, Sautin YY, Glushakova O, Croker B, Atkinson MA, Tisher CC, Johnson RJ. Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy. J Am Soc Nephrol. 2006 Mar; 17(3):736-45. PMID: 16436494.
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    286. Sánchez-Lozada LG, Nakagawa T, Kang DH, Feig DI, Franco M, Johnson RJ, Herrera-Acosta J. Hormonal and cytokine effects of uric acid. Curr Opin Nephrol Hypertens. 2006 Jan; 15(1):30-3. PMID: 16340663.
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    287. Beaver TM, Winterstein AG, Shuster JJ, Gerhard T, Martin T, Alexander JA, Johnson RJ, Ejaz A, Hartzema AG. Effectiveness of nesiritide on dialysis or all-cause mortality in patients undergoing cardiothoracic surgery. Clin Cardiol. 2006 Jan; 29(1):18-24. PMID: 16477773.
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    288. Nakagawa T, Mazzali M, Kang DH, Sánchez-Lozada LG, Herrera-Acosta J, Johnson RJ. Uric acid--a uremic toxin? Blood Purif. 2006; 24(1):67-70. PMID: 16361844.
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    289. Rodriguez-Iturbe B, Johnson RJ. Role of inflammatory cells in the kidney in the induction and maintenance of hypertension. Nephrol Dial Transplant. 2006 Feb; 21(2):260-3. PMID: 16326746.
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    290. Nakagawa T, Tuttle KR, Short RA, Johnson RJ. Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome. Nat Clin Pract Nephrol. 2005 Dec; 1(2):80-6. PMID: 16932373.
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    291. Long DA, Newaz MA, Prabhakar SS, Price KL, Truong LD, Feng L, Mu W, Oyekan AO, Johnson RJ. Loss of nitric oxide and endothelial-derived hyperpolarizing factor-mediated responses in aging. Kidney Int. 2005 Nov; 68(5):2154-63. PMID: 16221214.
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    292. Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ. IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol. 2005 Dec; 16(12):3651-60. PMID: 16251240.
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    293. Kang DH, Park SK, Lee IK, Johnson RJ. Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. J Am Soc Nephrol. 2005 Dec; 16(12):3553-62. PMID: 16251237.
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    294. Thadhani RI, Johnson RJ, Karumanchi SA. Hypertension during pregnancy: a disorder begging for pathophysiological support. Hypertension. 2005 Dec; 46(6):1250-1. PMID: 16246974.
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    295. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, Ouyang X, Feig DI, Block ER, Herrera-Acosta J, Patel JM, Johnson RJ. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006 Mar; 290(3):F625-31. PMID: 16234313.
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    296. Sekhon I, Munjal S, Croker B, Johnson RJ, Ejaz AA. Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephrotic syndrome. Am J Kidney Dis. 2005 Oct; 46(4):e55-8. PMID: 16183408.
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    297. Kang DH, Han L, Ouyang X, Kahn AM, Kanellis J, Li P, Feng L, Nakagawa T, Watanabe S, Hosoyamada M, Endou H, Lipkowitz M, Abramson R, Mu W, Johnson RJ. Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate transporter. Am J Nephrol. 2005 Sep-Oct; 25(5):425-33. PMID: 16113518.
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    298. Eto N, Kojima I, Uesugi N, Inagi R, Miyata T, Fujita T, Johnson RJ, Shankland SJ, Nangaku M. Protection of endothelial cells by dextran sulfate in rats with thrombotic microangiopathy. J Am Soc Nephrol. 2005 Oct; 16(10):2997-3005. PMID: 16093450.
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    299. Hurtado A, Johnson RJ. Hygiene hypothesis and prevalence of glomerulonephritis. Kidney Int Suppl. 2005 Aug; (97):S62-7. PMID: 16014103.
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    300. Long DA, Mu W, Price KL, Johnson RJ. Blood vessels and the aging kidney. Nephron Exp Nephrol. 2005; 101(3):e95-9. PMID: 16043968.
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    301. Ouyang X, Le TH, Roncal C, Gersch C, Herrera-Acosta J, Rodriguez-Iturbe B, Coffman TM, Johnson RJ, Mu W. Th1 inflammatory response with altered expression of profibrotic and vasoactive mediators in AT1A and AT1B double-knockout mice. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F902-10. PMID: 15928210.
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    302. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, Krotova K, Block ER, Prabhakar S, Johnson RJ. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005 May; 67(5):1739-42. PMID: 15840020.
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    303. Johnson RJ, Segal MS, Srinivas T, Ejaz A, Mu W, Roncal C, Sánchez-Lozada LG, Gersch M, Rodriguez-Iturbe B, Kang DH, Acosta JH. Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol. 2005 Jul; 16(7):1909-19. PMID: 15843466.
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    304. Hediger MA, Johnson RJ, Miyazaki H, Endou H. Molecular physiology of urate transport. Physiology (Bethesda). 2005 Apr; 20:125-33. PMID: 15772301.
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    305. Stenvinkel P, Ketteler M, Johnson RJ, Lindholm B, Pecoits-Filho R, Riella M, Heimbürger O, Cederholm T, Girndt M. IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. Kidney Int. 2005 Apr; 67(4):1216-33. PMID: 15780075.
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    306. Johnson RJ, Rodriguez-Iturbe B, Kang DH, Feig DI, Herrera-Acosta J. A unifying pathway for essential hypertension. Am J Hypertens. 2005 Mar; 18(3):431-40. PMID: 15797666.
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    307. Short RA, Johnson RJ, Tuttle KR. Uric acid, microalbuminuria and cardiovascular events in high-risk patients. Am J Nephrol. 2005 Jan-Feb; 25(1):36-44. PMID: 15724081.
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    308. Nakagawa T, Lan HY, Glushakova O, Zhu HJ, Kang DH, Schreiner GF, Böttinger EP, Johnson RJ, Sautin YY. Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts. J Am Soc Nephrol. 2005 Apr; 16(4):899-904. PMID: 15716330.
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    309. Li QZ, Li P, Garcia GE, Johnson RJ, Feng L. Genomic profiling of neutrophil transcripts in Asian Qigong practitioners: a pilot study in gene regulation by mind-body interaction. J Altern Complement Med. 2005 Feb; 11(1):29-39. PMID: 15750361.
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    310. Johnson RJ, Rodriguez-Iturbe B, Nakagawa T, Kang DH, Feig DI, Herrera-Acosta J. Subtle renal injury is likely a common mechanism for salt-sensitive essential hypertension. Hypertension. 2005 Mar; 45(3):326-30. PMID: 15655117.
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    311. Sánchez-Lozada LG, Tapia E, Santamaría J, Avila-Casado C, Soto V, Nepomuceno T, Rodríguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats. Kidney Int. 2005 Jan; 67(1):237-47. PMID: 15610247.
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    312. Sánchez-Lozada LG, Tapia E, Rodríguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Hemodynamics of hyperuricemia. Semin Nephrol. 2005 Jan; 25(1):19-24. PMID: 15660330.
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    313. Johnson RJ, Titte S, Cade JR, Rideout BA, Oliver WJ. Uric acid, evolution and primitive cultures. Semin Nephrol. 2005 Jan; 25(1):3-8. PMID: 15660328.
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    314. Kang DH, Kang SW, Jeong HJ, Kim YS, Yang CW, Johnson RJ. Transplant graft vasculopathy: an emerging target for prevention and treatment of renal allograft dysfunction. Yonsei Med J. 2004 Dec 31; 45(6):1053-8. PMID: 15627297.
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    315. Kanellis J, Feig DI, Johnson RJ. Does asymptomatic hyperuricaemia contribute to the development of renal and cardiovascular disease? An old controversy renewed. Nephrology (Carlton). 2004 Dec; 9(6):394-9. PMID: 15663643.
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    316. Johnson RJ, Feig DI, Herrera-Acosta J, Kang DH. Resurrection of uric acid as a causal risk factor in essential hypertension. Hypertension. 2005 Jan; 45(1):18-20. PMID: 15557387.
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    317. Nakagawa T, Li JH, Garcia G, Mu W, Piek E, Böttinger EP, Chen Y, Zhu HJ, Kang DH, Schreiner GF, Lan HY, Johnson RJ. TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int. 2004 Aug; 66(2):605-13. PMID: 15253713.
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    318. Watanabe S, Mu W, Kahn A, Jing N, Li JH, Lan HY, Nakagawa T, Ohashi R, Johnson RJ. Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells. Am J Nephrol. 2004 Jul-Aug; 24(4):387-92. PMID: 15256805.
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    319. Kanellis J, Garcia GE, Li P, Parra G, Wilson CB, Rao Y, Han S, Smith CW, Johnson RJ, Wu JY, Feng L. Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Am J Pathol. 2004 Jul; 165(1):341-52. PMID: 15215188; PMCID: PMC1618548.
    320. Feig DI, Nakagawa T, Karumanchi SA, Oliver WJ, Kang DH, Finch J, Johnson RJ. Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int. 2004 Jul; 66(1):281-7. PMID: 15200435.
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    321. Srinivas TR, Herrera-Acosta J, Feig DI, Kang DH, Segal MS, Johnson RJ. Diuretic-induced hyperuricemia does not decrease cardiovascular risk. J Hypertens. 2004 Jul; 22(7):1415-7; author reply 1417-9. PMID: 15201561.
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    322. Nakagawa T, Lan HY, Zhu HJ, Kang DH, Schreiner GF, Johnson RJ. Differential regulation of VEGF by TGF-beta and hypoxia in rat proximal tubular cells. Am J Physiol Renal Physiol. 2004 Oct; 287(4):F658-64. PMID: 15187003.
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    323. Khosla UM, Johnson RJ. Hypertension in the hemodialysis patient and the "lag phenomenon": insights into pathophysiology and clinical management. Am J Kidney Dis. 2004 Apr; 43(4):739-51. PMID: 15042553.
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    324. Rodríguez-Iturbe B, Vaziri ND, Herrera-Acosta J, Johnson RJ. Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all. Am J Physiol Renal Physiol. 2004 Apr; 286(4):F606-16. PMID: 15001451.
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    325. Johnson RJ, Rideout BA. Uric acid and diet--insights into the epidemic of cardiovascular disease. N Engl J Med. 2004 Mar 11; 350(11):1071-3. PMID: 15014177.
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    326. Long DA, Price KL, Herrera-Acosta J, Johnson RJ. How does angiotensin II cause renal injury? Hypertension. 2004 Apr; 43(4):722-3. PMID: 14967828.
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    327. Ohashi R, Nakagawa T, Watanabe S, Kanellis J, Almirez RG, Schreiner GF, Johnson RJ. Inhibition of p38 mitogen-activated protein kinase augments progression of remnant kidney model by activating the ERK pathway. Am J Pathol. 2004 Feb; 164(2):477-85. PMID: 14742254; PMCID: PMC1602246.
    328. Kang DH, Finch J, Nakagawa T, Karumanchi SA, Kanellis J, Granger J, Johnson RJ. Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens. 2004 Feb; 22(2):229-35. PMID: 15076175.
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    329. Jefferson JA, Simoni J, Escudero E, Hurtado ME, Swenson ER, Wesson DE, Schreiner GF, Schoene RB, Johnson RJ, Hurtado A. Increased oxidative stress following acute and chronic high altitude exposure. High Alt Med Biol. 2004; 5(1):61-9. PMID: 15072717.
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    330. Kanellis J, Bick R, Garcia G, Truong L, Tsao CC, Etemadmoghadam D, Poindexter B, Feng L, Johnson RJ, Sheikh-Hamad D. Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis. Am J Physiol Renal Physiol. 2004 Feb; 286(2):F356-62. PMID: 14570698.
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    331. Taneda S, Hudkins KL, Topouzis S, Gilbertson DG, Ophascharoensuk V, Truong L, Johnson RJ, Alpers CE. Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury. J Am Soc Nephrol. 2003 Oct; 14(10):2544-55. PMID: 14514732.
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    332. Bravo J, Quiroz Y, Pons H, Parra G, Herrera-Acosta J, Johnson RJ, Rodríguez-Iturbe B. Vimentin and heat shock protein expression are induced in the kidney by angiotensin and by nitric oxide inhibition. Kidney Int Suppl. 2003 Oct; (86):S46-51. PMID: 12969127.
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    333. Quiroz Y, Bravo J, Herrera-Acosta J, Johnson RJ, Rodríguez-Iturbe B. Apoptosis and NFkappaB activation are simultaneously induced in renal tubulointerstitium in experimental hypertension. Kidney Int Suppl. 2003 Oct; (86):S27-32. PMID: 12969124.
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    334. Sánchez-Lozada LG, Tapia E, Johnson RJ, Rodríguez-Iturbe B, Herrera-Acosta J. Glomerular hemodynamic changes associated with arteriolar lesions and tubulointerstitial inflammation. Kidney Int Suppl. 2003 Oct; (86):S9-14. PMID: 12969121.
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    335. Johnson RJ, Hurtado A, Merszei J, Rodriguez-Iturbe B, Feng L. Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide. Am J Kidney Dis. 2003 Sep; 42(3):575-81. PMID: 12955687.
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    336. Feig DI, Johnson RJ. Hyperuricemia in childhood primary hypertension. Hypertension. 2003 Sep; 42(3):247-52. PMID: 12900431; PMCID: PMC1800942.
    337. Matsui K, Nagy-Bojarsky K, Laakkonen P, Krieger S, Mechtler K, Uchida S, Geleff S, Kang DH, Johnson RJ, Kerjaschki D, Kang DH. Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels. J Am Soc Nephrol. 2003 Aug; 14(8):1981-9. PMID: 12874451.
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    338. Kanellis J, Johnson RJ. Editorial comment--Elevated uric acid and ischemic stroke: accumulating evidence that it is injurious and not neuroprotective. Stroke. 2003 Aug; 34(8):1956-7. PMID: 12843345.
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    339. Garcia GE, Xia Y, Ku G, Johnson RJ, Wilson CB, Feng L. IL-18 translational inhibition restricts IFN-gamma expression in crescentic glomerulonephritis. Kidney Int. 2003 Jul; 64(1):160-9. PMID: 12787406.
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    340. Kanellis J, Nakagawa T, Herrera-Acosta J, Schreiner GF, Rodríguez-Iturbe B, Johnson RJ. A single pathway for the development of essential hypertension. Cardiol Rev. 2003 Jul-Aug; 11(4):180-96. PMID: 12852795.
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    341. Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol. 2003 Jun; 14(6):1535-48. PMID: 12761254.
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    342. Mazzali M, Jefferson JA, Ni Z, Vaziri ND, Johnson RJ. Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertension. Kidney Int. 2003 Jun; 63(6):2088-93. PMID: 12753295.
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    343. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, Wamsley A, Sheikh-Hamad D, Lan HY, Feng L, Johnson RJ. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003 Jun; 41(6):1287-93. PMID: 12743010.
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    344. Nakagawa T, Kang DH, Ohashi R, Suga S, Herrera-Acosta J, Rodriguez-Iturbe B, Johnson RJ. Tubulointerstitial disease: role of ischemia and microvascular disease. Curr Opin Nephrol Hypertens. 2003 May; 12(3):233-41. PMID: 12698060.
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    345. Hare JM, Johnson RJ. Uric acid predicts clinical outcomes in heart failure: insights regarding the role of xanthine oxidase and uric acid in disease pathophysiology. Circulation. 2003 Apr 22; 107(15):1951-3. PMID: 12707249.
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    346. Li JH, Huang XR, Zhu HJ, Oldfield M, Cooper M, Truong LD, Johnson RJ, Lan HY. Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. FASEB J. 2004 Jan; 18(1):176-8. PMID: 12709399.
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    347. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003 Jun; 41(6):1183-90. PMID: 12707287.
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    348. Garcia GE, Xia Y, Harrison J, Wilson CB, Johnson RJ, Bacon KB, Feng L. Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis. Am J Pathol. 2003 Apr; 162(4):1061-73. PMID: 12651599; PMCID: PMC1851244.
    349. Suga S, Yasui N, Yoshihara F, Horio T, Kawano Y, Kangawa K, Johnson RJ. Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms. J Am Soc Nephrol. 2003 Feb; 14(2):397-406. PMID: 12538740.
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    350. Kang DH, Johnson RJ. Vascular endothelial growth factor: a new player in the pathogenesis of renal fibrosis. Curr Opin Nephrol Hypertens. 2003 Jan; 12(1):43-9. PMID: 12496665.
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    351. Wesson JA, Johnson RJ, Mazzali M, Beshensky AM, Stietz S, Giachelli C, Liaw L, Alpers CE, Couser WG, Kleinman JG, Hughes J. Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. J Am Soc Nephrol. 2003 Jan; 14(1):139-47. PMID: 12506146.
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    352. Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, Rodriguez-Iturbe B, Herrera-Acosta J, Johnson RJ. Hyperuricemia causes glomerular hypertrophy in the rat. Am J Nephrol. 2003 Jan-Feb; 23(1):2-7. PMID: 12373074.
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    353. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002 Dec; 13(12):2888-97. PMID: 12444207.
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    354. Sánchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaría J, Nakagawa T, Rodríguez-Iturbe B, Johnson RJ, Herrera-Acosta J. Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1105-10. PMID: 12372787.
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    355. Nangaku M, Yamada K, Gariepy CE, Miyata T, Inagi R, Kurokawa K, Yanagisawa M, Fujita T, Johnson RJ. ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy. Kidney Int. 2002 Sep; 62(3):922-8. PMID: 12164874.
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    356. Watanabe S, Kang DH, Feng L, Nakagawa T, Kanellis J, Lan H, Mazzali M, Johnson RJ. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension. 2002 Sep; 40(3):355-60. PMID: 12215479.
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    357. Kang DH, Nakagawa T, Feng L, Johnson RJ. Nitric oxide modulates vascular disease in the remnant kidney model. Am J Pathol. 2002 Jul; 161(1):239-48. PMID: 12107108; PMCID: PMC1850677.
    358. Mazzali M, Hughes J, Dantas M, Liaw L, Steitz S, Alpers CE, Pichler RH, Lan HY, Giachelli CM, Shankland SJ, Couser WG, Johnson RJ. Effects of cyclosporine in osteopontin null mice. Kidney Int. 2002 Jul; 62(1):78-85. PMID: 12081566.
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    359. Rodríguez-Iturbe B, Quiroz Y, Herrera-Acosta J, Johnson RJ, Pons HA. The role of immune cells infiltrating the kidney in the pathogenesis of salt-sensitive hypertension. J Hypertens Suppl. 2002 Jun; 20(3):S9-14. PMID: 12184057.
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    360. Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lan HY. Smad7 inhibits fibrotic effect of TGF-Beta on renal tubular epithelial cells by blocking Smad2 activation. J Am Soc Nephrol. 2002 Jun; 13(6):1464-72. PMID: 12039975.
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    361. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F991-7. PMID: 11997315.
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    362. Johnson RJ, Rodríguez-Iturbe B, Schreiner GF, Herrera-Acosta J. Hypertension: a microvascular and tubulointerstitial disease. J Hypertens Suppl. 2002 Jun; 20(3):S1-7. PMID: 12184051.
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    363. Jefferson JA, Escudero E, Hurtado ME, Kelly JP, Swenson ER, Wener MH, Burnier M, Maillard M, Schreiner GF, Schoene RB, Hurtado A, Johnson RJ. Hyperuricemia, hypertension, and proteinuria associated with high-altitude polycythemia. Am J Kidney Dis. 2002 Jun; 39(6):1135-42. PMID: 12046023.
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    364. Hugo C, Kang DH, Johnson RJ. Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model. Nephron. 2002 Apr; 90(4):460-70. PMID: 11961406.
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    365. Johnson RJ, Herrera-Acosta J, Schreiner GF, Rodriguez-Iturbe B. Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N Engl J Med. 2002 Mar 21; 346(12):913-23. PMID: 11907292.
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    366. Kang DH, Kanellis J, Hugo C, Truong L, Anderson S, Kerjaschki D, Schreiner GF, Johnson RJ. Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol. 2002 Mar; 13(3):806-16. PMID: 11856789.
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    367. Suga S, Mazzali M, Ray PE, Kang DH, Johnson RJ. Angiotensin II type 1 receptor blockade ameliorates tubulointerstitial injury induced by chronic potassium deficiency. Kidney Int. 2002 Mar; 61(3):951-8. PMID: 11849449.
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    368. Jefferson JA, Escudero E, Hurtado ME, Pando J, Tapia R, Swenson ER, Prchal J, Schreiner GF, Schoene RB, Hurtado A, Johnson RJ. Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels. Lancet. 2002 Feb 02; 359(9304):407-8. PMID: 11844517.
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    369. Rodríguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chávez M, Herrera-Acosta J, Johnson RJ, Pons HA. Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol. 2002 Feb; 282(2):F191-201. PMID: 11788432.
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